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2x44

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2x44, resolution 2.60Å ()
Related: 1ah1, 1h6e, 1i8l, 1i85


Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


STRUCTURE OF A STRAND-SWAPPED DIMERIC FORM OF CTLA-4

Publication Abstract from PubMed

We present the crystal structure of an immunoglobulin light-chain-like domain, CTLA-4, as a strand-swapped dimer displaying cis-trans proline isomerisation and native-like hydrogen bonding. We also show that CTLA-4 can form amyloid-like fibres and amorphous deposits explainable by the same strand swapping. Our results suggest a molecular basis for the pathological aggregation of immunoglobulin domains and why amyloid-like fibres are more often composed of homologous rather than heterologous subunits.

Domain metastability: a molecular basis for immunoglobulin deposition?, Sonnen AF, Yu C, Evans EJ, Stuart DI, Davis SJ, Gilbert RJ, J Mol Biol. 2010 Jun 4;399(2):207-13. Epub 2010 Apr 13. PMID:20394753

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

2x44 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Sonnen AF, Yu C, Evans EJ, Stuart DI, Davis SJ, Gilbert RJ. Domain metastability: a molecular basis for immunoglobulin deposition? J Mol Biol. 2010 Jun 4;399(2):207-13. Epub 2010 Apr 13. PMID:20394753 doi:10.1016/j.jmb.2010.04.011

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