1k8s

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Revision as of 22:49, 24 November 2007

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BULGED ADENOSINE IN AN RNA DUPLEX

Overview

Bulges are common structural motifs in RNA secondary structure and are, thought to play important roles in RNA-protein and RNA-drug interactions., Adenosine bases are the most commonly occurring unpaired base in double, helical RNA secondary structures. The solution conformation and dynamics, of a 25-nucleotide RNA duplex containing an unpaired adenosine, r(GGCAGAGUGCCGC): r(GCGGCACCUGCC) have been studied by NMR spectroscopy, and MORASS iterative relaxation matrix structural refinement. The results, show that the bulged adenosine residue stacks into the RNA duplex with, little perturbation around the bulged region. Most of the bases in the RNA, duplex adopt C(3)'-endo conformation, exhibiting the N-type sugar pucker, as found in the A form helices. The sugars of the bulged residue and the, 5' flanking residue to it are found to exhibit C(2)'-endo conformation., None of the residues are in syn conformation.

About this Structure

1K8S is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Solution conformation of a bulged adenosine base in an RNA duplex by relaxation matrix refinement., Thiviyanathan V, Guliaev AB, Leontis NB, Gorenstein DG, J Mol Biol. 2000 Jul 28;300(5):1143-54. PMID:10903860

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