8vjs
From Proteopedia
(Difference between revisions)
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| - | == | + | ==Cryo-EM structure of Tulane virus 9-6-17 variant capsid protein VP1 9-14-18 without DTT treatment== |
| - | <StructureSection load='8vjs' size='340' side='right'caption='[[8vjs]]' scene=''> | + | <StructureSection load='8vjs' size='340' side='right'caption='[[8vjs]], [[Resolution|resolution]] 2.73Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VJS FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[8vjs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Tulane_virus Tulane virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VJS FirstGlance]. <br> |
| - | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.73Å</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vjs OCA], [https://pdbe.org/8vjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vjs RCSB], [https://www.ebi.ac.uk/pdbsum/8vjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vjs ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vjs OCA], [https://pdbe.org/8vjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vjs RCSB], [https://www.ebi.ac.uk/pdbsum/8vjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vjs ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Human noroviruses (HuNoVs) are a major cause of acute gastroenteritis, contributing significantly to annual foodborne illness cases. However, studying these viruses has been challenging due to limitations in tissue culture techniques for over four decades. Tulane virus (TV) has emerged as a crucial surrogate for HuNoVs due to its close resemblance in amino acid composition and the availability of a robust cell culture system. Initially isolated from rhesus macaques in 2008, TV represents a novel Calicivirus belonging to the Recovirus genus. Its significance lies in sharing the same host cell receptor, histo-blood group antigen (HBGA), as HuNoVs. In this study, we introduce, through cryo-electron microscopy (cryo-EM), the structure of a specific TV variant (the 9-6-17 TV) that has notably lost its ability to bind to its receptor, B-type HBGA-a finding confirmed using an enzyme-linked immunosorbent assay (ELISA). These results offer a profound insight into the genetic modifications occurring in TV that are necessary for adaptation to cell culture environments. This research significantly contributes to advancing our understanding of the genetic changes that are pivotal to successful adaptation, shedding light on fundamental aspects of Calicivirus evolution. | ||
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| + | The 2.6 A Structure of a Tulane Virus Variant with Minor Mutations Leading to Receptor Change.,Sun C, Huang P, Xu X, Vago FS, Li K, Klose T, Jiang XJ, Jiang W Biomolecules. 2024 Jan 16;14(1):119. doi: 10.3390/biom14010119. PMID:38254719<ref>PMID:38254719</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 8vjs" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Tulane virus]] |
| + | [[Category: Jiang W]] | ||
| + | [[Category: Sun C]] | ||
Current revision
Cryo-EM structure of Tulane virus 9-6-17 variant capsid protein VP1 9-14-18 without DTT treatment
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