1pvs

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Image:1pvs.gif

Template:STRUCTURE 1pvs

3-methyladenine Glcosylase II(AlkA) Hypoxanthine complex


Overview

Escherichia coli (E. coli) protein 3-methyladenine-DNA glycosylase II (AlkA) functions primarily by removing alkylation damage from duplex and single stranded DNA. A crystal structure of AlkA was refined to 2.0 A resolution. This structure in turn was used to refine an AlkA-hypoxanthine (substrate) complex structure to 2.4 A resolution. The complex structure shows hypoxanthine located in AlkA's active site stacked between residues W218 and Y239. The structural analysis of the AlkA and AlkA-hypoxanthine structures indicate that free hypoxanthine binding in the active site may inhibit glycosylase activity.

About this Structure

1PVS is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

3-methyladenine-DNA glycosylase II: the crystal structure of an AlkA-hypoxanthine complex suggests the possibility of product inhibition., Teale M, Symersky J, DeLucas L, Bioconjug Chem. 2002 May-Jun;13(3):403-7. PMID:12009927 Page seeded by OCA on Sat May 3 05:32:36 2008

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