Nonstructural protein: Difference between revisions

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<StructureSection load='1nhu' size='350' side='right' caption='Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry [[1nhu]])' scene='46/461364/Cv/1'>
<StructureSection load='1nhu' size='350' side='right' caption='Hepatitis virus nonstructural protein (PDB entry [[1nhu]])' scene=''>
__TOC__
[[Nonstructural protein]] (NS) is a protein encoded by a virus which is not part of the viral particle<ref>PMID:23405236</ref>. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro).  For homology model and multiple sequence alignment see<br />
[[Nonstructural protein]] (NS) is a protein encoded by a virus which is not part of the viral particle<ref>PMID:23405236</ref>. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro).  For homology model and multiple sequence alignment see<br />
*[[User:Michael Strong/H1N1/NS]]<br />
*[[User:Michael Strong/H1N1/NS]]<br />
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*[[Student Project 4 for UMass Chemistry 423 Spring 2015]].
*[[Student Project 4 for UMass Chemistry 423 Spring 2015]].


== Structural highlights ==
For NS1 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP1]].<br />
For NS2 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP2]].<br />
For NS3 of SARS-CoV-2 see [[SARS-CoV-2 enzyme Papain-like]].<br />
For NS4 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP4]].<br />
For NS6 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP6]].<br />
For NS7 or '''replicase polyprotein 1ab light chain''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP7]].<br />
For NS8 or '''replicase polyprotein 1ab heavy chain''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP8]].<br />
For NS9 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP9]].<br />
For NS10 or '''replicase polyprotein 1ab''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP10]].<br />
For NS12 of SARS-CoV-2 see also [[Vitamin B12 may inhibit RNA‐dependent‐RNA polymerase activity of nsp12 from the SARS‐CoV‐2 vi]].<br />
For NS12+NS8+NS7 or RNA-dependent RNA polymerase of SARS-CoV-2 see [[SARS-CoV-2 enzyme RdRp]].<br />
SARS-CoV-2 NS12+NS8+NS7+NS13+RNA is called '''replication-transcription complex'''.<br />           
For NS16+NS10 of SARS-CoV-2 see [[SARS-CoV-2 enzyme 2'-O-MT]].<br />
For NS13 of SARS-CoV-2 see [[Unwinding the helicase NSP13]].<br />


== Relevance ==


</StructureSection>
The drug Victrelis (generic name boceprevir) binds to NS3 of the hepatitis C virus and is used for treatment of the disease.  See [[Bailey Dove/Victrelis]].
== 3D Structures of Nonstructural protein ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
== Structural highlights ==
{{#tree:id=OrganizedByTopic|openlevels=0|
<scene name='46/461364/Cv/4'>Hepatitis virus NS active site shows hydrogen bond interactions and hydrophobic pocket interactions</scene><ref>PMID:12509436</ref>.


*Nonstructural protein
== 3D Structures of Nonstructural protein ==
[[Nonstructural protein  3D structures]]


**[[3o9q]], [[4opa]], [[4oph]] – IvNS1 (mutant) – Influenza virus<br />
</StructureSection>
**[[3o9r]], [[3o9s]], [[3o9t]], [[3o9u]], [[3f5t]] – IvNS1<br />
**[[3m8a]], [[2z0a]], [[1xeq]], [[1ail]] – IvNS1 RNA-binding domain<br />
**[[3p31]] – IvNS1 C terminal effector domain<br />
**[[3p38]], [[3p39]] – IvNS1 C terminal effector domain (mutant)<br />
**[[1ns1]] - IvNS1 RNA-binding domain - NMR<br />
**[[3m5r]], [[2gx9]] - IvNS1 effector domain<br />
**[[1pd3]] – IvNS2 M1-binding domain<br />
**[[3l6p]], [[3lkw]] – DvNS2B/3 protease domain (mutant) – Dengue virus<br />
**[[4r05]] – DvNS5 residues 2491-2752 <br />
**[[2o1j]] – RvNSP4 diarrhea-inducing domain – Rotavirus<br />
**[[2gu0]] – RvNS2<br />
**[[2ajj]], [[2ajm]], [[2ajn]], [[2ajo]] – NS5A membrane-anchor domain – bovine viral diarrhea virus – NMR<br />
**[[1fw5]] – NSP1 membrane-binding domain – Semliki forest virus – NMR<br />
**[[1qol]] – NSP20A (mutant) - Foot-and-mouth disease virus<br />
**[[1nhu]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 – Hepatitis C virus<br />
**[[1r7c]], [[1r7d]], [[1r7e]], [[1r7f]], [[1r7g]] - HvNS5A membrane-anchor domain - NMR<br />
**[[2gdt]], [[2hsx]] – SvNS1 (mutant) – Sars coronavirus – NMR<br />
**[[2jzd]], [[2jze]], [[2jzf]], [[2rnk]] – SvNS3 residues 527-651 – NMR<br />
**[[2kaf]] - SvNS3 residues 1473-1532 – NMR <br />
**[[2kys]] – SvNS7 – NMR<br />
**[[2l8k]] – NS7 residues 1454-1575 – NMR<br />
**[[3mtv]] – NS1 residues 181-383 – PRRS virus <br />
**[[3zfn]], [[3zfo]], [[3zfq]], [[3zfp]], [[3zfr]], [[3zft]], [[3zfu]] – Npro (mutant) – Pestivirus<br />
**[[4x2z]] – NS3 residues 1174-1483 – Avian infectious bronchitis virus<br />
 
*Nonstructural protein binary complex
 
**[[2xbm]] – DvNS5 methyltransferase domain + RNA<br />
**[[3p8z]] - DvNS5 methyltransferase domain + SAH + inhibitor<br />
**[[2hye]] – SvNSV + DNA damage-binding protein + cullin-4A + ring-box protein – Simian virus 5<br />
**[[2b5l]] - SvNSV + DNA damage-binding protein<br />
**[[1nhv]], [[1nhu]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 + inhibitor<br />
**[[1dxp]], [[1dy8]], [[1dy9]], [[1w3c]] – HvNS4A + HvHelicase NS3<br />
**[[4k8b]] - HvNS4A + HvProtease NS3 + inhibitor<br />
**[[4a1t]], [[4a1x]] - HvNS4A + peptide inhibitor<br />
**[[3phe]] – HvNS5B + quinolone derivative<br />
**[[3ub0]] – NSP6 + NSP7 – Feline infectious peritonitis virus<br />
**[[1knz]] – RvNSP34 N terminal + mRNA<br />
**[[1lj2]] – RvNSP34 C terminal + eukaryotic protein synthesis initiation factor peptide<br />
**[[4r8r]] – DvNS5 residues 2491-2752 + adenosyl-Met<br />
**[[4r8s]] – DvNS5 residues 2491-2752 + sinefungin<br />


}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 07:27, 8 July 2026

Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry 1nhu)

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References

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Alexander Berchansky, Michal Harel

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