1evh

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Image:1evh.jpg

1evh, resolution 1.8Å

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EVH1 DOMAIN FROM MURINE ENABLED IN COMPLEX WITH ACTA PEPTIDE

Overview

The Enabled/VASP homology 1 (EVH1; also called WH1) domain is an, interaction module found in several proteins implicated in actin-based, cell motility. EVH1 domains bind the consensus proline-rich motif FPPPP, and are required for targeting the actin assembly machinery to sites of, cytoskeletal remodeling. The crystal structure of the mammalian Enabled, (Mena) EVH1 domain complexed with a peptide ligand reveals a mechanism of, recognition distinct from that used by other proline-binding modules. The, EVH1 domain fold is unexpectedly similar to that of the pleckstrin, homology domain, a membrane localization module. This finding demonstrates, the functional plasticity of the pleckstrin homology fold as a binding, scaffold and suggests that membrane association may play an auxiliary role, in EVH1 targeting.

About this Structure

1EVH is a Single protein structure of sequence from Mus musculus with ACE as ligand. Full crystallographic information is available from OCA.

Reference

Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly., Prehoda KE, Lee DJ, Lim WA, Cell. 1999 May 14;97(4):471-80. PMID:10338211

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