8hf3
From Proteopedia
Cryo-EM structure of human ZDHHC9/GCP16 complex
Structural highlights
DiseaseZDHC9_HUMAN Lujan-Fryns syndrome. The disease is caused by variants affecting the gene represented in this entry. FunctionZDHC9_HUMAN Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (Probable). The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (PubMed:16000296). May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942).[1] [2] (Microbial infection) Through a sequential action with ZDHHC20, rapidly and efficiently palmitoylates SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell.[3] References
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Categories: Homo sapiens | Large Structures | Hu Q | Liu S | Wu J | Yang A | Zhang Y
