Rab5 GDP/GTP exchange factor

From Proteopedia

spinqualitylabelsall models Human rabex-5 complex with rabaptin (PDB code 4n3z). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Rab5 GDP/GTP exchange factor (Rabex5) is a guanine nucleotide exchange factor. It forms a tight complex with rabaptin which augments its exchange activity. The rabex5-rabaptin complex is critical to endosomal fusion. Disease Relevance Structural highlights

3D Structures of Rab5 GDP/GTP exchange factor

Updated on 04-January-2015

1txu – hRabex5 Vps9 domain – human
4n3x – hRabex5 CC domain
2fid, 2fif – bRabex5 zinc finger and ubiquitin interacting motif + ubiquitin – bovine
2c7m, 2c7n – hRabex5 ubiquitin interacting motif + ubiquitin
2ot3 – hRabex5 Vps9 domain + Ras-related protein Rab21
4n3x – hRabex5 CC domain + Rabaptin
4n3z – hRabex5 5δ + Rabaptin
4q9u – hRabex5 5δ (mutant) + Ras-related protein Rab5A

References