4cpc

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(Difference between revisions)

Revision as of 20:19, 11 August 2016

Crystal structure of human synaptonemal complex protein SYCP3

Structural highlights

4cpc is a 8 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[SYCP3_HUMAN] Male infertility with normal virilization due to meiosis defect. The disease is caused by mutations affecting the gene represented in this entry.

Function

[SYCP3_HUMAN] Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).^[1]

Publication Abstract from PubMed

The synaptonemal complex (SC) is an evolutionarily-conserved protein assembly that holds together homologous chromosomes during prophase of the first meiotic division. Whilst essential for meiosis and fertility, the molecular structure of the SC has proved resistant to elucidation. The SC protein SYCP3 has a crucial but poorly understood role in establishing the architecture of the meiotic chromosome. Here we show that human SYCP3 forms a highly-elongated helical tetramer of 20 nm length. N-terminal sequences extending from each end of the rod-like structure bind double-stranded DNA, enabling SYCP3 to link distant sites along the sister chromatid. We further find that SYCP3 self-assembles into regular filamentous structures that resemble the known morphology of the SC lateral element. Together, our data form the basis for a model in which SYCP3 binding and assembly on meiotic chromosomes leads to their organisation into compact structures compatible with recombination and crossover formation.

A molecular model for the role of SYCP3 in meiotic chromosome organisation.,Syrjanen JL, Pellegrini L, Davies OR Elife. 2014 Jun 20:e02963. doi: 10.7554/eLife.02963. PMID:24950965^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Miyamoto T, Hasuike S, Yogev L, Maduro MR, Ishikawa M, Westphal H, Lamb DJ. Azoospermia in patients heterozygous for a mutation in SYCP3. Lancet. 2003 Nov 22;362(9397):1714-9. PMID:14643120 doi:http://dx.doi.org/S0140-6736(03)14845-3
↑ Syrjanen JL, Pellegrini L, Davies OR. A molecular model for the role of SYCP3 in meiotic chromosome organisation. Elife. 2014 Jun 20:e02963. doi: 10.7554/eLife.02963. PMID:24950965 doi:http://dx.doi.org/10.7554/eLife.02963

1 Structural highlights
2 Disease
3 Function
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/4cpc"

@@ Line 1: / Line 1: @@
 ==Crystal structure of human synaptonemal complex protein SYCP3==
 <StructureSection load='4cpc' size='340' side='right' caption='[[4cpc]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[4cpc]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CPC FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cpc RCSB], [http://www.ebi.ac.uk/pdbsum/4cpc PDBsum]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cpc OCA], [http://pdbe.org/4cpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cpc RCSB], [http://www.ebi.ac.uk/pdbsum/4cpc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cpc ProSAT]</span></td></tr>
 </table>
 == Disease ==
@@ Line 17: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4cpc" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>

4cpc

From Proteopedia

Revision as of 20:19, 11 August 2016

Crystal structure of human synaptonemal complex protein SYCP3

Structural highlights

Disease

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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