1fbv

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[[Image:1fbv.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1fbv| PDB=1fbv | SCENE= }}
{{STRUCTURE_1fbv| PDB=1fbv | SCENE= }}
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'''STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES'''
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===STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES===
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==Overview==
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Ubiquitin-protein ligases (E3s) regulate diverse cellular processes by mediating protein ubiquitination. The c-Cbl proto-oncogene is a RING family E3 that recognizes activated receptor tyrosine kinases, promotes their ubiquitination by a ubiquitin-conjugating enzyme (E2) and terminates signaling. The crystal structure of c-Cbl bound to a cognate E2 and a kinase peptide shows how the RING domain recruits the E2. A comparison with a HECT family E3-E2 complex indicates that a common E2 motif is recognized by the two E3 families. The structure reveals a rigid coupling between the peptide binding and the E2 binding domains and a conserved surface channel leading from the peptide to the E2 active site, suggesting that RING E3s may function as scaffolds that position the substrate and the E2 optimally for ubiquitin transfer.
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The line below this paragraph, {{ABSTRACT_PUBMED_10966114}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10966114 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10966114}}
==About this Structure==
==About this Structure==
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[[Category: Ubiquitination]]
[[Category: Ubiquitination]]
[[Category: Zap-70]]
[[Category: Zap-70]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:08:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:00:58 2008''

Revision as of 00:01, 1 July 2008

Image:1fbv.png

Template:STRUCTURE 1fbv

STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES

Template:ABSTRACT PUBMED 10966114

About this Structure

1FBV is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases., Zheng N, Wang P, Jeffrey PD, Pavletich NP, Cell. 2000 Aug 18;102(4):533-9. PMID:10966114

Page seeded by OCA on Tue Jul 1 03:00:58 2008

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