1pvs

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Image:1pvs.gif

1pvs, resolution 2.40Å

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3-methyladenine Glcosylase II(AlkA) Hypoxanthine complex

Overview

Escherichia coli (E. coli) protein 3-methyladenine-DNA glycosylase II, (AlkA) functions primarily by removing alkylation damage from duplex and, single stranded DNA. A crystal structure of AlkA was refined to 2.0 A, resolution. This structure in turn was used to refine an AlkA-hypoxanthine, (substrate) complex structure to 2.4 A resolution. The complex structure, shows hypoxanthine located in AlkA's active site stacked between residues, W218 and Y239. The structural analysis of the AlkA and AlkA-hypoxanthine, structures indicate that free hypoxanthine binding in the active site may, inhibit glycosylase activity.

About this Structure

1PVS is a Single protein structure of sequence from Escherichia coli with 7HP as ligand. Active as DNA-3-methyladenine glycosylase II, with EC number 3.2.2.21 Full crystallographic information is available from OCA.

Reference

3-methyladenine-DNA glycosylase II: the crystal structure of an AlkA-hypoxanthine complex suggests the possibility of product inhibition., Teale M, Symersky J, DeLucas L, Bioconjug Chem. 2002 May-Jun;13(3):403-7. PMID:12009927

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