1ofc
From Proteopedia
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[[Image:1ofc.gif|left|200px]] | [[Image:1ofc.gif|left|200px]] | ||
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'''NUCLEOSOME RECOGNITION MODULE OF ISWI ATPASE''' | '''NUCLEOSOME RECOGNITION MODULE OF ISWI ATPASE''' | ||
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[[Category: Grune, T.]] | [[Category: Grune, T.]] | ||
[[Category: Muller, C W.]] | [[Category: Muller, C W.]] | ||
| - | [[Category: | + | [[Category: Atpase]] |
| - | [[Category: | + | [[Category: Chromatin remodeling factor]] |
| - | [[Category: | + | [[Category: Iswi]] |
| - | [[Category: | + | [[Category: Nucleosome recognition]] |
| - | [[Category: | + | [[Category: Sant domain]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:46:39 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 00:46, 3 May 2008
NUCLEOSOME RECOGNITION MODULE OF ISWI ATPASE
Overview
Energy-dependent nucleosome remodeling emerges as a key process endowing chromatin with dynamic properties. However, the principles by which remodeling ATPases interact with their nucleosome substrate to alter histone-DNA interactions are only poorly understood. We have identified a substrate recognition domain in the C-terminal half of the remodeling ATPase ISWI and determined its structure by X-ray crystallography. The structure comprises three domains, a four-helix domain with a novel fold and two alpha-helical domains related to the modules of c-Myb, SANT and SLIDE, which are linked by a long helix. An integrated structural and functional analysis of these domains provides insight into how ISWI interacts with the nucleosomal substrate.
About this Structure
1OFC is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWI., Grune T, Brzeski J, Eberharter A, Clapier CR, Corona DF, Becker PB, Muller CW, Mol Cell. 2003 Aug;12(2):449-60. PMID:14536084 Page seeded by OCA on Sat May 3 03:46:39 2008
