4x3p
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Sirt2 in complex with a myristoyl peptide== |
| - | + | <StructureSection load='4x3p' size='340' side='right' caption='[[4x3p]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4x3p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X3P FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3LX:TRIDECANETHIAL'>3LX</scene>, <scene name='pdbligand=CNA:CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>CNA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x3o|4x3o]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x3p OCA], [http://pdbe.org/4x3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x3p RCSB], [http://www.ebi.ac.uk/pdbsum/4x3p PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN]] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Hao, Q]] | [[Category: Hao, Q]] | ||
| - | [[Category: Zhang, W]] | ||
[[Category: Wang, Y]] | [[Category: Wang, Y]] | ||
| + | [[Category: Zhang, W]] | ||
| + | [[Category: Hydrolase-peptide complex]] | ||
| + | [[Category: Myristoyl peptide]] | ||
| + | [[Category: Sirt2]] | ||
Revision as of 20:21, 13 January 2016
Sirt2 in complex with a myristoyl peptide
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