2nms
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(New page: 200px<br /> <applet load="2nms" size="450" color="white" frame="true" align="right" spinBox="true" caption="2nms, resolution 2.60Å" /> '''The Crystal Structu...)
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Revision as of 20:53, 12 November 2007
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The Crystal Structure of the Extracellular Domain of the Inhibitor Receptor Expressed on Myeloid Cells IREM-1
Overview
The immune receptors expressed on myeloid cells (IREM) are type I, transmembrane proteins encoded on human chromosome 17 (17q25.1), whose, function is believed to be important in controlling inflammation. To date, three IREM receptors have been identified. IREM-1 functions as an, inhibitory receptor, whereas IREM-2 and IREM-3 serve an activating, function. Here, we report the crystal structure of IREM-1 extracellular, domain at 2.6 A resolution. The overall fold of IREM-1 resembles that of a, V-type immunoglobulin domain, and reveals overall close homology with, immunoglobulin domains from other immunoreceptors such as CLM-1, TREM-1, TLT-1 and NKp44. Comparing the surface electrostatic potential and, hydrophobicity of IREM-1 with its murine homologous CLM-1, we observed, unique structural properties for the complementary determining region of, IREM-1, which suggests that they may be involved in recognition of the, IREM-1 ligand. Particularly interesting is the structural conformation and, physical properties of the antibody's equivalent CDR3 loop, which we show, to be a structurally variable region of the molecule and therefore could, be the main structural determinant for ligand discrimination and binding., In addition, the analysis of the IREM-1 structure revealed the presence of, four structurally different cavities. Three of these cavities form a, continuous hydrophobic groove on the IREM-1 surface, which point to a, region of the molecule capable of accommodating potential ligands.
About this Structure
2NMS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The Crystal Structure of the Extracellular Domain of the Inhibitor Receptor Expressed on Myeloid Cells IREM-1., Marquez JA, Galfre E, Dupeux F, Flot D, Moran O, Dimasi N, J Mol Biol. 2007 Mar 23;367(2):310-8. Epub 2007 Jan 10. PMID:17275839
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