Helicase 3D structures: Difference between revisions

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
*Helicase Mot1
*Helicase Mot1
**[[3oc3]] – Hel MOT1 heat domain + TFIID-1 – ''Encephalitozoon cuniculi''<BR />
**[[3oc3]] – Hel MOT1 heat domain + TFIID-1 – ''Encephalitozoon cuniculi''<BR />
*Helicase 308
*Helicase 308
**[[2p6r]] – AfHel 308 + DNA – ''Archaeoglobus fulgidus''<BR />
**[[2p6r]] – AfHel 308 + DNA – ''Archaeoglobus fulgidus''<BR />
**[[2p6u]] - AfHel 308
**[[2p6u]] - AfHel 308
**[[9b15]] - AfHel 308 (mutant)
**[[9b15]] - AfHel 308 (mutant)
*DNA helicase
*DNA helicase
**[[3fld]] – EcHel I C terminal – ''Escherichia coli''<BR />
**[[3fld]] – EcHel I C terminal – ''Escherichia coli''<BR />
**[[4l0j]] – EcHel I translocation domain<br />
**[[4l0j]] – EcHel I translocation domain<br />
Line 24: Line 18:
**[[6fws]], [[6fwr]] – EcHel I + DNA + ADP <br />
**[[6fws]], [[6fwr]] – EcHel I + DNA + ADP <br />
**[[1e0j]], [[1e0k]] – Hel 4D domain – Phage T7
**[[1e0j]], [[1e0k]] – Hel 4D domain – Phage T7
*DNA helicase II or UvrD
*DNA helicase II or UvrD
**[[1q2z]], [[1rw2]] – hHel II KU86 C terminal – human - NMR<BR />
**[[1q2z]], [[1rw2]] – hHel II KU86 C terminal – human - NMR<BR />
**[[5y58]] – yHel II + DNA – yeast<br />
**[[5y58]] – yHel II + DNA – yeast<br />
Line 44: Line 36:
**[[7egt]] – TtHel II + UvrB – ''Thermus thermophilus''<br />
**[[7egt]] – TtHel II + UvrB – ''Thermus thermophilus''<br />
**[[9dci]], [[9des]] – MtHel + DNA – Cryo EM<br />
**[[9dci]], [[9des]] – MtHel + DNA – Cryo EM<br />
*DNA helicase IV or HelD
*DNA helicase IV or HelD
**[[6vsx]] – BsHelD C-terminal – ''Bacillus subtilis'' <BR />
**[[6vsx]] – BsHelD C-terminal – ''Bacillus subtilis'' <BR />
**[[6wvk]], [[6zca]], [[6zfb]], [[8xa8]] – BsHelD in RNA polymerase - Cryo EM<BR />
**[[6wvk]], [[6zca]], [[6zfb]], [[8xa8]] – BsHelD in RNA polymerase - Cryo EM<BR />
*ATP-dependent helicase ATRX
*ATP-dependent helicase ATRX
**[[3qln]] - hATRX ADD domain residues 167-289 <BR />
**[[3qln]] - hATRX ADD domain residues 167-289 <BR />
**[[2ld1]], [[2jm1]] - hATRX ADD domain - NMR<BR />
**[[2ld1]], [[2jm1]] - hATRX ADD domain - NMR<BR />
Line 62: Line 50:
**[[2wjy]] - hRENT1 helicase CH domains<BR />
**[[2wjy]] - hRENT1 helicase CH domains<BR />
**[[2xzo]] – hRENT1 helicase domain + RNA<BR />
**[[2xzo]] – hRENT1 helicase domain + RNA<BR />
*ATP-dependent helicase Fun30
*ATP-dependent helicase Fun30
**[[5gn1]] – yFun C-terminal<br />
**[[5gn1]] – yFun C-terminal<br />
*ATP-dependent helicase Rho or transcription termination factor  Rho
*ATP-dependent helicase Rho or transcription termination factor  Rho
**[[3l0o]] – TmRho – ''Thermotoga maritima''<BR />
**[[3l0o]] – TmRho – ''Thermotoga maritima''<BR />
**[[6wa8]] – EcRho + ATP<br />
**[[6wa8]] – EcRho + ATP<br />
Line 92: Line 76:
**[[6xas]], [[6xav]], [[6z9p]], [[6z9s]], [[6z9t]], [[6z9q]], [[6z9r]], [[7adc]], [[7adb]], [[7add]], [[7ade]], [[8e3h]], [[8e5p]], [[8e70]] – EcRho in transcription termination complex – Cryo EM<br />
**[[6xas]], [[6xav]], [[6z9p]], [[6z9s]], [[6z9t]], [[6z9q]], [[6z9r]], [[7adc]], [[7adb]], [[7add]], [[7ade]], [[8e3h]], [[8e5p]], [[8e70]] – EcRho in transcription termination complex – Cryo EM<br />
**[[7oqh]] – MtRho in transcription termination complex – Cryo EM<br />
**[[7oqh]] – MtRho in transcription termination complex – Cryo EM<br />
*ATP-dependent helicase MFD see [[Transcription-repair coupling factor]]
*ATP-dependent helicase MFD see [[Transcription-repair coupling factor]]
*ATP-dependent helicase HEPA or RNA polymerase-associaed protein RapA
*ATP-dependent helicase HEPA or RNA polymerase-associaed protein RapA
**[[6bog]], [[8so8]], [[8sp4]], [[8spg]] – EcHEPA<br />
**[[6bog]], [[8so8]], [[8sp4]], [[8spg]] – EcHEPA<br />
**[[4s20]], [[7mkn]], [[7mkq]], [[8t0l]] – EcHEPA in RNA polymerase complex – Cryo EM<br />
**[[4s20]], [[7mkn]], [[7mkq]], [[8t0l]] – EcHEPA in RNA polymerase complex – Cryo EM<br />
**[[7m8e]] – EcHEPA in elongation complex – Cryo EM<br />  
**[[7m8e]] – EcHEPA in elongation complex – Cryo EM<br />  
*ATP-dependent helicase E1
*ATP-dependent helicase E1
**[[2v9p]], [[5a9k]] – bPvE1 helicase domain – Bovine papillomavirus<br />
**[[2v9p]], [[5a9k]] – bPvE1 helicase domain – Bovine papillomavirus<br />
**[[2gxa]] – bPvE1 + DNA + Mg-ADP<br />
**[[2gxa]] – bPvE1 + DNA + Mg-ADP<br />
**[[7apd]] – bPvE1 in replication fork complex – Cryo EM<br />
**[[7apd]] – bPvE1 in replication fork complex – Cryo EM<br />
**[[1tue]] – hPvE1 + E2 – human papillomavirus
**[[1tue]] – hPvE1 + E2 – human papillomavirus
*ATP-dependent helicase CHD
*ATP-dependent helicase CHD
**[[2b2y]] – hCHD1 <br />
**[[2b2y]] – hCHD1 <br />
**[[4b4c]] – hCHD1 DNA-binding domain<br />
**[[4b4c]] – hCHD1 DNA-binding domain<br />
Line 133: Line 110:
**[[5j70]] - yCHD1 chromodomain 1 + DNA<br />
**[[5j70]] - yCHD1 chromodomain 1 + DNA<br />
**[[5o9g]], [[6g0l]], [[7nkx]], [[7tn2]] - yCHD1 in nucleosome – Cryo EM<br />
**[[5o9g]], [[6g0l]], [[7nkx]], [[7tn2]] - yCHD1 in nucleosome – Cryo EM<br />
*ATP-dependent helicase Sth1
*ATP-dependent helicase Sth1
**[[6kmb]], [[6mr4]], [[6uy1]] – ySth1 bromodomain 1248-1359 <br />
**[[6kmb]], [[6mr4]], [[6uy1]] – ySth1 bromodomain 1248-1359 <br />
**[[6lqz]] – ySth1 1183-1240 + TFIID subunit 14 - NMR<br />
**[[6lqz]] – ySth1 1183-1240 + TFIID subunit 14 - NMR<br />
Line 142: Line 117:
**[[6k15]], [[6v8o]], [[6v92]] – ySth1 in RSC core – Cryo EM<br />
**[[6k15]], [[6v8o]], [[6v92]] – ySth1 in RSC core – Cryo EM<br />
**[[6kw3]], [[6kw4]], [[6kw5]], [[6tda]] – ySth1 in RSC + nucleosome – Cryo EM<br />
**[[6kw3]], [[6kw4]], [[6kw5]], [[6tda]] – ySth1 in RSC + nucleosome – Cryo EM<br />
*ATP-dependent helicase GTF2F2 or general transcription factor IIF subunit 2
*ATP-dependent helicase GTF2F2 or general transcription factor IIF subunit 2
**[[7nvr]], [[7nvs]], [[7nvt]], [[7nvu]], [[7nvy]], [[7nvz]], [[7nw0]], [[7zwd]], [[7zx7]], [[7zx8]], [[8bvw]], [[8byq]], [[8bz1]], [[8s51]], [[8s52]], [[8s55]], [[8s5n]], [[8wad]], [[8wak]], [[8wal]], [[8wan]], [[8wap]], [[8waq]], [[8war]], [[8was]], [[8wat]], [[8wau]], [[8wav]], [[8waw]], [[8wax]], [[8way]], [[8waz]], [[8wb0]] – hGTF2F2 in RNA polymerase II core – Cryo EM<br />
**[[7nvr]], [[7nvs]], [[7nvt]], [[7nvu]], [[7nvy]], [[7nvz]], [[7nw0]], [[7zwd]], [[7zx7]], [[7zx8]], [[8bvw]], [[8byq]], [[8bz1]], [[8s51]], [[8s52]], [[8s55]], [[8s5n]], [[8wad]], [[8wak]], [[8wal]], [[8wan]], [[8wap]], [[8waq]], [[8war]], [[8was]], [[8wat]], [[8wau]], [[8wav]], [[8waw]], [[8wax]], [[8way]], [[8waz]], [[8wb0]] – hGTF2F2 in RNA polymerase II core – Cryo EM<br />
**[[5iy6]], [[5iy7]], [[5iy8]], [[5iy9]], [[5iya]], [[5iyb]], [[5iyc]], [[5iyd]], [[6o9l]], [[7edx]], [[7eg7]], [[7eg8]], [[7eg9]], [[7ega]], [[7egb]], [[7egc]], [[7ena]], [[7enc]], [[8gxq]], [[8gxs]] – hGTF2F2 in core-PIC – Cryo EM<br />
**[[5iy6]], [[5iy7]], [[5iy8]], [[5iy9]], [[5iya]], [[5iyb]], [[5iyc]], [[5iyd]], [[6o9l]], [[7edx]], [[7eg7]], [[7eg8]], [[7eg9]], [[7ega]], [[7egb]], [[7egc]], [[7ena]], [[7enc]], [[8gxq]], [[8gxs]] – hGTF2F2 in core-PIC – Cryo EM<br />
**[[7lbm]] – hGTF2F2 in transcription complex – Cryo EM<br />
**[[7lbm]] – hGTF2F2 in transcription complex – Cryo EM<br />
*ATP-dependent DNA helicase  
*ATP-dependent DNA helicase  
**[[7a8r]] – bADDH + ADP - bovine<br />
**[[7a8r]] – bADDH + ADP - bovine<br />
**[[8add]] – zADDH - zebrafish<br />
**[[8add]] – zADDH - zebrafish<br />
*ATP-dependent DNA helicase PIF1
*ATP-dependent DNA helicase PIF1
**[[5fhh]], [[6hpt]] – hPIF residues 200-641<br />
**[[5fhh]], [[6hpt]] – hPIF residues 200-641<br />
**[[6hpu]], [[6hpq]], [[6hph]] – hPIF residues 206-620 + nucleotide<br />
**[[6hpu]], [[6hpq]], [[6hph]] – hPIF residues 206-620 + nucleotide<br />
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**[[5ftc]], [[5ftf]] – BaPIF + ADP<br />
**[[5ftc]], [[5ftf]] – BaPIF + ADP<br />
**[[7otj]] – PIF + DNA + ADP – ''Candida albicans''<br />
**[[7otj]] – PIF + DNA + ADP – ''Candida albicans''<br />
*ATP-dependent DNA helicase TA0057
*ATP-dependent DNA helicase TA0057
**[[5h8w]] – TaTA0 + DNA – ''Thermoplasma acidophilum''<br />
**[[5h8w]] – TaTA0 + DNA – ''Thermoplasma acidophilum''<br />
*ATP-dependent DNA helicase LHR
*ATP-dependent DNA helicase LHR
**[[5v9x]] – MsLHR + DNA – ''Mycobacterium smegmatis''<br />
**[[5v9x]] – MsLHR + DNA – ''Mycobacterium smegmatis''<br />
*Dead box ATP-dependent RNA helicase
*Dead box ATP-dependent RNA helicase
**[[4xw3]] – hDDX1 SPRY domain 72-283<br />
**[[4xw3]] – hDDX1 SPRY domain 72-283<br />
**[[8tbx]] – hDDX1 1-74, 286-674 + ADP<br />
**[[8tbx]] – hDDX1 1-74, 286-674 + ADP<br />
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**[[7bbb]] - EcDbpA residues 218-445 - NMR<br />
**[[7bbb]] - EcDbpA residues 218-445 - NMR<br />
**[[6aib]] – SaDB CSHA N-terminal – ''Staphylococcus aureus''<br />
**[[6aib]] – SaDB CSHA N-terminal – ''Staphylococcus aureus''<br />
*''Dead box ATP-dependent RNA helicase complexes''
*''Dead box ATP-dependent RNA helicase complexes''
**[[3fmo]], [[3fhc]] – hDbp5 + Nup214<BR />
**[[3fmo]], [[3fhc]] – hDbp5 + Nup214<BR />
**[[3fht]] – hDbp5 + AMPPNP + RNA<BR />
**[[3fht]] – hDbp5 + AMPPNP + RNA<BR />
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**[[6aic]] – SaDB CSHA N-terminal + AMP <br />
**[[6aic]] – SaDB CSHA N-terminal + AMP <br />
**[[7ase]], [[7ask]] – DDX60 in 43S preinitiation complex complex – ''Trypanosoma cruzi'' - Cryo EM<br />
**[[7ase]], [[7ask]] – DDX60 in 43S preinitiation complex complex – ''Trypanosoma cruzi'' - Cryo EM<br />
* DEAH box RNA helicase
* DEAH box RNA helicase
**[[2eqs]] – hDHX8 S1 domain residues 260-355<br />
**[[2eqs]] – hDHX8 S1 domain residues 260-355<br />
**[[3i4u]] – hDHX8 residues 950-1183<br />
**[[3i4u]] – hDHX8 residues 950-1183<br />
Line 333: Line 292:
**[[6heg]], [[6eud]] – EcHrpB + ADP<br />
**[[6heg]], [[6eud]] – EcHrpB + ADP<br />
**[[8cnt]] – ThtPrp2 + ADP – ''Thermochaetoides thermophila''<br />
**[[8cnt]] – ThtPrp2 + ADP – ''Thermochaetoides thermophila''<br />
*ATP-dependent RNA helicase
*ATP-dependent RNA helicase
**[[2g9n]] - hEIF4A dead domain 1-406<br />
**[[2g9n]] - hEIF4A dead domain 1-406<br />
**[[5zbz]] - hEIF4A dead domain + sanguinarine<br />
**[[5zbz]] - hEIF4A dead domain + sanguinarine<br />
Line 360: Line 317:
**[[2vso]], [[2vsx]] – yEIF4A + initiation factor 4F middle domain<BR />
**[[2vso]], [[2vsx]] – yEIF4A + initiation factor 4F middle domain<BR />
**[[2g9n]] - hEIF4A dead domain
**[[2g9n]] - hEIF4A dead domain
*Viral ATP-dependent RNA helicase NS3
*Viral ATP-dependent RNA helicase NS3
**[[3o8b]], [[3o8d]], [[1cu1]], [[8ohm]], [[1hei]], [[4a92]], [[3rvb]], [[5wdx]] – HvHel NS3 residues 1186-1658 – Hepatitis C virus<BR />
**[[3o8b]], [[3o8d]], [[1cu1]], [[8ohm]], [[1hei]], [[4a92]], [[3rvb]], [[5wdx]] – HvHel NS3 residues 1186-1658 – Hepatitis C virus<BR />
**[[1onb]], [[1jr6]] - HvHel NS3 arginine-rich domain residues 1353-1507 – NMR<BR />
**[[1onb]], [[1jr6]] - HvHel NS3 arginine-rich domain residues 1353-1507 – NMR<BR />
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**[[4cbg]], [[4cbh]], [[4cbi]], [[4cbl]], [[4cbm]] - Hel NS3 helicase domain – pestivirus<br />
**[[4cbg]], [[4cbh]], [[4cbi]], [[4cbl]], [[4cbm]] - Hel NS3 helicase domain – pestivirus<br />
**[[7nno]], [[7oj4]] - TbevHel NS3 helicase domain – Tick-bourne encephalitis virus<br />
**[[7nno]], [[7oj4]] - TbevHel NS3 helicase domain – Tick-bourne encephalitis virus<br />
*''Viral ATP-dependent RNA helicase NS3 complexes''
*''Viral ATP-dependent RNA helicase NS3 complexes''
**[[3o8c]], [[3o8r]], [[3kqh]], [[3kqk]], [[3kql]], [[3kqn]], [[3kqu]], [[1a1v]] - HvHel NS3 + RNA<BR />
**[[3o8c]], [[3o8r]], [[3kqh]], [[3kqk]], [[3kql]], [[3kqn]], [[3kqu]], [[1a1v]] - HvHel NS3 + RNA<BR />
**[[2f55]] - HvHel NS3 + DNA<br />
**[[2f55]] - HvHel NS3 + DNA<br />
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**[[7bm0]] - TbevHel NS3 helicase domain + AMPPNP <br />
**[[7bm0]] - TbevHel NS3 helicase domain + AMPPNP <br />
**[[6jim]] - Hel NS3 helicase domain + RNA – chikungunya virus<br />
**[[6jim]] - Hel NS3 helicase domain + RNA – chikungunya virus<br />
*ATP-dependent RNA helicase SUV3
*ATP-dependent RNA helicase SUV3
**[[3rc3]], [[7w1r]] – hSUV3 residues 47-722<BR />
**[[3rc3]], [[7w1r]] – hSUV3 residues 47-722<BR />
**[[3og8]] – hDDX58 C terminal + RNA<BR />
**[[3og8]] – hDDX58 C terminal + RNA<BR />
**[[3rc8]] - hSUV3 residues 47-722 + RNA<BR />
**[[3rc8]] - hSUV3 residues 47-722 + RNA<BR />
**[[6f4a]] – ySUV3 + exoribonuclease II + RNA<br />
**[[6f4a]] – ySUV3 + exoribonuclease II + RNA<br />
*ATP-dependent RNA helicase A
*ATP-dependent RNA helicase A
**[[3llm]] – hHel A<BR />
**[[3llm]] – hHel A<BR />
**[[3vyx]], [[3vyy]] - hHel A RNA-binding domain + RNA<br />
**[[3vyx]], [[3vyy]] - hHel A RNA-binding domain + RNA<br />
**[[1whq]], [[2rs6]], [[2rs7]] – Hel A RNA-binding domain – mouse - NMR<BR />
**[[1whq]], [[2rs6]], [[2rs7]] – Hel A RNA-binding domain – mouse - NMR<BR />
*ATP-dependent RNA helicase Rep
*ATP-dependent RNA helicase Rep
**[[8h56]] – pcvRep – Porcine circovirus <br />
**[[8h56]] – pcvRep – Porcine circovirus <br />
**[[7lar]], [[7las]] – pcvRep + DNA + ADP – Cryo EM<br />
**[[7lar]], [[7las]] – pcvRep + DNA + ADP – Cryo EM<br />
*ATP-dependent RNA helicase Repa
*ATP-dependent RNA helicase Repa
**[[1uaa]] – EcRepa + DNA<br />
**[[1uaa]] – EcRepa + DNA<br />
**[[1nlf]] - EcRepa + sulfate<br />
**[[1nlf]] - EcRepa + sulfate<br />
**[[1g8y]], [[1olo]] - EcRepa  
**[[1g8y]], [[1olo]] - EcRepa  
*ATP-dependent RNA helicase HEF
*ATP-dependent RNA helicase HEF
**[[1x2i]] – HEF DNA-binding domain – ''Pyrococcus furiosus''
**[[1x2i]] – HEF DNA-binding domain – ''Pyrococcus furiosus''
*ATP-dependent RNA helicase Srmb
*ATP-dependent RNA helicase Srmb
**[[2yjt]] - EcSrmb residues 219-388 + RRAA<br />
**[[2yjt]] - EcSrmb residues 219-388 + RRAA<br />
*ATP-dependent RNA helicase Dhh1
*ATP-dependent RNA helicase Dhh1
**[[4bru]] – yDhh1 (mutant) + EDC3<br />
**[[4bru]] – yDhh1 (mutant) + EDC3<br />
**[[4brw]] – yDhh1 (mutant) + PAT1<br />
**[[4brw]] – yDhh1 (mutant) + PAT1<br />
**[[1s2m]] – yDhh1p<br />
**[[1s2m]] – yDhh1p<br />
*Werner syndrome ATP-dependent DNA helicase
*Werner syndrome ATP-dependent DNA helicase
**[[2e1e]], [[2e1f]], [[2dgz]] – hWRN HRDC domain 1142-1242<BR />
**[[2e1e]], [[2e1f]], [[2dgz]] – hWRN HRDC domain 1142-1242<BR />
**[[2fbt]] - hWRN exonuclease domain 38-236<BR />
**[[2fbt]] - hWRN exonuclease domain 38-236<BR />
Line 454: Line 391:
**[[8yle]] - hWRN 517-945 + AMPPCP<br />
**[[8yle]] - hWRN 517-945 + AMPPCP<br />
**[[2e6l]], [[2e6m]] - mWRN exonuclease domain  
**[[2e6l]], [[2e6m]] - mWRN exonuclease domain  
*ATP-dependent DNA helicase Q
*ATP-dependent DNA helicase Q
**[[2v1x]] - hQ1 residues 49-616<BR />
**[[2v1x]] - hQ1 residues 49-616<BR />
**[[2wwy]], [[4u7d]], [[8yrs]] – hQ1 residues 49-616 + DNA<br />
**[[2wwy]], [[4u7d]], [[8yrs]] – hQ1 residues 49-616 + DNA<br />
Line 470: Line 405:
**[[8qq2]], [[8qw8]], [[8qw9]], [[9ei1]], [[9ei2]], [[9ei3]], [[9ei4]] – hQ5 in elongation complex – Cryo EM<br />
**[[8qq2]], [[8qw8]], [[8qw9]], [[9ei1]], [[9ei2]], [[9ei3]], [[9ei4]] – hQ5 in elongation complex – Cryo EM<br />
**[[9hvo]], [[9hvq]], [[9hwg]] – hQ5 in transcription complex – Cryo EM<br />
**[[9hvo]], [[9hvq]], [[9hwg]] – hQ5 in transcription complex – Cryo EM<br />
*ATP-dependent DNA helicase RecG
*ATP-dependent DNA helicase RecG
**[[1gm5]] – TmRecG  + DNA <BR />
**[[1gm5]] – TmRecG  + DNA <BR />
 
**[[9wm3]] – EcRecG  <BR />
**[[9wm0]] – EcRecG  + DNA <BR />
**[[9wm1]], [[9wm2]] – EcRecG  + DNA + ADP<BR />
*ATP-dependent DNA helicase RecQ (Bloom Syndrome helicase)
*ATP-dependent DNA helicase RecQ (Bloom Syndrome helicase)
**[[4cgz]], [[4o3m]] - hRecQ catalytic domain + DNA<br />
**[[4cgz]], [[4o3m]] - hRecQ catalytic domain + DNA<br />
**[[4cdg]] - hRecQ catalytic domain + nanobody<br />
**[[4cdg]] - hRecQ catalytic domain + nanobody<br />
Line 488: Line 422:
**[[1oyw]] - EcRecQ catalytic domain<BR />
**[[1oyw]] - EcRecQ catalytic domain<BR />
**[[1oyy]] - EcRecQ catalytic domain + ATP<BR />
**[[1oyy]] - EcRecQ catalytic domain + ATP<BR />
*ATP-dependent DNA helicase RuvA, RuvB
*ATP-dependent DNA helicase RuvA, RuvB
**[[2ztc]], [[2ztd]], [[2zte]], [[2h5x]] – MtRuvA – ''Mycobacterium tuberculosis''<BR />
**[[2ztc]], [[2ztd]], [[2zte]], [[2h5x]] – MtRuvA – ''Mycobacterium tuberculosis''<BR />
**[[7oa5]] - MlRuvA – ''Mycobacterium leprae''<BR />
**[[7oa5]] - MlRuvA – ''Mycobacterium leprae''<BR />
Line 506: Line 438:
**[[7x5a]], [[7x7p]], [[7x7q]] - PaRuvB in Holliday junciton – Cryo EM<br />
**[[7x5a]], [[7x7p]], [[7x7q]] - PaRuvB in Holliday junciton – Cryo EM<br />
**[[7pbl]], [[7pbm]], [[7pbn]], [[7pbo]], [[7pbp]], [[7pbq]], [[7pbr]], [[7pbs]], [[7pbt]], [[7pbu]] – RuvA + RuvB + DNA – ''Streptococcus thermophiles'' – Cryo EM<br />
**[[7pbl]], [[7pbm]], [[7pbn]], [[7pbo]], [[7pbp]], [[7pbq]], [[7pbr]], [[7pbs]], [[7pbt]], [[7pbu]] – RuvA + RuvB + DNA – ''Streptococcus thermophiles'' – Cryo EM<br />
*ATP-dependent DNA helicase RuvB-like
*ATP-dependent DNA helicase RuvB-like
**[[2c9o]] – hRuvBL1 + ADP<br />
**[[2c9o]] – hRuvBL1 + ADP<br />
**[[6h7x]] – hRuvBL2<br />
**[[6h7x]] – hRuvBL2<br />
Line 528: Line 458:
**[[8ooc]] – ThtRuvBL1 + ThtRuvBL2 + INO80 + Vps72 + ADP + ATP - Cryo EM<br />
**[[8ooc]] – ThtRuvBL1 + ThtRuvBL2 + INO80 + Vps72 + ADP + ATP - Cryo EM<br />
**[[5f4h]], [[5yww]] – RuvBL (mutant) - ''Sulfolobus islandicus''<br />
**[[5f4h]], [[5yww]] – RuvBL (mutant) - ''Sulfolobus islandicus''<br />
*ATP-dependent DNA helicase UVSW
*ATP-dependent DNA helicase UVSW
**[[2oca]], [[1rif]]- T4UVSW (mutant) – Enterobacteria phage T4<BR />
**[[2oca]], [[1rif]]- T4UVSW (mutant) – Enterobacteria phage T4<BR />
**[[2jpn]] - T4UVSW
**[[2jpn]] - T4UVSW
*ATP-dependent DNA helicase DDA
*ATP-dependent DNA helicase DDA
**[[3upu]] – T4DDA + DNA<br />
**[[3upu]] – T4DDA + DNA<br />
**[[8s9i]] – T4DDA + DT8 + Gp32 peptide<br />
**[[8s9i]] – T4DDA + DT8 + Gp32 peptide<br />
**[[8gme]] – T4DDA + DT17 + Gp32 <br />
**[[8gme]] – T4DDA + DT17 + Gp32 <br />
*ATP-dependent DNA helicase DDM1
*ATP-dependent DNA helicase DDM1
**[[7ux9]], [[8j90]], [[8wh5]] – AtDDM1 in nucleosome complex + DNA – Cryo EM<br />
**[[7ux9]], [[8j90]], [[8wh5]] – AtDDM1 in nucleosome complex + DNA – Cryo EM<br />
**[[8kcb]], [[8kcc]], [[8skz]], [[8wh8]], [[8wh9]], [[8wha]] – AtDDM1 in nucleosome complex + DNA + ADP – Cryo EM<br />
**[[8kcb]], [[8kcc]], [[8skz]], [[8wh8]], [[8wh9]], [[8wha]] – AtDDM1 in nucleosome complex + DNA + ADP – Cryo EM<br />
*ATP-dependent DNA helicase PriA
*ATP-dependent DNA helicase PriA
**[[2d7e]] – EcPriA DNA-binding domain<BR />
**[[2d7e]] – EcPriA DNA-binding domain<BR />
**[[2d7g]], [[2d7h]], [[2dwl]], [[2dwm]], [[2dwn]] – EcPriA N terminal + polynucleotide<br />
**[[2d7g]], [[2d7h]], [[2dwl]], [[2dwm]], [[2dwn]] – EcPriA N terminal + polynucleotide<br />
Line 552: Line 474:
**[[4nl4]] – KpPriA + ADP<br />
**[[4nl4]] – KpPriA + ADP<br />
**[[4nl8]] – KpPriA + peptide<br />
**[[4nl8]] – KpPriA + peptide<br />
*ATP-dependent DNA helicase PcrA
*ATP-dependent DNA helicase PcrA
**[[1qhg]] – GsPcrA (mutant) + ADPNP <BR />
**[[1qhg]] – GsPcrA (mutant) + ADPNP <BR />
**[[1qhh]] - GsPcrA + ADPNP<br />
**[[1qhh]] - GsPcrA + ADPNP<br />
Line 560: Line 480:
**[[1pjr]] - GsPcrA<br />
**[[1pjr]] - GsPcrA<br />
**[[5dma]] – GsPcrA C-terminal tudor domain<br />
**[[5dma]] – GsPcrA C-terminal tudor domain<br />
*DNA helicase mcm8 or minichromosome maintenance 8; Domains – N-terminal 1-376; WH 770-840
*DNA helicase mcm8 or minichromosome maintenance 8; Domains – N-terminal 1-376; WH 770-840
**[[6l0o]] – hMcm8 WH domain<BR />
**[[6l0o]] – hMcm8 WH domain<BR />
**[[7dp3]] – hMcm8 N-terminal<BR />
**[[7dp3]] – hMcm8 N-terminal<BR />
Line 571: Line 489:
**[[8rig]] – yMcm8 + DNA – Cryo EM<BR />
**[[8rig]] – yMcm8 + DNA – Cryo EM<BR />
**[[8q67]] – Mcm (mutant) – ''Candidatus acidiphilum''<BR />
**[[8q67]] – Mcm (mutant) – ''Candidatus acidiphilum''<BR />


*DnaB helicase or replicative DNA helicase
*DnaB helicase or replicative DNA helicase
**[[3gxv]], [[4zc0]] – HpDnaB – ''Helicobacter pylori''<BR />
**[[3gxv]], [[4zc0]] – HpDnaB – ''Helicobacter pylori''<BR />
**[[4a1f]] – HpDnaB C terminal<br />
**[[4a1f]] – HpDnaB C terminal<br />
Line 602: Line 518:
**[[8a3v]] – VcDnaB + DCIA<br />
**[[8a3v]] – VcDnaB + DCIA<br />
**[[4nmn]] – AaDnaB + ADP – ''Aquifex aeolicus''<br />
**[[4nmn]] – AaDnaB + ADP – ''Aquifex aeolicus''<br />
*DnaB-like replicative helicase or Gp41
*DnaB-like replicative helicase or Gp41
**[[3bgw]] – BpDnaB-like – Bacillus phage SPP1<BR />
**[[3bgw]] – BpDnaB-like – Bacillus phage SPP1<BR />
**[[3bh0]] - BpDnaB-like G40P ATPase domain<BR />
**[[3bh0]] - BpDnaB-like G40P ATPase domain<BR />
Line 611: Line 525:
**[[8dvi]] – T4DnaB-like + DNA primase + DNA – Cryo EM<BR />
**[[8dvi]] – T4DnaB-like + DNA primase + DNA – Cryo EM<BR />
**[[8gao]] – T4DnaB-like + DNA primase + DNA + RNA – Cryo EM<BR />
**[[8gao]] – T4DnaB-like + DNA primase + DNA + RNA – Cryo EM<BR />
*DnaC helicase
*DnaC helicase
**[[2vyf]]– GkDnaC – ''Geobacillus kaustophilus''<br />
**[[2vyf]]– GkDnaC – ''Geobacillus kaustophilus''<br />
**[[2vye]] – GkDnaC + DNA <br />
**[[2vye]] – GkDnaC + DNA <br />
Line 620: Line 532:
**[[6qel]] – EcDnaC + replicative DNA Hel - Cryo EM<br />
**[[6qel]] – EcDnaC + replicative DNA Hel - Cryo EM<br />
**[[6qem]] – EcDnaC + replicative DNA Hel + DNA - Cryo EM<br />
**[[6qem]] – EcDnaC + replicative DNA Hel + DNA - Cryo EM<br />
*Helicase BLM
*Helicase BLM
**[[7auc]] – hBLM 636-1298<br />
**[[7auc]] – hBLM 636-1298<br />
**[[7aud]] – hBLM 636-1298 + DNA<br />
**[[7aud]] – hBLM 636-1298 + DNA<br />
Line 630: Line 540:
**[[5lut]] – BLM DHBN domain - chicken<br />
**[[5lut]] – BLM DHBN domain - chicken<br />
**[[5lus]] – BLM DHBN domain - pelican<br />
**[[5lus]] – BLM DHBN domain - pelican<br />
*Helicase CA8 or Prp28
*Helicase CA8 or Prp28
**[[4w7s]] – yCa8<br />
**[[4w7s]] – yCa8<br />
**[[5dtu]] – CtPrp28 + ADP<br />
**[[5dtu]] – CtPrp28 + ADP<br />
*Helicase NSP see [[Nonstructural protein]]
*Helicase NSP see [[Nonstructural protein]]
*Helicase SEN1
*Helicase SEN1
**[[5mzn]], [[6i59]] – ySEN1<br />
**[[5mzn]], [[6i59]] – ySEN1<br />
**[[6o3w]], [[6o3x]], [[6o3y]] – ySEN1 + Nrd1<br />
**[[6o3w]], [[6o3x]], [[6o3y]] – ySEN1 + Nrd1<br />
**[[8ran]], [[8rao]] – ySEN1 + RNA – Cryo EM<br />
**[[8ran]], [[8rao]] – ySEN1 + RNA – Cryo EM<br />
**[[8ram]], [[8rap]] – ySEN1 in RNA polymerase complex – Cryo EM<br />
**[[8ram]], [[8rap]] – ySEN1 in RNA polymerase complex – Cryo EM<br />
*Helicase DinG
*Helicase DinG
**[[6fws]], [[6fwr]] – EcDinG + DNA + ADP<br />
**[[6fws]], [[6fwr]] – EcDinG + DNA + ADP<br />
**[[8rfj]] – DinG in crispr effector complex + DNA – ''Pseudomonas oleovorans'' – Cryo EM<br />
**[[8rfj]] – DinG in crispr effector complex + DNA – ''Pseudomonas oleovorans'' – Cryo EM<br />
**[[8s35]] – KpDinG in crispr effector complex + DNA – Cryo EM<br />
**[[8s35]] – KpDinG in crispr effector complex + DNA – Cryo EM<br />
*Helicase SNF2
*Helicase SNF2
**[[5x0x]], [[5x0y]], [[5z3o]], [[5z3u]], [[5z3v]], [[6iy2]], [[6iy3]], [[6uxw]], [[7c4j]], [[7egm]], [[7egp]] – ySNF2 in nucleosome – Cryo EM<br />
**[[5x0x]], [[5x0y]], [[5z3o]], [[5z3u]], [[5z3v]], [[6iy2]], [[6iy3]], [[6uxw]], [[7c4j]], [[7egm]], [[7egp]] – ySNF2 in nucleosome – Cryo EM<br />
**[[1z5z]] – SsSNF2 C terminal – ''Sulfolobus solfataricus''<br />
**[[1z5z]] – SsSNF2 C terminal – ''Sulfolobus solfataricus''<br />
**[[1z63]] - SsSNF2 ATPase core + DNA<br />
**[[1z63]] - SsSNF2 ATPase core + DNA<br />
**[[1z6a]] - SsSNF2 ATPase core
**[[1z6a]] - SsSNF2 ATPase core
*Helicase SKI or superkiller protein  
*Helicase SKI or superkiller protein  
**[[7qdy]], [[7qdz]], [[7qe0]] – hSKI2W + TPR repeat protein + SKI8 + RNA – Cryo EM<br />
**[[7qdy]], [[7qdz]], [[7qe0]] – hSKI2W + TPR repeat protein + SKI8 + RNA – Cryo EM<br />
**[[7qdr]], [[7qds]] – hSKI2W + TPR repeat protein + SKI8 – Cryo EM<br />
**[[7qdr]], [[7qds]] – hSKI2W + TPR repeat protein + SKI8 – Cryo EM<br />
Line 672: Line 571:
**[[4a4z]] – ySKI2 + AMPPNP<br />
**[[4a4z]] – ySKI2 + AMPPNP<br />
**[[2va8]] – SsSKI2<br />
**[[2va8]] – SsSKI2<br />
*Helicase SRCAP
*Helicase SRCAP
**[[9ca9]] – hSRCAP complex – Cryo EM<br />
**[[9ca9]] – hSRCAP complex – Cryo EM<br />
**[[9ca7]], [[9ca8]], [[9caa]], [[9cab]] – hSRCAP in nucleosome complex – Cryo EM<br />
**[[9ca7]], [[9ca8]], [[9caa]], [[9cab]] – hSRCAP in nucleosome complex – Cryo EM<br />
**[[8x15]], [[8x19]], [[8x1c]] – hSRCAP-C in nucleosome complex – Cryo EM<br />
**[[8x15]], [[8x19]], [[8x1c]] – hSRCAP-C in nucleosome complex – Cryo EM<br />
*Helicase SWR1
*Helicase SWR1
**[[5i9e]] – ySWR1 + actin + actin-related protein<br />
**[[5i9e]] – ySWR1 + actin + actin-related protein<br />
**[[8qku]], [[8qkv]], [[8qyv]], [[8qz0]], [[9b1d]], [[9b1e]], [[9fbw]] – ySWR1 in nucleosome – Cryo EM<br />
**[[8qku]], [[8qkv]], [[8qyv]], [[8qz0]], [[9b1d]], [[9b1e]], [[9fbw]] – ySWR1 in nucleosome – Cryo EM<br />
*Helicase XPD
*Helicase XPD
**[[3crv]], [[3crw]], [[5h8c]] – XPD – ''Sulfolobus acidocaldarius''<br />
**[[3crv]], [[3crw]], [[5h8c]] – XPD – ''Sulfolobus acidocaldarius''<br />
**[[4a15]] - TaXPD + DNA <br />
**[[4a15]] - TaXPD + DNA <br />
Line 691: Line 584:
**[[2vl7]] - XPD - ''Sulfolobus tokodaii''<br />
**[[2vl7]] - XPD - ''Sulfolobus tokodaii''<br />
**[[5ivw]] - hXPD + XPB + TFIIH ubunits 2,3,4,5 + SCP-X + SCP-Ybr />
**[[5ivw]] - hXPD + XPB + TFIIH ubunits 2,3,4,5 + SCP-X + SCP-Ybr />
*Pre-mRNA-splicing Helicase or Brr2 or ski2-like
*Pre-mRNA-splicing Helicase or Brr2 or ski2-like
**[[4f92]] – hBrr2 402-2125<br />
**[[4f92]] – hBrr2 402-2125<br />
**[[4f91]] – hBrr2 helicase region 394-213<br />
**[[4f91]] – hBrr2 helicase region 394-213<br />
Line 715: Line 606:
**[[6qv4]] – CtBrr2 + ATPgS<br />
**[[6qv4]] – CtBrr2 + ATPgS<br />
**[[6qv3]] – CtBrr2 + ADP<br />
**[[6qv3]] – CtBrr2 + ADP<br />
*crispr-associated helicase Cas3
*crispr-associated helicase Cas3
**[[4q2c]] – TteCas3 – ''Thermobaculum terrenum''<br />
**[[4q2c]] – TteCas3 – ''Thermobaculum terrenum''<br />
**[[4q2d]] – TteCas3 + DTP<br />
**[[4q2d]] – TteCas3 + DTP<br />
Line 728: Line 617:
**[[8wtk]] – PhCas3 – ''Pyrococcus horikoshii''<br />
**[[8wtk]] – PhCas3 – ''Pyrococcus horikoshii''<br />
**[[8wtl]] – PhCas3 + ATP <br />
**[[8wtl]] – PhCas3 + ATP <br />
*Helicase aquarius or intron-binding protein aquarius
*Helicase aquarius or intron-binding protein aquarius
**[[4pj3]] – hHA + AMPPNP <br />
**[[4pj3]] – hHA + AMPPNP <br />
**[[6id0]], [[6id1]], [[8i0p]], [[8i0r]]. [[8i0s]], [[8i0t]], [[8i0u]], [[8i0v]], [[8i0w]] – hHA in spliceosome – Cryo EM<br />
**[[6id0]], [[6id1]], [[8i0p]], [[8i0r]]. [[8i0s]], [[8i0t]], [[8i0u]], [[8i0v]], [[8i0w]] – hHA in spliceosome – Cryo EM<br />

Latest revision as of 07:32, 24 September 2026

3D structures of helicase

Updated on 24-September-2026

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Openfox

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