Helicase 3D structures

3D structures of helicase

Updated on 24-September-2026

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• Helicase Mot1
  • 3oc3 – Hel MOT1 heat domain + TFIID-1 – Encephalitozoon cuniculi
    
• Helicase 308
  • 2p6r – AfHel 308 + DNA – Archaeoglobus fulgidus
    
  • 2p6u - AfHel 308
  • 9b15 - AfHel 308 (mutant)
• DNA helicase
  • 3fld – EcHel I C terminal – Escherichia coli
    
  • 4l0j – EcHel I translocation domain
    
  • 2q7t, 2q7u – EcHel I relaxase domain (mutant)
    
  • 1p4d - EcHel I relaxase domain
    
  • 4n8o, 5n8o - EcHel I + DNA
    
  • 2a0i - EcHel I (mutant) + DNA
    
  • 6fws, 6fwr – EcHel I + DNA + ADP
    
  • 1e0j, 1e0k – Hel 4D domain – Phage T7
• DNA helicase II or UvrD
  • 1q2z, 1rw2 – hHel II KU86 C terminal – human - NMR
    
  • 5y58 – yHel II + DNA – yeast
    
  • 6yhz – yHel II C terminal - NMR
    
  • 7egs – yHel II C terminal + RNA polymerase
    
  • 5y59 – yHel II subunit 2 + Sir4P peptide
    
  • 8s8p – yHel II subunit 1,2 + RAP1 + DNA – Cryo EM
    
  • 3lfu – EcHel II
    
  • 2is1, 2is2 - EcHel II (mutant) + DNA
    
  • 2is4, 2is6 - EcHel II (mutant) + ADP + DNA
    
  • 4c2t, 4c2u, 4c30 – DrHel II + DNA - Deinococcus radiodurans
    
  • 6ppj, 7lhl – MsHel (mutant) – Mycobacterium smegmatis – Cryo EM
    
  • 9dqs – MsHel Tudor domain 731-783
    
  • 6ppr, 6ppu – MsHel + DNA – Cryo EM
    
  • 8q3i, 8qn8, 8qu6, 8r2m – MsHel in RNA polymerase complex – Cryo EM
    
  • 6yi2 – EcHel 645-720 - NMR
    
  • 7egt – TtHel II + UvrB – Thermus thermophilus
    
  • 9dci, 9des – MtHel + DNA – Cryo EM
    
• DNA helicase IV or HelD
  • 6vsx – BsHelD C-terminal – Bacillus subtilis
    
  • 6wvk, 6zca, 6zfb, 8xa8 – BsHelD in RNA polymerase - Cryo EM
    
• ATP-dependent helicase ATRX
  • 3qln - hATRX ADD domain residues 167-289
    
  • 2ld1, 2jm1 - hATRX ADD domain - NMR
    
  • 3ql9, 4w5a – hATRX ADD domain + histone H3 peptide
    
  • 2lbm - hATRX ADD domain + histone H3 peptide – NMR
    
  • 3qla, 3qlc - hATRX ADD domain (mutant) + histone H3 peptide
    
  • 5y6o – hATRX N terminal + ATRX
    
  • 2xzp - hRENT1 helicase domain
    
  • 2wjv - hRENT1 helicase CH and C terminal domains
    
  • 2wjy - hRENT1 helicase CH domains
    
  • 2xzo – hRENT1 helicase domain + RNA
    
• ATP-dependent helicase Fun30
  • 5gn1 – yFun C-terminal
    
• ATP-dependent helicase Rho or transcription termination factor Rho
  • 3l0o – TmRho – Thermotoga maritima
    
  • 6wa8 – EcRho + ATP
    
  • 9gcu – EcRho + ADP
    
  • 8q3n – EcRho + ADP – Cryo EM
    
  • 8q3p, 8q3q – EcRho (mutant) + ADP – Cryo EM
    
  • 8q3o, 9ff7 – EcRho + pppGppp – Cryo EM
    
  • 3ice, 8e5l – EcRho + ADP + BeF3 + RNA
    
  • 2ht1, 5jjl - EcRho + RNA
    
  • 8e6w - EcRho + RNA – Cryo EM
    
  • 1a8v, 1a62 – EcRho RNA-binding domain 1-118
    
  • 1a63 - EcRho RNA-binding domain – NMR
    
  • 2a8v – EcRho RNA-binding domain + RNA
    
  • 5jjk – EcRho (mutant) + RNA
    
  • 1pv4 – EcRho + DNA
    
  • 8ptg – EcRho + RNA – Cryo EM
    
  • 1pvo – EcRho + ssRNA + ANPPNP
    
  • 1xpr, 1xpu, 1xpo - EcRho + ssRNA + antibiotic
    
  • 6duq – EcRho + NusG + Ru12
    
  • 8ptm, 8ptn, 8pto, 8ptp, 8w8d - EcRho + ROF + ADP – Cryo EM
    
  • 8peu, 8pew, 8pex, 8pey, 9gcs, 9gct - EcRho + polarity suppression protein + ATPgS – Cryo EM
    
  • 7x2r – EcRho in transcription termination complex
    
  • 6xas, 6xav, 6z9p, 6z9s, 6z9t, 6z9q, 6z9r, 7adc, 7adb, 7add, 7ade, 8e3h, 8e5p, 8e70 – EcRho in transcription termination complex – Cryo EM
    
  • 7oqh – MtRho in transcription termination complex – Cryo EM
    
• ATP-dependent helicase MFD see Transcription-repair coupling factor
• ATP-dependent helicase HEPA or RNA polymerase-associaed protein RapA
  • 6bog, 8so8, 8sp4, 8spg – EcHEPA
    
  • 4s20, 7mkn, 7mkq, 8t0l – EcHEPA in RNA polymerase complex – Cryo EM
    
  • 7m8e – EcHEPA in elongation complex – Cryo EM
    
• ATP-dependent helicase E1
  • 2v9p, 5a9k – bPvE1 helicase domain – Bovine papillomavirus
    
  • 2gxa – bPvE1 + DNA + Mg-ADP
    
  • 7apd – bPvE1 in replication fork complex – Cryo EM
    
  • 1tue – hPvE1 + E2 – human papillomavirus
• ATP-dependent helicase CHD
  • 2b2y – hCHD1
    
  • 4b4c – hCHD1 DNA-binding domain
    
  • 2b2t, 2b2u, 2b2v, 2b2w – hCHD1 (mutant) + histone H3 tail
    
  • 4nw2, 4o42 – hCHD1 + NS1 peptide
    
  • 2n5n – hCHD1 N-terminal – NMR
    
  • 9ear, 9gd1, 9gd2, 9gd3, 9n6h, 9n6k – hCHD1 in nucleosome – Cryo EM
    
  • 2ee1 – hCHD4 chromodomain 2 618-674 – NMR
    
  • 4o9i – hCHD4 chromodomain 1+2 499-677
    
  • 2l5u – hCHD4 PHD1 domain 365-420 – NMR
    
  • 6q3m – hCHD4 PHD2+chromodomain 1,2
    
  • 2l75 – hCHD4 PHD2 domain 446-501 + histone H3 peptide – NMR
    
  • 6ryr, 6ryu – hCHD4 in nucleosome – Cryo EM
    
  • 6guu – hCHD5 PHD2 domain
    
  • 2epb – hCHD6 chromodomain – NMR
    
  • 2ckc, 2v0e, 2v0f – hCHD7 BRK domain - NMR
    
  • 2dl6 – hCHD8 BRK domain - NMR
    
  • 2cka – hCHD8
    
  • 2h1e, 2xb0, 3mwy – yCHD1 chromodomain
    
  • 2dy7 - yCHD1 chromodomain 1 1006-1274 – NMR
    
  • 2dy8 - yCHD1 chromodomain 2 – NMR
    
  • 3ted - yCHD1 chromodomain 1 + DNA
    
  • 5j70 - yCHD1 chromodomain 1 + DNA
    
  • 5o9g, 6g0l, 7nkx, 7tn2 - yCHD1 in nucleosome – Cryo EM
    
• ATP-dependent helicase Sth1
  • 6kmb, 6mr4, 6uy1 – ySth1 bromodomain 1248-1359
    
  • 6lqz – ySth1 1183-1240 + TFIID subunit 14 - NMR
    
  • 6kmj, 7f3s – ySth1 bromodomain + hisone H3
    
  • 6vz4, 6vzg – ySth1 + ARP7 + ARP9 + RTT102 – Cryo EM
    
  • 6k15, 6v8o, 6v92 – ySth1 in RSC core – Cryo EM
    
  • 6kw3, 6kw4, 6kw5, 6tda – ySth1 in RSC + nucleosome – Cryo EM
    
• ATP-dependent helicase GTF2F2 or general transcription factor IIF subunit 2
  • 7nvr, 7nvs, 7nvt, 7nvu, 7nvy, 7nvz, 7nw0, 7zwd, 7zx7, 7zx8, 8bvw, 8byq, 8bz1, 8s51, 8s52, 8s55, 8s5n, 8wad, 8wak, 8wal, 8wan, 8wap, 8waq, 8war, 8was, 8wat, 8wau, 8wav, 8waw, 8wax, 8way, 8waz, 8wb0 – hGTF2F2 in RNA polymerase II core – Cryo EM
    
  • 5iy6, 5iy7, 5iy8, 5iy9, 5iya, 5iyb, 5iyc, 5iyd, 6o9l, 7edx, 7eg7, 7eg8, 7eg9, 7ega, 7egb, 7egc, 7ena, 7enc, 8gxq, 8gxs – hGTF2F2 in core-PIC – Cryo EM
    
  • 7lbm – hGTF2F2 in transcription complex – Cryo EM
    
• ATP-dependent DNA helicase
  • 7a8r – bADDH + ADP - bovine
    
  • 8add – zADDH - zebrafish
    
• ATP-dependent DNA helicase PIF1
  • 5fhh, 6hpt – hPIF residues 200-641
    
  • 6hpu, 6hpq, 6hph – hPIF residues 206-620 + nucleotide
    
  • 9fb8 – hPIF residues 206-620 + inhibitor
    
  • 9fi9 – hPIF residues 206-620 (mutant) + inhibitor
    
  • 5o6b, 5o6d – yPIF residues 237-780 + DNA + ATP
    
  • 5o6e, 8xak – yPIF residues 237-780 + DNA + ADP
    
  • 6s3e, 7ada – ToPIF residues 64-507 – Thermus oshimai
    
  • 6xzt – ToPIF (mutant)
    
  • 6s3p, 7bil, 7oar – ToPIF + DNA
    
  • 6s3h, 6s3i, 6s3m, 6s3n, 6s3o – ToPIF + DNA + ADP
    
  • 5ftd – BaPIF - Bacterioides
    
  • 5fte, 6l3g – BaPIF + DNA + ADP
    
  • 5ftb – BaPIF + AMPPNP
    
  • 5ftc, 5ftf – BaPIF + ADP
    
  • 7otj – PIF + DNA + ADP – Candida albicans
    
• ATP-dependent DNA helicase TA0057
  • 5h8w – TaTA0 + DNA – Thermoplasma acidophilum
    
• ATP-dependent DNA helicase LHR
  • 5v9x – MsLHR + DNA – Mycobacterium smegmatis
    
• Dead box ATP-dependent RNA helicase
  • 4xw3 – hDDX1 SPRY domain 72-283
    
  • 8tbx – hDDX1 1-74, 286-674 + ADP
    
  • 2i4i – hDDX3X residues 167-581
    
  • 4px9 - hDDX3X residues 135-407
    
  • 4pxa - hDDX3X residues 135-407 (mutant)
    
  • 5e7i - hDDX3X residues 133-584
    
  • 2jgn – hDDX3X helicase domain residues 408-579
    
  • 4a4d – hDDX5 N-terminal
    
  • 4ct5 – hDDX6 95-469
    
  • 6uv0 – hDDX17 core domain
    
  • 3ly5 – hDDX18 dead domain
    
  • 6l5l, 6l5o – hDDX21 residues 120-495 (mutant)
    
  • 2rb4 – hDDX25 helicase domain
    
  • 2p6n – hDDX41 helicase domain (mutant)
    
  • 5gvr, 5gvs – hDDX41 DEAD domain 169-399
    
  • 8dpe – hDDX42
    
  • 2e29, 2m3d - hDDX50 GUCT domain - NMR
    
  • 3iuy – hDDX53
    
  • 8fkp, 8fkq, 8fkr, 8fks, 8fkt, 8fku, 8fkv, 8fkw, 8fkx, 8fky – hDDX54 in pre-60S ribosome – Cryo EM
    
  • 1vec – hP54 N terminal
    
  • 3fho – fyDbp5 – fission yeast
    
  • 8ark – yDbp2
    
  • 2kbe – yDbp5 N terminal – NMR
    
  • 2kbf - yDbp5 C terminal – NMR
    
  • 3gfp - yDbp5 C-terminal
    
  • 2hjv – BsDbpA domain 2
    
  • 2g0c - BsDbpA RNA-binding domain
    
  • 3eaq, 3ear, 3eas – TtHera residues 215-426
    
  • 3i31, 4i68, 5mao - TtHera RRM residues 431-517
    
  • 4i69 - TtHera RRM (mutant)
    
  • 3i32 - TtHera residues 218-517
    
  • 3nej - TtHera N terminal (mutant)
    
  • 4kbf, 4kbg - TtHera core 8-372
    
  • 5ivl – GsDB CSHA - Geobacillus stearothermophilus
    
  • 5b88 - EcDbp RRM-like domain - NMR
    
  • 5gju - EcDbp residues 6-210
    
  • 5gi4 - EcDbp residues 218-445
    
  • 7bbb - EcDbpA residues 218-445 - NMR
    
  • 6aib – SaDB CSHA N-terminal – Staphylococcus aureus
    
• Dead box ATP-dependent RNA helicase complexes
  • 3fmo, 3fhc – hDbp5 + Nup214
    
  • 3fht – hDbp5 + AMPPNP + RNA
    
  • 6cz5 - hDDX3X residues 132-607 + AMP
    
  • 8ssw - hDDX3X residues 132-607 + ADP
    
  • 6o5f, 7liu - hDDX3X + RNA
    
  • 5e7m, 5e7j – hDDX3X catalytic domain + nucleotide
    
  • 8iju - hDDX39A
    
  • 7znl, 8r7k, 8r7l, 9dlp - hDDX39B in TREX-2 complex – Cryo EM
    
  • 3fe2 – hDDX5 + ADP
    
  • 2wax, 2way, 6f9s – hDDX6 C terminal + peptide
    
  • 2pl3 – hDDX10 DEAD domain + ADP
    
  • 6uv1, 6uv2, 6uv3, 6uv4 – hDDX17 core domain + RNA
    
  • 6b4k – hDDX19B residues 54-479 + ANP
    
  • 6b4j, 6b4i – hDDX19B residues 54-479 + GLE1 + Nup42 + ANP
    
  • 3fmp – hDDX19B + Nup214
    
  • 3g0h – hDDX19B residues 54-275 + ATP analog + RNA
    
  • 3ews - hDDX19B residues 54-275 + ADP
    
  • 3b7g – hDDX20 + AMPPNP
    
  • 6l5m – hDDX21 + AMP
    
  • 6l5n – hDDX21 + RNA
    
  • 7oi6 – hDDX28 in 39S mitoribosome – Cryo EM
    
  • 7apk – hDDX39B in transcription-export complex – Cryo EM
    
  • 7evn, 7evo – hDDX42 in spliceosome – Cryo EM
    
  • 8hk1 – hDDX42 in pre-17S U2 – Cryo EM
    
  • 7q3l – hDDX46 in pre-17S U2 – Cryo EM
    
  • 3ber – hDDX47 + AMP
    
  • 6icz – hDDX48 in spliceosome – Cryo EM
    
  • 2j0s, 2j0q, 2hyi – hDDX48 + protein mago nashi homolog + RNA-binding protein 8A + protein CASC3 + RNA
    
  • 2j0u - hDDX48 + protein CASC3
    
  • 3dkp – hDDX52 domain I + ADP
    
  • 3og8 – hDDX58 C terminal + RNA
    
  • 2db3 – DmVASA residues 200-623 + RNA – Drosophila melanogaster
    
  • 5nt7 – DmVASA RecA-like domain + maternal effect protein
    
  • 4d25 – VASA (mutant) + RNA + AMPPNP - bee
    
  • 3rrm – yDBP5 residues 91-482 (mutant) + GLE1 + NUP159 + ADP + IP6
    
  • 3rrn - yDbp5 residues 91-482 (mutant) + GLE1 + IP6
    
  • 5elx - yDbp5 residues 91-482 + RNA
    
  • 3pew, 3pey - yDbp5 residues 91-482 (mutant) + ADP + BeF3 + RNA
    
  • 3peu, 3pev - yDbp5 C-terminal (mutant) + GLE1 + IP6
    
  • 3i5x, 3i5y – yMSS116 + AMPPNP + RNA
    
  • 3sqw, 3sqx - yMSS116 + AMPPNP + RNA
    
  • 3i61, 4tyw, 4tyy, 4tz0, 4tz6 - yMSS116 + nucleotide + BeF3 + RNA
    
  • 3i62 - yMSS116 + ADP + AlF4 + RNA
    
  • 4tyn - yMSS116 + ADP + DNA
    
  • 4db2 - yMSS116 domain 2 + RNA
    
  • 4db4 - yMSS116 domain 2 + RNA + DNA
    
  • 8arp – yDbp2 + ADP
    
  • 2xau, 3kx2, 5jpt – yPrp43 + nucleotide
    
  • 5i8q - yPrp43 + ADPNP + RNA
    
  • 8rdy - yPrp43 + Pxr1 + ADP – Cryo EM
    
  • 8enk – yDDX39B + Tho1 + RNA
    
  • 5ltk, 5ltj, 5d0u - CtPrp43 + ADP – Chaetomium thermophilum
    
  • 5lta - CtPrp43 + ADP + RNA
    
  • 3jrv – DDX3X + protein K7 – Vaccinia virus
    
  • 3nbf - TtHera N terminal (mutant) + 8-oxo-ADP
    
  • 4i67 - TtHera RRM + RNA
    
  • 3moj - BsDbpA RNA-binding domain + RNA
    
  • 7pli, 7pmm, 7pmq - EcDbpA + RNA
    
  • 6aic – SaDB CSHA N-terminal + AMP
    
  • 7ase, 7ask – DDX60 in 43S preinitiation complex complex – Trypanosoma cruzi - Cryo EM
    
• DEAH box RNA helicase
  • 2eqs – hDHX8 S1 domain residues 260-355
    
  • 3i4u – hDHX8 residues 950-1183
    
  • 6hys – hDHX8 helicase domain residues 548-1220 + ATP
    
  • 6hyt – hDHX8 helicase domain + ADP
    
  • 6hyu – hDHX8 helicase domain + RNA
    
  • 5mqf, 7w59 – hDHX8 in pre-C*-I complex – Cryo EM
    
  • 3llm – hDHX9 NBD 329-563
    
  • 3vyx, 3vyy – hDHX9 RNA-binding domain 152-264 + RNA
    
  • 9mfo, 9mft – hDHX9 RNA-binding domain + inhibitor + ADP
    
  • 5xdr – hDHX15 residues 110-795 (mutant)
    
  • 8ejm – hDHX15 residues 110-795 + SUGP1
    
  • 6sh6, 6sh7 – hDHX15 + Nfkb-repressing factor + ADP
    
  • 8ro2 – hDHX15 in spliceosome – Cryo EM
    
  • 5z58 – hDHX16 in spliceosome – Cryo EM
    
  • 2n16 – hDHX36 G-quadruplex domain 53-70 - NMR
    
  • 7a5p – hDHX38 in spliceosome – Cryo EM
    
  • 2rqa – hDHX58 C terminal – NMR
    
  • 6q6r – hDHX36 G-quadruplex domain + DNA
    
  • 2n21 – hDHX36 G-quadruplex domain + DNA - NMR
    
  • 8vv2, 8vvd – hDHX36 48-1010 + RNA – Cryo EM
    
  • 5e3h - hDHX58 residues 232-925 + RNA
    
  • 3eqt- hDHX58 residues 541-678 + RNA
    
  • 5vha – bDHX36 residues 150-1010
    
  • 5vhc, 5vhd – bDHX36 residues 150-1010 + ADP
    
  • 5vhe – bDHX36 residues 56-1010 + DNA
    
  • 8szp, 8szq, 8szr, 8szs – DHX9 residues 151-1151 + ADP - dog
    
  • 9mfr – DHX9 residues 151-1151 + inhibitor + ADP - cat
    
  • 9cpa – DHX29 in 43S pre-initiation complex – rabbit - Cryo EM
    
  • 2rs6, 2rs7 – mDHX9 RNA-binding domain – NMR
    
  • 6up2 – mDHX36
    
  • 6up4 – mDHX36 + ADP
    
  • 6up3 – mDHX36 + ANP
    
  • 5n6e, 5n8r, 5n8s, 5n8u, 5n8z, 5n90, 5n94, 5n98, 5n9a, 5n9f – DmDHX36 + DNA
    
  • 7dcq – yPrp2 – Cryo EM
    
  • 7dcr – yPrp2 + Spp2 – Cryo EM
    
  • 7dd3 – yPrp2 + Spp2 + RNA – Cryo EM
    
  • 7dcp – yPrp2 + Spp2 + ADP – Cryo EM
    
  • 7d4i – yDhr1 in 90S ribosome – Cryo EM
    
  • 6h57 – yDhr1
    
  • 9esh – fyDHX in spliceosome – Cryo EM
    
  • 6zwx, 8po6 – EcHrpA
    
  • 7akp – EcHrpA (mutant)
    
  • 6zww – EcHrpA + RNA
    
  • 8po7, 8po8 – EcHrpA + DNA + ADP
    
  • 6heg, 6eud – EcHrpB + ADP
    
  • 8cnt – ThtPrp2 + ADP – Thermochaetoides thermophila
    
• ATP-dependent RNA helicase
  • 2g9n - hEIF4A dead domain 1-406
    
  • 5zbz - hEIF4A dead domain + sanguinarine
    
  • 5zc9 - hEIF4A dead domain + ATP + RNA
    
  • 8huj, 9dts - hEIF4A dead domain + EIF4G + RNA – Cryo EM
    
  • 8xxn - hEIF4A dead domain in 43S ribosome – Cryo EM
    
  • 6ieg - hDOB1 residues 70-1042
    
  • 6ro1 - hDOB1 residues 70-1042 + NVL
    
  • 6ieh - hDOB1 residues 70-1042 + NRDE2
    
  • 6c90 - hDOB1 residues 70-600 + ZCCHC8
    
  • 6d6r, 6d6q - hDOB1 in exosome + RNA – Cryo EM
    
  • 7z4y – hMTR4 in exosome – Cryo EM
    
  • 9i8v – zADRH in tRNA ligase complex – Cryo EM
    
  • 5z3g, 6c0f, 6cb1, 6em3, 6em4, 6em5, 7r6q, 7r72, 8e5t, 8esq, 8esr, 8etg, 8eth, 8eti, 8eup, 8euy, 8ev3, 8v83, 8v84, 8v85, 8v87 - yHas1 in 60S ribosome biogenesis intermediate + RNA – Cryo EM
    
  • 2xzl – yNAM7 CH and helicase domains + RNA
    
  • 2xgj – yDOB1 residues 81-1073 + RNA
    
  • 4u4c - yDOB1 residues 81-1073 + poly(A) RNA polymerase protein 2
    
  • 4qu4 - yDOB1
    
  • 5ooq - yDOB1 residues 81-1073 + NOP53
    
  • 5suq – ySUB2 + TEX1 + THO2
    
  • 5sup – ySUB2 + YRA1 + RNA
    
  • 8u8c – ySUB2 + SAC3 + THP1 + SEM1
    
  • 7apx, 7luv, 7v2y – ySUB2 in THO complex – Cryo EM
    
  • 2vso, 2vsx – yEIF4A + initiation factor 4F middle domain
    
  • 2g9n - hEIF4A dead domain
• Viral ATP-dependent RNA helicase NS3
  • 3o8b, 3o8d, 1cu1, 8ohm, 1hei, 4a92, 3rvb, 5wdx – HvHel NS3 residues 1186-1658 – Hepatitis C virus
    
  • 1onb, 1jr6 - HvHel NS3 arginine-rich domain residues 1353-1507 – NMR
    
  • 2jlq, 2bhr, 2bmf, 2whx, 2wzq – DvHel NS3 residues 1646-2092 – Dengue virus
    
  • 5xc7 – DvHel NS3 residues 1646-2092 (mutant)
    
  • 2z83 – Hel NS3 residues 167-624 – Japanese encephalitis virus
    
  • 2v8o, 2wv9 - Hel NS3 helicase domain – Murray valley encephalitis virus
    
  • 2qeq - Hel NS3 residues 1691-2124 – Kunjin virus
    
  • 5txg, 5jmt, 5rhy, 5vi7, 5jps, 6adw, 6mh3 - ZvHel NS3 helicase domain 1674-2119 – Zika virus
    
  • 5k8u, 5k8l, 5k8i, 5jwh, 5jrz - ZvHel NS3 residues 164-621
    
  • 5x8y - ZvHel NS1 residues 168-352
    
  • 2v6i – KvHel helicase domain – Kokobera virus
    
  • 2v6j - KvHel helicase domain (mutant)
    
  • 5wso, 5gvu - Hel NS3 residues 1939-2414 – bovine viral diarrhea virus
    
  • 1yks, 5ffm - Hel NS3 helicase domain – yellow fever virus
    
  • 7wd4 - Hel NS3 helicase domain – ilheus virus
    
  • 4cbg, 4cbh, 4cbi, 4cbl, 4cbm - Hel NS3 helicase domain – pestivirus
    
  • 7nno, 7oj4 - TbevHel NS3 helicase domain – Tick-bourne encephalitis virus
    
• Viral ATP-dependent RNA helicase NS3 complexes
  • 3o8c, 3o8r, 3kqh, 3kqk, 3kql, 3kqn, 3kqu, 1a1v - HvHel NS3 + RNA
    
  • 2f55 - HvHel NS3 + DNA
    
  • 2f9v - HvHel NS3 protease domain + polyprotein
    
  • 2a4g, 1rtl, 1w3c, 1dxp - HvHel NS3 protease domain + NS4A peptide
    
  • 2zjo, 4ok5, 4oks, 4wxp, 4wxr - HvHel NS3 + inhibitor
    
  • 5e4f - HvHel NS3 + ADP
    
  • 2a4q, 2a4r, 2f9u, 2fm2, 1dy8, 1dy9 - HvHel NS3 protease domain + NS4A peptide + inhibitor
    
  • 2jlr - DvHel NS3 helicase domain + AMPPNP
    
  • 2jls - DvHel NS3 helicase domain + ADP
    
  • 2jlu, 2jlw, 5xc6 - DvHel NS3 helicase domain + RNA
    
  • 2jlv - DvHel NS3 helicase domain + AMPPNP + RNA
    
  • 2jlx, 2jly, 2jlz - DvHel NS3 helicase domain + ADP + RNA
    
  • 2vbc - DvHel NS3 residues helicase domain + NS2A peptide
    
  • 5k8t - ZvHel NS3 residues 164-621 + GTP
    
  • 5gjc - ZvHel NS3 helicase domain + ATP
    
  • 5gjb - ZvHel NS3 helicase domain + RNA
    
  • 5y4z - ZvHel NS3 helicase domain + AMPPNP
    
  • 5rhg, ]]5rhh]], 5rhi, 5rhj, 5rhk, 5rhl, 5rhm, 5rho, 5rhp, 5rhq, 5rhr, 5rhs, 5rht, 5rhu, 5rhv, 5rhw, 5rhx, 8um3, 8v7r, 8v7u - ZvHel NS3 helicase domain + inhibitor
    
  • 5y6m, 5y6n, 6adx, 6ady, 6rwz, 6s0j - ZvHel NS3 helicase domain + ADP
    
  • 7blv, 7nxu - TbevHel NS3 helicase domain + ADP
    
  • 7bm0 - TbevHel NS3 helicase domain + AMPPNP
    
  • 6jim - Hel NS3 helicase domain + RNA – chikungunya virus
    
• ATP-dependent RNA helicase SUV3
  • 3rc3, 7w1r – hSUV3 residues 47-722
    
  • 3og8 – hDDX58 C terminal + RNA
    
  • 3rc8 - hSUV3 residues 47-722 + RNA
    
  • 6f4a – ySUV3 + exoribonuclease II + RNA
    
• ATP-dependent RNA helicase A
  • 3llm – hHel A
    
  • 3vyx, 3vyy - hHel A RNA-binding domain + RNA
    
  • 1whq, 2rs6, 2rs7 – Hel A RNA-binding domain – mouse - NMR
    
• ATP-dependent RNA helicase Rep
  • 8h56 – pcvRep – Porcine circovirus
    
  • 7lar, 7las – pcvRep + DNA + ADP – Cryo EM
    
• ATP-dependent RNA helicase Repa
  • 1uaa – EcRepa + DNA
    
  • 1nlf - EcRepa + sulfate
    
  • 1g8y, 1olo - EcRepa
• ATP-dependent RNA helicase HEF
  • 1x2i – HEF DNA-binding domain – Pyrococcus furiosus
• ATP-dependent RNA helicase Srmb
  • 2yjt - EcSrmb residues 219-388 + RRAA
    
• ATP-dependent RNA helicase Dhh1
  • 4bru – yDhh1 (mutant) + EDC3
    
  • 4brw – yDhh1 (mutant) + PAT1
    
  • 1s2m – yDhh1p
    
• Werner syndrome ATP-dependent DNA helicase
  • 2e1e, 2e1f, 2dgz – hWRN HRDC domain 1142-1242
    
  • 2fbt - hWRN exonuclease domain 38-236
    
  • 2fbv, 2fbx, 2fby, 2fc0 - hWRN exonuclease domain + metal ion
  • 9og3, 9og8 - hWRN exonuclease domain + inhibitor
  • 3aaf – hWRN C terminal 949-1079 + DNA
    
  • 6yhr - hWRN 517-1094
    
  • 8yle - hWRN 517-945 + AMPPCP
    
  • 2e6l, 2e6m - mWRN exonuclease domain
• ATP-dependent DNA helicase Q
  • 2v1x - hQ1 residues 49-616
    
  • 2wwy, 4u7d, 8yrs – hQ1 residues 49-616 + DNA
    
  • 5lst – hQ4 residues 427-1116
    
  • 2kmu – hQ4 N terminal - NMR
    
  • 5lb8 – hQ5 11-526
    
  • 8rl6 – hQ5 12-453 – Cryo EM
    
  • 5lb5, 5lb3 – hQ5 + ADP
    
  • 5lba – hQ5 + urea derivative
    
  • 7zml, 7zmm, 7zmn, 7zmp, 7zmq, 7zmt, 7zmv – hQ5 + nanobody
    
  • 8rl5, 8rla – hQ5 + gluebody – Cryo EM
    
  • 8rl9 – hQ5 + GFP + gluebody – Cryo EM
    
  • 8qq2, 8qw8, 8qw9, 9ei1, 9ei2, 9ei3, 9ei4 – hQ5 in elongation complex – Cryo EM
    
  • 9hvo, 9hvq, 9hwg – hQ5 in transcription complex – Cryo EM
    
• ATP-dependent DNA helicase RecG
  • 1gm5 – TmRecG + DNA
    
  • 9wm3 – EcRecG
    
  • 9wm0 – EcRecG + DNA
    
  • 9wm1, 9wm2 – EcRecG + DNA + ADP
    
• ATP-dependent DNA helicase RecQ (Bloom Syndrome helicase)
  • 4cgz, 4o3m - hRecQ catalytic domain + DNA
    
  • 4cdg - hRecQ catalytic domain + nanobody
    
  • 1d8b - yRecQ HRDC domain - NMR
    
  • 3iuo – RecQ residues 604-725 – Porphyromonas gingivalis
    
  • 2rhf – DrRecQ HRDC domain 3 – Deinococcus radiodurans
    
  • 2ma1 - DrRecQ HRDC domain – NMR
    
  • 4q48 - DrRecQ catalytic domain
    
  • 4q47 - DrRecQ catalytic domain + ADP
    
  • 1wud - EcRecQ HRDC domain
    
  • 1oyw - EcRecQ catalytic domain
    
  • 1oyy - EcRecQ catalytic domain + ATP
    
• ATP-dependent DNA helicase RuvA, RuvB
  • 2ztc, 2ztd, 2zte, 2h5x – MtRuvA – Mycobacterium tuberculosis
    
  • 7oa5 - MlRuvA – Mycobacterium leprae
    
  • 7oa5 - MlRuvA + DNA
    
  • 1cuk, 1hjp – EcRuvA
    
  • 1d8l – EcRuvA N terminal
    
  • 1c7y, 1bdx – EcRuvA + DNA
    
  • 1hqc – TtRuvB
    
  • 8efv, 8efy – TtRuvB + DNA – Cryo EM
    
  • 1ixr, 1ixs – TtRuvA + RuvB (mutant)
    
  • 1in4 – TmRuvB
    
  • 1in5, 1in6, 1in7, 1in8, 1j7k – TmRuvB (mutant)
    
  • 3pfi – RuvB + ADP – Campylobacter jejuni
    
  • 6blb, 7x5b - PaRuvB + ADP - Pseudomonas aeruginosa
    
  • 7x5a, 7x7p, 7x7q - PaRuvB in Holliday junciton – Cryo EM
    
  • 7pbl, 7pbm, 7pbn, 7pbo, 7pbp, 7pbq, 7pbr, 7pbs, 7pbt, 7pbu – RuvA + RuvB + DNA – Streptococcus thermophiles – Cryo EM
    
• ATP-dependent DNA helicase RuvB-like
  • 2c9o – hRuvBL1 + ADP
    
  • 6h7x – hRuvBL2
    
  • 3uk6 – hRuvBL2 + ADP
    
  • 2cqa – hRuvBL2 C-terminal - NMR
    
  • 2xsz – hRuvBL1 + hRuvBL2 + ATP
    
  • 6qi8, 6qi9 – hRuvBL1 + hRuvBL2 + ADP
    
  • 5oaf – hRuvBL1 + hRuvBL2 + ADP - Cryo EM
    
  • 6fo1 – hRuvBL1 + hRuvBL2 + RPAP3 + ADP - Cryo EM
    
  • 6igm, 9ca9 – hRuvBL1 + hRuvBL2 + actin-related protein + helicase SRCAP + protein - Cryo EM
    
  • 6hts, 8av6 – hRuvBL1 + hRuvBL2 + INO80 + ARP5 + histones + DNA - Cryo EM
    
  • 9eq2 – AtRuvBL in RT2 complex – Arabidopsis thaliana - Cryo EM
    
  • 5oun – yRuvBL2 DII domain - yeast - NMR
    
  • 6gej, 6gen – yRuvBL1 + yRuvBL2 + vacuolar protein sorting-associated proteins + ARP6 + SWR complex protein 6 + histones + helicase SWR1 + ADP + ATP + DNA - Cryo EM
    
  • 4wvy – CtRuvBL1 + CtRuvBL2 + ATP
    
  • 4ww4 – CtRuvBL1 + CtRuvBL2 + ADP
    
  • 6fhs – CtRuvBL1 + CtRuvBL2 + INO80 + LES2 + LES5 + ARP5 + ADP + ATP - Cryo EM
    
  • 6fml – CtRuvBL1 + CtRuvBL2 + INO80 + LES2 + LES6 + actin-related protein + histones + ADP + ATP + DNA - Cryo EM
    
  • 8ooc – ThtRuvBL1 + ThtRuvBL2 + INO80 + Vps72 + ADP + ATP - Cryo EM
    
  • 5f4h, 5yww – RuvBL (mutant) - Sulfolobus islandicus
    
• ATP-dependent DNA helicase UVSW
  • 2oca, 1rif- T4UVSW (mutant) – Enterobacteria phage T4
    
  • 2jpn - T4UVSW
• ATP-dependent DNA helicase DDA
  • 3upu – T4DDA + DNA
    
  • 8s9i – T4DDA + DT8 + Gp32 peptide
    
  • 8gme – T4DDA + DT17 + Gp32
    
• ATP-dependent DNA helicase DDM1
  • 7ux9, 8j90, 8wh5 – AtDDM1 in nucleosome complex + DNA – Cryo EM
    
  • 8kcb, 8kcc, 8skz, 8wh8, 8wh9, 8wha – AtDDM1 in nucleosome complex + DNA + ADP – Cryo EM
    
• ATP-dependent DNA helicase PriA
  • 2d7e – EcPriA DNA-binding domain
    
  • 2d7g, 2d7h, 2dwl, 2dwm, 2dwn – EcPriA N terminal + polynucleotide
    
  • 6dgd – KpPriA + DNA – Klebsiella pneumoniae
    
  • 4nl4 – KpPriA + ADP
    
  • 4nl8 – KpPriA + peptide
    
• ATP-dependent DNA helicase PcrA
  • 1qhg – GsPcrA (mutant) + ADPNP
    
  • 1qhh - GsPcrA + ADPNP
    
  • 2pjr, 3pjr - GsPcrA + DNA
    
  • 1pjr - GsPcrA
    
  • 5dma – GsPcrA C-terminal tudor domain
    
• DNA helicase mcm8 or minichromosome maintenance 8; Domains – N-terminal 1-376; WH 770-840
  • 6l0o – hMcm8 WH domain
    
  • 7dp3 – hMcm8 N-terminal
    
  • 7wi7 – hMcm8 N-terminal + hMcm9 N-terminal
    
  • 7w7p, 7yox – hMcm8 N-terminal + hMcm9 N-terminal – Cryo EM
    
  • 8s94 – hMcm8 (mutant) + hMcm9 (mutant) – Cryo EM
    
  • 8s91, 8s92 – hMcm8 N-terminal (mutant) + hMcm9 N-terminal (muant) + ADP – Cryo EM
    
  • 8rig – yMcm8 + DNA – Cryo EM
    
  • 8q67 – Mcm (mutant) – Candidatus acidiphilum
    
• DnaB helicase or replicative DNA helicase
  • 3gxv, 4zc0 – HpDnaB – Helicobacter pylori
    
  • 4a1f – HpDnaB C terminal
    
  • 2r6d – BsDnaB – Bacillus stearothermophilus
    
  • 2r6e, 2r6d - GsDnaB
    
  • 2r5u – MtDnaB N terminal
    
  • 2q6t – DnaB – Thermus aquaticus
    
  • 1mi8, 6frh – SyDnaB – Synechocystis
    
  • 6frg, 6fre – SyDnaB (mutant)
    
  • 6bbm – EcDnaB + replication protein P – Cryo EM
    
  • 7t21 – EcDnaB + DNA + ADP – Cryo EM
    
  • 7t22, 9eco – EcDnaB (mutant) + DNA primase + DNA + ADP – Cryo EM
    
  • 9oa1, 9oa2 – EcDnaB + helicase loader + ADP – Cryo EM
    
  • 1b79 - EcDnaB N terminal
    
  • 1jwe - EcDnaB N terminal - NMR
    
  • 6kza - EcDnaB C terminal + DnaC
    
  • 7t20 - EcDnaB + DNA + AMPPNP
    
  • 4esv – BsDnaB + DNA
    
  • 4m4w – BsDnaB in primosome
    
  • 2r6c, 2r6a – BsDnaB + DnaG helicase-binding domain
    
  • 6bs8, 6own – MsDnaB 238-376
    
  • 6rix, 6riy – DnaB (mutant) – Mycobacterium chimaera
    
  • 6own, 6bs8 – MsDnaB 238-376
    
  • 7qxm – VcDnaB – Vibrio cholerae
    
  • 9dls – VcDnaB – Cryo EM
    
  • 6t66 – VcDnaB + GDP
    
  • 8a3v – VcDnaB + DCIA
    
  • 4nmn – AaDnaB + ADP – Aquifex aeolicus
    
• DnaB-like replicative helicase or Gp41
  • 3bgw – BpDnaB-like – Bacillus phage SPP1
    
  • 3bh0 - BpDnaB-like G40P ATPase domain
    
  • 8due – T4DnaB-like + DNA
    
  • 8dtp, 8dw6 – T4DnaB-like + DNA – Cryo EM
    
  • 8dvi – T4DnaB-like + DNA primase + DNA – Cryo EM
    
  • 8gao – T4DnaB-like + DNA primase + DNA + RNA – Cryo EM
    
• DnaC helicase
  • 2vyf– GkDnaC – Geobacillus kaustophilus
    
  • 2vye – GkDnaC + DNA
    
  • 3ec2 – AaDnaC
    
  • 3ecc – AaDnaC + ADP
    
  • 6qel – EcDnaC + replicative DNA Hel - Cryo EM
    
  • 6qem – EcDnaC + replicative DNA Hel + DNA - Cryo EM
    
• Helicase BLM
  • 7auc – hBLM 636-1298
    
  • 7aud – hBLM 636-1298 + DNA
    
  • 5lup, 5mk5 – hBLM DHBN domain 362-414
    
  • 2mh9, 3we2, 3we3 – hBLM RQC domain 1068-1209
    
  • 2kv2 – hBLM HRDC domain 1210-1294 - NMR
    
  • 5lut – BLM DHBN domain - chicken
    
  • 5lus – BLM DHBN domain - pelican
    
• Helicase CA8 or Prp28
  • 4w7s – yCa8
    
  • 5dtu – CtPrp28 + ADP
    
• Helicase NSP see Nonstructural protein
• Helicase SEN1
  • 5mzn, 6i59 – ySEN1
    
  • 6o3w, 6o3x, 6o3y – ySEN1 + Nrd1
    
  • 8ran, 8rao – ySEN1 + RNA – Cryo EM
    
  • 8ram, 8rap – ySEN1 in RNA polymerase complex – Cryo EM
    
• Helicase DinG
  • 6fws, 6fwr – EcDinG + DNA + ADP
    
  • 8rfj – DinG in crispr effector complex + DNA – Pseudomonas oleovorans – Cryo EM
    
  • 8s35 – KpDinG in crispr effector complex + DNA – Cryo EM
    
• Helicase SNF2
  • 5x0x, 5x0y, 5z3o, 5z3u, 5z3v, 6iy2, 6iy3, 6uxw, 7c4j, 7egm, 7egp – ySNF2 in nucleosome – Cryo EM
    
  • 1z5z – SsSNF2 C terminal – Sulfolobus solfataricus
    
  • 1z63 - SsSNF2 ATPase core + DNA
    
  • 1z6a - SsSNF2 ATPase core
• Helicase SKI or superkiller protein
  • 7qdy, 7qdz, 7qe0 – hSKI2W + TPR repeat protein + SKI8 + RNA – Cryo EM
    
  • 7qdr, 7qds – hSKI2W + TPR repeat protein + SKI8 – Cryo EM
    
  • 9g8m, 9g8n, 9g8o, 9g8p – hSKI2W in exosome complex – Cryo EM
    
  • 9g8r – hSKI2 + SKI3 + SKI8 homolog + ERFS – Cryo EM
    
  • 4buj – ySKI2 + SKI3 + SKI8
    
  • 9g8q – ySKI2 + SKI3 + SKI8 – Cryo EM
    
  • 8q9t, 8qca – ySKI2 + SKI3 + SKI8 + RNA – Cryo EM
    
  • 8qcb – ySKI2 + SKI3 + SKI7 + antiviral protein SKI8 + RNA – Cryo EM
    
  • 8qcf – ySKI2 in exosome complex + RNA – Cryo EM
    
  • 4a4k – ySKI2 insertion domain
    
  • 4a4z – ySKI2 + AMPPNP
    
  • 2va8 – SsSKI2
    
• Helicase SRCAP
  • 9ca9 – hSRCAP complex – Cryo EM
    
  • 9ca7, 9ca8, 9caa, 9cab – hSRCAP in nucleosome complex – Cryo EM
    
  • 8x15, 8x19, 8x1c – hSRCAP-C in nucleosome complex – Cryo EM
    
• Helicase SWR1
  • 5i9e – ySWR1 + actin + actin-related protein
    
  • 8qku, 8qkv, 8qyv, 8qz0, 9b1d, 9b1e, 9fbw – ySWR1 in nucleosome – Cryo EM
    
• Helicase XPD
  • 3crv, 3crw, 5h8c – XPD – Sulfolobus acidocaldarius
    
  • 4a15 - TaXPD + DNA
    
  • 2vsf - TaXPD
    
  • 2vl7 - XPD - Sulfolobus tokodaii
    
  • 5ivw - hXPD + XPB + TFIIH ubunits 2,3,4,5 + SCP-X + SCP-Ybr />
• Pre-mRNA-splicing Helicase or Brr2 or ski2-like
  • 4f92 – hBrr2 402-2125
    
  • 4f91 – hBrr2 helicase region 394-213
    
  • 6s8o – hBrr2 helicase region (mutant)
    
  • 4f93 – hBrr2 helicase region (mutant) + ATP + ADP
    
  • 8bch – hBrr2 helicase region + sulfaguanidine
    
  • 5urj, 5urk, 5urm – hBrr2 helicase region + inhibitor
    
  • 4kit, 6s8q, 6s9i, 8bc9 – hBrr2 helicase region + pre-mRNA-splicing factor 8
    
  • 8bc8, 8bcb, 8bcc, 8bcd, 8bcf , 8bcg – hBrr2 helicase region + pre-mRNA-splicing factor 8 + inhibitor
    
  • 7os2 – hBrr2 helicase region + pre-mRNA-splicing factor 8 + telomere length and silencing protein – Cryo EM
    
  • 7os1 – hBrr2 helicase region + WBP-4 – Cryo EM
    
  • 7px3 – hBrr2 helicase region + pre-mRNA-splicing factor 8 + TSSC4 – Cryo EM
    
  • 3jcm, 3jcr, 5gap – hBrr2 helicase region in U4/U6.U5 snRNP complex – Cryo EM
    
  • 7bdi, 7bdj, 7bdk, 7bdl – hBrr2 394-2136 + pre-mRNA-splicing factor 8 + nucleotide
    
  • 3hib, 3im1, 3im2 – yBrr2 2nd SEC63 domain
    
  • 4bgd, 5m5p, 5m52, 5dca – yBrr2 + pre-mRNA-splicing factor 8
    
  • 5gan, 5gao – yBrr2 in U4/U6.U5 complex – Cryo EM
    
  • 5lj5, 5lqw – yBrr2 in spliceosome – Cryo EM
    
  • 6qws – CtBrr2 473-2193
    
  • 4rvq – CtBrr2 PWI-like domain 287-422
    
  • 6qv4 – CtBrr2 + ATPgS
    
  • 6qv3 – CtBrr2 + ADP
    
• crispr-associated helicase Cas3
  • 4q2c – TteCas3 – Thermobaculum terrenum
    
  • 4q2d – TteCas3 + DTP
    
  • 4qqw, 4qqx – TfCas3 – Thermobifida fusca
    
  • 4qqy – TfCas3 + ADP + HD nuclease
    
  • 4qqz – TfCas3 + AMPPNP
    
  • 6c66 – TfCas3 + Cse1 + Cse3 + Cse4 + Cas5e – Cryo EM
    
  • 5gqh – PaCas3 + anti-crispr protein 3
    
  • 5b7i – PaCas3 + ACRF3
    
  • 8wtk – PhCas3 – Pyrococcus horikoshii
    
  • 8wtl – PhCas3 + ATP
    
• Helicase aquarius or intron-binding protein aquarius
  • 4pj3 – hHA + AMPPNP
    
  • 6id0, 6id1, 8i0p, 8i0r. 8i0s, 8i0t, 8i0u, 8i0v, 8i0w – hHA in spliceosome – Cryo EM
    
  • 3jb9 – fyHA in spliceosome – Cryo EM
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Openfox