1q1v

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Template:STRUCTURE 1q1v

Contents

Structure of the Oncoprotein DEK: a putative DNA-binding Domain Related to the Winged Helix Motif

Template:ABSTRACT PUBMED 15238633

Disease

[DEK_HUMAN] Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene.

Function

[DEK_HUMAN] Involved in chromatin organization.[1]

About this Structure

1q1v is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Devany M, Kotharu NP, Matsuo H. Solution NMR structure of the C-terminal domain of the human protein DEK. Protein Sci. 2004 Aug;13(8):2252-9. Epub 2004 Jul 6. PMID:15238633 doi:10.1110/ps.04797104
  1. ↑ Hu HG, Scholten I, Gruss C, Knippers R. The distribution of the DEK protein in mammalian chromatin. Biochem Biophys Res Commun. 2007 Jul 13;358(4):1008-14. Epub 2007 May 21. PMID:17524367 doi:10.1016/j.bbrc.2007.05.019

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