Heat Shock Protein structures: Difference between revisions

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**[[1ons]] – EcHsp31<br />
**[[1ons]] – EcHsp31<br />
**[[3gla]], [[3gt6]], [[3guf]]  – Hsp – ''Xanthomonas axonopodis''<br />
**[[3gla]], [[3gt6]], [[3guf]]  – Hsp – ''Xanthomonas axonopodis''<br />
**[[3aac]], [3vqk]] – StHsp14 – ''Sulfolobus tokodaii''<br />
**[[3aac]], [[3vqk]] – StHsp14 – ''Sulfolobus tokodaii''<br />
**[[3aab]], [[3vql]], [[3vqm]] – StHsp14 (mutant)<br />
**[[3aab]], [[3vql]], [[3vqm]] – StHsp14 (mutant)<br />
**[[3w1z]] – Hsp16 – ''Schizosacchromyces pombe''<br />
**[[3w1z]] – Hsp16 – ''Schizosacchromyces pombe''<br />
Line 41: Line 41:
**[[6l6m]] – Hsp18.5 – ''Entamoeba histolytica''<br />
**[[6l6m]] – Hsp18.5 – ''Entamoeba histolytica''<br />
**[[4fei]] – Hsp17.7 – ''Deinococcus radiodurans''<br />
**[[4fei]] – Hsp17.7 – ''Deinococcus radiodurans''<br />
**[[1shs]], [[4eld]], [[4i88]] – Hsp – ''Methanococcus jannaschii''<br />
**[[1shs]], [[4eld]], [[4i88]] – MjHsp – ''Methanococcus jannaschii''<br />
**[[9nv4]], [[9nv7]], [[9nv8]], [[9nvc]], [[9nvf]], [[9nvi]], [[9nvj]], [[9nvk]] – MjHsp16.5 <br />
**[[8wp9]] – MjHsp16.5 – Cryo EM<br />
**[[2bol]] – Hsp – ''Taenia saginata''<br />
**[[2bol]] – Hsp – ''Taenia saginata''<br />
**[[5zul]] – MmaHsp – ''Mycobacterium marinum''<br />
**[[5zul]] – MmaHsp – ''Mycobacterium marinum''<br />
**[[5zs6]], [[5zs3]] – MmaHsp + peptide<br />
**[[5zs3]], [[5zs6]] – MmaHsp + peptide<br />
**[[7ck4]] – Hsp – ''Synechococcus'' phage<br />
**[[7ck4]] – Hsp – ''Synechococcus'' phage<br />
**[[6ewn]] – HspA – ''Thermosynechococcus vulcanus''<br />
**[[6ewn]] – HspA – ''Thermosynechococcus vulcanus''<br />
Line 59: Line 61:
*HslV, HslU, HslJ or ATP-dependent protease ATPase subunit HsIU
*HslV, HslU, HslJ or ATP-dependent protease ATPase subunit HsIU


**[[1e94]], [[1yyf]], [[1g4a]], [[1g4b]], [[1hqy]], [[1ht1]], [[1ht2]], [[5ji3]] – EcHslV+HslU <br />
**[[1e94]], [[1g4a]], [[1g4b]], [[1hqy]], [[1ht1]], [[1ht2]], [[1yyf]], [[5ji3]] – EcHslV+HslU <br />
**[[5txv]] – EcHslU<br />
**[[5txv]] – EcHslU<br />
**[[6pxl]], [[6pxk]] – EcHslU + ADP<br />
**[[6pxk]], [[6pxl]] – EcHslU + ADP<br />
**[[5ji2]], [[6pxi]] – EcHslV + EcHslU (mutant)<br />
**[[5ji2]], [[6pxi]] – EcHslV + EcHslU (mutant)<br />
**[[1ned]] – EcHslV<br />
**[[1ned]] – EcHslV<br />
Line 103: Line 105:
* Hsp60 mitochondrial
* Hsp60 mitochondrial
**[[7azp]], [[7l7l]], [[7l7s]] – hHsp60 – Cryo EM<br />
**[[7azp]], [[7l7l]], [[7l7s]], [[8g7j]], [[9es3]] – hHsp60 – Cryo EM<br />
**[[7azp]], [[7l7l]], [[7l7s]], [[8g7j]] – hHsp60 – Cryo EM<br />
**[[8u39]] – hHsp60 (mutant) - Cryo EM
**[[8u39]] – hHsp60 (mutant) - Cryo EM
**[[9es6]] – hHsp60 + ADP – Cryo EM<br />
**[[8g7k]] – hHsp60 (mutant) + ADP – Cryo EM
**[[8g7k]] – hHsp60 (mutant) + ADP – Cryo EM
**[[8g7m]], [[8g7o]] – hHsp60 (mutant) + ATP – Cryo EM
**[[9es2]] – hHsp60 + ATP – Cryo EM
**[[8g7l]], [[8g7m]], [[8g7o]] – hHsp60 (mutant) + ATP – Cryo EM
**[[4pj1]], [[6ht7]] – hHsp60 + hHsp10 + ADP<br />
**[[4pj1]], [[6ht7]] – hHsp60 + hHsp10 + ADP<br />
**[[6mrc]], [[6mrd]] – hHsp60 + hHsp10 + ADP – Cryo EM<br />
**[[6mrc]], [[6mrd]], [[9es4]], [[9es5]] – hHsp60 + hHsp10 + ADP – Cryo EM<br />
**[[9es0]], [[9es1]] – hHsp60 + hHsp10 + ATP – Cryo EM<br />
**[[8g7n]] – hHsp60 (mutant) + hHsp10 + ATP – Cryo EM<br />
**[[7v98]], [[7v9r]] – Hsp60 – Epinephelus coioides


* Hsp60 - the large subunit of the chaperonin molecule GroEL ; See [[Chaperonin]]
* Hsp60 - the large subunit of the chaperonin molecule GroEL ; See [[Chaperonin]]
Line 119: Line 125:
* Hsp70 – 3 domains: N-terminus ATPase hydrolyzes ATP to ADP (NBD) residues 1-380; hydrophobic amino acid binding domain (SBD) residues 381-564: C-terminus lid domain (CT) residues 534-641.  
* Hsp70 – 3 domains: N-terminus ATPase hydrolyzes ATP to ADP (NBD) residues 1-380; hydrophobic amino acid binding domain (SBD) residues 381-564: C-terminus lid domain (CT) residues 534-641.  


**[[5bn8]], [[2e88]], [[1s3x]], [[1hjo]], [[6g3s]], [[6g3r]], [[6fhk]] – hHsp70 NBD <br />
**[[1hjo]], [[1s3x]], [[2e88]], [[5bn8]], [[6fhk]], [[6g3r]], [[6g3s]] – hHsp70 NBD <br />
**[[5bn9]], [[5bpl]], [[5bpm]], [[5bpn]]  – hHsp70 NBD (mutant)<br />
**[[5bn9]], [[5bpl]], [[5bpm]], [[5bpn]]  – hHsp70 NBD (mutant)<br />
**[[3a8y]] – hHsp70 NBD+BAG domain regulator protein<br />
**[[3a8y]] – hHsp70 NBD+BAG domain regulator protein<br />
Line 127: Line 133:
**[[6b1m]] - hHsp70 NBD (mutant) + ANP<br />
**[[6b1m]] - hHsp70 NBD (mutant) + ANP<br />
**[[2e8a]] - hHsp70 NBD+AMPPNP<br />
**[[2e8a]] - hHsp70 NBD+AMPPNP<br />
**[[3jxu]], [[3i33]], [[3gdq]], [[3fe1]] - hHsp70 NBD+ADP+P<br />
**[[3fe1]], [[3gdq]], [[3i33]], [[3jku]] - hHsp70 NBD+ADP+P<br />
**[[3iuc]], [[3atu]], [[3atv]], [[3ay9]] - hHsp70 NBD+ADP<br />
**[[3atu]], [[3atv]], [[3ay9]], [[3iuc]] - hHsp70 NBD+ADP<br />
**[[3lof]] – hHsp70 CT<br />
**[[3lof]] – hHsp70 CT<br />
**[[4po2]] - hHsp70 CT + peptide<br />
**[[4po2]] - hHsp70 CT + peptide<br />
**[[2lmg]] – hHsp70 CT - NMR<br />
**[[2lmg]] – hHsp70 CT - NMR<br />
**[[3dob]], [[3dqg]], [[2op6]] - CeHsp70 SBD – ''Caenoharbditis elegans''<br />
**[[4i2w]] – CeHsp70 + myosin chaperone<br />
**[[2p32]] - CeHsp70 CT<br />
**[[1xqs]] – hHsp70 SBD + Hsp-binding protein core domain<br />
**[[1xqs]] – hHsp70 SBD + Hsp-binding protein core domain<br />
**[[4j8f]], [[4wv5]], [[5xi9]], [[5gjj]] - hHsp70 SBD<br />
**[[4j8f]], [[4wv5]], [[5gjj]], [[5xi9]] - hHsp70 SBD<br />
**[[5xir]] - hHsp70 SBD (mutant)<br />
**[[5xir]] - hHsp70 SBD (mutant)<br />
**[[4wv7]] - hHsp70 SBD + novolactone<br />
**[[4wv7]] - hHsp70 SBD + novolactone<br />
**[[1hx1]] - bHsp70 NBD + molecular chaperone regulator 1 BAG domain<br />
**[[1hx1]] - bHsp70 NBD + molecular chaperone regulator 1 BAG domain<br />
**[[2op6]], [[3dob]], [[3dqg]] - CeHsp70 SBD – ''Caenoharbditis elegans''<br />
**[[4i2w]] – CeHsp70 + myosin chaperone<br />
**[[2p32]] - CeHsp70 CT<br />
**[[1q5l]] - EcHsp70 SBD +peptide - NMR<br />
**[[1q5l]] - EcHsp70 SBD +peptide - NMR<br />
**[[3gl1]] - ScHsp70 NBD – ''Saccharomyces cerevisiae''<br />
**[[7rax]] - EcHsp70 NBD + ATP <br />
**[[2d2e]], [[3d2f]] – ScHsp70 NBD+SSE1(Hsp110)<br />
**[[3gl1]] - yHsp70 NBD <br />
**[[2d2e]], [[3d2f]] – yHsp70 NBD+SSE1(Hsp110)<br />
**[[3lca]] – yHsp70 Ssa1 CT+yTOM71<br />
**[[3lca]] – yHsp70 Ssa1 CT+yTOM71<br />
**[[2v7y]] – Hsp70 NBD+SBD – ''Geobacillus kaustophilus''<br />
**[[2v7y]] – Hsp70 NBD+SBD – ''Geobacillus kaustophilus''<br />
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**[[3kvg]] - CpHsp70 NBD+AMPPNP<br />
**[[3kvg]] - CpHsp70 NBD+AMPPNP<br />
**[[3l4i]] - CpHsp70 NBD+ADP+P<br />
**[[3l4i]] - CpHsp70 NBD+ADP+P<br />
**[[8w1m]] – TtHsp70 NTD+ADP <br />
**[[6rzq]] – PfHsp70 NTD+ANP <br />
**[[6rzq]] – PfHsp70 NTD+ANP <br />
**[[6s02]] – PfHsp70 NTD+ADP <br />
**[[6s02]] – PfHsp70 NTD+ADP <br />
Line 153: Line 161:
**[[7nqr]], [[7nqs]], [[7nqu]], [[7nqz]] - PfHsp70 NBD + inhibitor<br />
**[[7nqr]], [[7nqs]], [[7nqu]], [[7nqz]] - PfHsp70 NBD + inhibitor<br />
**[[6zhi]] - PfHsp70 CT + peptide<br />
**[[6zhi]] - PfHsp70 CT + peptide<br />
**[[8gb3]] - MtHsp70 + Grpe – Cryo EM<br />


*Hsp70 family protein 5 or endoplasmic reticulum chaperone BIP
*Hsp70 family protein 5 or endoplasmic reticulum chaperone BIP
Line 158: Line 167:
**[[6cz1]], [[6dfm]], [[6dfo]], [[6do2]], [[6dws]] - hBIP ATPase domain + adenosine derivative 26-407<br />
**[[6cz1]], [[6dfm]], [[6dfo]], [[6do2]], [[6dws]] - hBIP ATPase domain + adenosine derivative 26-407<br />
**[[6hab]] - haBIP (mutant) - hamster <br />
**[[6hab]] - haBIP (mutant) - hamster <br />
**[[6h9u]], [[6ha7]] - haBIP + mesencephalic atrocyte-derived neurotrophic factor - hamster <br />
**[[6h9u]], [[6ha7]] - haBIP + mesencephalic atrocyte-derived neurotrophic factor <br />


*DnaK or chaperone protein DnaK (Hsp70 from ''E. coli'') Domains: NBD 1-383; SBD 389-607  
*DnaK or chaperone protein DnaK (Hsp70 from ''E. coli'') Domains: NBD 1-383; SBD 389-607  
Line 169: Line 178:
**[[1dkg]] - EcDnaK NBD (mutant) + nucleotide exchange factor<br />
**[[1dkg]] - EcDnaK NBD (mutant) + nucleotide exchange factor<br />
**[[4ani]] - EcDnaK NBD + SBD + nucleotide exchange factor<br />
**[[4ani]] - EcDnaK NBD + SBD + nucleotide exchange factor<br />
**[[1dkx]], [[1dkz]], [[4r5j]], [[4r5k]], [[4r5l]], [[4f01]] - EcDnaK NBD + sub<br />
**[[1dkx]], [[1dkz]], [[4f01]], [[4r5j]], [[4r5k]], [[4r5l]] - EcDnaK NBD + sub<br />
**[[4jn4]], [[4jne]] - EcDnaK NBD + SBD (mutant) + ATP<br />
**[[4jn4]], [[4jne]] - EcDnaK NBD + SBD (mutant) + ATP<br />
**[[4jnf]] - EcDnaK SBD (mutant) + ATP<br />
**[[4jnf]] - EcDnaK SBD (mutant) + ATP<br />
**[[1bpr]], [[1dg4]], [[2bpr]] - EcDnaK SBD – NMR<br />
**[[1bpr]], [[1dg4]], [[2bpr]] - EcDnaK SBD – NMR<br />
**[[1q5l]] - EcDnaK SBD + peptide – NMR<br />
**[[1q5l]] - EcDnaK SBD + peptide – NMR<br />
**[[3dpp]], [[3dpq]], [[3dpo]], [[1dky]], [[3qnj]], [[4e81]], [[4ezn]], [[4ezo]], [[4ezp]], [[4ezq]], [[4ezr]], [[4ezs]], [[4ezt]], [[4ezu]], [[4ezv]], [[4ezw]], [[4ezx]], [[4ezy]], [[4ezz]], [[4f00]], [[4hy9]], [[4hyb]], [[4jwc]], [[4jwd]], [[4jwe]], [[4jwi]], [[4r5i]], [[4f01]], [[7jmm]], [[7jn8]], [[7jn9]], [[7jne]], [[7n6j]], [[7n6k]], [[7n6l]], [[7n6m]] – EcDnaK SBD + peptide<br />
**[[1dky]], [[3dpo]], [[3dpp]], [[3dpq]], [[3qnj]], [[4e81]], [[4ezn]], [[4ezo]], [[4ezp]], [[4ezq]], [[4ezr]], [[4ezs]], [[4ezt]], [[4ezu]], [[4ezv]], [[4ezw]], [[4ezx]], [[4ezy]], [[4ezz]], [[4f00]], [[4f01]], [[4hy9]], [[4hyb]], [[4jwc]], [[4jwd]], [[4jwe]], [[4jwi]], [[4r5i]], [[7jmm]], [[7jn8]], [[7jn9]], [[7jne]], [[7n6j]], [[7n6k]], [[7n6l]], [[7n6m]] – EcDnaK SBD + peptide<br />
**[[7krw]], [[7kzi]], [[7kzu]] – EcDnaK/peptide<br />
**[[7krw]], [[7kzi]], [[7kzu]] – EcDnaK/peptide<br />
**[[1q5l]] - EcDnaK SBD +peptide – NMR<br />
**[[1q5l]] - EcDnaK SBD +peptide – NMR<br />
Line 190: Line 199:
**[[5f3k]], [[5f5r]] – hHsp75 NTD<br />
**[[5f3k]], [[5f5r]] – hHsp75 NTD<br />
**[[5hph]], [[7ulk]] – hHsp75 residues 60-554<br />
**[[5hph]], [[7ulk]] – hHsp75 residues 60-554<br />
**[[4z1f]], [[4z1g]], [[4z1h]], [[4z1i]], [[5y3n]], [[5y3o]], [[7c04]], [[7c05]], [[7c7b]], [[7c7c]] – hHsp75 + inhibitor<br />
**[[4z1f]], [[4z1g]], [[4z1h]], [[4z1i]], [[5y3n]], [[5y3o]], [[7c04]], [[7c05]], [[7c7b]], [[7c7c]], [[7u8u]], [[7u8v]], [[7u8w]], [[7u8x]] – hHsp75 + inhibitor<br />
**[[6xg6]] – hHsp75 residues 60-704 + ADP – Cryo EM<br />
**[[6xg6]] – hHsp75 residues 60-704 + ADP – Cryo EM<br />
**[[7kck]], [[7klu]], [[7klv]] – hHsp75 residues 60-704 + AMPPNP – Cryo EM<br />
**[[7kck]], [[7klu]], [[7klv]] – hHsp75 residues 60-704 + AMPPNP – Cryo EM<br />
Line 197: Line 206:
*Hsp83
*Hsp83


**[[8u1l]], [[8u1m]], [[8u1n]] – Hsp83 + ATP – cabbage looper – Cryo EM
**[[3u67]] – LmHsp83 NTD + ADP – ''Leishmania major''
**[[3u67]] – LmHsp83 NTD + ADP – ''Leishmania major''


Line 203: Line 213:
*''Hsp90-α NTD''
*''Hsp90-α NTD''


**[[3t0h]], [[5j2v]], [[6gpw]], [[7s8y]], [[7s8z]][[5xr]],  - hHsp90 NTD – human<br />
**[[3t0h]], [[5j2v]], [[6gpw]], [[7s8y]], [[7s8z]], [[8jr6]], [[8ki4]], [[9imw]] - hHsp90 NTD <br />
**[[5j80]], [[6gr4]], [[6gp4]] - hHsp90 NTD (mutant)<br />
**[[5j80]], [[6gp4]], [[6gr4]], [[8jr7]], [[8jra]], [[8x2r]] - hHsp90 NTD (mutant)<br />
**[[2h8m]], [[2hch]], [[2gqp]] – dHsp90B1 NTD <br />
**[[2gqp]], [[2h8m]], [[2hch]] – dHsp90B1 NTD <br />
**[[1yt1]], [[1yt2]] - dHsp90B1 NTD (mutant) <br />
**[[1yt1]], [[1yt2]] - dHsp90B1 NTD (mutant) <br />
**[[4x9l]] - Hsp90 NTD - rice<br />
**[[4x9l]] - riHsp90 NTD - rice<br />
**[[3h80]] – LmHsp90 NTD <br />
**[[3h80]] – LmHsp90 NTD <br />
**[[4gqt]] – CeHsp90 NTD<br />
**[[4gqt]] – CeHsp90 NTD<br />
Line 213: Line 223:
*''Hsp90-α NTD complexes''
*''Hsp90-α NTD complexes''


**[[6gqr]], [[3t0z]], [[3t2s]], [[3t10]], [[3t1k]], [[6gq6]], [[6gpy]], [[6gpt]], [[6gpr]], [[1byq]] - hHsp90-α NTD + nucleotide<br />
**[[1byq]], [[3t0z]], [[3t10]], [[3t1k]], [[3t2s]], [[6gq6]], [[6gpr]], [[6gpt]], [[6gpy]], [[6gqr]], [[7s90]] - hHsp90-α NTD + nucleotide<br />
**[[6gr5]], [[6gr3]], [[6gr1]], [[6gqu]], [[6gqs]], [[6gpp]], [[6gpo]], [[6gph]], [[6gpf]], [[6gp8]] - hHsp90-α NTD (mutant) + nucleotide<br />
**[[6gp8]], [[6gpf]], [[6gph]], [[6gpo]], [[6gpp]], [[6gqs]], [[6gqu]], [[6gr1]], [[6gr3]], [[6gr5]] - hHsp90-α NTD (mutant) + nucleotide<br />
**[[3k97]], [[3hek]], [[3mnq]] – hHsp90 NTD+pyrrolidin derivative <br />
**[[3hek]], [[3k97]], [[3mnq]] – hHsp90 NTD+pyrrolidin derivative <br />
**[[3k98]], [[3k99]], [[3qtf]], [[5lo5]], [[7lsz]], [[7lt0]] - hHsp90 NTD+indole derivative<br />
**[[3k98]], [[3k99]], [[3qtf]], [[5lo5]], [[7lsz]], [[7lt0]] - hHsp90 NTD+indole derivative<br />
**[[3r91]] - hHsp90 NTD (mutant) +indole derivative<br />
**[[3r91]] - hHsp90 NTD (mutant) +indole derivative<br />
**[[3hhu]], [[4jql]] - hHsp90 NTD+ carbamic acid derivative<br />
**[[3hhu]], [[4jql]] - hHsp90 NTD+ carbamic acid derivative<br />
**[[3ft8]], [[3ft5]], [[4cwf]], [[4cwn]], [[4cwo]], [[4cwp]], [[4cwq]], [[4cwr]], [[4cws]], [[4cwt]], [[6ei5]], [[5od7]] - hHsp90 NTD+quinazoline derivative inhibitor<br />
**[[3ft5]], [[3ft8]], [[4cwf]], [[4cwn]], [[4cwo]], [[4cwp]], [[4cwq]], [[4cwr]], [[4cws]], [[4cwt]], [[5od7]], [[6ei5]] - hHsp90 NTD+quinazoline derivative inhibitor<br />
**[[2k5b]] - hHsp90 NTD+Cdc37 – NMR - docking<br />
**[[2k5b]] - hHsp90 NTD+Cdc37 – NMR - docking<br />
**[[3eko]], [[3ekr]] - hHsp90 NTD+dihydroxyphenyl amide<br />
**[[3eko]], [[3ekr]] - hHsp90 NTD+dihydroxyphenyl amide<br />
**[[3bm9]], [[3bmy]], [[5xrd]], [[5xre]], [[5xrb]], [[5xr9]], [[5xr5]], [[5xqe]], [[5xqd]] - hHsp90 NTD+ oxazole derivative<br />
**[[3bm9]], [[3bmy]], [[5xqd]], [[5xqe]], [[5xr5]], [[5xr9]], [[5xrb]], [[5xrd]], [[5xre]] - hHsp90 NTD+ oxazole derivative<br />
**[[2of6]], [[3b24]], [[3b27]], [[3b28]], [[3r92]] - hHsp90 NTD+triazine derivative<br />
**[[2of6]], [[3b24]], [[3b27]], [[3b28]], [[3r92]] - hHsp90 NTD+triazine derivative<br />
**[[5j20]], [[5j27]], [[5j2x]], [[5j64]], [[5j6l]], [[5j6m]], [[5j82]], [[5j86]], [[5j8m]], [[5j6n]], [[5j8u]], [[5j9x]], [[8agi]], [[8agl]] - hHsp90-α NTD +triazol derivative<br />
**[[5j20]], [[5j27]], [[5j2x]], [[5j64]], [[5j6l]], [[5j6m]], [[5j6n]], [[5j82]], [[5j86]], [[5j8m]], [[5j8u]], [[5j9x]], [[8agi]], [[8agl]] - hHsp90-α NTD +triazol derivative<br />
**[[8agj]] - hHsp90-a NTD (mutant) +triazol derivative<br />
**[[8agj]] - hHsp90-a NTD (mutant) +triazol derivative<br />
**[[2qfo]], [[3nmq]], [[3r4m]], [[3r4n]], [[3r4o]], [[3r4p]], [[3b25]], [[3b26]], [[2jcc]], [[3rlp]], [[3rlq]], [[3rlr]], [[2wi1]], [[2wi2]], [[2wi3]], [[2wi4]], [[2wi5]], [[2wi6]], [[2wi7]], [[2jjc]], [[5fnc]], [[7dmc]], [[7s98]], [[7s99]], [[7s9f]], [[7s9g]], [[7s9h]], [[7s9i]] - hHsp90 NTD+pyrimidine derivative<br />
**[[2jcc]], [[2jjc]], [[2qfo]], [[2wi1]], [[2wi2]], [[2wi3]], [[2wi4]], [[2wi5]], [[2wi6]], [[2wi7]], [[3b25]], [[3b26]], [[3nmq]], [[3r4m]], [[3r4n]], [[3r4o]], [[3r4p]], [[3rlp]], [[3rlq]], [[3rlr]], [[5fnc]], [[7dmc]], [[7s98]], [[7s99]], [[7s9f]], [[7s9g]], [[7s9h]], [[7s9i]] - hHsp90 NTD+pyrimidine derivative<br />
**[[7a90]], [[7s95]] - hHsp90 NTD+ adenine <br />
**[[7a90]], [[7s95]] - hHsp90 NTD+ adenine <br />
**[[6f1n]] - hHsp90 NTD+pyridine derivative<br />
**[[6f1n]] - hHsp90 NTD+pyridine derivative<br />
**[[1uy6]], [[1uy7]], [[1uy8]], [[1uy9]], [[1uyc]], [[1uyd]], [[1uye]], [[1uyf]], [[1uyg]], [[1uyh]], [[1uyi]], [[1uyk]], [[1uyl]], [[6el5]], [[2fwy]], [[2fwz]], [[2h55]], [[3o0i]], [[6cyh]], [[6cyg]], [[6b9a]], [[6b99]] - hHsp90 NTD+purine derivative<br />
**[[1uy6]], [[1uy7]], [[1uy8]], [[1uy9]], [[1uyc]], [[1uyd]], [[1uye]], [[1uyf]], [[1uyg]], [[1uyh]], [[1uyi]], [[1uyk]], [[1uyl]], [[2fwy]], [[2fwz]], [[2h55]], [[3o0i]], [[6b99]], [[6b9a]], [[6cyg]], [[6cyh]], [[6el5]] - hHsp90 NTD+purine derivative<br />
**[[6n8x]] - hHsp90-a residues 123-358 + purine derivative<br />
**[[6n8x]], [[8sbt]] - hHsp90-a residues 123-358 + purine derivative<br />
**[[6olx]] - hHsp90-a residues 123-358 (mutant) + purine derivative<br />
**[[6olx]] - hHsp90-a residues 123-358 (mutant) + purine derivative<br />
**[[2qg0]], [[2bz5]] - hHsp90 NTD+sulfonamide derivative<br />
**[[2bz5]], [[2qg0]] - hHsp90 NTD+sulfonamide derivative<br />
**[[2yi0]], [[2yi5]], [[2yi6]], [[2yi7]], [[5fnd]] - hHsp90 NTD + thiadiazole derivative<br />
**[[2yi0]], [[2yi5]], [[2yi6]], [[2yi7]], [[5fnd]] - hHsp90 NTD + thiadiazole derivative<br />
**[[4hy6]], [[6ey8]], [[6ey9]], [[6eya]], [[6eyb]], [[5odx]], [[5oci]], [[5nyh]], [[5lny]], [[5lnz]], [[5lo0]], [[5lo1]], [[5lo6]], [[6lti]], [[6ltk]] - hHsp90 NTD + indazole derivative<br />
**[[4hy6]], [[5oci]], [[5odx]], [[5nyh]], [[5lny]], [[5lnz]], [[5lo0]], [[5lo1]], [[5lo6]], [[6ey8]], [[6ey9]], [[6eya]], [[6eyb]], [[6lti]], [[6ltk]] - hHsp90 NTD + indazole derivative<br />
**[[5nyi]] - hHsp90 NTD + resorcinol derivative<br />
**[[5nyi]] - hHsp90 NTD + resorcinol derivative<br />
**[[2qg2]], [[2cvi]], [[2cvj]], [[2uwd]], [[4b7p]] - hHsp90 NTD+oxazole derivative<br />
**[[2cvi]], [[2cvj]], [[2qg2]], [[2uwd]], [[4b7p]] - hHsp90 NTD+oxazole derivative<br />
**[[3d0b]], [[3rkz]], [[3wq9]] - hHsp90 NTD+benzamide derivative<br />
**[[3d0b]], [[3rkz]], [[3wq9]] - hHsp90 NTD+benzamide derivative<br />
**[[3inw]], [[3inx]] - hHsp90 NTD+pochoxime derivative<br />
**[[3inw]], [[3inx]] - hHsp90 NTD+pochoxime derivative<br />
**[[2ccs]], [[2cct]], [[2ccu]], [[2byh]], [[2byi]], [[2bsm]], [[2bt0]], [[1yc3]], [[1yc1]], [[1yc4]], [[6eln]], [[6elo]], [[6elp]], [[6fcj]], [[5zr3]], [[5zrd]] - hHsp90 NTD+pyrazol derivative<br />
**[[1yc1]], [[1yc3]], [[1yc4]], [[2byh]], [[2byi]], [[2bsm]], [[2bt0]], [[2ccs]], [[2cct]], [[2ccu]], [[5zr3]], [[5zrd]] [[6eln]], [[6elo]], [[6elp]], [[6fcj]] - hHsp90 NTD+pyrazol derivative<br />
**[[2ye2]], [[2ye3]], [[2ye4]], [[2ye5]], [[2ye6]], [[2ye7]], [[2ye8]], [[2ye9]], [[2yea]], [[2yeb]], [[2yec]], [[2yed]], [[2yee]], [[2yef]], [[2yeg]], [[2yeh]], [[2yei]], [[2yej]], [[2yjw]], [[2yjx]], [[2yk2]], [[2yk9]], [[2ykb]], [[2ykc]], [[2yke]], [[2yki]], [[2ykj]], [[3ow6]], [[3owb]], [[3owd]], [[3qdd]], [[3tuh]], [[3vha]], [[3vhc]], [[3vhd]], [[4awo]], [[4awp]], [[4awq]], [[4eeh]], [[4eft]], [[4efu]], [[4egh]], [[4egi]], [[4egk]], [[4fcp]], [[4fcq]], [[4fcr]], [[3wha]], [[4bqg]], [[4bqj]], [[4l8z]], [[4l90]], [[4l91]], [[4l93]], [[4lwe]], [[4l94]], [[4lwf]], [[4lwg]], [[4lwh]], [[4lwi]], [[4nh7]], [[4nh8]], [[4nh9]], [[4o09]], [[4o0b]], [[4r3m]], [[4u93]], [[4w7t]], [[4xip]], [[4xiq]], [[4xir]], [[4xit]], [[4ykq]], [[4ykr]], [[4ykt]], [[4yku]], [[4ykw]], [[4ykx]], [[4yky]], [[4ykz]], [[5cf0]], [[5fnf]], [[5ggz]], [[5m4e]], [[5m4h]], [[6ceo]], [[5vyy]], [[5t21]], [[5lq9]], [[5lr1]], [[5lr7]], [[5lrl]], [[5lrz]], [[5ls1]], [[5h22]], [[6hhr]], [[6lr9]], [[6lt8]], [[6tn4]], [[6tn5]], [[6u98]], [[6u99]], [[6u9a]], [[6u9b]] - hHsp90 NTD + inhibitor<br />
**[[2ye2]], [[2ye3]], [[2ye4]], [[2ye5]], [[2ye6]], [[2ye7]], [[2ye8]], [[2ye9]], [[2yea]], [[2yeb]], [[2yec]], [[2yed]], [[2yee]], [[2yef]], [[2yeg]], [[2yeh]], [[2yei]], [[2yej]], [[2yjw]], [[2yjx]], [[2yk2]], [[2yk9]], [[2ykb]], [[2ykc]], [[2yke]], [[2yki]], [[2ykj]], [[3ow6]], [[3owb]], [[3owd]], [[3qdd]], [[3tuh]], [[3vha]], [[3vhc]], [[3vhd]], [[3wha]], [[4awo]], [[4awp]], [[4awq]], [[4bqg]], [[4bqj]], [[4eeh]], [[4eft]], [[4efu]], [[4egh]], [[4egi]], [[4egk]], [[4fcp]], [[4fcq]], [[4fcr]], [[4l8z]], [[4l90]], [[4l91]], [[4l93]], [[4l94]], [[4lwe]], [[4lwf]], [[4lwg]], [[4lwh]], [[4lwi]], [[4nh7]], [[4nh8]], [[4nh9]], [[4o09]], [[4o0b]], [[4r3m]], [[4u93]], [[4w7t]], [[4xip]], [[4xiq]], [[4xir]], [[4xit]], [[4ykq]], [[4ykr]], [[4ykt]], [[4yku]], [[4ykw]], [[4ykx]], [[4yky]], [[4ykz]], [[5cf0]], [[5fnf]], [[5ggz]], [[5h22]], [[5lq9]], [[5lr1]], [[5lr7]], [[5lrl]], [[5lrz]], [[5ls1]], [[5m4e]], [[5m4h]], [[5t21]], [[5vyy]], [[6ceo]], [[6hhr]], [[6lr9]], [[6lt8]], [[6tn4]], [[6tn5]], [[6u98]], [[6u99]], [[6u9a]], [[6u9b]], [[7h9k]], [[7h9l]], [[7h9m]], [[7h9n]], [[7h9o]], [[7h9p]], [[7h9r]], [[7h9s]], [[7h9t]], [[7h9u]], [[7h9v]], [[7h9w]], [[7h9x]], [[7h9y]], [[7h9z]], [[7ha0]], [[7ha1]], [[7ha2]], [[7ha3]], [[7ha4]], [[7ha5]], [[7ha7]], [[7ha8]], [[7ha9]], [[7hab]], [[7hac]], [[7had]], [[7hae]], [[7haf]], [[7hag]], [[7hah]], [[7haj]], [[7hak]], [[7hal]], [[7ham]], [[7han]], [[7hao]], [[7hap]], [[7haq]], [[7har]], [[7has]], [[7hat]], [[7hau]], [[7haw]], [[7hax]], [[7hay]], [[7haz]], [[7hb0]], [[7hb1]], [[7hb2]], [[7hb3]], [[7hb4]], [[7hb6]], [[7hb8]], [[7hb9]], [[7hba]], [[7hbb]], [[7hbc]], [[7hbd]], [[7hbe]], [[7hbf]], [[7hbg]], [[7hbh]], [[7hbj]], [[7hbk]], [[7hbl]], [[7hbn]], [[7hbp]], [[7hbq]], [[7hbs]], [[7hbt]], [[7hbu]], [[7hbv]], [[7hbw]], [[7hbx]], [[7hby]], [[7hbz]], [[7hc0]], [[7hc1]], [[7hc2]], [[7hc3]], [[8w4v]], [[8w8k]], [[9auu]] - hHsp90 NTD + inhibitor<br />
**[[2xhr]], [[2xht]], [[2xhx]], [[2xjg]], [[2xjj]], [[2xjx]], [[2xk2]], [[2xdx]], [[2xdu]], [[2xds]], [[2xdl]], [[2xdk]], [[2xab]], [[2vcj]], [[2vci]], [[3hyy]], [[3hyz]], [[3hz1]], [[3hz5]], [[3mnr]], [[2af6]] - hHsp90 NTD+ antigen<br />
**[[2af6]], [[2vcj]], [[2vci]], [[2xab]], [[2xdk]], [[2xdl]], [[2xds]], [[2xdu]], [[2xdx]], [[2xhr]], [[2xht]], [[2xhx]], [[2xjg]], [[2xjj]], [[2xjx]], [[2xk2]], [[3hyy]], [[3hyz]], [[3hz1]], [[3hz5]], [[3mnr]] - hHsp90 NTD+ antigen<br />
**[[1osf]], [[1yer]], [[1yes]], [[1yet]], [[6lsz]] - hHsp90 NTD+ drug <br />
**[[1osf]], [[1yer]], [[1yes]], [[1yet]], [[6lsz]] - hHsp90 NTD+ drug <br />
**[[2hg1]], [[2gfd]], [[2fyp]], [[2exl]], [[1u0z]], [[1qy8]], [[1ysz]], [[1u2o]], [[6d28]], [[6d1x]], [[1qye]], [[3o2f]], [[6d1x]], [[6d28]] - dHsp90B1 NTD+ligand<br />
**[[1qy8]], [[1qye]], [[1u0z]], [[1u2o]], [[1ysz]], [[2hg1]], [[2gfd]], [[2fyp]], [[2exl]], [[3o2f]], [[6d28]], [[6d1x]] - dHsp90B1 NTD+ligand<br />
**[[2esa]] - dHsp90B1 NTD (mutant) +ligand<br />
**[[2esa]] - dHsp90B1 NTD (mutant) +ligand<br />
**[[1yt0]], [[1tc6]], [[1tba]], [[1tc0]] - dHsp90B1 NTD+ nucleotide<br />
**[[1tba]], [[1tc0]], [[1tc6]], [[1yt0]] - dHsp90B1 NTD+ nucleotide<br />
**[[5wmt]], [[6aol]], [[6aom]], [[6asq]], [[6baw]], [[6c91]], [[6cyi]] - dHsp90B1 NTD+ inhibitor<br />
**[[5wmt]], [[6aol]], [[6aom]], [[6asq]], [[6baw]], [[6c91]], [[6cyi]] - dHsp90B1 NTD+ inhibitor<br />
**[[6asp]] - dHsp90B1 NTD + drug <br />
**[[6asp]] - dHsp90B1 NTD + drug <br />
Line 256: Line 266:
**[[3ied]] - PfHsp90 NTD+ANP <br />
**[[3ied]] - PfHsp90 NTD+ANP <br />
**[[3k60]] - PfHsp90 NTD+ADP<br />
**[[3k60]] - PfHsp90 NTD+ADP<br />
**[[6cji]] – CaHsp90 NTD – ''Candida albicans''<br />
**[[6cjl]], [[6cjp]] – CaHsp90 NTD + radicicol<br />
**[[6cjj]] – CaHsp90 NTD + ADP<br />
**[[6cjr]], [[6cjs]] – CaHsp90 NTD + inhibitor<br />
**[[7k9s]], [[7k9u]], [[7k9v]], [[7k9w]] – CnHsp90 NTD + inhibitor<br />
**[[7k9s]], [[7k9u]], [[7k9v]], [[7k9w]] – CnHsp90 NTD + inhibitor<br />


Line 291: Line 297:
**[[7l7j]] - hHsp90 + P23 + ANP – Cryo EM <br />
**[[7l7j]] - hHsp90 + P23 + ANP – Cryo EM <br />
**[[7krj]] - hHsp90 + GR + P23 + ATP – Cryo EM <br />
**[[7krj]] - hHsp90 + GR + P23 + ATP – Cryo EM <br />
**[[8ffv]], [[8ffw]] - hHsp90 + GR + FKBP54 + ATP – Cryo EM <br />
**[[8h77]] - hHsp90 + AhR + P23 + XAP2 + ADP – Cryo EM <br />
**[[8h77]] - hHsp90 + AhR + P23 + XAP2 + ADP – Cryo EM <br />
**[[7l7i]] - hHsp90 + FKBP51 + P23 + ANP – Cryo EM <br />
**[[7l7i]] - hHsp90 + FKBP51 + P23 + ANP – Cryo EM <br />
Line 299: Line 306:
**[[2ioq]] - EcHsp90 <br />
**[[2ioq]] - EcHsp90 <br />


*Hsp90-β
*Hsp90-beta


**[[8eob]] - hHsp90 – Cryo EM <br />
**[[8eob]] - hHsp90 – Cryo EM <br />
Line 305: Line 312:
**[[5fwk]], [[5fwl]], [[5fwm]], [[5fwp]] – hHsp90 + CDC37 + CDK4<br />
**[[5fwk]], [[5fwl]], [[5fwm]], [[5fwp]] – hHsp90 + CDC37 + CDK4<br />
**[[1uym]], [[6n8y]], [[7ulj]] - hHsp90 NTD+ purine inhibitor<br />
**[[1uym]], [[6n8y]], [[7ulj]] - hHsp90 NTD+ purine inhibitor<br />
**[[5uc4]], [[5uch]], [[5uci]], [[5ucj]], [[4o04]], [[4o05]], **[[4o07]] - hHsp90-b NTD + inhibitor<br />
**[[4o04]], [[4o05]], [[4o07]], [[5uc4]], [[5uch]], [[5uci]], [[5ucj]] - hHsp90-b NTD + inhibitor<br />
**[[3nmq]] - hHsp90 NTD+pyrimidine derivative
**[[3nmq]] - hHsp90 NTD+pyrimidine derivative
**[[3pry]] – hHsp90 MD<br />
**[[3pry]] – hHsp90 MD<br />
**[[7zub]] - hHsp90 + AIP + AH receptor + ADP -  Cryo EM <br />
**[[7zub]], [[8qmo]] - hHsp90 + AIP + AH receptor + ADP -  Cryo EM <br />
**[[8e0a]] - hHsp90 + AIPL1 + ANP – Cryo EM <br />
**[[8eoa]] - hHsp90 + AIPL1 + ANP – Cryo EM <br />
**[[7z37]], [[7z38]] - hHsp90 + Cdc37 + RAF-1 – Cryo EM <br />
**[[7z37]], [[7z38]] - hHsp90 + Cdc37 + RAF-1 – Cryo EM <br />
**[[8gae]] - hHsp90 + Cdc37 + RAF-1 + PP5 – Cryo EM <br />
**[[8gae]], [[8gft]] - hHsp90 + Cdc37 + RAF-1 + PP5 – Cryo EM <br />
**[[7zr0]] - hHsp90 + Cdc37 + BRAF – Cryo EM <br />
**[[7zr0]] - hHsp90 + Cdc37 + BRAF – Cryo EM <br />
**[[8fx4]] - hHsp90 + Cdc37 + GC-C – Cryo EM <br />
**[[7zr5]], [[7zr6]] - hHsp90 + Cdc37 + BRAF + PP5 – Cryo EM <br />
**[[7zr5]], [[7zr6]] - hHsp90 + Cdc37 + BRAF + PP5 – Cryo EM <br />
**[[7y04]] - mHsp90 + AH receptor + P23 + ADP -  mouse - Cryo EM <br />
**[[7y04]] - mHsp90 + AH receptor + P23 + ADP -  mouse - Cryo EM <br />
* Hsp90 homolog
**[[6cji]] – CaHsp90H NTD – ''Candida albicans''<br />
**[[6cjl]], [[6cjp]] – CaHsp90H NTD + radicicol<br />
**[[6cjj]] – CaHsp90H NTD + ADP<br />
**[[9mtb]] – CaHsp90H NTD + ANP<br />
**[[6cjr]], [[6cjs]], [[9msq]], [[9msu]], [[9msv]], [[8msx]], [[9mt3]], [[9mt9]] – CaHsp90H NTD + inhibitor<br />


* Hsp82 is the yeast equivalent of Hsp90 in mammals  
* Hsp82 is the yeast equivalent of Hsp90 in mammals  
Line 323: Line 339:
**[[2wep]] – yHsp82 NTD (mutant)+ADP<br />
**[[2wep]] – yHsp82 NTD (mutant)+ADP<br />
**[[2akp]], [[3c0e]] - yHsp82 NTD (mutant)<br />
**[[2akp]], [[3c0e]] - yHsp82 NTD (mutant)<br />
**[[1weq]], [[3c11]], [[2yga]], [[2wer]], [[2yge]], [[2ygf]] - yHsp82 NTD (mutant)+ antibiotic<br />
**[[1weq]], [[2yga]], [[2yge]], [[2ygf]], [[3c11]] - yHsp82 NTD (mutant)+ antibiotic<br />
**[[2iws]], [[2iwu]], [[2iwx]], [[2cgf]], 1bgq, [[2fxs]], [[4as9]], [[4asa]], [[4asb]], [[4asf]], [[4asg]], [[2weq]], [[1ah4]], [[1bgq]] - yHsp82 NTD +antibiotic<br />
**[[1ah4]], [[1bgq]], [[2cgf]], [[2fxs]], [[2iws]], [[2iwu]], [[2iwx]], [[2weq]], [[4as9]], [[4asa]], [[4asb]], [[4asf]], [[4asg]] - yHsp82 NTD +antibiotic<br />
**[[8oxu]] - yHsp82 NTD + inhibitor <br />
**[[2vw5]], [[2vwc]] - yHsp82 NTD +7-o-carbamoylpremacbecin<br />
**[[2vw5]], [[2vwc]] - yHsp82 NTD +7-o-carbamoylpremacbecin<br />
**[[2fxs]] - yHsp82 NTD +radamide<br />
**[[2fxs]] - yHsp82 NTD +radamide<br />
Line 339: Line 356:
* Hsp100 are named ClpA or ClpB or ClpC or ClpL or ClpP
* Hsp100 are named ClpA or ClpB or ClpC or ClpL or ClpP


**[[1r6b]], [[1ksf]] – EcClpA (mutant) <br />
**[[1ksf]], [[1r6b]] – EcClpA (mutant) <br />
**[[1r6c]], [[1k6k]] – EcClpA N-terminal <br />
**[[1k6k]], [[1r6c]] – EcClpA N-terminal <br />
**[[1r6o]], [[1r6q]] – EcClpA N-terminal + ClpS<br />
**[[1r6o]], [[1r6q]] – EcClpA N-terminal + ClpS<br />
**[[1mg9]], [[1lzw]], [[1mbu]], [[1mbv]], [[1mbx]] – EcClpA + YLJA<br />
**[[1lzw]], [[1mbu]], [[1mbv]], [[1mbx]], [[1mg9]] – EcClpA + YLJA<br />
**[[6w1z]], [[6w20]], [[6w21]], [[6w22]], [[6w23]], [[6w24]] – EcClpA + RepA + GFP + ADP + ATP – Cryo EM<br />
**[[6w1z]], [[6w20]], [[6w21]], [[6w22]], [[6w23]], [[6w24]] – EcClpA + RepA + GFP + ADP + ATP – Cryo EM<br />
**[[6uqe]], [[6uqo]] – EcClpA + ClpP + RepA + GFP + ADP + ATPgS – Cryo EM<br />
**[[6uqe]], [[6uqo]] – EcClpA + ClpP + RepA + GFP + ADP + ATPgS – Cryo EM<br />
**[[4ciu]] - EcClpB (mutant)<br />
**[[4ciu]] - EcClpB (mutant)<br />
**[[4d2u]], [[4d2x]], [[4d2q]] - EcClpB – Cryo EM<br />
**[[4d2q]], [[4d2u]], [[4d2x]] - EcClpB – Cryo EM<br />
**[[5og1]], [[5ofo]] - EcClpB + ATPgS – Cryo EM<br />
**[[5ofo]], [[5og1]] - EcClpB + ATPgS – Cryo EM<br />
**[[6qs8]], [[6qs7]], [[6qs6]], [[6og3]] - EcClpB (mutant) + casein – Cryo EM<br />
**[[6og3]], [[6qs6]], [[6qs7]], [[6qs8]] - EcClpB (mutant) + casein – Cryo EM<br />
**[[6og2]] - EcClpB (mutant) + ADP – Cryo EM<br />
**[[6og2]] - EcClpB (mutant) + ADP – Cryo EM<br />
**[[6og1]] - EcClpB (mutant) + ADP + ATPgS – Cryo EM<br />
**[[6og1]] - EcClpB (mutant) + ADP + ATPgS – Cryo EM<br />
Line 391: Line 408:
**[[7tfm]] – ClpP N-domain – ''Leishmania mexicana''<br />
**[[7tfm]] – ClpP N-domain – ''Leishmania mexicana''<br />


*Hsp101
*Hsp101 or chaperone protein ClpB1


**[[9ip0]] – riHsp101 - Cryo EM<br />
**[[6e11]], [[6e10]] – PfPTEX core – Cryo EM<br />
**[[6e11]], [[6e10]] – PfPTEX core – Cryo EM<br />


*Hsp104
*Hsp104


**[[5kne]], [[6n8z]], [[6n8v]], [[6n8t]] – yHsp104 - Cryo EM<br />
**[[5kne]], [[6n8t]], [[6n8v]], [[6n8z]] – yHsp104 - Cryo EM<br />
**[[6ahf]] – yHsp104 (mutant) – Cryo EM<br />
**[[6ahf]] – yHsp104 (mutant) – Cryo EM<br />
**[[5u2u]], [[6amn]], [[5wbw]] – yHsp104 NTD<br />
**[[5u2u]], [[5wbw]], [[6amn]] – yHsp104 NTD<br />
**[[5vy8]] – yHsp104 + ADP<br />
**[[5vy8]] – yHsp104 + ADP<br />
**[[5vy9]], [[5vya]] – yHsp104 + casein<br />
**[[5vy9]], [[5vya]] – yHsp104 + casein<br />
Line 413: Line 431:


**[[6gfa]] – hHsp110 + ATP<br />
**[[6gfa]] – hHsp110 + ATP<br />
**[[3d2e]], [[3d2f]], [[3c7n]] – ySse1+Hsc70 <br />
**[[3c7n]], [[3d2e]], [[3d2f]] – ySse1+Hsc70 <br />
**[[2qxl]] – ySse1<br />
**[[2qxl]] – ySse1<br />
**[[2llv]] – ySti1 domain 1 – NMR<br />
**[[2llv]] – ySti1 domain 1 – NMR<br />
Line 419: Line 437:
**[[3upv]] – ySti1 TPR repeats 7-9 + ySse1 peptide<br />
**[[3upv]] – ySti1 TPR repeats 7-9 + ySse1 peptide<br />
**[[3uq3]] - ySti1 TPR repeats 4-9 + peptide<br />
**[[3uq3]] - ySti1 TPR repeats 4-9 + peptide<br />
**[[5z8q]], [[5z8i]] – ySsa1 SBD - NMR<br />
**[[5z8i]], [[5z8q]] – ySsa1 SBD - NMR<br />


*HspA5 or Grp78 or Endoplasmic reticulum chaperone BIP or 78 kDa glucose-related protein; Domains – NBD 26-407; SBD 418-637
*HspA5 or Grp78 or Endoplasmic reticulum chaperone BIP or 78 kDa glucose-related protein; Domains – NBD 26-407; SBD 418-637
Line 433: Line 451:
**[[6cz1]], [[6dfm]], [[6dfo]], [[6do2]], [[6dws]] – hHspA5 + adenosine derivative<br />
**[[6cz1]], [[6dfm]], [[6dfo]], [[6do2]], [[6dws]] – hHspA5 + adenosine derivative<br />
**[[6zmd]] – hHspA5 + FICD + ANP <br />
**[[6zmd]] – hHspA5 + FICD + ANP <br />
**[[6eob]], [[6eoc]], [[7a4u]] – haHspA5 28-549 - hamster<br />
**[[6eob]], [[6eoc]], [[7a4u]] – haHspA5 28-549 <br />
**[[6hab]] – haHspA5 (mutant)<br />
**[[6hab]] – haHspA5 (mutant)<br />
**[[5e86]] – haHspA5 SBD <br />
**[[5e86]] – haHspA5 SBD <br />
Line 471: Line 489:
**[[4hwi]], [[5aqf]], [[5aqg]], [[5aqh]], [[5aqi]], [[5aqj]], [[5aqgk]], [[5aql]], [[5aqm]], [[5aqn]], [[5aqo]], [[5aqp]], [[5aqq]], [[5aqr]], [[5aqs]], [[5aqt]], [[5aqu]], [[5aqv]]  - hHsc70 NBD+BAG domain regulator protein<br />
**[[4hwi]], [[5aqf]], [[5aqg]], [[5aqh]], [[5aqi]], [[5aqj]], [[5aqgk]], [[5aql]], [[5aqm]], [[5aqn]], [[5aqo]], [[5aqp]], [[5aqq]], [[5aqr]], [[5aqs]], [[5aqt]], [[5aqu]], [[5aqv]]  - hHsc70 NBD+BAG domain regulator protein<br />
**[[2qw9]] – bHsc70 NBD – bovine<br />
**[[2qw9]] – bHsc70 NBD – bovine<br />
**[[2bup]], [[1bup]], [[1qqm]], [[1qqn]], [[1qqo]] - bHsc70 NBD (mutant)<br />
**[[1bup]], [[1qqm]], [[1qqn]], [[1qqo]], [[2bup]] - bHsc70 NBD (mutant)<br />
**[[4fl9]], [[1yuw]] - bHsp70 NBD + SBD<br />
**[[1yuw]], [[4fl9]] - bHsp70 NBD + SBD<br />
**[[2qwl]], [[2qwm]], [[1atr]], [[1ats]], [[1hpm]], [[1nga]], [[1ngb]], [[1ngc]], [[1ngd]], [[3hsc]] - bHsc70 NBD+ADP<br />
**[[1atr]], [[1ats]], [[1hpm]], [[1nga]], [[1ngb]], [[1ngc]], [[1ngd]], [[2qwl]], [[2qwm]], [[3hsc]] - bHsc70 NBD+ADP<br />
**[[2qwn]], [[2qwo]], [[2qwp]], [[2qwq]], [[2qwr]] - bHsc70 NBD (mutant)+ auxilin protein<br />
**[[2qwn]], [[2qwo]], [[2qwp]], [[2qwq]], [[2qwr]] - bHsc70 NBD (mutant)+ auxilin protein<br />
**[[1ba0]], [[1ba1]] – bHsc70 NBD (mutant) + ADP<br />
**[[1ba0]], [[1ba1]] – bHsc70 NBD (mutant) + ADP<br />
Line 481: Line 499:
**[[1hx1]] - bHsc70 NBD + molecular chaperone regulator 1 BAG domain<br />
**[[1hx1]] - bHsc70 NBD + molecular chaperone regulator 1 BAG domain<br />
**[[2v7z]] – rHsc70 NBD + SBD – rat<br />
**[[2v7z]] – rHsc70 NBD + SBD – rat<br />
**[[7hsc]], [[1ckr]] - rHsc70 sub - NMR<br />
**[[1ckr]], [[7hsc]] - rHsc70 sub - NMR<br />
 
**[[3cqx]] - Hsc70 NBD+BAG domain regulator protein <br />
**[[3cqx]] - Hsc70 NBD+BAG domain regulator protein <br />


Line 494: Line 513:
*''Hsc90''
*''Hsc90''


**[[4xkk]], [[4xe2]], [[4xka]], [[4xko]] – smHsc90 NTD – slime mold<br />
**[[4xe2]], [[4xka]], [[4xkk]], [[4xko]] – smHsc90 NTD – slime mold<br />
**[[4xcj]], [[4xc0]], [[4xcl]], [[4xd8]] – smHsc90 NTD + nucleotide<br />
**[[4xc0]], [[4xcj]], [[4xcl]], [[4xd8]] – smHsc90 NTD + nucleotide<br />
**[[4xdm]] – smHsc90 NTD + antibiotic<br />
**[[4xdm]] – smHsc90 NTD + antibiotic<br />
}}
}}


[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 06:56, 11 August 2025

3D Structures of Heat Shock Proteins

Updated on 11-August-2025

    • 7azp, 7l7l, 7l7s, 8g7j, 9es3 – hHsp60 – Cryo EM
    • 8u39 – hHsp60 (mutant) - Cryo EM
    • 9es6 – hHsp60 + ADP – Cryo EM
    • 8g7k – hHsp60 (mutant) + ADP – Cryo EM
    • 9es2 – hHsp60 + ATP – Cryo EM
    • 8g7l, 8g7m, 8g7o – hHsp60 (mutant) + ATP – Cryo EM
    • 4pj1, 6ht7 – hHsp60 + hHsp10 + ADP
    • 6mrc, 6mrd, 9es4, 9es5 – hHsp60 + hHsp10 + ADP – Cryo EM
    • 9es0, 9es1 – hHsp60 + hHsp10 + ATP – Cryo EM
    • 8g7n – hHsp60 (mutant) + hHsp10 + ATP – Cryo EM
    • 7v98, 7v9r – Hsp60 – Epinephelus coioides
  • Hsp60 - the large subunit of the chaperonin molecule GroEL ; See Chaperonin
  • Hsp65
    • 3rtk – MtHsp65 – Mycobacterium tuberculosis
  • Hsp70 – 3 domains: N-terminus ATPase hydrolyzes ATP to ADP (NBD) residues 1-380; hydrophobic amino acid binding domain (SBD) residues 381-564: C-terminus lid domain (CT) residues 534-641.
  • Hsp70 family protein 5 or endoplasmic reticulum chaperone BIP
    • 6cz1, 6dfm, 6dfo, 6do2, 6dws - hBIP ATPase domain + adenosine derivative 26-407
    • 6hab - haBIP (mutant) - hamster
    • 6h9u, 6ha7 - haBIP + mesencephalic atrocyte-derived neurotrophic factor
  • DnaK or chaperone protein DnaK (Hsp70 from E. coli) Domains: NBD 1-383; SBD 389-607
  • Hsp75 or TRAP-1

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