1ahp

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[[Image:1ahp.gif|left|200px]]
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{{STRUCTURE_1ahp| PDB=1ahp | SCENE= }}
{{STRUCTURE_1ahp| PDB=1ahp | SCENE= }}
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'''OLIGOSACCHARIDE SUBSTRATE BINDING IN ESCHERICHIA COLI MALTODEXTRIN PHSPHORYLASE'''
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===OLIGOSACCHARIDE SUBSTRATE BINDING IN ESCHERICHIA COLI MALTODEXTRIN PHSPHORYLASE===
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==Overview==
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The crystal structure of E. coli maltodextrin phosphorylase co-crystallized with an oligosaccharide has been solved at 3.0 A resolution, providing the first structure of an oligosaccharide bound at the catalytic site of an alpha-glucan phosphorylase. An induced fit mechanism brings together two domains across the catalytic site tunnel. A stacking interaction between the glucosyl residue and the aromatic group of a tyrosine residue at a sub-site remote (8 A) from the catalytic site provides a key element in substrate recognition; mutation of this residue to Ala decreases the Kcat/Km by 10(4). Extrapolation of the results to substrate binding across the site of attack by phosphorolysis indicates a likely alteration in the glycosidic torsion angles from their preferred values, an alteration that appears to be important for the catalytic mechanism.
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(as it appears on PubMed at http://www.pubmed.gov), where 9145112 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9145112}}
==About this Structure==
==About this Structure==
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[[Category: Stacking]]
[[Category: Stacking]]
[[Category: Substrate]]
[[Category: Substrate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:17:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:52:34 2008''

Revision as of 13:52, 30 June 2008

Image:1ahp.png

Template:STRUCTURE 1ahp

OLIGOSACCHARIDE SUBSTRATE BINDING IN ESCHERICHIA COLI MALTODEXTRIN PHSPHORYLASE

Template:ABSTRACT PUBMED 9145112

About this Structure

1AHP is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Oligosaccharide substrate binding in Escherichia coli maltodextrin phosphorylase., O'Reilly M, Watson KA, Schinzel R, Palm D, Johnson LN, Nat Struct Biol. 1997 May;4(5):405-12. PMID:9145112

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