4zk4

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<StructureSection load='4zk4' size='340' side='right'caption='[[4zk4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4zk4' size='340' side='right'caption='[[4zk4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zk4]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZK4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zk4]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZK4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TII:(5R)-1-METHYL-7-[5-(PROPAN-2-YLOXY)PYRIDIN-3-YL]-1,7-DIAZASPIRO[4.4]NONANE'>TII</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TII:(5R)-1-METHYL-7-[5-(PROPAN-2-YLOXY)PYRIDIN-3-YL]-1,7-DIAZASPIRO[4.4]NONANE'>TII</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zjt|4zjt]], [[4zk1|4zk1]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zk4 OCA], [https://pdbe.org/4zk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zk4 RCSB], [https://www.ebi.ac.uk/pdbsum/4zk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zk4 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHRNA3, NACHRA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6500 APLCA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zk4 OCA], [http://pdbe.org/4zk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4zk4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zk4 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACHA3_HUMAN ACHA3_HUMAN] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.[https://www.uniprot.org/uniprot/Q8WSF8_APLCA Q8WSF8_APLCA]
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==See Also==
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*[[Acetylcholine binding protein 3D structures|Acetylcholine binding protein 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aplca]]
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[[Category: Aplysia californica]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bobango, J]]
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[[Category: Bobango J]]
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[[Category: Talley, T T]]
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[[Category: Talley TT]]
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[[Category: Wu, J]]
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[[Category: Wu J]]
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[[Category: Acetylcholine]]
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[[Category: Acetylcholine binding protein]]
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[[Category: Achbp]]
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[[Category: Nicotinic]]
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[[Category: Receptor]]
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Revision as of 07:31, 18 May 2023

Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with 7-(5-isopropoxy-pyridin-3-yl)-1-methyl-1,7-diaza-spiro[4.4]nonane

PDB ID 4zk4

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