Structural highlights
Publication Abstract from PubMed
Incorporation of pseudoisocytidine (psC), a neutral analogue of protonated cytidine, in i-motifs has been studied by spectroscopic methods. Our results show that neutral psC:C base pairs can stabilize i-motifs at neutral pH, but the stabilization only occurs when psC:C base pairs are located at the ends of intercalated C:C+ stacks. When psC occupies central positions, the resulting i-motifs are only observed at low pH and psC:C+ or psC:psC+ hemiprotonated base pairs are formed instead of their neutral analogs. Overall, our results suggest that positively charged base pairs are necessary to stabilize this non-canonical DNA structure.
The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures.,Mir B, Soles X, Gonzalez C, Escaja N Sci Rep. 2017 Jun 5;7(1):2772. doi: 10.1038/s41598-017-02723-y. PMID:28584239[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Mir B, Soles X, Gonzalez C, Escaja N. The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures. Sci Rep. 2017 Jun 5;7(1):2772. doi: 10.1038/s41598-017-02723-y. PMID:28584239 doi:http://dx.doi.org/10.1038/s41598-017-02723-y
