2n4q

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==Solution NMR structure of CBX8 in complex with AF9 (CBX8-AF9)==
==Solution NMR structure of CBX8 in complex with AF9 (CBX8-AF9)==
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<StructureSection load='2n4q' size='340' side='right'caption='[[2n4q]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='2n4q' size='340' side='right'caption='[[2n4q]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2n4q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N4Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2n4q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N4Q FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mv7|2mv7]], [[2lm0|2lm0]]</div></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n4q OCA], [https://pdbe.org/2n4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n4q RCSB], [https://www.ebi.ac.uk/pdbsum/2n4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n4q ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CBX8, PC3, RC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), MLLT3, AF9, YEATS3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n4q OCA], [https://pdbe.org/2n4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n4q RCSB], [https://www.ebi.ac.uk/pdbsum/2n4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n4q ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
 
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[[https://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN]] A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein.
 
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN]] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref>
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[https://www.uniprot.org/uniprot/CBX8_HUMAN CBX8_HUMAN]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bushweller, J H]]
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[[Category: Bushweller JH]]
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[[Category: Kuntimaddi, A]]
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[[Category: Kuntimaddi A]]
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[[Category: Leach, B I]]
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[[Category: Leach BI]]
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[[Category: Af4]]
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[[Category: Af9]]
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[[Category: Cbx8]]
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[[Category: Chromobox homolog 8]]
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[[Category: Dot1l]]
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[[Category: H3k27me3]]
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[[Category: Hpc3]]
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[[Category: Idp]]
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[[Category: Intrinsically disordered protein]]
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[[Category: Leukemia]]
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[[Category: Mixed lineage leukemia]]
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[[Category: Mll]]
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[[Category: Mll-af9]]
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[[Category: Mllt3]]
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[[Category: Polycomb]]
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[[Category: Polycomb group protein]]
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[[Category: Prc1]]
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[[Category: Transcription]]
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Revision as of 10:18, 15 March 2023

Solution NMR structure of CBX8 in complex with AF9 (CBX8-AF9)

PDB ID 2n4q

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