Heat Shock Protein structures

3D Structures of Heat Shock Proteins

Updated on 11-August-2025

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• Small Hsp
  • 2wj7, 3l1g – hHspB5 crystallin domain – human
    
  • 6f2r - hHsp β2 + hHsp 3
    
  • 4jus - hHsp20 β6 residues 57-160
    
  • 4jut - hHsp20 β6 residues 57-160 (mutant)
    
  • 5lum - hHsp20 β6 ACD domain
    
  • 5ltw, 5lu1, 5lu2 - hHsp20 β6 residues 1-149 + 14-3-3 sigma
    
  • 6dv5 - hHsp27 β1
    
  • 6gjh - hHsp27 β1 crystallin domain +peptide
    
  • 3q9p, 3q9q – hHsp28 β1
    
  • 2n3j, 4mjh - hHsp28 β1 crystallin domain
    
  • 2wj5 – rHsp20 crystallin domain – rat
    
  • 1gme – wHsp 17kD – wheat
    
  • 2byu - wHsp 17kD – Cryo EM
    
  • 5ds1 - pHsp 17.7 - pea
    
  • 5ds2 - pHsp 18.1
    
  • 7bzw - AtHsp 21 – Arabidopsis thaliana - Cryo EM
    
  • 7bzy - AtHsp 21 + DXPS - Cryo EM
    
  • 5nms - AtHsp 25.3 - Cryo EM
    
  • 2h50, 2h53 – yHsp26 – yeast
    
  • 2l9q, 2ljl, 4axp – yHsp12 - NMR
    
  • 4rzk, 4yl9 - SsHsp20 – Sulfolobus solfataricus
    
  • 4ylb, 4ylc - SsHsp20 (mutant)
    
  • 5z81 – VcHsp15 – Vibrio cholerae
    
  • 4i2n – VcHsp31
    
  • 3bbu – EcHsp15 - Escherichia coli – Cryo-EM
    
  • 1dm9 – EcHsp15
    
  • 8ap4 – EcHsp15 in 50S ribosome – Cryo-EM
    
  • 1ons – EcHsp31
    
  • 3gla, 3gt6, 3guf – Hsp – Xanthomonas axonopodis
    
  • 3aac, 3vqk – StHsp14 – Sulfolobus tokodaii
    
  • 3aab, 3vql, 3vqm – StHsp14 (mutant)
    
  • 3w1z – Hsp16 – Schizosacchromyces pombe
    
  • 5j7n – Hsp – Xylella fastidiosa
    
  • 6l6m – Hsp18.5 – Entamoeba histolytica
    
  • 4fei – Hsp17.7 – Deinococcus radiodurans
    
  • 1shs, 4eld, 4i88 – MjHsp – Methanococcus jannaschii
    
  • 9nv4, 9nv7, 9nv8, 9nvc, 9nvf, 9nvi, 9nvj, 9nvk – MjHsp16.5
    
  • 8wp9 – MjHsp16.5 – Cryo EM
    
  • 2bol – Hsp – Taenia saginata
    
  • 5zul – MmaHsp – Mycobacterium marinum
    
  • 5zs3, 5zs6 – MmaHsp + peptide
    
  • 7ck4 – Hsp – Synechococcus phage
    
  • 6ewn – HspA – Thermosynechococcus vulcanus
    
• Hsp33
  • 3kkl – yHsp33
    
  • 1hw7, 3m7m – EcHsp33 NTD
    
  • 1i7f – EcHsp33 chaperone domain (mutant)
    
  • 1xjh - EcHsp33 CT - NMR
    
  • 1vq0 – Hsp33 – Thermotoga maritima
    
  • 1vzy – Hsp33 – Bacillus subtilis
• HslV, HslU, HslJ or ATP-dependent protease ATPase subunit HsIU
  • 1e94, 1g4a, 1g4b, 1hqy, 1ht1, 1ht2, 1yyf, 5ji3 – EcHslV+HslU
    
  • 5txv – EcHslU
    
  • 6pxk, 6pxl – EcHslU + ADP
    
  • 5ji2, 6pxi – EcHslV + EcHslU (mutant)
    
  • 1ned – EcHslV
    
  • 4g4e – EcHslV (mutant)
    
  • 2kts – EcHslJ - NMR
    
  • 1g41 – HiHslU – Haemophilus influenza
    
  • 1im2 – HiHslU NBD
    
  • 1kyi – HiHslV + HiHslU + ATP + inhibitor
    
  • 6kww – SaHslU – Staphylococcus aureus
    
  • 7mhb – HslU + ADP – Brucella abortus
    
• Hsp40 or DnaJ homolog subfamily C member 12
  • 2qld – hHsp40 residues 158-340
    
  • 1hdj, 2ctq, 2lgw, 2m6y, 6iws – hHsp40 J domain 1-76 - NMR
    
  • 6byr – hHsp40 J domain 1-70 + CAMP-dependent protein kinase
    
  • 6z5n – hHsp40 1-110 – NMR
    
  • 6cgh – hHsp40 346-432 – NMR
    
  • 6u3r, 6u3s – hHsp40 1-127+CT – NMR
    
  • 7jsq – hHsp40 CT – NMR
    
  • 7ndx – hHsp40 CT + NudC peptide
    
  • 7ciz, 7cj0 – hHsp40 CT + DNA replication licensing factor + histone H3.4 + histone H4
    
  • 6jmg – DnaJ + GTP - frog
    
  • 6ekb – AtDnaJ 57-136 (mutant)
    
  • 6ekc – AtDnaJ 57-136 (mutant) + RbcL
    
  • 1c3g – yHsp40 CT
    
  • 5vso – yHsp40 J domain – NMR
    
  • 1bq0, 1bqz, 1xbl – EcHsp40 N-terminal - NMR
    
  • 1exk – EcHsp40 Cys-rich domain - NMR
    
  • 4j7z – TtHsp40 residues 2-114 (mutant - Thermus thermophilus
    
  • 6prp – TtDnaJ/DnaK - NMR
    
  • 6psi – TtDnaJ + alkaline phosphatase - NMR
    
  • 6jzb – SpDnaJ – Streptococcus pneumoniae - NMR
    
  • 6rzy – PfHsp40 residues 81-148 – Plasmodium falciparum
    
• Hsp47
  • 4au4 – dHsp47 - dog
    
  • 3zha – dHsp47 + collagen peptide
    
• Hsp60 mitochondrial

• • 7azp, 7l7l, 7l7s, 8g7j, 9es3 – hHsp60 – Cryo EM
    
  • 8u39 – hHsp60 (mutant) - Cryo EM
  • 9es6 – hHsp60 + ADP – Cryo EM
    
  • 8g7k – hHsp60 (mutant) + ADP – Cryo EM
  • 9es2 – hHsp60 + ATP – Cryo EM
  • 8g7l, 8g7m, 8g7o – hHsp60 (mutant) + ATP – Cryo EM
  • 4pj1, 6ht7 – hHsp60 + hHsp10 + ADP
    
  • 6mrc, 6mrd, 9es4, 9es5 – hHsp60 + hHsp10 + ADP – Cryo EM
    
  • 9es0, 9es1 – hHsp60 + hHsp10 + ATP – Cryo EM
    
  • 8g7n – hHsp60 (mutant) + hHsp10 + ATP – Cryo EM
    
  • 7v98, 7v9r – Hsp60 – Epinephelus coioides
• Hsp60 - the large subunit of the chaperonin molecule GroEL ; See Chaperonin
• Hsp65
  • 3rtk – MtHsp65 – Mycobacterium tuberculosis
    
• Hsp70 – 3 domains: N-terminus ATPase hydrolyzes ATP to ADP (NBD) residues 1-380; hydrophobic amino acid binding domain (SBD) residues 381-564: C-terminus lid domain (CT) residues 534-641.
  • 1hjo, 1s3x, 2e88, 5bn8, 6fhk, 6g3r, 6g3s – hHsp70 NBD
    
  • 5bn9, 5bpl, 5bpm, 5bpn – hHsp70 NBD (mutant)
    
  • 3a8y – hHsp70 NBD+BAG domain regulator protein
    
  • 4io8, 5aqw, 5aqx, 5aqy, 5aqz, 5ar0, 5mkr, 5mks - hHsp70 NBD + inhibitor
    
  • 6b1i - hHsp70 NBD + ADP
    
  • 6b1n, 6zyi - hHsp70 NBD (mutant) + ADP
    
  • 6b1m - hHsp70 NBD (mutant) + ANP
    
  • 2e8a - hHsp70 NBD+AMPPNP
    
  • 3fe1, 3gdq, 3i33, 3jku - hHsp70 NBD+ADP+P
    
  • 3atu, 3atv, 3ay9, 3iuc - hHsp70 NBD+ADP
    
  • 3lof – hHsp70 CT
    
  • 4po2 - hHsp70 CT + peptide
    
  • 2lmg – hHsp70 CT - NMR
    
  • 1xqs – hHsp70 SBD + Hsp-binding protein core domain
    
  • 4j8f, 4wv5, 5gjj, 5xi9 - hHsp70 SBD
    
  • 5xir - hHsp70 SBD (mutant)
    
  • 4wv7 - hHsp70 SBD + novolactone
    
  • 1hx1 - bHsp70 NBD + molecular chaperone regulator 1 BAG domain
    
  • 2op6, 3dob, 3dqg - CeHsp70 SBD – Caenoharbditis elegans
    
  • 4i2w – CeHsp70 + myosin chaperone
    
  • 2p32 - CeHsp70 CT
    
  • 1q5l - EcHsp70 SBD +peptide - NMR
    
  • 7rax - EcHsp70 NBD + ATP
    
  • 3gl1 - yHsp70 NBD
    
  • 2d2e, 3d2f – yHsp70 NBD+SSE1(Hsp110)
    
  • 3lca – yHsp70 Ssa1 CT+yTOM71
    
  • 2v7y – Hsp70 NBD+SBD – Geobacillus kaustophilus
    
  • 3l6q - CpHsp70 NBD – Cryptosporidium parvum
    
  • 3kvg - CpHsp70 NBD+AMPPNP
    
  • 3l4i - CpHsp70 NBD+ADP+P
    
  • 8w1m – TtHsp70 NTD+ADP
    
  • 6rzq – PfHsp70 NTD+ANP
    
  • 6s02 – PfHsp70 NTD+ADP
    
  • 7ooe, 7oog, 7p31 – PfHsp70 NTD+AMP derivative + inhibitor
    
  • 7nqr, 7nqs, 7nqu, 7nqz - PfHsp70 NBD + inhibitor
    
  • 6zhi - PfHsp70 CT + peptide
    
  • 8gb3 - MtHsp70 + Grpe – Cryo EM
    
• Hsp70 family protein 5 or endoplasmic reticulum chaperone BIP
  • 6cz1, 6dfm, 6dfo, 6do2, 6dws - hBIP ATPase domain + adenosine derivative 26-407
    
  • 6hab - haBIP (mutant) - hamster
    
  • 6h9u, 6ha7 - haBIP + mesencephalic atrocyte-derived neurotrophic factor
    
• DnaK or chaperone protein DnaK (Hsp70 from E. coli) Domains: NBD 1-383; SBD 389-607
  • 4b9q - EcDnaK NBD + SBD + ATP
    
  • 7ko2, 7krt, 7kru, 7krv - EcDnaK (mutant) + ATP
    
  • 5oow - EcDnaK + AMPPCP
    
  • 5nro – EcDnaK (mutant) + DnaJ
    
  • 2kho – EcDnaK – NMR
    
  • 1dkg - EcDnaK NBD (mutant) + nucleotide exchange factor
    
  • 4ani - EcDnaK NBD + SBD + nucleotide exchange factor
    
  • 1dkx, 1dkz, 4f01, 4r5j, 4r5k, 4r5l - EcDnaK NBD + sub
    
  • 4jn4, 4jne - EcDnaK NBD + SBD (mutant) + ATP
    
  • 4jnf - EcDnaK SBD (mutant) + ATP
    
  • 1bpr, 1dg4, 2bpr - EcDnaK SBD – NMR
    
  • 1q5l - EcDnaK SBD + peptide – NMR
    
  • 1dky, 3dpo, 3dpp, 3dpq, 3qnj, 4e81, 4ezn, 4ezo, 4ezp, 4ezq, 4ezr, 4ezs, 4ezt, 4ezu, 4ezv, 4ezw, 4ezx, 4ezy, 4ezz, 4f00, 4f01, 4hy9, 4hyb, 4jwc, 4jwd, 4jwe, 4jwi, 4r5i, 7jmm, 7jn8, 7jn9, 7jne, 7n6j, 7n6k, 7n6l, 7n6m – EcDnaK SBD + peptide
    
  • 7krw, 7kzi, 7kzu – EcDnaK/peptide
    
  • 1q5l - EcDnaK SBD +peptide – NMR
    
  • 4r5g - EcDnaK CT + inhibitor
    
  • 4rtf - MtDnaK + ATP – Mycobacterium tuberculosis
    
  • 6w6e - MtDnaK NBD + ClpB + ADP
    
  • 7l6n - MtDnaK NBD + ClpB + ADP – Cryo EM
    
  • 5obx - MgDnaK NBD – Mycoplasma genitalium
    
  • 5obv, 5obu - MgDnaK NBD (mutant)
    
  • 5oby - MgDnaK NBD + AMPPNP
    
  • 5obw - MgDnaK NBD + ATP
    
• Hsp75 or TRAP-1

• • 5f3k, 5f5r – hHsp75 NTD
    
  • 5hph, 7ulk – hHsp75 residues 60-554
    
  • 4z1f, 4z1g, 4z1h, 4z1i, 5y3n, 5y3o, 7c04, 7c05, 7c7b, 7c7c, 7u8u, 7u8v, 7u8w, 7u8x – hHsp75 + inhibitor
    
  • 6xg6 – hHsp75 residues 60-704 + ADP – Cryo EM
    
  • 7kck, 7klu, 7klv – hHsp75 residues 60-704 + AMPPNP – Cryo EM
    
  • 7kcl, 7kcm – hHsp75 residues 60-704 + SDHB + AMPPNP – Cryo EM
    
• Hsp83
  • 8u1l, 8u1m, 8u1n – Hsp83 + ATP – cabbage looper – Cryo EM
  • 3u67 – LmHsp83 NTD + ADP – Leishmania major
• Hsp90 – 4 domains: N-terminus (NTD) residues 1-236; linker 237-283; middle (MD) 284-543; C-terminus (CT)
• Hsp90-α NTD
  • 3t0h, 5j2v, 6gpw, 7s8y, 7s8z, 8jr6, 8ki4, 9imw - hHsp90 NTD
    
  • 5j80, 6gp4, 6gr4, 8jr7, 8jra, 8x2r - hHsp90 NTD (mutant)
    
  • 2gqp, 2h8m, 2hch – dHsp90B1 NTD
    
  • 1yt1, 1yt2 - dHsp90B1 NTD (mutant)
    
  • 4x9l - riHsp90 NTD - rice
    
  • 3h80 – LmHsp90 NTD
    
  • 4gqt – CeHsp90 NTD
    
• Hsp90-α NTD complexes
  • 1byq, 3t0z, 3t10, 3t1k, 3t2s, 6gq6, 6gpr, 6gpt, 6gpy, 6gqr, 7s90 - hHsp90-α NTD + nucleotide
    
  • 6gp8, 6gpf, 6gph, 6gpo, 6gpp, 6gqs, 6gqu, 6gr1, 6gr3, 6gr5 - hHsp90-α NTD (mutant) + nucleotide
    
  • 3hek, 3k97, 3mnq – hHsp90 NTD+pyrrolidin derivative
    
  • 3k98, 3k99, 3qtf, 5lo5, 7lsz, 7lt0 - hHsp90 NTD+indole derivative
    
  • 3r91 - hHsp90 NTD (mutant) +indole derivative
    
  • 3hhu, 4jql - hHsp90 NTD+ carbamic acid derivative
    
  • 3ft5, 3ft8, 4cwf, 4cwn, 4cwo, 4cwp, 4cwq, 4cwr, 4cws, 4cwt, 5od7, 6ei5 - hHsp90 NTD+quinazoline derivative inhibitor
    
  • 2k5b - hHsp90 NTD+Cdc37 – NMR - docking
    
  • 3eko, 3ekr - hHsp90 NTD+dihydroxyphenyl amide
    
  • 3bm9, 3bmy, 5xqd, 5xqe, 5xr5, 5xr9, 5xrb, 5xrd, 5xre - hHsp90 NTD+ oxazole derivative
    
  • 2of6, 3b24, 3b27, 3b28, 3r92 - hHsp90 NTD+triazine derivative
    
  • 5j20, 5j27, 5j2x, 5j64, 5j6l, 5j6m, 5j6n, 5j82, 5j86, 5j8m, 5j8u, 5j9x, 8agi, 8agl - hHsp90-α NTD +triazol derivative
    
  • 8agj - hHsp90-a NTD (mutant) +triazol derivative
    
  • 2jcc, 2jjc, 2qfo, 2wi1, 2wi2, 2wi3, 2wi4, 2wi5, 2wi6, 2wi7, 3b25, 3b26, 3nmq, 3r4m, 3r4n, 3r4o, 3r4p, 3rlp, 3rlq, 3rlr, 5fnc, 7dmc, 7s98, 7s99, 7s9f, 7s9g, 7s9h, 7s9i - hHsp90 NTD+pyrimidine derivative
    
  • 7a90, 7s95 - hHsp90 NTD+ adenine
    
  • 6f1n - hHsp90 NTD+pyridine derivative
    
  • 1uy6, 1uy7, 1uy8, 1uy9, 1uyc, 1uyd, 1uye, 1uyf, 1uyg, 1uyh, 1uyi, 1uyk, 1uyl, 2fwy, 2fwz, 2h55, 3o0i, 6b99, 6b9a, 6cyg, 6cyh, 6el5 - hHsp90 NTD+purine derivative
    
  • 6n8x, 8sbt - hHsp90-a residues 123-358 + purine derivative
    
  • 6olx - hHsp90-a residues 123-358 (mutant) + purine derivative
    
  • 2bz5, 2qg0 - hHsp90 NTD+sulfonamide derivative
    
  • 2yi0, 2yi5, 2yi6, 2yi7, 5fnd - hHsp90 NTD + thiadiazole derivative
    
  • 4hy6, 5oci, 5odx, 5nyh, 5lny, 5lnz, 5lo0, 5lo1, 5lo6, 6ey8, 6ey9, 6eya, 6eyb, 6lti, 6ltk - hHsp90 NTD + indazole derivative
    
  • 5nyi - hHsp90 NTD + resorcinol derivative
    
  • 2cvi, 2cvj, 2qg2, 2uwd, 4b7p - hHsp90 NTD+oxazole derivative
    
  • 3d0b, 3rkz, 3wq9 - hHsp90 NTD+benzamide derivative
    
  • 3inw, 3inx - hHsp90 NTD+pochoxime derivative
    
  • 1yc1, 1yc3, 1yc4, 2byh, 2byi, 2bsm, 2bt0, 2ccs, 2cct, 2ccu, 5zr3, 5zrd 6eln, 6elo, 6elp, 6fcj - hHsp90 NTD+pyrazol derivative
    
  • 2ye2, 2ye3, 2ye4, 2ye5, 2ye6, 2ye7, 2ye8, 2ye9, 2yea, 2yeb, 2yec, 2yed, 2yee, 2yef, 2yeg, 2yeh, 2yei, 2yej, 2yjw, 2yjx, 2yk2, 2yk9, 2ykb, 2ykc, 2yke, 2yki, 2ykj, 3ow6, 3owb, 3owd, 3qdd, 3tuh, 3vha, 3vhc, 3vhd, 3wha, 4awo, 4awp, 4awq, 4bqg, 4bqj, 4eeh, 4eft, 4efu, 4egh, 4egi, 4egk, 4fcp, 4fcq, 4fcr, 4l8z, 4l90, 4l91, 4l93, 4l94, 4lwe, 4lwf, 4lwg, 4lwh, 4lwi, 4nh7, 4nh8, 4nh9, 4o09, 4o0b, 4r3m, 4u93, 4w7t, 4xip, 4xiq, 4xir, 4xit, 4ykq, 4ykr, 4ykt, 4yku, 4ykw, 4ykx, 4yky, 4ykz, 5cf0, 5fnf, 5ggz, 5h22, 5lq9, 5lr1, 5lr7, 5lrl, 5lrz, 5ls1, 5m4e, 5m4h, 5t21, 5vyy, 6ceo, 6hhr, 6lr9, 6lt8, 6tn4, 6tn5, 6u98, 6u99, 6u9a, 6u9b, 7h9k, 7h9l, 7h9m, 7h9n, 7h9o, 7h9p, 7h9r, 7h9s, 7h9t, 7h9u, 7h9v, 7h9w, 7h9x, 7h9y, 7h9z, 7ha0, 7ha1, 7ha2, 7ha3, 7ha4, 7ha5, 7ha7, 7ha8, 7ha9, 7hab, 7hac, 7had, 7hae, 7haf, 7hag, 7hah, 7haj, 7hak, 7hal, 7ham, 7han, 7hao, 7hap, 7haq, 7har, 7has, 7hat, 7hau, 7haw, 7hax, 7hay, 7haz, 7hb0, 7hb1, 7hb2, 7hb3, 7hb4, 7hb6, 7hb8, 7hb9, 7hba, 7hbb, 7hbc, 7hbd, 7hbe, 7hbf, 7hbg, 7hbh, 7hbj, 7hbk, 7hbl, 7hbn, 7hbp, 7hbq, 7hbs, 7hbt, 7hbu, 7hbv, 7hbw, 7hbx, 7hby, 7hbz, 7hc0, 7hc1, 7hc2, 7hc3, 8w4v, 8w8k, 9auu - hHsp90 NTD + inhibitor
    
  • 2af6, 2vcj, 2vci, 2xab, 2xdk, 2xdl, 2xds, 2xdu, 2xdx, 2xhr, 2xht, 2xhx, 2xjg, 2xjj, 2xjx, 2xk2, 3hyy, 3hyz, 3hz1, 3hz5, 3mnr - hHsp90 NTD+ antigen
    
  • 1osf, 1yer, 1yes, 1yet, 6lsz - hHsp90 NTD+ drug
    
  • 1qy8, 1qye, 1u0z, 1u2o, 1ysz, 2hg1, 2gfd, 2fyp, 2exl, 3o2f, 6d28, 6d1x - dHsp90B1 NTD+ligand
    
  • 2esa - dHsp90B1 NTD (mutant) +ligand
    
  • 1tba, 1tc0, 1tc6, 1yt0 - dHsp90B1 NTD+ nucleotide
    
  • 5wmt, 6aol, 6aom, 6asq, 6baw, 6c91, 6cyi - dHsp90B1 NTD+ inhibitor
    
  • 6asp - dHsp90B1 NTD + drug
    
  • 7d1v, 7d22, 7d24, 7d25, 7d26 - mHsp90-a NTD + inhibitor - mouse
    
  • 2jki - baHsp90 NTD+SGT1 domain protein – barley
    
  • 2xcm – baHsp90 NTD+CGT1+RAR1
    
  • 1a4h - yHsp90 NTD + antibiotic
    
  • 3q5j, 3q5k, 3q5l - LmHsp90 NTD + inhibitor
    
  • 3o6o, 3omu, 3opd – TbHsp90 NTD+inhibitor – Trypanosoma brucei
    
  • 3ied - PfHsp90 NTD+ANP
    
  • 3k60 - PfHsp90 NTD+ADP
    
  • 7k9s, 7k9u, 7k9v, 7k9w – CnHsp90 NTD + inhibitor
    
• Hsp90-a NTD+linker residues 1-293
  • 7ur3 - hHsp90 + inhibitor
    
• Hsp90-α MD
  • 6ksq - hHsp90 MD
    
  • 2gq0 - EcHsp90 MD
    
• Hsp90-α CT
  • 1sf8 – EcHsp90 CT
    
  • 3hjc - LmHsp90 CT
    
• Hsp90-α NTD + MD
  • 2o1w - dHsp90B1 NTD+MD
    
• Hsp90-α MD + CT residues 293-732
  • 3q6m, 3q6n, 7rxz, 7ry0, 7ry1 - hHsp90 MD + CT
    
  • 2o1t – dHsp90B1 MD+CT
    
• Hsp90-α full length 1-732
  • 2qf6 - hHsp90 + antigen
    
  • 5fwk, 5fwl, 5fwm, 5fwp – hHsp90 + CDC37 + CDK4
    
  • 7l7j - hHsp90 + P23 + ANP – Cryo EM
    
  • 7krj - hHsp90 + GR + P23 + ATP – Cryo EM
    
  • 8ffv, 8ffw - hHsp90 + GR + FKBP54 + ATP – Cryo EM
    
  • 8h77 - hHsp90 + AhR + P23 + XAP2 + ADP – Cryo EM
    
  • 7l7i - hHsp90 + FKBP51 + P23 + ANP – Cryo EM
    
  • 7kw7 - hHsp90 + Hsp70 + GR + STI1 + ADP – Cryo EM
    
  • 2o1u – dHsp90B1+AMPPNP
    
  • 2o1v - dHsp90B1+ADP
    
  • 1y4s, 1y4u, 2iop, 2ior - EcHsp90+ADP
    
  • 2ioq - EcHsp90
    
• Hsp90-beta
  • 8eob - hHsp90 – Cryo EM
    
  • 6n8w - hHsp90 NTD
    
  • 5fwk, 5fwl, 5fwm, 5fwp – hHsp90 + CDC37 + CDK4
    
  • 1uym, 6n8y, 7ulj - hHsp90 NTD+ purine inhibitor
    
  • 4o04, 4o05, 4o07, 5uc4, 5uch, 5uci, 5ucj - hHsp90-b NTD + inhibitor
    
  • 3nmq - hHsp90 NTD+pyrimidine derivative
  • 3pry – hHsp90 MD
    
  • 7zub, 8qmo - hHsp90 + AIP + AH receptor + ADP - Cryo EM
    
  • 8eoa - hHsp90 + AIPL1 + ANP – Cryo EM
    
  • 7z37, 7z38 - hHsp90 + Cdc37 + RAF-1 – Cryo EM
    
  • 8gae, 8gft - hHsp90 + Cdc37 + RAF-1 + PP5 – Cryo EM
    
  • 7zr0 - hHsp90 + Cdc37 + BRAF – Cryo EM
    
  • 8fx4 - hHsp90 + Cdc37 + GC-C – Cryo EM
    
  • 7zr5, 7zr6 - hHsp90 + Cdc37 + BRAF + PP5 – Cryo EM
    
  • 7y04 - mHsp90 + AH receptor + P23 + ADP - mouse - Cryo EM
    
• Hsp90 homolog
  • 6cji – CaHsp90H NTD – Candida albicans
    
  • 6cjl, 6cjp – CaHsp90H NTD + radicicol
    
  • 6cjj – CaHsp90H NTD + ADP
    
  • 9mtb – CaHsp90H NTD + ANP
    
  • 6cjr, 6cjs, 9msq, 9msu, 9msv, 8msx, 9mt3, 9mt9 – CaHsp90H NTD + inhibitor
    
• Hsp82 is the yeast equivalent of Hsp90 in mammals
  • 1ah6, 1ah8 – yHsp82 NTD
    
  • 2xd6, 2xx2, 2xx4, 2xx5, 4ce1, 4ce2, 4ce3 - yHsp82 NTD+macrolactone
    
  • 1amw – yHsp82 NTD+ADP
    
  • 2wep – yHsp82 NTD (mutant)+ADP
    
  • 2akp, 3c0e - yHsp82 NTD (mutant)
    
  • 1weq, 2yga, 2yge, 2ygf, 3c11 - yHsp82 NTD (mutant)+ antibiotic
    
  • 1ah4, 1bgq, 2cgf, 2fxs, 2iws, 2iwu, 2iwx, 2weq, 4as9, 4asa, 4asb, 4asf, 4asg - yHsp82 NTD +antibiotic
    
  • 8oxu - yHsp82 NTD + inhibitor
    
  • 2vw5, 2vwc - yHsp82 NTD +7-o-carbamoylpremacbecin
    
  • 2fxs - yHsp82 NTD +radamide
    
  • 1zw9 - yHsp82 NTD + adenine derivative
    
  • 1zwh - yHsp82 NTD + radester amine
    
  • 2brc, 2bre, 1am1 - yHsp82 NTD+pyrazol derivative
    
  • 2cg9 – yHsp82+co-chaperone SBA1
    
  • 2cge - yHsp82 MD+CT+co-chaperone SBA1
    
  • 1hk7 - yHsp82 MD
    
  • 1usu, 1usv - yHsp82 MD+co-chaperone AHA1
    
  • 1us7 - yHsp82 NTD+co-chaperone cdc37
    
  • 3fp2 – yHsp82 CT+TOM71
• Hsp100 are named ClpA or ClpB or ClpC or ClpL or ClpP
  • 1ksf, 1r6b – EcClpA (mutant)
    
  • 1k6k, 1r6c – EcClpA N-terminal
    
  • 1r6o, 1r6q – EcClpA N-terminal + ClpS
    
  • 1lzw, 1mbu, 1mbv, 1mbx, 1mg9 – EcClpA + YLJA
    
  • 6w1z, 6w20, 6w21, 6w22, 6w23, 6w24 – EcClpA + RepA + GFP + ADP + ATP – Cryo EM
    
  • 6uqe, 6uqo – EcClpA + ClpP + RepA + GFP + ADP + ATPgS – Cryo EM
    
  • 4ciu - EcClpB (mutant)
    
  • 4d2q, 4d2u, 4d2x - EcClpB – Cryo EM
    
  • 5ofo, 5og1 - EcClpB + ATPgS – Cryo EM
    
  • 6og3, 6qs6, 6qs7, 6qs8 - EcClpB (mutant) + casein – Cryo EM
    
  • 6og2 - EcClpB (mutant) + ADP – Cryo EM
    
  • 6og1 - EcClpB (mutant) + ADP + ATPgS – Cryo EM
    
  • 6qs4 - EcClpB + casein + ADP + ATPgS – Cryo EM
    
  • 6rn4 - EcClpB (mutant) + casein + ATPgS – Cryo EM
    
  • 6oax, 6oay - EcClpB (mutant) + casein + ADP + ATPgS – Cryo EM
    
  • 1khy – EcClpB NTD
    
  • 1jbk – EcClpB nucleotide binding domain 1
    
  • 1yg6 – EcClpP
    
  • 1yg8, 3hln – EcClpP (mutant)
    
  • 2fzs, 7mk5 – EcClpP + inhibitor
    
  • 6nb1 – EcClpP + activator
    
  • 3mt6 – EcClpP + Adep1
    
  • 6wr2, 6wsg – EcClpP + ClpX – Cryo EM
    
  • 6wrf – EcClpP + ClpX + GFP – Cryo EM
    
  • 8et3 – EcClpP + ClpX + GFP + SSPB – Cryo EM
    
  • 4iod, 4irf - PfClpB
    
  • 1qvr - TtClpB
    
  • 4fct - TtClpB CT
    
  • 4lj4 - TtClpB nucleotide binding domain 2
    
  • 4hse - TtClpB nucleotide binding domain 1 + ADP
    
  • 4lj5 - TtClpB nucleotide binding domain 2 + ADP
    
  • 4lj6 - TtClpB nucleotide binding domain 2 + AMPPCP
    
  • 4lj9, 4lja - TtClpB nucleotide binding domain 2 (mutant) + AMPPCP
    
  • 4lj8 - TtClpB nucleotide binding domain 2 (mutant) + ADP
    
  • 4lj7 - TtClpB nucleotide binding domain 2 (mutant) + ADP derivative
    
  • 4fcv, 4fcw, 4fd2 - TtClpB CT (mutant)
    
  • 3zri - VcClpB NTD – Vibrio cholerae
    
  • 3zrj - VcClpB NTD + peptide
    
  • 6ed3 - MtClpB – Cryo EM
    
  • 6w6e - MtClpB + ADP + ATPgS – Cryo EM
    
  • 6dju, 6djv - MtClpB + casein + ATPgS – Cryo EM
    
  • 6em8, 6em9 - SaClpC – Cryo EM
    
  • 6emw - SaClpC + MecA – Cryo EM
    
  • 6pba, 6pbq - MtClpC NTD
    
  • 6pbs - MtClpC NTD + ecumicin
    
  • 6cn8 - MtClpC NTD + rufomycin
    
  • 6lsy - SpClpL – Cryo EM
    
  • 6lt4 - SpClpL + ATPgS – Cryo EM
    
  • 7m1l, 7m1m – ClpP2 – Pseudomonas aeruginosa
    
  • 6cfd – ClpP + antibiotic – Enterococcus faecium
    
  • 7tfm – ClpP N-domain – Leishmania mexicana
    
• Hsp101 or chaperone protein ClpB1
  • 9ip0 – riHsp101 - Cryo EM
    
  • 6e11, 6e10 – PfPTEX core – Cryo EM
    
• Hsp104
  • 5kne, 6n8t, 6n8v, 6n8z – yHsp104 - Cryo EM
    
  • 6ahf – yHsp104 (mutant) – Cryo EM
    
  • 5u2u, 5wbw, 6amn – yHsp104 NTD
    
  • 5vy8 – yHsp104 + ADP
    
  • 5vy9, 5vya – yHsp104 + casein
    
  • 5vjh – yHsp104 + casein + ATP-γ-S
    
  • 5u2l – CaHsp104 NTD – Candida albicans
    
  • 6d00 – CtHsp104 – Calcarisporiella thermophila - Cryo EM
    
  • 6azy – CtHsp104 (mutant)
    
  • 5zui – ChtHsp104 – Chaetomium thermophilum
    
  • 7cg3 – ChtHsp104 - Cryo EM
    
  • 5d4w – ChtHsp104 (mutant)
    
• Hsp110 in mammals is named Sse1, Sse2 in yeast
  • 6gfa – hHsp110 + ATP
    
  • 3c7n, 3d2e, 3d2f – ySse1+Hsc70
    
  • 2qxl – ySse1
    
  • 2llv – ySti1 domain 1 – NMR
    
  • 2llw – ySti1 domain 2 – NMR
    
  • 3upv – ySti1 TPR repeats 7-9 + ySse1 peptide
    
  • 3uq3 - ySti1 TPR repeats 4-9 + peptide
    
  • 5z8i, 5z8q – ySsa1 SBD - NMR
    
• HspA5 or Grp78 or Endoplasmic reticulum chaperone BIP or 78 kDa glucose-related protein; Domains – NBD 26-407; SBD 418-637
  • 3ldn – hHspA5 NBD
    
  • 5e85 – hHspA5 SBD domain
    
  • 5ex5, 5exw, 5ey4 – hHspA5 + ATP analog
    
  • 3ldl, 5e84, 5f1x, 6asy – hHspA5 + ATP
    
  • 3iuc, 5evz, 5f0x – hHspA5 + ADP derivative
    
  • 5f2r – hHspA5 + ACP
    
  • 3ldo – hHspA5 + ANP
    
  • 3ldp – hHspA5 + inhibitor
    
  • 6cz1, 6dfm, 6dfo, 6do2, 6dws – hHspA5 + adenosine derivative
    
  • 6zmd – hHspA5 + FICD + ANP
    
  • 6eob, 6eoc, 7a4u – haHspA5 28-549
    
  • 6hab – haHspA5 (mutant)
    
  • 5e86 – haHspA5 SBD
    
  • 6zyh, 7a4v – haHspA5 + ADP
    
  • 5o4p – haHspA5 + AMP
    
  • 6eof – haHspA5 + AMP + ADP
    
  • 6eoe – haHspA5 + ADP
    
  • 7b7z, 7b80 – haHspA5 + FICD + AMP
    
  • 6h9u, 6ha7 – haHspA5 NBD + MANF
    
• HspQ
  • 5ycq – EcHspQ
    
• Hsp DegP or Periplasmic serine endoprotease DegP; Domains PDZ1 38-385; PDZ2 400-474
  • 3mh4 – EcDegP
    
  • 1ky9 – EcDegP (mutant)
    
  • 8f0a, 8f0u, 8f1t, 8f1u, 8f21 – EcDegP + telomeric repeat-binding factor peptide – Cryo EM
    
  • 2zle, 4a8d – EcDegP + OmpC – Cryo EM
    
  • 3cs0, 3mh5, 3mh6, 3mh7, 3ou0, 6jjk, 6jjl, 6jjo – EcDegP + peptide
    
  • 3otp – EcDegP + lysozyme
    
• Heat shock cognate protein (Hsc)
• Hsc20
  • 3bvo - hHsc20
    
• Hsc70
  • 3fzf - hHsc70 NBD+BAG domain regulator protein+ATP
    
  • 3fzh, 3fzm, 3ldq, 3m3z - hHsc70 NBD+BAG domain regulator protein+ adenosine derivative
    
  • 3fzk, 3fzl - hHsc70 NBD+BAG domain regulator protein+ purine derivative
    
  • 4h5n, 4h5r, 4h5v, 4h5w - hHsc70 NBD
    
  • 4h5t, 6zyj - hHsc70 NBD + ADP
    
  • 4hwi, 5aqf, 5aqg, 5aqh, 5aqi, 5aqj, 5aqk, 5aql, 5aqm, 5aqn, 5aqo, 5aqp, 5aqq, 5aqr, 5aqs, 5aqt, 5aqu, 5aqv - hHsc70 NBD+BAG domain regulator protein
    
  • 2qw9 – bHsc70 NBD – bovine
    
  • 1bup, 1qqm, 1qqn, 1qqo, 2bup - bHsc70 NBD (mutant)
    
  • 1yuw, 4fl9 - bHsp70 NBD + SBD
    
  • 1atr, 1ats, 1hpm, 1nga, 1ngb, 1ngc, 1ngd, 2qwl, 2qwm, 3hsc - bHsc70 NBD+ADP
    
  • 2qwn, 2qwo, 2qwp, 2qwq, 2qwr - bHsc70 NBD (mutant)+ auxilin protein
    
  • 1ba0, 1ba1 – bHsc70 NBD (mutant) + ADP
    
  • 1kax, 1kay, 1kaz - bHsc70 NBD (mutant) + ATP
    
  • 1nge, 1ngf, 1ngg, 1ngh - bHsc70 NBD + ATP
    
  • 1ngi, 1ngj - bHsc70 NBD + phosphoaminophosphonic acid
    
  • 1hx1 - bHsc70 NBD + molecular chaperone regulator 1 BAG domain
    
  • 2v7z – rHsc70 NBD + SBD – rat
    
  • 1ckr, 7hsc - rHsc70 sub - NMR
    
  • 3cqx - Hsc70 NBD+BAG domain regulator protein
    
• Hsc82
  • 6xlc - yHsc82 + ANP
    
  • 6xlh - yHsc82 MD+co-chaperone AHA1 + ADP + ATPgS
    
  • 6xld, 6xle, 6xlf - yHsc82 MD+co-chaperone AHA1 + ANP
    
  • 6xlb - yHsc82 MD+co-chaperone AHA1 + ANP – Cryo EM
    
  • 6xlg - yHsc82 MD+co-chaperone AHA1 + ATPgS
    
• Hsc90
  • 4xe2, 4xka, 4xkk, 4xko – smHsc90 NTD – slime mold
    
  • 4xc0, 4xcj, 4xcl, 4xd8 – smHsc90 NTD + nucleotide
    
  • 4xdm – smHsc90 NTD + antibiotic
    

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Michal Harel, Jaime Prilusky, Joel L. Sussman, Openfox