Structural highlights
Publication Abstract from PubMed
The TEG gene cluster was recently isolated from an environmental DNA library and is predicted to encode the biosynthesis of a polysulfated glycopeptide congener. Three closely related sulfotransferases found in the TEG gene cluster (Teg12, Teg13 and Teg14) have been shown to sulfate the teicoplanin aglycone at three unique sites. Crystal structures of the first sulfotransferase from the TEG cluster, Teg12, in complex with the teicoplanin aglycone and its desulfated cosubstrate PAP have recently been reported [Bick et al. (2010), Biochemistry, 49, 4159-4168]. Here, the 2.7 A resolution crystal structure of the apo form of Teg14 is reported. Teg14 sulfates the hydroxyphenylglycine at position 4 in the teicoplanin aglycone. The Teg14 structure is discussed and is compared with those of other bacterial 3'-phosphoadenosine 5'-phosphosulfate-dependent sulfotransferases.
The 2.7 A resolution structure of the glycopeptide sulfotransferase Teg14.,Bick MJ, Banik JJ, Darst SA, Brady SF Acta Crystallogr D Biol Crystallogr. 2010 Dec;66(Pt 12):1278-86. Epub 2010, Nov 16. PMID:21123867[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Bick MJ, Banik JJ, Darst SA, Brady SF. The 2.7 A resolution structure of the glycopeptide sulfotransferase Teg14. Acta Crystallogr D Biol Crystallogr. 2010 Dec;66(Pt 12):1278-86. Epub 2010, Nov 16. PMID:21123867 doi:10.1107/S0907444910036681
