3cse

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Image:3cse.png

Template:STRUCTURE 3cse

Contents

Candida glabrata Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)

Template:ABSTRACT PUBMED 18804036

About this Structure

3cse is a 2 chain structure of Dihydrofolate reductase with sequence from Candida glabrata. Full crystallographic information is available from OCA.

See Also

Reference

  • Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC. Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase. Chem Biol. 2008 Sep 22;15(9):990-6. PMID:18804036 doi:S1074-5521(08)00280-9
  • Liu J, Bolstad DB, Bolstad ES, Wright DL, Anderson AC. Towards new antifolates targeting eukaryotic opportunistic infections. Eukaryot Cell. 2009 Apr;8(4):483-6. Epub 2009 Jan 23. PMID:19168759 doi:10.1128/EC.00298-08

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