1hcd

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[[Image:1hcd.jpg|left|200px]]
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{{STRUCTURE_1hcd| PDB=1hcd | SCENE= }}
{{STRUCTURE_1hcd| PDB=1hcd | SCENE= }}
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'''STRUCTURE OF HISACTOPHILIN IS SIMILAR TO INTERLEUKIN-1 BETA AND FIBROBLAST GROWTH FACTOR'''
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===STRUCTURE OF HISACTOPHILIN IS SIMILAR TO INTERLEUKIN-1 BETA AND FIBROBLAST GROWTH FACTOR===
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==Overview==
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The fast reaction of the actin-based cytoskeleton in motile cells after stimulation with a chemoattractant requires a signal-transduction chain that creates a very specific environment at distinct regions beneath the plasma membrane. Dictyostelium hisactophilin, a unique actin-binding protein, is a submembranous pH sensor that signals slight changes of the H+ concentration to actin by inducing actin polymerization and binding to microfilaments only at pH values below seven. It has a relative molecular mass of 13.5K and its most unusual feature is the presence of 31 histidine residues among its total of 118 amino acids. The transduction of an external signal from the plasma membrane to the cytoskeleton is poorly understood. Here we report the protein's structure in solution determined by nuclear magnetic resonance spectroscopy. The nuclear Overhauser effect intensities of the three-dimensional nuclear Overhauser spectra were used directly in the calculations. The overall folding of histactophilin is similar to that of interleukin-1 beta and fibroblast growth factor, but the primary amino-acid sequence of hisactophilin is unrelated to these two proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 1436061 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1436061}}
==About this Structure==
==About this Structure==
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1HCD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCD OCA].
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1HCD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCD OCA].
==Reference==
==Reference==
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[[Category: Wiltscheck, R.]]
[[Category: Wiltscheck, R.]]
[[Category: Actin binding]]
[[Category: Actin binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:41:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 07:58:44 2008''

Revision as of 04:58, 1 July 2008

Image:1hcd.png

Template:STRUCTURE 1hcd

STRUCTURE OF HISACTOPHILIN IS SIMILAR TO INTERLEUKIN-1 BETA AND FIBROBLAST GROWTH FACTOR

Template:ABSTRACT PUBMED 1436061

About this Structure

1HCD is a Single protein structure of sequence from Dictyostelium discoideum. Full experimental information is available from OCA.

Reference

Structure of hisactophilin is similar to interleukin-1 beta and fibroblast growth factor., Habazettl J, Gondol D, Wiltscheck R, Otlewski J, Schleicher M, Holak TA, Nature. 1992 Oct 29;359(6398):855-8. PMID:1436061

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