Mitogen-activated protein kinase 3D structures

3D Structures of Mitogen-activated protein kinase

Updated on 29-March-2026

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• MAPK1 or Erk2
  • 4g6n, 4g6o, 4gsb – hMAPK1 - human
    
  • 6d5y, 7e73, 7e75, 8rlx, 8rmb – hMAPK1 (mutant)
    
  • 6rfo – hMAPK1/MAPK14 peptide
    
  • 1tvo, 1wzy, 2ojg, 2oji, 2ojj, 3i5z, 3i60, 3sa0, 3w55, 4fux, 4fuy, 4fv0, 4fv1, 4fv2, 4fv3, 4fv4, 4fv5, 4fv6, 4fv7, 4fv8, 4fv9, 4n4s, 4o6e, 4qp1, 4qp2, 4qp3, 4qp4, 4qp6, 4qp7, 4qp8, 4qp9 4qpa, 4qta, 4qte, 4xj0, 4xne, 4xoy, 4xoz, 4xp0, 4xp2, 4xp3, 4xrj, 4xrl, 4zzm, 4zzn, 4zzo, 5bue, 5bui, 5buj, 5bvd, 5bve, 5bvf, 5hd4, 5hd7, 5k4i, 5ke0, 5lcj, 5lck, 5ngu, 5nhf, 5nhh, 5nhj, 5nhl, 5nho, 5nhp, 5nhv, 5u6i, 5wp1, 6dcg, 6dmg, 6g54, 6g8x, 6g91, 6g92, 6g93, 6g97, 6g9a, 6g9d, 6g9h, 6g9j, 6g9k, 6g9m, 6g9n, 6g9n, 6gdq, 6gdm, 6ge0, 6gjd, 6gjb, 6nbs, 6oph, 6opi, 6q7k, 6q7s, 6q7t, 6qa1, 6qa3, 6qa4, 6qag, 6qah, 6qal, 6qaq, 6qaw, 6rq4, 7auv, 7nqq, 7nqw, 7nr3, 7nr5, 7nr8, 7nr9, 7w5o, 7x4u, 7xc1, 8ao2, 8ao3, 8ao4, 8ao5, 8ao6, 8ao7, 8ao8, 8ao9, 8aoa, 8aob, 8aoc, 8aod, 8aoe, 8aof, 8aog, 8aoh, 8aoi, 8aoj, 8zjv, 9lnr – hMAPK1+inhibitor - human
    
  • 8u8j, 8u8k – hMAPK1 (mutant) +inhibitor
    
  • 8pst, 8psw, 8psy, 8pt0, 8pt1, 8pt3, 8pt5, 8r5f – hMAPK1+ cyclohexanone-based inhibitor
    
  • 2y9q – hMAPK1 + MAP kinase-interacting Ser/Thr protein kinase peptide
    
  • 3tei, 4h3p, 4nif – hMAPK1 (mutant) + ribosomal protein S6 kinase α-1
    
  • 4iz5, 4iz7, 4iza – hMAPK1 (mutant) + astrocytic phosphoprotein
    
  • 4fmq – hMAPK1 + MAPK docking peptide
    
  • 5v61, 5v62, 6slg – hMAPK1 + ERK2 peptide + inhibitor
    
  • 4h3q – hMAPK1 + MAP2K 2 peptide
    
  • 8pvu – hMAPK1 + deoxyhypusine synthase
    
  • 8psr – hMAPK1 + peptide
    
  • 5ax3 – hMAPK1 + allosteric inhibitor peptide
    
  • 7opm – hMAPK1 + inhibitor peptide + ORF45
    
  • 4n0s – hMAPK1 + cafeic acid
    
  • 4zxt – hMAPK1 + catechol
    
  • 8qr2, 8qr3, 8qr4, 8qr5, 8qr6, 8qr7, 8qr8, 8qr9, 8qra, 8qrb, 8qrc – hMAPK1 + macrocyclic ligand
    
  • 5v60 – hMAPK1 + ACP
    
  • 6opg – hMAPK1 + AMPPNP
    
  • 8rqv, 8rqw, 8rqx – hMAPK1 (mutant) + AMPPNP
    
  • 5umo, 4s31 - rMAPK1 - rat
    
  • 1gol, 3r63, 4s2z, 4s30, 6rfp, 8rm2 - rMAPK1 (mutant)
    
  • 2z7l, 3c9w, 3qyw, 3qyz, 4qyy, 6cpw, 6fi3, 6fi6, 6fj0, 6fjb, 6fjz, 6fle, 6flv, 6fma, 6fn5, 6fq7, 6fr1, 6frp, 6fxv, 6oph, 6opi, 6opk - rMAPK1+inhibitor
    
  • 2gph - rMAPK1 (mutant)+HEPTP (mutant)
    
  • 3o71 - rMAPK1 + colorectal cancer peptide
    
  • 2fys - rMAPK1 + KIM peptide
    
  • 7ugb - rMAPK1 + ISG20 peptide
    
  • 4s32 – rMAPK1 + AMPPNP
    
  • 4s33, 4s34 – rMAPK1 (mutant) + AMPPNP
    
  • 4gt3, 4gva – rMAPK1 + nucleotide
    
  • 4i5h – rMAPK1 (mutant) + inhibitor
    
  • 3o71 - rMAPK1 + colorectal cancer peptide
    
  • 3zu7, 3zuv – rMAPK1 + ankyrin repeat protein
    
  • 2y4i – raMAPK1+kinase suppressor of RAS 2 – rabbit
    
  • 3oz6 - MAPK1 - Cryptosporidium parvum
• MAPK2
  • 1kwp – hMAPK2
    
  • 3gok - hMAPK2 kinase domain
    
  • 2jbo, 2jbp, 2p3g, 2pzy – hMAPK2 kinase domain +inhibitor
    
  • 3a2c, 3fpm, 3fyj, 3fyk, 3kc3, 3r2b, 3r2y, 3r30, 3wi6 - hMAPK2 kinase domain +inhibitor
    
  • 3ka0, 3kga, 3m2w, 3m42 – hMAPK2 kinase domain (mutant)+inhibitor
    
  • 2oza – hMAPK2+ hMAPK14
    
  • 4tyh, 6tca - hMAPK2+ hMAPK14 + inhibitor
    
  • 1nxk – hMAPK2 + staurosporine
    
  • 1ny3 – hMAPK2 + ADP
    
  • 2npt - hMAPK2 PHOX domain + hMAPK5
    
  • 2erk – rMAPK2
    
  • 3erk, 4erk – rMAPK2+inhibitor
    
• MAPK3 or Erk1
  • 2zoq – hMAPK3
    
  • 3fhr, 3fxw, 3r1n, 3she, 4qtb, 6ges – hMAPK3 kinase domain +inhibitor
    
• MAPK4
  • 7w5c – AtMAPK4 residues 18-372 + MAP2K peptide – Arabidopsis thaliana
    
• MAPK5
  • 9bu4 – hMAPK5 (mutant) 320-466 + inhibitor
    
• MAPK6 or Erk3
  • 7aqb – hMAPK6
    
  • 6yky, 6ylc, 6yll – hMAPK6 kinase domain +inhibitor
    
  • 6dtl – AtMAPK6 residues 32-395
    
• MAPK7 or Erk5 kinase domain
  • 4ic8 – hMAPK7
    
  • 4b99, 4zsg, 4zsj, 4zsl, 5byy, 5byz, 5o7i, 6hkm, 6hkn, 7pus, 9lta – hMAPK7+inhibitor
    
  • 4ic7 – hMAPK7+ MAP2K 5
    
• MAPK8 or JNK1
  • 8x5m - hMAPK8 JNK1
    
  • 2g01, 2gmx, 3o17, 3vud, 3vug, 3vuh, 3vui, 3vuk, 3vul, 3vum – hMAPK8 (mutant)+JIP1 peptide
    
  • 1ukh, 1uki, 9ft9 - jMAPK8 JNK1+JIP1 peptide
    
  • 6f5e - hMAPK8 JNK1+JIP1 peptide + darpin
    
  • 5lw1 - hMAPK8 JNK1+JIP1 peptide + darpin + pepstatin
    
  • 3v3v - hMAPK8 JNK1+JIP1 peptide + quercedagetin
    
  • 3o2m - hMAPK8 (mutant)+JIP1 peptide+biaryl tetrazole
    
  • 2xrw, 2xs0 - hMAPK8 + NFAT peptide
    
  • 4ux9 – hMAPK8 + MAPKK7 peptide
    
  • 6zr5 – hMAPK8 + ATF-2 peptide
    
  • 4yr8 – hMAPK8 + MKP7
    
  • 3elj, 3pze, 4awi, 4l7f, 4qtd - hMAPK8+inhibitor
    
  • 8pt8, 8pt9, 8pta, 8r5e - hMAPK8+ cyclohexanone-based inhibitor
    
  • 4e73, 4g1w, 4hys, 4hyu, 4izy – hMAPK8 + JIP1 +inhibitor
    
  • 2h96, 2no3 – hMAPK8 (mutant)+inhibitor
    
• MAPK9 or JNK2
  • 3e7o, 7cml - hMAPK9 (mutant)
    
  • 3npc – hMAPK9 (mutant)+inhibitor
    
  • 7n8t – hMAPK9 + AMP
    
• MAPK10 or JNK3
  • 8wgf – hMAPK10 catalytic domain
    
  • 1pmn, 1pmu, 1pmv, 2b1p, 2exc, 2o0u, 2o2u, 2ok1, 2p33, 2r9s, 2waj, 2zdt, 2zdu, 3cgf, 3cgo, 3da6, 3fi2, 3fi3, 3fv8, 3g90, 3g9l, 3g9n, 3kvx, 3oy1, 3rtp, 3tti, 3ttj, 3v6r, 3v6s, 4kkh, 4u79, 4whz, 4x21, 4y46, 4y5h, 4z9l, 6ekd, 6emh, 7ksi, 7ksj, 7ksk, 7ore, 7orf, 7s1n, 8bzp, 8elc, 8vnx, 8vo4, 8vs0, 8vtf – hMAPK10 catalytic domain + inhibitor
    
  • 3ptg, 4h39 - hMAPK10 catalytic domain + JIP1 peptide
    
  • 4h36 – hMAPK10 catalytic domain + ATF2 peptide
    
  • 4h3b – hMAPK10 catalytic domain + SAB peptide
    
  • 4kke, 4kkg – hMAPK10 catalytic domain + AMPPNP
    
  • 6eq9 – hMAPK10 catalytic domain + ACP
    
  • 7yl1 – hMAPK10 catalytic domain + purine derivative
    
  • 3oxi - hMAPK10 + MAPK8 interacting protein + inhibitor
    
• MAPK11
  • 8ygw – hMAPK11 catalytic domain
    
  • 3gp0 – hMAPK11+inhibitor
    
  • 3gc8, 3gc9 – hMAPK11 (mutant)+inhibitor
    
• MAPK12
  • 7cga – hMAPK12
    
  • 6una – hMAPK12 (mutant)
    
• MAPK13
  • 3coi, 4myg, 4yno, 8x23 – hMAPK13
    
  • 4eyj, 4eym, 5ekn, 5eko - hMAPK13 +inhibitor
    
• MAPK14 or p38 alpha
  • 1cm8, 1r39, 1wbo, 1wfc, 2npq, 3hvc, 3mgy, 3mh0, 3mh1, 3mh2, 3mh3, 3npq, 5etc, 5eti, 5uoj, 9cj2 – hMAPK14
    
  • 2lgc – hMAPK14 – NMR
    
  • 1r3c, 2fsl, 2fsm, 2fso, 2fst, 3od6, 3ody, 3odz, 3oef, 3p4k, 4e5a, 4geo – hMAPK14 (mutant)
    
  • 1di9, 1kv1, 1kv2, 1m7q, 1ouk, 1ouy, 1oz1, 1zyj, 1w7h, 1w82, 1w83, 1w84, 1wbn, 1wbs, 1wbt, 1wbv, 1wbw, 1yqj, 1zz2, 1zzl, 2baj, 2bak, 2bal, 2baq, 2ewa, 2gfs, 2puu, 2qd9, 2rg5, 2rg6, 2yis, 2yiw, 2yix, 2zaz, 2zb0, 2zb1, 3bv2, 3bv3, 3bx5, 3c5u, 3ctq, 3d7z, 3d83, 3dt1, 3e92, 3e93, 3fc1, 3fi4, 3fkl, 3fkn, 3fko, 3fl4, 3flm, 3fln, 3fln, 3flq, 3fls, 3flw, 3fly, 3flz, 3fmh, 3fmj, 3fmk, 3fml, 3fmm, 3fmn, 3fsf, 3fsk, 3gcu, 3gfe, 3gi3, 3ha8, 3hec, 3heg, 3hl7, 3hll, 3hp2, 3hp5, 3hrb, 3huc, 3hv4, 3hv5, 3hv6, 3hv7, 3iph, 3itz, 3k3i, 3kf7, 3kq7, 3k3i, 3l8x, 3lfa, 3lhj, 3mpt, 3mw1, 3mvl, 3mvm, 3new, 3nnu, 3nnv, 3nnw, 3nnx, 3nww, 3ocg, 3pg3, 3qud, 3que, 3rin, 3roc, 3s3i, 3s4q, 3u8w, 3uvp, 3uvq, 3uvr, 3zs5, 3zsg, 3zsh, 3zsi, 3zya, 4a9y, 4aa0, 4aa4, 4aa5, 4aac, 4dli, 4dlj, 4e5b, 4eh2, 4eh3, 4eh4, 4eh5, 4eh6, 4eh7, 4eh8, 4eh9, 4ehv, 4ewq, 4f9w, 4f9y, 4fa2, 4kin, 4kip, 4kiq, 4l8m, 4r3c, 4zth, 5lar, 5ml5, 5mtx, 5mty, 5mz3, 5n63, 5n64, 5n65, 5n66, 5n67, 5n68, 5o8u, 5o8v, 5omg, 5omh, 5tbe, 5tco, 5wjj, 5xyx, 5xyy, 6anl, 6hwt, 6hwu, 6hwv, 6m95, 6m9l, 6ohd, 6qdz, 6qe1, 6sfi, 6sfj, 6sfk, 6sfo, 6so1, 6so2, 6so4, 6sod, 6soi, 6sot, 6sou, 6sov, 6sp9, 6spl, 6zwp, 7z6i, 8vxe, 8x38, 8yd9, 9cj4, 9d75, 9d7n, 9mhb, 9nyt, 9o4l, 9y8b, 9ylh, 9yty - hMAPK14+inhibitor
    
  • 1a9u, 1bl6, 1bl7, 1bmk, 1ian, 1ove, 2i0h, 3ds6, 3gc7, 3gcp, 3gcq, 3gcs, 3gcv, 3hub, 3hv3, 3iw5, 3iw6, 3iw7, 3iw8, 3k3j, 3l8s, 3lfb, 3lfc, 3lfd, 3lfe, 3lff, 3mpa, 3o8p, 3o8t, 3o8u, 3obg, 3obj, 3oc1, 5o8u, 5o8v, 7pvu - hMAPK14 (mutant)+inhibitor
    
  • 9cj1, 9cj3, 9cj5 - hMAPK14+ drug
    
  • 4e6a, 4e6c, 4e8a - hMAPK14+ lipid
    
  • 8a8m – hMAPK14 (mutant) + dual specificity MAP2K – Cryo EM
    
  • 2y8o – hMAPK14 (mutant) + dual specificity MAP2K peptide
    
  • 4ka3, 4loo, 4lop, 4loq – hMAPK14 + docking peptide
    
  • 8yp8 – hMAPK14 + Tyr-protein phosphatase non-receptor peptide
    
  • 5eta, 6zqs – hMAPK14 + peptide
    
  • 3tg1 – hMAPK14 + MAPK phosphatase 5
    
  • 5etf – hMAPK14 + MAPKK 6
    
  • 8acm, 8aco - mMAPK14
    
  • 2gtm, 2gtn, 3p5k, 3p78, 3p79, 3p7a, 3p7b, 3p7c, 6sp9, 6spl, 6so1, 6so2, 6so4, 6sod, 6soi, 6sot, 6sou, 6sov, 6y4t, 6y4u, 6y4v, 6y4w, 6y4x, 6y6v, 6yjc, 6yk7, 6zwr, 7bdo, 7bdq, 7be4, 7be5, 8efj, 8vmh, 8vmm, 8vt6, 8vwm - mMAPK14+inhibitor
    
  • 1ywr, 2ghl, 2ghm, 6y7w, 6y7x, 6y7y, 6y7z, 6y80, 6y81, 6y82, 6y85, 6y8h, 6ycu, 6ycw - mMAPK14 (mutant)+inhibitor
    
  • 3py3 - mMAPK14 phosphorylated
    
  • 1yw2, 5uoj - mMAPK14 (mutant)
    
  • 1lew - mMAPK14+MEF2A
    
  • 1lez - mMAPK14+MKK3B
    
  • 8ype, 8ypf - mMAPK14+ ATF-2
    
  • 5nzz – mMAPK14 + TGF
    
  • 5o90 – mMAPK14 (mutant) + TGF peptide
    
  • 7z9t – mMAPK14 (mutant) + ATPgS + inhibitor
    
  • 3oht – MAPK14 – Salmo salar
    
• MAPK Fus3
  • 2f9f, 2b9g – yMAPK Fus3 – yeast
    
  • 2fa2 – yMAPK Fus3 (mutant)
    
  • 2f49 - yMAPK Fus3 +STE5 peptide
    
  • 2b9h, 2b9i - yMAPK Fus3 (mutant)+MSG5 peptide
    
  • 2b9j - yMAPK Fus3 (mutant)+FAR1 peptide
    
• MAPK
  • 3rp9 – TgMAPK – Toxoplasma gondii
    
  • 6v6a – TgMAPK + AC9 peptide
    
  • 3uib – MAPK + inhibitor – Leishmania major
    
• MAPK MPS1
  • 8ztc – PoMAPK – Pyricularia oryzae
    
  • 8h59 – PoMAPK + inhibitor
    

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