Antibody

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Glycosylated human Igg with heavy chains (red and light red), light chains (aqua and green) (PDB code 1hzh)

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3D Printed Physical Model of an Anitbody

Shown below is a 3D printed physical model of an Antibody. The protein is displayed as an alpha carbon backbone, with the heavy chains colored white, the light chains colored red, and the glycan colored blue.


The MSOE Center for BioMolecular Modeling

The MSOE Center for BioMolecular Modeling uses 3D printing technology to create physical models of protein and molecular structures, making the invisible molecular world more tangible and comprehensible. To view more protein structure models, visit our Model Gallery.


References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Roit, I. M. Roit's Essential Immunology. Oxford: Blackwell Science Ltd., 1997.
  2. Parker DC. T cell-dependent B cell activation. Annu Rev Immunol. 1993;11:331-60. PMID:8476565 doi:http://dx.doi.org/10.1146/annurev.iy.11.040193.001555
  3. Rus H, Cudrici C, Niculescu F. The role of the complement system in innate immunity. Immunol Res. 2005;33(2):103-12. PMID:16234578 doi:10.1385/IR:33:2:103
  4. Roux KH. Immunoglobulin structure and function as revealed by electron microscopy. Int Arch Allergy Immunol. 1999 Oct;120(2):85-99. PMID:10545762
  5. Putnam FW, Liu YS, Low TL. Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain. J Biol Chem. 1979 Apr 25;254(8):2865-74. PMID:107164
  6. Woof JM, Burton DR. Human antibody-Fc receptor interactions illuminated by crystal structures. Nat Rev Immunol. 2004 Feb;4(2):89-99. PMID:15040582 doi:10.1038/nri1266
  7. Putnam FW, Liu YS, Low TL. Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain. J Biol Chem. 1979 Apr 25;254(8):2865-74. PMID:107164
  8. Harris LJ, Larson SB, Hasel KW, McPherson A. Refined structure of an intact IgG2a monoclonal antibody. Biochemistry. 1997 Feb 18;36(7):1581-97. PMID:9048542 doi:http://dx.doi.org/10.1021/bi962514+
  9. Hochman J, Inbar D, Givol D. An active antibody fragment (Fv) composed of the variable portions of heavy and light chains. Biochemistry. 1973 Mar 13;12(6):1130-5. PMID:4569769
  10. Putnam FW, Liu YS, Low TL. Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain. J Biol Chem. 1979 Apr 25;254(8):2865-74. PMID:107164
  11. Woof JM, Burton DR. Human antibody-Fc receptor interactions illuminated by crystal structures. Nat Rev Immunol. 2004 Feb;4(2):89-99. PMID:15040582 doi:10.1038/nri1266
  12. Wright A, Morrison SL. Effect of glycosylation on antibody function: implications for genetic engineering. Trends Biotechnol. 1997 Jan;15(1):26-32. PMID:9032990 doi:10.1016/S0167-7799(96)10062-7
  13. Heyman B. Complement and Fc-receptors in regulation of the antibody response. Immunol Lett. 1996 Dec;54(2-3):195-9. PMID:9052877
  14. Ravetch JV, Bolland S. IgG Fc receptors. Annu Rev Immunol. 2001;19:275-90. PMID:11244038 doi:19/1/275
  15. Fanning LJ, Connor AM, Wu GE. Development of the immunoglobulin repertoire. Clin Immunol Immunopathol. 1996 Apr;79(1):1-14. PMID:8612345
  16. Diaz M, Casali P. Somatic immunoglobulin hypermutation. Curr Opin Immunol. 2002 Apr;14(2):235-40. PMID:11869898
  17. Borghesi L, Milcarek C. From B cell to plasma cell: regulation of V(D)J recombination and antibody secretion. Immunol Res. 2006;36(1-3):27-32. PMID:17337763 doi:10.1385/IR:36:1:27
  18. Durandy A. Activation-induced cytidine deaminase: a dual role in class-switch recombination and somatic hypermutation. Eur J Immunol. 2003 Aug;33(8):2069-73. PMID:12884279 doi:10.1002/eji.200324133
  19. CHOWN B, LEWIS M, KAITA K. A new Kell blood-group phenotype. Nature. 1957 Oct 5;180(4588):711. PMID:13477267
  20. Burnette WN. "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal Biochem. 1981 Apr;112(2):195-203. PMID:6266278
  21. Brehm-Stecher BF, Johnson EA. Single-cell microbiology: tools, technologies, and applications. Microbiol Mol Biol Rev. 2004 Sep;68(3):538-59. PMID:15353569 doi:10.1128/MMBR.68.3.538-559.2004

Additional Pages

See Also

Proteopedia Page Contributors and Editors (what is this?)

David Canner, Michal Harel, Alexander Berchansky, Wayne Decatur, Mark Hoelzer, Eric Martz

DOI: https://dx.doi.org/10.14576/347149.1842037 (?)
Citation: Martz E, Canner D, Decatur W, Berchansky A, Harel M, 2013, "Antibody", Proteopedia, DOI: https://dx.doi.org/10.14576/347149.1842037
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