Hemoglobin 3D structures

Updated on 15-May-2023 - For a general description of the protein see Hemoglobin

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• Hemoglobin α subunit + β subunit

• • 3odq, 3kmf, 3dut, 2dn2, 1xxt, 1xz2, 1rq3, 1uiw, 1kd2, 1lfl, 1dke, 1qi8, 1a3n, 2hhd, 2hhe, 1hga, 1hgb, 1hgc, 2hhb, 3hhb, 4hhb, 2hbs, 1a3o, 1hbs, 3p5q, 4n7n, 7dy3, 7dy4, 7ud7 - hHb α+β - human
    
  • 6nbd, 6nbc, 7vde, 7xgy - hHb α+β – Cryo EM
    
  • 5ni1 - hHb α+β - Volta phase
    
  • 2dxm - hHb α+β – neutron
    
  • 2h35, 2m6z - hHb α+β – NMR
    
  • 1fn3, 1nih, 4n7p, 4n7o, 6lcw, 6lcx - hHb α+β+ Ni containing heme
    
  • 1qsh, 1qsi - hHb α+β+ Mg containing heme
    
  • 1xy0, 1xz5, 1xzu, 1xzv, 1y0a, 1y0c, 1y0t, 1y0w, 1y22, 1y2z, 1y31, 1y35, 1y45, 1y46, 1y4b, 1y4f, 1y4g, 1y4p, 1y4q, 1y4r, 1y4v, 1xye, 1xz4, 1xz7, 1y09, 1y0d, 1o1j, 1o1k, 1o1l, 1o1m, 1o1n, 1o1o, 1o1p, 1j7s, 1j7w, 1j7y, 1c7b, 1c7c, 1c7d, 1ch4, 1bzz, 6hbw, 1abw, 1a30, 1a00, 1a01, 1a0u, 1a0z, 1gbu, 1gli, 1hdb, 1dxt, 1dxu, 1dxv, 4mqh, 4mqi, 7uvb - hHb α+β (mutant)
    
  • 1bz0 - hHb α+β A
    
  • 1cbl - hHb α+β β4
    
  • 1bij, 1cls - hHb α+β A crosslinked
    
  • 1fdh - hHb α+β F
    
  • 2hbs - hHb α+β S (mutant)
    
  • 3pi8, 3pi9, 3pia, 2qsp, 2qss, 1hda - bHb α+β - bovine
    
  • 6ii1 - bHb α+β+ Co containing heme
    
  • 1hds - Hb α+β S – white-tail deer
    
  • 3pel, 3gou, 2qls - Hb α+β - dog
    
  • 3hyu - gpHb α+β - Guinea pig
    
  • 3lqd - Hb α+β - European hare
    
  • 3dht - rHb α+β – rat
    
  • 3gys, 3gqp, 3d4x, 3gqr - Hb α+β – cat
    
  • 3gdj - Hb α+β – camel
    
  • 3eu1, 3d1a - gHb α+β – goat
    
  • 3cy5 - Hb α+β – buffalo
    
  • 3vre, 3vrg - maHb α+β – mammoth
    
  • 2zlt, 2zlu, 2zlv, 2zlw, 2zlx, 1y8h, 1y8i, 1y8k, 1ns6, 1ibe, 2dhb, 6r2o, 6sva - hoHb α+β – horse
    
  • 1s0h - Hb α+β – donkey
    
  • 1fhj - Hb α+β – wolf
    
  • 2b7h - Hb α+β - crab-eating fox
    
  • 4yu4, 4yu3 - Hb α+β - mongoose
    
  • 3hrw - mHb α+β – mouse
    
  • 5ker, 4h2l - Hb α+β - deer mouse
    
  • 3k8b, 6zmx, 6zmy - tHb α+β - turkey
    
  • 3eok - Hb α+β – duck
    
  • 2zfb - Hb α+β - parrot
    
  • 3a59 - osHb α+β – ostrich
    
  • 3mjp - Hb α+β - Japanese quail
    
  • 3mju - pHb α+β - pigeon
    
  • 1hv4 - bgHb α+β – Bar-headed goose
    
  • 1hbr - cHb α+β D – chicken
    
  • 3wr1 - Hb α+β - cormorant
    
  • 3bom - trHb α+β - trout
    
  • 1out - trHb α+β (mutant)
    
  • 2peg, 2h8d, 2h8f, 1s5x, 1s5y, 1hbh - ErHb α+β - Emerald rockcod
    
  • 3mkb – Hb α+β – Mako shark
    
  • 1it2 - haHb α+β - hagfish
    
  • 1v4w, 1v4x - btHb α+β - Bluefin tuna
    
  • 1cg5 - rsHb α+β – Red stingray
    
  • 3lhb, 1f5o, 1uc3 - slHb α+β – Sea lamprey
    
  • 6hit - Hb α2+β4 – cod
    
  • 2c0k - Hb α+β – botfly
    
  • 3at5, 3at6 – Hb α+β – Podocnemis unifilis
    
  • 1wmu, 1v75 - GgHb α+βD- Geochelone gigantean
    
  • 3ng6, 3nfe, 2aa1 - TnHb α+β Trematomus newnesi
    
• Hemoglobin α subunit + β subunit complex
  • 2w6v - hHb α+β + Xe
    
  • 2w72 - Hb α+β (mutant) + Xe
    
  • 3b75 - hHb α+β + glucose
    
  • 2d5z, 2d60 - hHb α+β + L35
    
  • 3ic0, 3ic2, 1qxd, 1qxe, 3r5i, 5urc, 5ufj, 5u3i, 5e83, 4rom, 4rol, 6bnr - hHb α+β + antisickling agent
    
  • 6bwu, 6bwp - hHb + modifying agent
    
  • 5ucu - hHb α+β + H2S
    
  • 5kdq - hHb α+β + aryloxyalkanoic acid
    
  • 3whm - hHb α+β + crown ether
    
  • 1k0y - hHb α+β + sites-linking compound
    
  • 1g9v, 4l7y - hHb α+β + allosteric effector
    
  • 5x2u, 5x2r - hHb +  + phosphate
    
  • 5ksj, 5ksi - hHb +  + sphingosine phosphate
    
  • 5x2t, 5x2s - hHb +  + benzafibrate
    
  • 1b86, 3wcp - hHb α+β + phosphoglycerate
    
  • 6di4 - hHb α+β + vanillin derivative
    
  • 7jjq - hHb α+β + amphetamine derivative
    
  • 3bev – cHb α + MHC I + β-microglobulin
    
  • 8dov - hHb α+β + SHR
    
  • 7pch, 7pcq - hHb a + b + iron-regulated surface determinant protein H – Cryo EM
    
• Hb  a
  • 3ovu - hHb a + a-HB-stabilizing protein + iron-regulated surface determinant protein H
    
• Hb β 
  • 6fqf - hHb
    
• Hemoglobin α subunit+ γ-2 subunit

• • 4mqj - hHb α+γ-2
    
  • 4mqk - hHb α+γ-2 (mutant)
    
  • 7qu4 - hHb (mutant) +γ-2
    

• Human hemoglobin variants

• • 2yrs - hHb D Los Angeles α+β
    
  • 1r1y - hHb α+β Bassett
    
  • 1r1x - hHb α+β Bassett (mutant) + CO
    
  • 1i3d - hHb α+β Bart’s + CO
    
  • 1a9w - hHb α+β Gower II + CO
    
  • 1bab - hHb α+β Thionville
    
  • 1hba, 1hbb - hHb α+β Rothschild
    
  • 1cmy - hHb α+β Ypsilanti + CO
    
• Hemoglobin ζ
  • 3w4u - hHb ζ+β
    

• Hemoglobin

• • 3wtg - Hb – emu
    
  • 3ogb, 2w6x, 2w6y – SwHb (mutant) – Sperm whale
    
  • 2bk9 – DmHb - Drosophila melanogaster
    
  • 4bja - Hb – Caenorhabditis elegans
    
  • 6otw, 6otx, 6oty - Hb II + Hb III – thick lucine
    
  • 2r50 - Hb – corn
    
  • 2gnv, 2gnw – rHb (mutant) – rice
    
  • 1d8u – rHb
    
  • 3qqq – Hb non-symbiotic – Poison peach
    
  • 7zos – Hb non-symbiotic – sugar beet
    
  • 2bmm – TfHb – Thermobifida fusca
    
  • 4uzv – TfHb (mutant)
    
  • 1kfr, 1h97 – Hb – Paramphistomum epiclitum
    
  • 1gcv – MgHb - Mustelus griseus
    
  • 1vhb, 3tld, 3tm3 – VsHb – Vitreoscilla stercoraria
    
  • 3tm9 – VsHb (mutant)
    
  • 4vhb – VsHb + SCN
    
  • 1hlb, 1hlm – Hb – Caudina arenicola
    
  • 2hbg - GdHb – Glycera dibranchiata
    
  • 3qqr – Hb non-legume – Parasponia andersonii
    
  • 2ksc, 1mwb – Hb – Synechococcus – NMR
    
  • 2zwj, 1x3k, 3arj, 3ark, 3arl - TaHb V – Tokunagayusurika akamusi
    
  • 1x46 – TaHb VII
    
  • 3lb1, 3lb2, 3lb3, 3lb4 – dehaloperoxidase AoHb+inhibitor – Amphitrite ornate
    
  • 3k3u - dehaloperoxidase AoHb (mutant)
    
  • 2xyk – 2-on-2 Hb – Agrobacterium tumefaciens
    
  • 2hz1, 1rtx – SyHb – Synechocystis
    
  • 2hz3 – SyHb (mutant)
    

• Mini hemoglobin

• • 2xkg, 2xkh, 2xki, 2vyy, 2vyz, 4f68, 4f69, 4f6b, 4f6d, 4f6f, 4f6g, 4f6i, 4f6j – ClMiHb (mutant) – Cerebratulus lacteus
    
  • 4avd – ClMiHb + CO
    
  • 4ave – ClMiHb
    
• Giant hemoglobin
  • 1x9f – GiHb+CO – worm
    
  • 2zs0, 2zs1, 2zfo, 2d2m, 2d2n, 7e96, 7e97, 7e98, 7e99 – GiHb+O2 – Beard worm
    
  • 1yhu – GiHb+O2 – Tube worm
    
  • 3wct, 3wcu, 3wcv, 3wcw, 7vlc, 7vle 7vlf - GiHb+O2 – Vent tube worm
    
  • 4u8u – GtGIHb + CN – Glossoscolex taulistus
    
  • 4wch – GtGIHb chain D + O2
    

• Truncated hemoglobin

• • 4c44, 4c0n - TrHb – Arabidopsis thaliana
    
  • 1dlw – TrHb – Paramecium caudatum
    
  • 2bkm - TrHb +O2 - Geobacillus stearothermophilus
    
  • 5ab8 - MtTrHb - Mycobacterium tuberculosis
    
  • 1idr – MtTrHb + O2
    
  • 1rte, 1s56 – MtTrHb + CN
    
  • 1s61 – MtTrHb+ butyl-isocyanide
    
  • 2ig3 – TrHb III +CN – Campylobacter jejuni
    
  • 1ux8 – TrHb+CN – Bacillus subtilis
    
  • 5v3t - BaTrHb+CN – Bacillus anthracis
    
  • 5v3u, 5v3v – BaTrHb (mutant) +CN
    
  • 1uvx, 1uvy – TrHb + CN – Chlamydomonas moewusii
    
  • 6cii, 6td7 - CrTrHb + CN – Chlamydomonas reinhardtii
    
  • 6bme, 4xdi - CrTrHb 4
    
  • 3aq5 – TpTrHb+ O2 – Tetrahymena pyriformis
    
  • 3aq6 – TpTrHb III
    
  • 3aq7, 3aq8, 3aq9 - TpHb III (mutant)
    
  • 7tt9 - TrHb – Shewanella benthica
    
• Methemoglobin α subunit + β subunit
  • 1jy7, 1bz1, 6nq5 - hMetHb α+β
    
  • 1vwt - hMetHb α+β (mutant)
    
  • 4xs0 - hMetHb α+β + ISDH
    
  • 6hk2 - hMetHb + + chelator + O2
    
  • 1ns9, 2mhb - hoMetHb α+β
    
  • 2qu0 - MetHb α+β – sheep
    
  • 2pgh - piMetHb α+β - pig
    
  • 3dhr - pMetHb α+β
    
  • 1c40 - bgMetHb α+β
    
  • 3hf4 - rMetHb α+β
    
  • 2ri4 - gMetHb α+β
    
  • 3gqg - roMetHb α+β
    
  • 2r1h - trMetHb α+β
    
  • 1dtm, 1duo - SwMdetHb (mutant) + methylimidazole
    
  • 1duk - SwMdetHb
    
  • 3bj1, 3bj2, 3bj3, 1xq5 - MetHb α+β – yellow perch
    
  • 2hz2 – SyMetHb (mutant)
    
  • 1moh - LpMetHb + H2S - Lucina pectinata
    
  • 1flp, 3pi1, 3pi2, 3pi3, 3pi4 – LpMetHb
    
  • 7pcf - MetHb a + b - Staphylococcus aureus
    

• Leghemoglobin

• • 1lh1, 1lh2, 1lh3, 1lh5, 1lh6, 1lh7, 2lh1, 2lh2, 2lh3, 2lh5, 2lh6, 2lh7, 1gdj – LlLegHb – Lupinus luteus
    
  • 2gdm – LlLegHb + O2
    
  • 1gdi – LlLegHb + CO
    
  • 1gdl – LlLegHb + NO
    
  • 1gdk – LlLegHb + isoquinoline
    
  • 1bin – SoLegHb – Soybean
    
  • 1fsl – SoLegHb + nicotinate

• Hemoglobin α subunit + β subunit + CO

• • 3d17, 1yzi, 1j3y, 1j3z, 1j40, 1j41, 1ljw, 1ird, 1bbb, 1hco, 2hco, 2dn3, 3s65, 5e6e, 6hal, 6kao, 6kap, 6kaq, 6kar, 6kas, 6kat, 6kau, 6kav, 6kye, 6l5v, 6l5w, 6l5x, 6l5y, 7aet, 7k4m, 7uf6, 7uf7, 8egi - hHb α+β + CO
    
  • 1mko - hHb α+β A + CO
    
  • 1cbm - hHb α+β β4 + CO
    
  • 1nej - hHb α+β S + CO
    
  • 1m9p - hHb α+β C + CO
    
  • 1coh - hHb α+β Co containing heme + CO
    
  • 6ka9, 6kae, 6kah, 6kai - hHb +  Ni containing heme + CO
    
  • 1hab, 1hac, 1sdk, 1sdl - hHb α+β A crosslinked + CO
    
  • 3nl7, 3nml, 3nmm, 1yvq, 1yvt, 1yff, 1aj9, 1rvw, 3qjb, 3qjc, 3qjd, 3qje, 3s66, 4mqc, 4mqg, 5sw7 - hHb α+β (mutant) + CO
    
  • 1k1k - hHb α+β C (mutant) + CO
    
  • 3hxn - hHb α+β +CO+inositol hexakisphosphate
    
  • 4ni1, 4ni0 - hHb α+β + CO + thiol derivative
    
  • 6xd9, 6xdt, 6xe7, 7jxz - hHb + + CO + antisickling drug
    
  • 1jeb – hHb/mHb α+β +CO
    
  • 1fsx, 1g08, 1g09, 1g0a, 1g0b, 6ihx - bHb α+β +CO
    
  • 1iwh - hoHb α+β +CO
    
  • 2d5x - hoHb α+β + CO + L35
    
  • 3vrf - maHb α+β + CO
    
  • 1ouu - trHb α+β (mutant) + CO
    
  • 6rp5 - Hb + + CO – Patagonian blennie
    
  • 3gkv, 1pbx - roHb α+β + CO
    
  • 1it3 - haHb α+β +CO
    
  • 1spg - Hb α+β + CO - Spot croaker
    
  • 1f5p – SlHb V + CO
    
  • 2z6n - GgHb α+β +CO
    
  • 1v4u - BtHb α+β
    
  • 3a9m, 3a5a, 3a5b, 3a5g – TaHb V+CO
    
  • 1gcw – MgHb + CO
    
  • 1vre, 1vrf - GdHb IV+ CO – NMR
    
  • 1hbg, 1hbg – GdHb + CO
    
  • 1cg8 - rsHb α+β + CO
    
  • 4esa - Hb α+β + CO – Eleginops maclovinus
    
  • 4iro – TbHb α+β + CO – Trematomus bernacchii
    
  • 5lfg, 3d1k, 1la6, 1t1n – TnHb α+β + CO
    

• Hemoglobin α subunit + β subunit + O2

• • 2dn1, 1lfq, 1lft, 1lfv, 1lfy, 1lfz, 1gzx, 1thb, 1hho, 5hy8, 6bb5, 5woh, 5wog, 7ud8 – hHb α+β +O2
    
  • 1yeo, 1yh9, 1yhe, 1yhr, 1yie, 1yih, 1yen, 1yeq, 1yeu, 1yev, 1yg5, 1ygd, 1ygf, 1y8w, 1ydz, 1ye0, 1ye1, 1ye2, 1y7z, 1y83, 1y85, 1y5f, 1y5j, 1y5k, 1y7c, 1y7d, 1y7g, 1gbv - hHb α+β (mutant) + O2
    
  • 7jy0, 7jy1, 7jy3 - hHb + O2 + pyrazole derivative
    
  • 3ciu - bHb α+β +O+glycosylation
    
  • 1qpw - piHb α+β +O2 - pig
    
  • 2rao - Hb α+β + O2 – rabbit
    
  • 3fh9 - Hb α+β +O2 – Indian flying fox
    
  • 1faw - Hb α+β +O2 – Grayleg goose
    
  • 3fs4 - osHb α+β + O2
    
  • 2r80 - pHb α+β +O2
    
  • 2qmb - tHb α+β +O2 - turkey
    
  • 1ash – Hb + O2 – Pig roundworm
    
  • 2vyw – Hb+O2 – Fasciola Hepatica
    
  • 3a0g - GpHb α+β + O2
    
  • 3bcq - Hb α+β +O2 – Brycon cephalus
    
  • 2olp, 3pt7 - LpHb+O2
    
  • 1a4f – bgHb α+β +O2
    
  • 1v07 – ClMiHb (mutant) + O2
    
  • 1kr7 – ClMiHb + O2
    

• Hemoglobin α subunit + β subunit + CN

• • 1shr, 1si4 - hHb α+β + CN
    
  • 2hbc, 2hbd, 2hbe, 2hbf - hHb α+β A + isocyanide compound
    
  • 1nqp - hHb α+β E + CN
    
  • 1o1i, 1aby - hHb α+β (mutant)+CN
    
  • 1i3e - hMetHb α+β Bart’s + N3
    
  • 5c6e – hoHb α+β + CN
    
  • 2g3h – DmHb (mutant)+CN
    
  • 1ebc – SwMdetHb + CN
    
  • 2lhb – slHb V + CN
    
  • 2oif - Hb+CN – barley
    
  • 1s69 – SyHb + CN
    
  • 1s6a – SyHb + N3
    
  • 1jl6, 1jf4 – GdHb IV+ CN
    
  • 1jl7, 1jf3 – GdHb III + CN
    
  • 1dly – Hb + CN – Chlamydomonas eugametos
    
  • 1b0b, 1ebt, 3pt8 – LpHb + CN
    
  • 4vhb – VsHb + SCN
    
  • 3vhb – VsHb + imidazole
    
  • 2vhb – VsHb + N3
    
  • 1ith – Hb + CN – Urechis caupo
    
  • 4odc – TbHb α+β + CN
    

• Hemoglobin α subunit + β subunit + NO2

• • 3d7o, 3onz, 3oo4, 3oo5 - hHb α+β+NO2
    
  • 4n8t – hHb α+β + NO + NO2
    
  • 4m4b, 1buw, 4m4a - hHb α+β + nitroso derivative
    
• Hemoglobin α subunit + β subunit + NO
  • 1rqa - hHb α+β (mutant) + NO
    
  • 1rps, 1rq4 - hHb α+β+NO
    
  • 5e29 - hHb α+β + NO + drug
    
  • 4g51 – TbHb α+β + NO
    
• Dimeric hemoglobin (Globin-1)
  • 2z85, 2aur, 2av3, 1jzk, 1jzm, 4hbi, 2grf, 3uhk, 3uhn, 3uhq, 3uhr, 3uhs, 3uht, 3uhu, 3uhv, 3uhw, 3uhx, 3uhy, 3uhz, 3ui0, 3ugy, 6hbi- AcHb (mutant) - Ark clam
    
  • 4sdh - AcHb α+β
    
  • 3g46, 3g4q, 3g4r, 3g4u, 3g4v, 3g4w, 3g4y, 3g52, 3g53, 4hrr, 3sdh, 1nxf, 3uhd, 1nw1, 1nwn, 3qob]]3hbi]], – AcHb +CO
    
  • 2r4w, 2r4x, 2r4y, 2r4z, 2z8a, 2grh, 2auo, 2aup, 2auq, 2av0, 1jzl, 1jwn, 5hbi, 7hbi, 1grz, 3ugz, 3uh3, 3uh5, 3uh6, 3uh7, 3uhb, 3uhc, 3uhd, 3uhe, 3uhg, 3uhh, 3uhi, 7hbi – AcHb (mutant) + CO
    
  • 1hbi - AcHb +O2
    
  • 3zhw – EcHb - Escherichia coli
    
• Tetrameric hemoglobin (Globin-2)
  • 4hrt – globin-2 α+ Hb β - Inequivalve Ark
• Hemoglobin complex with protein
  • 3szk, 3s48 - hHb α+β + iron-regulated surface determinant protein H
    
  • 4fc3, 4ij2 - hHb α+β + iron-regulated surface determinant protein H
    
  • 5vmm - hHb α+β + iron-regulated cell wall-anchored protein
    
  • 6tb2 - hHb α+β + haptoglobin + heme transporter HARA
    
  • 4x0l - hHb α+β + haptoglobin + O2
    
  • 5hu6 - hHb α+β + haptoglobin + haptoglobin-Hb receptor + O2
    
  • 4wjg, 5jdo - hHb α+β + haptoglobin + haptoglobin-Hb receptor + haptoglobin receptor A + O2
    
  • 3ia3 - hHb α + α-Hb stabilizing protein
    
  • 1z8u, 1y01 - hHb α+α–Hb stabilizing protein (mutant)
    
  • 5ee4 - hHb α+β + Hb-haptoglobin utilization protein + O2
    
  • 7cue - hHb α+β + HID2
    
  • 4f4o - piHb α+β + haptoglobin
    
  • 5m3l – Hb D1+L1+L2+L3 + globin A+B+C – earthworm – Cryo EM
    
• Flavohemoglobin
  • 4g1v – yFHb - yeast
    
  • 4g1b – yFHb + econazole
    
  • 1gvh – EcFhb
    
  • 1cqx – CnFhb – Cupriavidus necator
    
  • 3ozu – CnFhb + miconazole
    
  • 3ozv – CnFhb + econazole
    
  • 3ozw – CnFhb + ketoconazole
    
  • 4eh1 – Fhb + FAD – Vibrio cholerae
    

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