CD81: Difference between revisions

Latest revision as of 08:50, 16 November 2022

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Human CD81 (magenta) complex with mouse antibody heavy chain (cyan), light chain (green) and glycerol (PDB code 6u9s)

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Function

CD81 is a cell-surface protein involved in a variety of biological responses like adhesion, morphology, activation, proliferation and differentiation of of B- and T-cells^[1]. CD81 belongs to the tetraspanin family - protein containing 4 transmembrane domains - which form microdomains in the cell surface with a variety of partner proteins. CD81 enables hepatitis C virus infection of human cells^[2].

Relevance

CD81 is widely expressed on the majority of tumor cells. Antibodies that target CD81 are a novel treatment against B-cell lymphoma^[3]. CD81-defficient mice are impaired in their ability to suppress the anti-tumor immune response.

Structural highlights

The structure of the complex of human CD81 with mouse antibody shows interactions of the CD81 helix D with the antibody heavy chain and CD81 residues in helix C with the light chain^[4].

↑ Levy S, Todd SC, Maecker HT. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu Rev Immunol. 1998;16:89-109. doi: 10.1146/annurev.immunol.16.1.89. PMID:9597125 doi:https://dx.doi.org/10.1146/annurev.immunol.16.1.89
↑ Luo RF, Zhao S, Tibshirani R, Myklebust JH, Sanyal M, Fernandez R, Gratzinger D, Marinelli RJ, Lu ZS, Wong A, Levy R, Levy S, Natkunam Y. CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas. Hum Pathol. 2010 Feb;41(2):271-80. doi: 10.1016/j.humpath.2009.07.022. Epub 2009 , Dec 8. PMID:20004001 doi:https://dx.doi.org/10.1016/j.humpath.2009.07.022
↑ Vences-Catalan F, Kuo CC, Rajapaksa R, Duault C, Andor N, Czerwinski DK, Levy R, Levy S. CD81 is a novel immunotherapeutic target for B cell lymphoma. J Exp Med. 2019 Jul 1;216(7):1497-1508. doi: 10.1084/jem.20190186. Epub 2019 May , 23. PMID:31123084 doi:https://dx.doi.org/10.1084/jem.20190186
↑ Susa KJ, Seegar TC, Blacklow SC, Kruse AC. A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking. Elife. 2020 Apr 27;9. pii: 52337. doi: 10.7554/eLife.52337. PMID:32338599 doi:https://dx.doi.org/10.7554/eLife.52337

3D structures of CD81

Updated on 16-November-2022

5tcx - hCD81 (mutant) - human
1g8q, 1iv5, 5m3t, 5m3d, 5m4r, 5m33, 5m2c, 3x0e - hCD81 extracellular domain 113-202
6ejm, 6ek2, 6ejg, 5dfw - hCD81 extracellular domain + Scfv
5dfv, 6u9s - hCD81 extracellular domain + antibody
7jic - hCD81 extracellular domain + CD19 + antibody – Cryo EM
3x0g - CD81 extracellular domain - green monkey
3x0f - CD81 extracellular domain - mouse
7mws - cttCD81 112-202 – cotton-top tamarin
7mwx - cttCD81 second extracellular domain + antibody + hepatitis virus core

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Levy S, Todd SC, Maecker HT. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu Rev Immunol. 1998;16:89-109. doi: 10.1146/annurev.immunol.16.1.89. PMID:9597125 doi:https://dx.doi.org/10.1146/annurev.immunol.16.1.89

[2] Luo RF, Zhao S, Tibshirani R, Myklebust JH, Sanyal M, Fernandez R, Gratzinger D, Marinelli RJ, Lu ZS, Wong A, Levy R, Levy S, Natkunam Y. CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas. Hum Pathol. 2010 Feb;41(2):271-80. doi: 10.1016/j.humpath.2009.07.022. Epub 2009 , Dec 8. PMID:20004001 doi:https://dx.doi.org/10.1016/j.humpath.2009.07.022

[3] Vences-Catalan F, Kuo CC, Rajapaksa R, Duault C, Andor N, Czerwinski DK, Levy R, Levy S. CD81 is a novel immunotherapeutic target for B cell lymphoma. J Exp Med. 2019 Jul 1;216(7):1497-1508. doi: 10.1084/jem.20190186. Epub 2019 May , 23. PMID:31123084 doi:https://dx.doi.org/10.1084/jem.20190186

[4] Susa KJ, Seegar TC, Blacklow SC, Kruse AC. A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking. Elife. 2020 Apr 27;9. pii: 52337. doi: 10.7554/eLife.52337. PMID:32338599 doi:https://dx.doi.org/10.7554/eLife.52337

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@@ Line 1: / Line 1: @@
+<StructureSection load='6u9s' size='400' side='right' caption='Human CD81 (magenta) complex with mouse antibody heavy chain (cyan), light chain (green) and glycerol (PDB code [[6u9s]])' scene='84/845937/Cv/2'>
-<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
-.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 == Function ==
-== Disease ==
+CD81 is a cell-surface protein involved in a variety of biological responses like adhesion, morphology, activation, proliferation and differentiation of of B- and T-cells<ref>PMID:9597125</ref>.  CD81 belongs to the tetraspanin family - protein containing 4 transmembrane domains - which form microdomains in the cell surface with a variety of partner proteins.  CD81 enables hepatitis C virus infection of human cells<ref>PMID:20004001</ref>.
 == Relevance ==
+CD81 is widely expressed on the majority of tumor cells.  Antibodies that target CD81 are a novel treatment against B-cell lymphoma<ref>PMID:31123084</ref>.  CD81-defficient mice are impaired in their ability to suppress the anti-tumor immune response.
 == Structural highlights ==
+The structure of the <scene name='84/845937/Cv/5'>complex of human CD81 with mouse antibody</scene> shows <scene name='84/845937/Cv/4'>interactions</scene> of the CD81 helix D with the antibody heavy chain and CD81 residues in helix C with the light chain<ref>PMID:32338599</ref>.
 </StructureSection>
 ==3D structures of CD81==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1g8q]] - hCD81 extracellular domain 113-202 - human<br />
+[[5tcx]] - hCD81 (mutant) - human<br />
-[[3k0g]] - CD81 extracellular domain - green monkey<br />
+[[1g8q]], [[1iv5]], [[5m3t]], [[5m3d]], [[5m4r]], [[5m33]], [[5m2c]], [[3x0e]] - hCD81 extracellular domain 113-202<br />
+[[6ejm]], [[6ek2]], [[6ejg]], [[5dfw]] - hCD81 extracellular domain + Scfv<br />
+[[5dfv]], [[6u9s]] - hCD81 extracellular domain + antibody<br />
+[[7jic]] - hCD81 extracellular domain + CD19 + antibody – Cryo EM<br />
+[[3x0g]] - CD81 extracellular domain - green monkey<br />
+[[3x0f]] - CD81 extracellular domain - mouse<br />
+[[7mws]] - cttCD81 112-202 – cotton-top tamarin<br />
+[[7mwx]] - cttCD81 second extracellular domain + antibody + hepatitis virus core <br />
 == References ==
 <references/>
+[[Category:Topic Page]]

CD81: Difference between revisions

Latest revision as of 08:50, 16 November 2022

Function

Relevance

Structural highlights

3D structures of CD81

References

Proteopedia Page Contributors and Editors (what is this?)

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