1ysy

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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam08716 nsp7]</span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ysy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysy OCA], [http://www.ebi.ac.uk/pdbsum/1ysy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ysy RCSB]</span>
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'''NMR Structure of the nonstructural Protein 7 (nsP7) from the SARS CoronaVirus'''
'''NMR Structure of the nonstructural Protein 7 (nsP7) from the SARS CoronaVirus'''
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Revision as of 13:44, 3 May 2008

Image:1ysy.gif

Template:STRUCTURE 1ysy

NMR Structure of the nonstructural Protein 7 (nsP7) from the SARS CoronaVirus


Overview

Here, we report the three-dimensional structure of severe acute respiratory syndrome coronavirus (SARS-CoV) nsP7, a component of the SARS-CoV replicase polyprotein. The coronavirus replicase carries out regulatory tasks involved in the maintenance, transcription, and replication of the coronavirus genome. nsP7 was found to assume a compact architecture in solution, which is comprised primarily of helical secondary structures. Three helices (alpha2 to alpha4) form a flat up-down-up antiparallel alpha-helix sheet. The N-terminal segment of residues 1 to 22, containing two turns of alpha-helix and one turn of 3(10)-helix, is packed across the surface of alpha2 and alpha3 in the helix sheet, with the alpha-helical region oriented at a 60 degrees angle relative to alpha2 and alpha3. The surface charge distribution is pronouncedly asymmetrical, with the flat surface of the helical sheet showing a large negatively charged region adjacent to a large hydrophobic patch and the opposite side containing a positively charged groove that extends along the helix alpha1. Each of these three areas is thus implicated as a potential site for protein-protein interactions.

About this Structure

1YSY is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.

Reference

Structural genomics of the severe acute respiratory syndrome coronavirus: nuclear magnetic resonance structure of the protein nsP7., Peti W, Johnson MA, Herrmann T, Neuman BW, Buchmeier MJ, Nelson M, Joseph J, Page R, Stevens RC, Kuhn P, Wuthrich K, J Virol. 2005 Oct;79(20):12905-13. PMID:16188992 Page seeded by OCA on Sat May 3 16:44:48 2008

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