1x1v

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[[Image:1x1v.gif|left|200px]]
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{{STRUCTURE_1x1v| PDB=1x1v | SCENE= }}
{{STRUCTURE_1x1v| PDB=1x1v | SCENE= }}
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'''Structure Of Banana Lectin- Methyl-Alpha-Mannose Complex'''
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===Structure Of Banana Lectin- Methyl-Alpha-Mannose Complex===
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==Overview==
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The crystal structure of a complex of methyl-alpha-D-mannoside with banana lectin from Musa paradisiaca reveals two primary binding sites in the lectin, unlike in other lectins with beta-prism I fold which essentially consists of three Greek key motifs. It has been suggested that the fold evolved through successive gene duplication and fusion of an ancestral Greek key motif. In other lectins, all from dicots, the primary binding site exists on one of the three motifs in the three-fold symmetric molecule. Banana is a monocot, and the three motifs have not diverged enough to obliterate sequence similarity among them. Two Greek key motifs in it carry one primary binding site each. A common secondary binding site exists on the third Greek key. Modelling shows that both the primary sites can support 1-2, 1-3, and 1-6 linked mannosides with the second residue interacting in each case primarily with the secondary binding site. Modelling also readily leads to a bound branched mannopentose with the nonreducing ends of the two branches anchored at the two primary binding sites, providing a structural explanation for the lectin's specificity for branched alpha-mannans. A comparison of the dimeric banana lectin with other beta-prism I fold lectins, provides interesting insights into the variability in their quaternary structure.
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The line below this paragraph, {{ABSTRACT_PUBMED_15958419}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15958419 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15958419}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Unusual sugar specificity of banana lectin from Musa paradisiaca and its probable evolutionary origin. Crystallographic and modelling studies., Singh DD, Saikrishnan K, Kumar P, Surolia A, Sekar K, Vijayan M, Glycobiology. 2005 Oct;15(10):1025-32. Epub 2005 Jun 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15958419 15958419]
Unusual sugar specificity of banana lectin from Musa paradisiaca and its probable evolutionary origin. Crystallographic and modelling studies., Singh DD, Saikrishnan K, Kumar P, Surolia A, Sekar K, Vijayan M, Glycobiology. 2005 Oct;15(10):1025-32. Epub 2005 Jun 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15958419 15958419]
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Purification, crystallization and preliminary X-ray structure analysis of the banana lectin from Musa paradisiaca., Singh DD, Saikrishnan K, Kumar P, Dauter Z, Sekar K, Surolia A, Vijayan M, Acta Crystallogr D Biol Crystallogr. 2004 Nov;60(Pt 11):2104-6. Epub 2004, Oct 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15502341 15502341]
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Structural basis for the carbohydrate specificities of artocarpin: variation in the length of a loop as a strategy for generating ligand specificity., Jeyaprakash AA, Srivastav A, Surolia A, Vijayan M, J Mol Biol. 2004 May 7;338(4):757-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15099743 15099743]
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Crystal structures of artocarpin, a Moraceae lectin with mannose specificity, and its complex with methyl-alpha-D-mannose: implications to the generation of carbohydrate specificity., Pratap JV, Jeyaprakash AA, Rani PG, Sekar K, Surolia A, Vijayan M, J Mol Biol. 2002 Mar 22;317(2):237-47. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11902840 11902840]
[[Category: Musa acuminata]]
[[Category: Musa acuminata]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Beta prism-i fold]]
[[Category: Beta prism-i fold]]
[[Category: Mannose specific]]
[[Category: Mannose specific]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:25:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:34:34 2008''

Revision as of 11:34, 28 July 2008

Image:1x1v.png

Template:STRUCTURE 1x1v

Structure Of Banana Lectin- Methyl-Alpha-Mannose Complex

Template:ABSTRACT PUBMED 15958419

About this Structure

1X1V is a Single protein structure of sequence from Musa acuminata. Full crystallographic information is available from OCA.

Reference

Unusual sugar specificity of banana lectin from Musa paradisiaca and its probable evolutionary origin. Crystallographic and modelling studies., Singh DD, Saikrishnan K, Kumar P, Surolia A, Sekar K, Vijayan M, Glycobiology. 2005 Oct;15(10):1025-32. Epub 2005 Jun 15. PMID:15958419

Purification, crystallization and preliminary X-ray structure analysis of the banana lectin from Musa paradisiaca., Singh DD, Saikrishnan K, Kumar P, Dauter Z, Sekar K, Surolia A, Vijayan M, Acta Crystallogr D Biol Crystallogr. 2004 Nov;60(Pt 11):2104-6. Epub 2004, Oct 20. PMID:15502341

Structural basis for the carbohydrate specificities of artocarpin: variation in the length of a loop as a strategy for generating ligand specificity., Jeyaprakash AA, Srivastav A, Surolia A, Vijayan M, J Mol Biol. 2004 May 7;338(4):757-70. PMID:15099743

Crystal structures of artocarpin, a Moraceae lectin with mannose specificity, and its complex with methyl-alpha-D-mannose: implications to the generation of carbohydrate specificity., Pratap JV, Jeyaprakash AA, Rani PG, Sekar K, Surolia A, Vijayan M, J Mol Biol. 2002 Mar 22;317(2):237-47. PMID:11902840

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