Nonstructural protein: Difference between revisions

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[[Image:3o9s.jpg|left|200px|thumb|Crystal Structure of Nonstructural protein dimer [[3o9s]]]]
<StructureSection load='1nhu' size='350' side='right' caption='Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry [[1nhu]])' scene='46/461364/Cv/1'>
{{STRUCTURE_3o9s|  PDB=3o9s  | SIZE=400| SCENE= |right|CAPTION=Nonstructural protein dimer [[3o9s]] }}
__TOC__
 
[[Nonstructural protein]] (NS) is a protein encoded by a virus which is not part of the viral particle<ref>PMID:23405236</ref>. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro).  For homology model and multiple sequence alignment see<br />
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
[[Nonstructural protein]] (NS) is a protein encoded by a virus which is not part of the viral particle. Pestivirus encode a NS at the N-terminal of their poluproteins (Npro).  images at the left and at the right correspond to one representative NS, ''i.e.'' the crystal structure of Nonstructural protein from Influenza virus ([[3o9s]]).  For homology model and multiple sequence alignment see<br />  
*[[User:Michael Strong/H1N1/NS]]<br />
*[[User:Michael Strong/H1N1/NS]]<br />
*[[User:Michael Strong/H1N1/NS1/MSA]]<br />
*[[User:Michael Strong/H1N1/NS1/MSA]]<br />
*[[User:Michael Strong/H1N1/NS2/MSA]].
*[[User:Michael Strong/H1N1/NS2/MSA]]<br />
*[[Student Project 4 for UMass Chemistry 423 Spring 2015]].


{{TOC limit|limit=2}}
For NS1 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP1]].<br />
<br />
For NS2 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP2]].<br />
For NS3 of SARS-CoV-2 see [[SARS-CoV-2 enzyme Papain-like]].<br />
For NS4 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP4]].<br />
For NS6 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP6]].<br />
For NS7 or '''replicase polyprotein 1ab light chain''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP7]].<br />
For NS8 or '''replicase polyprotein 1ab heavy chain''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP8]].<br />
For NS9 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP9]].<br />
For NS10 or '''replicase polyprotein 1ab''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP10]].<br />
For NS12 of SARS-CoV-2 see also [[Vitamin B12 may inhibit RNA‐dependent‐RNA polymerase activity of nsp12 from the SARS‐CoV‐2 vi]].<br />
For NS12+NS8+NS7 or RNA-dependent RNA polymerase of SARS-CoV-2 see [[SARS-CoV-2 enzyme RdRp]].<br />
SARS-CoV-2 NS12+NS8+NS7+NS13+RNA is called '''replication-transcription complex'''.<br />           
For NS16+NS10 of SARS-CoV-2 see [[SARS-CoV-2 enzyme 2'-O-MT]].<br />
For NS13 of SARS-CoV-2 see [[Unwinding the helicase NSP13]].<br />


== 3D Structures of Nonstructural protein ==
== Relevance ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
The drug Victrelis (generic name boceprevir) binds to NS3 of the hepatitis C virus and is used for treatment of the disease.  See [[Bailey Dove/Victrelis]].


[[3o9q]] – IvNS1 (mutant) – Influenza virus<br />
== Structural highlights ==
[[3o9r]], [[3o9s]], [[3o9t]], [[3o9u]], [[3f5t]] – IvNS1<br />
<scene name='46/461364/Cv/4'>Hepatitis virus NS active site shows hydrogen bond interactions and hydrophobic pocket interactions</scene><ref>PMID:12509436</ref>.
[[3m8a]], [[2z0a]], [[1xeq]], [[1ail]] – IvNS1 RNA-binding domain<br />
[[3p31]] – IvNS1 C terminal effector domain<br />
[[3p38]], [[3p39]] – IvNS1 C terminal effector domain (mutant)<br />
[[1ns1]] - IvNS1 RNA-binding domain - NMR<br />
[[3m5r]], [[2gx9]] - IvNS1 effector domain<br />
[[1pd3]] – IvNS2 M1-binding domain<br />
[[3l6p]], [[3lkw]] – DvNS2B/3 protease domain (mutant) – Dentue virus<br />
[[2o1j]] – RvNSP4 diarrhea-inducing domain – Rotavirus<br />
[[2gu0]] – RvNS2<br />
[[2ajj]], [[2ajm]], [[2ajn]], [[2ajo]] – NS5A membrane-anchor domain – bovine viral diarrhea virus – NMR<br />
[[1fw5]] – NSP1 membrane-binding domain – Semliki forest virus – NMR<br />
[[1qol]] – NSP20A (mutant) - Foot-and-mouth disease virus<br />
[[1nhu]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 – Hepatitis C virus<br />
[[1r7c]], [[1r7d]], [[1r7e]], [[1r7f]], [[1r7g]] - HvNS5A membrane-anchor domain - NMR<br />
[[2gdt]], [[2hsx]] – SvNS1 (mutant) – Sars coronavirus – NMR<br />
[[2jzd]], [[2jze]], [[2jzf]], [[2rnk]] – SvNS3 residues 527-651 – NMR<br />
[[2kaf]] - SvNS3 residues 1473-1532 – NMR <br />
[[2kys]] – SvNS7 – NMR<br />
[[2l8k]] – NS7 residues 1454-1575 – NMR<br />
[[3mtv]] – NS1 residues 181-383 – PRRS virus <br />
[[3zfn]], [[3zfo]], [[3zfq]], [[3zfp]], [[3zfr]], [[3zft]], [[3zfu]] – Npro (mutant) – Pestivirus<br />


===Nonstructural protein binary complex===
== 3D Structures of Nonstructural protein ==
[[Nonstructural protein  3D structures]]


[[2xbm]] – DvNS5 methyltransferase domain + RNA<br />  
</StructureSection>
[[2hye]] – SvNSV + DNA damage-binding protein + cullin-4A + ring-box protein – Simian virus 5<br />
[[2b5l]] - SvNSV + DNA damage-binding protein<br />
[[1nhv]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 + inhibitor<br />
[[1dxp]], [[1dy8]], [[1dy9]], [[1w3c]] – HvNS4A + HvHelicase NS3<br />
[[4a1t]], [[4a1x]] - HvNS4A + peptide inhibitor<br />
[[3phe]] – HvNS5B + quinolone derivative<br />
[[3ub0]] – NSP6 + NSP7 – Feline infectious peritonitis virus


== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 07:27, 8 July 2026

Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry 1nhu)

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References

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Alexander Berchansky, Michal Harel

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