Nonstructural protein: Difference between revisions

From Proteopedia
Jump to navigationJump to search
New page: left|200px|thumb|Crystal Structure of Nonstructural protein [[3o9s]] {{STRUCTURE_3o9s| PDB=3o9s | SIZE=300| SCENE= |right|CAPTION=Nonstructural protein 3o9s }} [[...
 
Michal Harel (talk | contribs)
32,820 edits
No edit summary
 
(48 intermediate revisions by 2 users not shown)
Line 1: Line 1:
[[Image:3o9s.jpg|left|200px|thumb|Crystal Structure of Nonstructural protein [[3o9s]]]]
<StructureSection load='1nhu' size='350' side='right' caption='Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry [[1nhu]])' scene='46/461364/Cv/1'>
{{STRUCTURE_3o9s|  PDB=3o9s  | SIZE=300| SCENE= |right|CAPTION=Nonstructural protein [[3o9s]] }}
__TOC__
[[Nonstructural protein]] (NS) is a protein encoded by a virus which is not part of the viral particle<ref>PMID:23405236</ref>. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro).  For homology model and multiple sequence alignment see<br />
*[[User:Michael Strong/H1N1/NS]]<br />
*[[User:Michael Strong/H1N1/NS1/MSA]]<br />
*[[User:Michael Strong/H1N1/NS2/MSA]]<br />
*[[Student Project 4 for UMass Chemistry 423 Spring 2015]].


[[Nonstructural protein]] (NS) is a protein encoded by a virus which is not part of the viral particle. The images at the left and at the right correspond to one representative NS, ''i.e.'' the crystal structure of Nonstructural protein from Influenza virus ([[3o9s]]).
For NS1 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP1]].<br />
For NS2 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP2]].<br />
For NS3 of SARS-CoV-2 see [[SARS-CoV-2 enzyme Papain-like]].<br />
For NS4 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP4]].<br />
For NS6 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP6]].<br />
For NS7 or '''replicase polyprotein 1ab light chain''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP7]].<br />
For NS8 or '''replicase polyprotein 1ab heavy chain''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP8]].<br />
For NS9 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP9]].<br />
For NS10 or '''replicase polyprotein 1ab''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP10]].<br />
For NS12 of SARS-CoV-2 see also [[Vitamin B12 may inhibit RNA‐dependent‐RNA polymerase activity of nsp12 from the SARS‐CoV‐2 vi]].<br />
For NS12+NS8+NS7 or RNA-dependent RNA polymerase of SARS-CoV-2 see [[SARS-CoV-2 enzyme RdRp]].<br />
SARS-CoV-2 NS12+NS8+NS7+NS13+RNA is called '''replication-transcription complex'''.<br />           
For NS16+NS10 of SARS-CoV-2 see [[SARS-CoV-2 enzyme 2'-O-MT]].<br />
For NS13 of SARS-CoV-2 see [[Unwinding the helicase NSP13]].<br />


{{TOC limit|limit=2}}
== Relevance ==
 
The drug Victrelis (generic name boceprevir) binds to NS3 of the hepatitis C virus and is used for treatment of the disease.  See [[Bailey Dove/Victrelis]].
 
== Structural highlights ==
<scene name='46/461364/Cv/4'>Hepatitis virus NS active site shows hydrogen bond interactions and hydrophobic pocket interactions</scene><ref>PMID:12509436</ref>.


== 3D Structures of Nonstructural protein ==
== 3D Structures of Nonstructural protein ==
[[Nonstructural protein  3D structures]]


3o9q – IvNS1 (mutant) – Influenza virus
</StructureSection>
3o9r, 3o9s, 3o9t, 3o9u, 3f5t – IvNS1
3m8a, 2z0a, 1xeq, 1ail – IvNS1 RNA-binding domain
1ns1 - IvNS1 RNA-binding domain - NMR
3m5r, 2gx9 - IvNS1 effector domain
1pd3 – IvNS2 M1-binding domain
3l6p, 3lkw – DvNS2B/3 protease domain (mutant) – Dentue virus
2o1j – RvNSP4 diarrhea-inducing domain – Rotavirus
2gu0 – RvNS2
2ajj, 2ajm, 2ajn, 2ajo – NS5A membrane-anchor domain – bovine viral diarrhea virus – NMR
1fw5 – NSP1 membrane-binding domain – Semliki forest virus – NMR
1qol – NSP20A (mutant) Foot-and-mouth disease virus
 
Nonstructural protein binary complex


2xbm – DvNS5 methyltransferase domain + RNA
== References ==
2hye – SvNSV + DNA damage-binding protein + cullin-4A + ring-box protein – Simian virus 5
<references/>
2b5l - SvNSV + DNA damage-binding protein
[[Category:Topic Page]]

Latest revision as of 07:27, 8 July 2026

Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry 1nhu)

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

Retrieved from "https://proteopedia.org/index.php?title=Nonstructural_protein&oldid=4464811"