Antibody

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Glycosylated human Igg with heavy chains (red and light red), light chains (aqua and green) (PDB code 1hzh)

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3D structure of antibody

3D structures of antibody

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Roit, I. M. Roit's Essential Immunology. Oxford: Blackwell Science Ltd., 1997.
  2. Parker DC. T cell-dependent B cell activation. Annu Rev Immunol. 1993;11:331-60. PMID:8476565 doi:http://dx.doi.org/10.1146/annurev.iy.11.040193.001555
  3. Rus H, Cudrici C, Niculescu F. The role of the complement system in innate immunity. Immunol Res. 2005;33(2):103-12. PMID:16234578 doi:10.1385/IR:33:2:103
  4. Roux KH. Immunoglobulin structure and function as revealed by electron microscopy. Int Arch Allergy Immunol. 1999 Oct;120(2):85-99. PMID:10545762
  5. Putnam FW, Liu YS, Low TL. Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain. J Biol Chem. 1979 Apr 25;254(8):2865-74. PMID:107164
  6. Woof JM, Burton DR. Human antibody-Fc receptor interactions illuminated by crystal structures. Nat Rev Immunol. 2004 Feb;4(2):89-99. PMID:15040582 doi:10.1038/nri1266
  7. Putnam FW, Liu YS, Low TL. Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain. J Biol Chem. 1979 Apr 25;254(8):2865-74. PMID:107164
  8. Harris LJ, Larson SB, Hasel KW, McPherson A. Refined structure of an intact IgG2a monoclonal antibody. Biochemistry. 1997 Feb 18;36(7):1581-97. PMID:9048542 doi:http://dx.doi.org/10.1021/bi962514+
  9. Hochman J, Inbar D, Givol D. An active antibody fragment (Fv) composed of the variable portions of heavy and light chains. Biochemistry. 1973 Mar 13;12(6):1130-5. PMID:4569769
  10. Putnam FW, Liu YS, Low TL. Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain. J Biol Chem. 1979 Apr 25;254(8):2865-74. PMID:107164
  11. Woof JM, Burton DR. Human antibody-Fc receptor interactions illuminated by crystal structures. Nat Rev Immunol. 2004 Feb;4(2):89-99. PMID:15040582 doi:10.1038/nri1266
  12. Wright A, Morrison SL. Effect of glycosylation on antibody function: implications for genetic engineering. Trends Biotechnol. 1997 Jan;15(1):26-32. PMID:9032990 doi:10.1016/S0167-7799(96)10062-7
  13. Heyman B. Complement and Fc-receptors in regulation of the antibody response. Immunol Lett. 1996 Dec;54(2-3):195-9. PMID:9052877
  14. Ravetch JV, Bolland S. IgG Fc receptors. Annu Rev Immunol. 2001;19:275-90. PMID:11244038 doi:19/1/275
  15. Fanning LJ, Connor AM, Wu GE. Development of the immunoglobulin repertoire. Clin Immunol Immunopathol. 1996 Apr;79(1):1-14. PMID:8612345
  16. Diaz M, Casali P. Somatic immunoglobulin hypermutation. Curr Opin Immunol. 2002 Apr;14(2):235-40. PMID:11869898
  17. Borghesi L, Milcarek C. From B cell to plasma cell: regulation of V(D)J recombination and antibody secretion. Immunol Res. 2006;36(1-3):27-32. PMID:17337763 doi:10.1385/IR:36:1:27
  18. Durandy A. Activation-induced cytidine deaminase: a dual role in class-switch recombination and somatic hypermutation. Eur J Immunol. 2003 Aug;33(8):2069-73. PMID:12884279 doi:10.1002/eji.200324133
  19. CHOWN B, LEWIS M, KAITA K. A new Kell blood-group phenotype. Nature. 1957 Oct 5;180(4588):711. PMID:13477267
  20. Burnette WN. "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal Biochem. 1981 Apr;112(2):195-203. PMID:6266278
  21. Brehm-Stecher BF, Johnson EA. Single-cell microbiology: tools, technologies, and applications. Microbiol Mol Biol Rev. 2004 Sep;68(3):538-59. PMID:15353569 doi:10.1128/MMBR.68.3.538-559.2004

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Proteopedia Page Contributors and Editors (what is this?)

David Canner, Michal Harel, Alexander Berchansky, Wayne Decatur, Eric Martz

DOI: http://dx.doi.org/10.14576/347149.1842037 (?)
Citation: Martz E, Canner D, Decatur W, Berchansky A, Harel M, 2013, "Antibody", Proteopedia, DOI: http://dx.doi.org/10.14576/347149.1842037
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