1itp

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{{STRUCTURE_1itp| PDB=1itp | SCENE= }}
{{STRUCTURE_1itp| PDB=1itp | SCENE= }}
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'''Solution Structure of POIA1'''
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===Solution Structure of POIA1===
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==Overview==
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Solution structure of POIA1 (Pleurotus ostreatus proteinase A inhibitor 1), which functions as an intramolecular chaperone and as an inhibitor to subtilisin, was determined. By making use of the fact that POIA1 is the only structured protein that shows homology to the propeptide of subtilisin, which is unstructured by itself, foldability of this protein was elucidated. It became clear that the evolutionarily conserved residues play two important roles, one for the maintenance of its own structure, and the other for the interaction with subtilisin. Structural softness and mutational tolerance contained in the POIA1 structure makes it an ideal material for designing a foldable protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 11916386 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11916386}}
==About this Structure==
==About this Structure==
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1ITP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pleurotus_ostreatus Pleurotus ostreatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ITP OCA].
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1ITP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pleurotus_ostreatus Pleurotus ostreatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ITP OCA].
==Reference==
==Reference==
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Propeptide]]
[[Category: Propeptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:24:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:58:57 2008''

Revision as of 10:58, 1 July 2008

Image:1itp.png

Template:STRUCTURE 1itp

Solution Structure of POIA1

Template:ABSTRACT PUBMED 11916386

About this Structure

1ITP is a Single protein structure of sequence from Pleurotus ostreatus. Full experimental information is available from OCA.

Reference

Structure of POIA1, a homologous protein to the propeptide of subtilisin: implication for protein foldability and the function as an intramolecular chaperone., Sasakawa H, Yoshinaga S, Kojima S, Tamura A, J Mol Biol. 2002 Mar 15;317(1):159-67. PMID:11916386

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