1k8h

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[[Image:1k8h.gif|left|200px]]
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{{STRUCTURE_1k8h| PDB=1k8h | SCENE= }}
{{STRUCTURE_1k8h| PDB=1k8h | SCENE= }}
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'''NMR Structure of Small Protein B (SmpB) from Aquifex aeolicus'''
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===NMR Structure of Small Protein B (SmpB) from Aquifex aeolicus===
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==Overview==
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Small protein B (SmpB) is an essential component of the highly conserved tmRNA-SmpB system that has the dual function of releasing stalled ribosomes from damaged messenger RNAs and targeting incompletely synthesized protein fragments for degradation. Nuclear magnetic resonance (NMR) analysis of SmpB from Aquifex aeolicus revealed an antiparallel beta-barrel structure, with three helices packed outside the core of the barrel. While the overall structure of SmpB appears to be unique, the structure does contain an embedded oligonucleotide binding fold; in this respect SmpB has similarity to several other RNA-binding proteins that are known to be associated with translation, including IF1, ribosomal protein S17 and the N-terminal domain of aspartyl tRNA synthetase. Conserved amino acids on the protein surface that are most likely to directly interact with the tmRNA were identified. The presence of widely separated clusters of conserved amino acids suggests that SmpB could function either by stabilizing two distal regions of the tmRNA, or by facilitating an interaction between the tmRNA and another component of the translational apparatus.
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The line below this paragraph, {{ABSTRACT_PUBMED_11927568}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11927568 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11927568}}
==About this Structure==
==About this Structure==
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1K8H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8H OCA].
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1K8H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8H OCA].
==Reference==
==Reference==
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[[Category: Smpb]]
[[Category: Smpb]]
[[Category: Ssra associated protein]]
[[Category: Ssra associated protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:25:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:56:36 2008''

Revision as of 06:56, 2 July 2008

Image:1k8h.png

Template:STRUCTURE 1k8h

NMR Structure of Small Protein B (SmpB) from Aquifex aeolicus

Template:ABSTRACT PUBMED 11927568

About this Structure

1K8H is a Single protein structure of sequence from Aquifex aeolicus. Full experimental information is available from OCA.

Reference

Structure of small protein B: the protein component of the tmRNA-SmpB system for ribosome rescue., Dong G, Nowakowski J, Hoffman DW, EMBO J. 2002 Apr 2;21(7):1845-54. PMID:11927568

Page seeded by OCA on Wed Jul 2 09:56:36 2008

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