Cytochrome P450: Difference between revisions

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The <scene name='43/430105/Cv/6'>heme moiety is stabilized by several side chains</scene>.  The <scene name='43/430105/Cv/7'>heme iron is pentacoordinated with Cys as one ligand</scene>.<ref>PMID:12861225</ref>
The <scene name='43/430105/Cv/6'>heme moiety is stabilized by several side chains</scene>.  The <scene name='43/430105/Cv/7'>heme iron is pentacoordinated with Cys as one ligand</scene>.<ref>PMID:12861225</ref>
== 3D Structures of Cytochrome P450  ==
[[Cytochrome P450  3D structures]]
</StructureSection>
</StructureSection>
== 3D Structures of Cytochrome P450  ==
== 3D Structures of Cytochrome P450  ==
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**[[2hi4]] – hP4501A2+naphthoflavone - human<br />
**[[2hi4]] – hP4501A2+naphthoflavone - human<br />
**[[4i8v]] - hP4501A1 +naphthoflavone<br />
**[[4i8v]] - hP4501A1 +naphthoflavone<br />
**[[6dwn]] - hP4501A1 + erlotinib<br />
**[[6dwm]] - hP4501A1 + bergamottin<br />
**[[3pm0]] - hP4501B1+naphthoflavone<br />
**[[3pm0]] - hP4501B1+naphthoflavone<br />
**[[6iq5]] - hP4501B1 + inhibitor<br />


* human P450 2 family  
* human P450 2 family  
   
   
**[[2pg5]], [[2pg6]], [[2pg7]] – hP4502A6 (mutant)<br />
**[[2pg5]], [[2pg6]], [[2pg7]] – hP4502A6 (mutant)<br />
**[[1pq2]] - hP4502C8<br />
**[[1og2]], [[1og5]] – hP4502C9 (mutant)<br />
**[[4gqs]] - hP4502C19 catalytic domain<br />
**[[2f9q]], [[3qm4]] – hP4502D6<br />
* human P450 2 family complex
**[[3ebs]] – hP4502A6 (mutant)+phenacetin<br />
**[[3ebs]] – hP4502A6 (mutant)+phenacetin<br />
**[[2fdu]], [[2fdv]], [[2fdw]], [[2fdy]] - hP4502A6+pyridine derivative<br />
**[[2fdu]], [[2fdv]], [[2fdw]], [[2fdy]] - hP4502A6+pyridine derivative<br />
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**[[3ua5]] – hP4502B6 (mutant) + amlodipine<br />
**[[3ua5]] – hP4502B6 (mutant) + amlodipine<br />
**[[4i91]], [[4zv8]] - hP4502B6 (mutant) + pinine<br />
**[[4i91]], [[4zv8]] - hP4502B6 (mutant) + pinine<br />
**[[5wbg]] - hP4502B6 (mutant) + HIV drug<br />
**[[3qoa]], [[2qu8]], [[3qu8]] – hP450 2B6 (mutant) + inhibitor<br />
**[[3qoa]], [[2qu8]], [[3qu8]] – hP450 2B6 (mutant) + inhibitor<br />
**[[4rql]], [[4rrt]] – hP450 2B6 (mutant) + volatile hydrocarbon<br />
**[[4rql]], [[4rrt]] – hP450 2B6 (mutant) + volatile hydrocarbon<br />
**[[5ufg]], [[5uec]], [[5uap]] – hP450 2B6 (mutant) + Br derivative<br />
**[[5uda]] – hP450 2B6 (mutant) + monoterpene borane<br />
**[[5e58]] – dwP450 2B35 + inhibitor – desert woodrat<br />
**[[5e58]] – dwP450 2B35 + inhibitor – desert woodrat<br />
**[[5e0e]] – dwP450 2B37 + inhibitor <br />
**[[5e0e]] – dwP450 2B37 + inhibitor <br />
Line 54: Line 71:
**[[2nni]] - hP4502C8+montelukast<br />
**[[2nni]] - hP4502C8+montelukast<br />
**[[2nnj]] - hP4502C8+felodipine<br />
**[[2nnj]] - hP4502C8+felodipine<br />
**[[1pq2]] - hP4502C8<br />
**[[1og2]], [[1og5]] – hP4502C9 (mutant)<br />
**[[1r9o]] – hP4502C9 (mutant)+flurbiprofen<br />
**[[1r9o]] – hP4502C9 (mutant)+flurbiprofen<br />
**[[5xxi]], [[5x23]], [[5x24]] - hP4502C9 (mutant) + blood pressure drug<br />
**[[5xxi]], [[5x23]], [[5x24]] - hP4502C9 (mutant) + blood pressure drug<br />
**[[5a5i]], [[5a5j]], [[5w0c]], [[5k7k]] - hP4502C9 + inhibitor<br />
**[[5a5i]], [[5a5j]], [[5w0c]], [[5k7k]] - hP4502C9 + inhibitor<br />
**[[4nz2]] - hP4502C9 (mutant) + inhibitor<br />
**[[4nz2]] - hP4502C9 (mutant) + inhibitor<br />
**[[4gqs]] - hP4502C19 catalytic domain<br />
**[[2f9q]], [[3qm4]] – hP4502D6<br />
**[[3tbg]], [[4wnw]] – hP4502D6 + thioridazine<br />
**[[3tbg]], [[4wnw]] – hP4502D6 + thioridazine<br />
**[[6csb]] - hP4502D6 (mutant) + thioridazine<br />
**[[3tda]] – hP4502D6 + prinomastat<br />
**[[3tda]] – hP4502D6 + prinomastat<br />
**[[6csd]] - hP4502D6 (mutant) + prinomastat<br />
**[[4wnt]] - hP4502D6 + ajmalicine<br />
**[[4wnt]] - hP4502D6 + ajmalicine<br />
**[[4wnu]], [[4wnv]] - hP4502D6 + quinine derivative<br />
**[[4wnu]], [[4wnv]] - hP4502D6 + quinine derivative<br />
Line 75: Line 90:
* human P450 3 family  
* human P450 3 family  


**[[5vcc]], [[5vcd]] - hP4503A4 (mutant) <br />
**[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br />
**[[5vcc]], [[5vcd]], [[4l3q]] - hP4503A4 (mutant) <br />
**[[2v0m]] – hP4503A4+ anti-fungal drug<br />
**[[2v0m]] – hP4503A4+ anti-fungal drug<br />
**[[2j0d]] - hP4503A4+ antibiotic<br />
**[[2j0d]] - hP4503A4+ antibiotic<br />
Line 83: Line 99:
**[[3ua1]] - hP4503A4 + ergocryptine<br />
**[[3ua1]] - hP4503A4 + ergocryptine<br />
**[[5vcg]] - hP4503A4 (mutant) + ergocryptine<br />
**[[5vcg]] - hP4503A4 (mutant) + ergocryptine<br />
**[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br />
**[[4ny4]], [[4d7d]], [[4d78]], [[4d75]], [[4d6z]], [[6bdm]], [[6bdk]], [[6bdi]], [[6bdh]], [[6bd8]], [[6bd7]], [[6bd6]], [[6bd5]], [[6bcz]], [[6ma8]], [[6ma7]], [[6ma6]], [[6dal]], [[6daj]], [[6dag]], [[6dac]], [[6dab]], [[6daa]], [[6da8]], [[6da5]], [[6da3]], [[6da2]] - hP4503A4 + inhibitor <br />
**[[4i3q]] - hP4503A4 (mutant) <br />
**[[4ny4]], [[4d7d]], [[4d78]], [[4d75]], [[4d6z]], [[6bdm]], [[6bdk]], [[6bdi]], [[6bdh]], [[6bd8]], [[6bd7]], [[6bd6]], [[6bd5]], [[6bcz]] - hP4503A4 + inhibitor <br />
**[[5te8]] - hP4503A4 + sedation drug <br />
**[[5te8]] - hP4503A4 + sedation drug <br />
**[[5a1p]], [[5a1r]] - hP4503A4 + progesterone <br />
**[[5a1p]], [[5a1r]] - hP4503A4 + progesterone <br />
**[[6mjm]] - hP4503A5 <br />
**[[5veu]] - hP4503A5 + inhibitor<br />


* human P450 7 family  
* human P450 7 family  
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*human P450 11 family
*human P450 11 family


**[[6m7x]] - hP450 CYP11B1 + fadrozole<br />
**[[4dvq]] - hP450 CYP11B2 + corticosterone<br />
**[[4dvq]] - hP450 CYP11B2 + corticosterone<br />
**[[4fdh]] - hP450 CYP11B2 + fadrozole<br />
**[[4fdh]] - hP450 CYP11B2 + fadrozole<br />
Line 112: Line 129:
* human P450 19 family (aromatase)
* human P450 19 family (aromatase)


**[[3eqm]], [[3s79]], [[4kq8]] - hP45019A1+androstenedione<br />
**[[5jkv]] - hP45019A1<br />
**[[5jkw]] - hP45019A1 + testosterone<br />
**[[3eqm]], [[3s79]], [[4kq8]], [[5jl6]], [[5jl7]], [[5jl9]] - hP45019A1+androstenedione<br />
**[[3s7s]] - hP45019A1 + exemestane<br />
**[[3s7s]] - hP45019A1 + exemestane<br />
**[[4gl5]], [[4gl7]] - hP45019A1 + inhibitor
**[[4gl5]], [[4gl7]] - hP45019A1 + inhibitor
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**[[5hdi]] - MtP450 CYP144A1<br />
**[[5hdi]] - MtP450 CYP144A1<br />


* P450cam  
* P450cam or camphor-5 momooxygenase


**[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]], [[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]], [[4ek1]], [[5wk7]] – PpP450cam(mutant) – ''Pseudomona putida''<br />
**[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]], [[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]], [[4ek1]], [[5wk7]] – PpP450cam(mutant) – ''Pseudomona putida''<br />
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**[[1j51]] - PpP450cam (mutant)+trichlorobenzene<br />
**[[1j51]] - PpP450cam (mutant)+trichlorobenzene<br />
**[[1mpw]] - PpP450cam (mutant)+trimethylbicycloheptene<br />
**[[1mpw]] - PpP450cam (mutant)+trimethylbicycloheptene<br />
**[[3oia]], [[3ol5]], [[3p6m]], [[3p6n]], [[3p6o]], [[3p6p]], [[3poq]], [[3por]], [[3pos]], [[3pot]], [[3pou]], [[3pov]], [[3pow]], [[3pox]] - PpP450cam (mutant)+substrate analog<br />
**[[3oia]], [[3ol5]], [[3p6m]], [[3p6n]], [[3p6o]], [[3p6p]], [[3poq]], [[3por]], [[3pos]], [[3pot]], [[3pou]], [[3pov]], [[3pow]], [[3pox]], [[3w9c]], [[5gxg]] - PpP450cam (mutant)+substrate analog<br />
**[[4jws]], [[4jwu]] - PpP450cam (mutant)+ putidaredoxin<br />
**[[4jws]], [[4jwu]] - PpP450cam (mutant)+ putidaredoxin<br />
**[[4jx1]] - PpP450cam (mutant)+ putidaredoxin + camphor + hydroxycamphor<br />
**[[4jx1]] - PpP450cam (mutant)+ putidaredoxin + camphor + hydroxycamphor<br />
**[[4jx1]] - PpP450cam (mutant)+ putidaredoxin + camphor + CN<br />
**[[2m56]] - PpP450cam + putidaredoxin + camphor <br />
**[[2m56]] - PpP450cam + putidaredoxin + camphor <br />
**[[3w9c]], [[5gxg]] - PpP450cam (mutant)+ putidaredoxin <br />
**[[3oft]], [[4c9m]], [[3lxh]], [[3lxi]], [[3ofu]], [[6hqw]] – NaP450 – ''Novosphignobium aromaticivorans''<br />
**[[3oft]], [[4c9m]], [[3lxh]], [[3lxi]], [[3ofu]] – NaP450 – ''Novosphignobium aromaticivorans''<br />
**[[4c9p]] - NaP450cam (mutant) + camphor <br />
**[[4c9p]] - NaP450cam (mutant) + camphor <br />
**[[4c9k]] - NaP450cam + camphor + hydroxycamphor<br />
**[[4c9k]] - NaP450cam + camphor + hydroxycamphor<br />
Line 205: Line 224:
*P450epoK
*P450epoK


**[[1pkf]] – ScP450epoK+epothilone D – ''Sorangium cellulosum''
**[[1q5e]] - ScP450epoK - ''Sorangium cellulosum''<br />
**[[1q5d]], [[1pkf]] – ScP450epoK+epothilone <br />


*P450cin
*P450cin
Line 217: Line 237:


**[[2bdm]] – rP450 CYP2B4 – rabbit<br />
**[[2bdm]] – rP450 CYP2B4 – rabbit<br />
**[[1po5]], [[3mvr]], [[3r1a]], [[3r1b]], [[5iut]], [[5iuz]], [[5em4]] - rP450 CYP2B4 (mutant)<br />
**[[1po5]], [[3mvr]], [[3r1a]], [[3r1b]], [[5iut]], [[5iuz]], [[5em4]], [[6bww]] - rP450 CYP2B4 (mutant)<br />
**[[1suo]],[[3g5n]], [[3g93]], [[2q6n]], [[3tk3]] - rP450 CYP2B4 (mutant)+imidazole derivative<br />
**[[1suo]],[[3g5n]], [[3g93]], [[2q6n]], [[3tk3]] - rP450 CYP2B4 (mutant)+imidazole derivative<br />
**[[4mgj]] - rP450 CYP2B4 (mutant)+ thiol derivative<br />
**[[4mgj]] - rP450 CYP2B4 (mutant)+ thiol derivative<br />
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**[[3uas]] - rP450 CYP CYP2B4 (mutant)+ inactivator<br />
**[[3uas]] - rP450 CYP CYP2B4 (mutant)+ inactivator<br />
**[[5t6q]] - rP450 CYP4B1 + octane<br />
**[[5t6q]] - rP450 CYP4B1 + octane<br />
**[[6c93]] - rP450 CYP4B1 (mutant) + octane<br />
**[[6c94]] - rP450 CYP4B1 + inhibitor<br />
**[[1dt6]] - rP450 CYP2C5 (mutant)<br />
**[[1dt6]] - rP450 CYP2C5 (mutant)<br />
**[[1nr6]] – rP450 CYP2C5+diclofenac<br />
**[[1nr6]] – rP450 CYP2C5+diclofenac<br />
**[[1n6b]] - rP450 CYP2C5+sulfaphenazole
**[[1n6b]] - rP450 CYP2C5+sulfaphenazole


*P450 BM3 or bifunctional P450/NADPH-P450 reductase
*P450 BM3 or bifunctional P450/NADPH-P450 reductase; Domains – heme 1-458; FMN 459-647; FAD 659-1049


**[[3cbd]], [[2bmh]], [[2j4s]], [[4zfa]] – BmP450 heme domain – ''Bacillus megaterium''<br />
**[[3cbd]], [[2bmh]], [[2j4s]], [[4zfa]], [[1bu7]] – BmP450 heme domain – ''Bacillus megaterium''<br />
**[[5zlh]], [[5zis]] - BmP450 heme domain + Mn-protoporphyrin<br />
**[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]], [[1jme]], [[1p0v]], [[1p0w]], [[1p0x]], [[1smi]], [[1yqp]], [[1yqo]], [[1zo4]], [[2nnb]], [[4hgj]], [[4h23]], [[4h24]], [[4kpb]], [[4kf0]], [[4kf2]], [[4wg2]], [[1fah]], [[4rsn]], [[4zf6]], [[5dyp]], [[5e7y]], [[5e9z]], [[5jqu]], [[5jqv]], [[5ucw]] - BmP450 heme domain (mutant)<br />
**[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]], [[1jme]], [[1p0v]], [[1p0w]], [[1p0x]], [[1smi]], [[1yqp]], [[1yqo]], [[1zo4]], [[2nnb]], [[4hgj]], [[4h23]], [[4h24]], [[4kpb]], [[4kf0]], [[4kf2]], [[4wg2]], [[1fah]], [[4rsn]], [[4zf6]], [[5dyp]], [[5e7y]], [[5e9z]], [[5jqu]], [[5jqv]], [[5ucw]] - BmP450 heme domain (mutant)<br />
**[[4dtw]], [[4due]], [[4duf]] - BmP450 heme domain (mutant) + serotonin<br />
**[[4dtw]], [[4due]], [[4duf]] - BmP450 heme domain (mutant) + serotonin<br />
Line 238: Line 261:
**[[2x7y]], [[2x80]] - BmP450 heme domain (mutant) + DMSO<br />
**[[2x7y]], [[2x80]] - BmP450 heme domain (mutant) + DMSO<br />
**[[4hgf]], [[4hgg]], [[4hgh]], [[4hgi]] - BmP450 heme domain (mutant) + styrene<br />
**[[4hgf]], [[4hgg]], [[4hgh]], [[4hgi]] - BmP450 heme domain (mutant) + styrene<br />
**[[4kew]], [[4key]], [[4o4p]], [[4zf8]] - BmP450 heme domain (mutant) + drug<br />
**[[4kew]], [[4key]], [[4o4p]], [[4zf8]], [[6h1l]], [[6h1o]], [[6h1s]], [[6h1t]] - BmP450 heme domain (mutant) + drug<br />
**[[3ekb]], [[3ekd]], [[3ekf]], [[2ij3]], [[2ij4]] - BmP450102 heme domain (mutant)<br />
**[[3ekb]], [[3ekd]], [[3ekf]], [[2ij3]], [[2ij4]] - BmP450102 heme domain (mutant)<br />
**[[2ij2]], [[2hpd]] - BmP450102 heme domain<br />
**[[2ij2]], [[2hpd]] - BmP450102 heme domain<br />
**[[4dqk]] - BmP450 FAD domain + FAD<br />
**[[4dqk]] - BmP450 FAD domain + FAD<br />
**[[4dql]] - BmP450 FAD domain + NADP + FAD<br />
**[[4dql]] - BmP450 FAD domain + NADP + FAD<br />
**[[3wsp]] - BmP450 + decoy molecule<br />
**[[3wsp]] - BmP450 heme domain + decoy molecule<br />
**[[2uwh]] - BmP450102+palmitic acid<br />
**[[2uwh]] - BmP450102+palmitic acid<br />
**[[3ben]] - BmP450 heme domain + inhibitor<br />
**[[3ben]] - BmP450 heme domain + inhibitor<br />
**[[2j1m]] - BmP450102 heme domain +DMSO<br />
**[[2j1m]] - BmP450102 heme domain +DMSO<br />
**[[5jtd]] - BmP450102 heme domain (mutant) +DMSO<br />
**[[5jtd]] - BmP450102 heme domain (mutant) +DMSO<br />
**[[1bvy]], [[1bu7]] – BmP450102A1 FMN domain<br />
**[[1bvy]] – BmP450102A1 heme+FMN domains<br />
**[[5e78]] - BmP450 + Co + sepulchrate<br />
**[[5e78]] - BmP450 heme domain + Co + sepulchrate<br />
**[[1fag]] – BmP450102A1+ palmitate<br />
**[[1fag]] – BmP450102A1 heme domain + palmitate<br />
**[[4zfb]], [[5dyz]] - BmP450 (mutant) + palmitate<br />
**[[4zfb]], [[5dyz]] - BmP450 (mutant) + palmitate<br />
**[[5b2v]], [[5b2y]], [[5xa3]], [[5xhj]] - BmP450 + amino acid derivative<br />
**[[5b2v]], [[5b2y]], [[5xa3]], [[5xhj]] - BmP450 heme domain + amino acid derivative<br />
**[[5b2u]], [[5b2w]], [[5b2x]] - BmP450 (mutant) + tryptophan derivative<br />
**[[5og9]] - BmP450 heme domain + testosterone<br />
**[[5b2u]], [[5b2w]], [[5b2x]] - BmP450 heme domain (mutant) + tryptophan derivative<br />
**[[4yt3]] - BmP450 CYP106A2 <br />
**[[4yt3]] - BmP450 CYP106A2 <br />
**[[5iki]] - BmP450 CYP106A2 + abietic acid <br />
**[[5iki]] - BmP450 CYP106A2 + abietic acid <br />
Line 264: Line 288:
**[[1ued]] – AoP450 oxyC – ''Amycolatopsis orientalis''<br />
**[[1ued]] – AoP450 oxyC – ''Amycolatopsis orientalis''<br />
**[[1lfk]], [[1lg9]], [[1lgf]] - AoP450 oxyB<br />
**[[1lfk]], [[1lg9]], [[1lgf]] - AoP450 oxyB<br />
**[[5ex6]], [[5ex9]], [[5ex8]] - P450 – ''Streptomyces toyocaensis''<br />
**[[5vws]] - P450 – ''Thermobispora bispora''<br />
**[[3p3l]], [[3p3o]], [[3p3x]], [[3p3z]] – P450 – ''Streptomyces thioluteus''<br />
**[[2rfb]] – PtP450 – ''Picrophilus torridus''<br />
**[[6gii]] – P450 – ''Tepidiphilus thermophilus''<br />
**[[1wiy]] – TtP450 – ''Thermus thermophilus''<br />
**[[4e2p]], [[5xw2]] - P450 – ''Streptococcus himastatinicus''<br />
**[[6g5q]], [[6g5o]] - P450 – ''Zobellia galactanivorans''<br />
**[[5ysm]] – AmP450 – ''Amycolatopsis mediterranei''<br />
**[[6f0c]], [[6f0b]] - P450 TXTC – ''Streptomyces acidiscabies''<br />
**[[5gwe]] – CgP450 CREJ – ''Corynebacterium glutamicum''<br />
**[[5y1i]] - P450 GFSF – ''Streptomyces graminofaciens''<br />
**[[1cpt]] – PsP450 TERP - ''Pseudomonas sp.''<br />
**[[4l0e]], [[4l0f]] - StP450 SKY32– ''Streptomyces''<br />
**[[3awp]], [[3awq]] - SpP450-α (mutant) - ''Sphingomonas paucimobilis''<br />
**[[3a4g]], [[3a4h]] – PaP450 VDH – ''Pseudonocardia autotrophica''<br />
**[[3a4z]], [[5gnm]], [[5gnl]] - PaP450 VDH (mutant)<br />
**[[3qi8]] – P450 – synthetic<br />
**[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br />
**[[2rcm]], [[3cli]] - AtP45074A - ''Arabidopsis thaliana''<br />
**[[5kyo]] - P450 CYP101J2 – ''Sphingobium yanoikuyae''<br />
**[[3nv5]], [[3nv6]], [[4dxy]] - NaP450 CYP101D2<br />
**[[4oqs]] - AoP450 CYP105AS1<br />
**[[4oqs]] - AoP450 CYP105AS1<br />
**[[5kyo]] - P450 CYP101J2 – ''Sphingobium yanoikuyae''<br />
**[[3abb]] – SaP450 CYP105D6 - ''Streptomyces avermitilis''<br />
**[[5fyf]] - MhP450 CYP153A – ''Marinobacter hydrocarbonoclasticus''<br />
**[[5ex6]] - P450 – ''Streptomyces toyocaensis''<br />
**[[5dqn]] - MsP450 CYP125A3 (mutant) – ''Mycobacterium smegmatis''<br />
**[[4wpz]] - SaP450 CYP107W1 – ''Streptomyces avermitilis''<br />
**[[3abb]] – SaP450 CYP105D6<br />
**[[3e5j]], [[3e5l]] - SaP450 CYP105P1 (mutant)<br />
**[[3e5j]], [[3e5l]] - SaP450 CYP105P1 (mutant)<br />
**[[1q5e]] - ScP450EPOK - ''Sorangium cellulosum''<br />
**[[2z3u]] - SsP450 CYP105A1 (mutant) – ''Streptomyces griseolus''<br />
**[[1io8]], [[5bv5]] – SsP450 CYP119 (mutant) – ''Sulfolobus solfataricus''<br />
**[[5xnt]] - P450 CYP106A2 – ''Bacillus butanolivorans''<br />
**[[1io9]], [[1io7]], [[1f4u]] - SsP450 CYP119<br />
**[[4wpz]] - SaP450 CYP107W1 <br />
**[[1cpt]] – P450 TERP – ''Pseudomonas sp.''<br />
**[[4l0e]], [[4l0f]] - StP450 SKY32– ''Streptomyces''<br />
**[[4r20]], [[4r21]] - P45017A2 – zebra fish<br />
**[[2whw]], [[2wi9]], [[2vz7]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br />
**[[2whw]], [[2wi9]], [[2vz7]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br />
**[[2bvj]] - SvP450107L1<br />
**[[2bvj]] - SvP450107L1<br />
**[[3p3l]], [[3p3o]], [[3p3x]], [[3p3z]] – P450 – ''Streptomyces thioluteus''<br />
**[[3tkt]] – NaP450 CYP108D1<br />
**[[2zqj]] – BsP450152A1 – ''Bacillus subtilis''<br />
**[[5ofq]] - BmP450 CYP109A2<br />
**[[4rm4]] - BsP450 CYP109B1<br />
**[[4rm4]] - BsP450 CYP109B1<br />
**[[2jjn]], [[2jjo]] - SeP450 CYP113A1 (mutant) - ''Saccharopolyspora erythraea''<br />
**[[1io8]], [[5bv5]] – SsP450 CYP119 (mutant) – ''Sulfolobus solfataricus''<br />
**[[1io9]], [[1io7]], [[1f4u]] - SsP450 CYP119<br />
**[[6cvc]] – MmP450 CYP124A1 – ''Mycobacterium marinum''<br />
**[[5dqn]] - MsP450 CYP125A3 (mutant) – ''Mycobacterium smegmatis''<br />
**[[3nc3]], [[3nc5]], [[3nc6]], [[3nc7]] - BsP450 CYP134A1 (mutant)<br />
**[[3nc3]], [[3nc5]], [[3nc6]], [[3nc7]] - BsP450 CYP134A1 (mutant)<br />
**[[2jjn]], [[2jjo]] - SeP450 CYP113A1 (mutant) - ''Saccharopolyspora erythraea''<br />
**[[2zqj]] – BsP450152A1 – ''Bacillus subtilis''<br />
**[[5fyf]] - MhP450 CYP153A – ''Marinobacter hydrocarbonoclasticus''<br />
**[[6hqg]] - P450 CYP153 – ''Phenylobacterium zucineum''<br />
**[[6hqd]] – PsP450 CYP153 <br />
**[[1gwi]] - ScP450 CYP154C1<br />
**[[6a7i]] - SvP450 CYP154C4 – ''Streptomyces violaceruber''<br />
**[[2nz5]], [[2nza]], [[2dkk]] – ScP450 CYP158A1 – ''Streptomyces coelicolor''<br />
**[[3r9b]] – MsP450 CYP164A2 <br />
**[[6dcd]] – MmP450 CYP164A6 <br />
**[[3o1a]] – P450 CYP165D3 – ''Actinoplanes teichomyceticus''<br />
**[[1n97]] – TtP450 CYP175A1<br />
**[[4dnz]] – RpP450 CYP199A4 – ''Rhodopseudomonas palustris''<br />
**[[2z3t]] - StrP450 CYP245A1 - ''Streptomyces sp.''<br />
**[[2z3t]] - StrP450 CYP245A1 - ''Streptomyces sp.''<br />
**[[2z3u]] - SsP450 CYP105A1 (mutant) – ''Streptomyces griseolus''<br />
**[[5liv]] - ScP450 CYP260A1 <br />
**[[5liv]] - ScP450 CYP260A1 <br />
**[[6f85]] - ScP450 CYP260A1 (mutant)<br />
**[[6f85]] - ScP450 CYP260A1 (mutant)<br />
**[[5hiw]] - ScP450 CYP260B1 <br />  
**[[5hiw]] - ScP450 CYP260B1 <br />  
**[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br />
**[[6gk5]] - ScP450 CYP267B1 <br />
**[[2rcm]], [[3cli]] - AtP45074A - ''Arabidopsis thaliana''<br />
**[[6g71]] - P450 CYP1232A24 - ''Arthrobacter''<br />
**[[3r9b]] – MsP450 CYP16A2 <br />
**[[2rfb]] – PtP450 – ''Picrophilus torridus''<br />
**[[2nz5]], [[2nza]], [[2dkk]] – ScP450 CYP158A1 – ''Streptomyces coelicolor''<br />
**[[1gwi]] - ScP450 CYP154C1<br />
**[[1wiy]] – TtP450 – ''Thermus thermophilus''<br />
**[[1n97]] – TtP450 CYP175A1<br />
**[[3nv5]], [[3nv6]], [[4dxy]] - NaP450 CYP101D2<br />
**[[3tkt]] – NaP450 CYP108D1<br />
**[[3awp]], [[3awq]] - SpP450-α (mutant) - ''Sphingomonas paucimobilis''<br />
**[[3a4g]], [[3a4h]] – PaP450 VDH – ''Pseudonocardia autotrophica''<br />
**[[3a4z]], [[5gnm]], [[5gnl]] - PaP450 VDH (mutant)<br />
**[[3qi8]] – P450 – synthetic<br />
**[[4dnz]] – RpP450 CYP199A4 – ''Rhodopseudomonas palustris''<br />
**[[3o1a]] – P450 CYP165D3 – ''Actinoplanes teichomyceticus''<br />
**[[4e2p]] - P450 – ''Streptococcus himastatinicus''<br />


*Other CYPs complexes
*Other CYPs complexes


**[[1q5d]] – ScP450EPOK+epothilone <br />
**[[2rfc]] – PtP450+phenylimidazole<br />
**[[1f4t]] - SsP450 CYP119+ phenylimidazole<br />
**[[3wec]] – P450 + dihydroxy-aurachin Re – ''Rhodococcus erythropolis''<br />
**[[4tt5]], [[4tuv]], [[4wpd]], [[4wqj]] - P450 CYP119+ imidazole derivative – ''Sulfolobus acidocaldarius''<br />
**[[5ysw]] – AmP450+ rifamycin <br />
**[[5omu]] – AmP450+ syringol <br />
**[[5oms]] – AmP450+ guaethol <br />
**[[5ncb]] – AmP450+ guayacol <br />
**[[5omr]] – AmP450+ vanilin <br />
**[[4pwv]], [[4pxh]] - StP450 SKY32 + peptidyl carrier protein domain<br />
**[[4pwv]], [[4pxh]] - StP450 SKY32 + peptidyl carrier protein domain<br />
**[[2zqx]] - BsP450 BS b +heptanoic acid<br />
**[[1izo]] – BsP450 BS beta+ palmitoleic acid<br />
**[[3awm]] – SpP450-α + palmitic acid <br />
**[[3a50]], [[3a51]] - PaP450 VDH (mutant) + vitamin D3<br />
**[[5xjn]] – CgP450 CREJ + ethylphenyl derivative<br />
**[[5fsa]] – P450 CYP51 (mutant) + posaconazole – ''Candida albicans''<br />
**[[2rch]], [[3dsi]] – AtP450 CYP74A+13(S)-HOD <br />
**[[3dsj]] - AtP450 CYP74A (mutant)+13(S)-HOD<br />
**[[2rcl]] - AtP450 CYP74A+vernolic acid<br />
**[[3dsk]] - AtP450 CYP74A (mutant)+ vernolic acid<br />
**[[3cv9]], [[2zbz]] - SgP450 CYP105A1 (mutant)+vitamin D3<br />
**[[2zbx]] - SgP450 CYP105A1+imidazole<br />
**[[5x7e]] - SsP450 CYP105A1 (mutant)+vitamin D2<br /
**[[3aba]] – SaP450 CYP105P1+filipin I <br />
**[[3aba]] – SaP450 CYP105P1+filipin I <br />
**[[3e5k]] - SaP450 CYP105P1 (mutant)+4-phenylimidazole<br />
**[[3e5k]] - SaP450 CYP105P1 (mutant)+4-phenylimidazole<br />
**[[4oqr]] - AoP450 CYP105AS1 (mutant) + compactin<br />
**[[1jin]], [[1jip]] - SeP450 CYP107A1+ ketoconazole <br />
**[[1jio]], [[1oxa]] - SeP450 CYP107A1+6DEB<br />
**[[1eup]] – SeP450 CYP107A1+androstendione<br />
**[[1egy]] - SeP450 CYP107A1+aminophenanthrene<br />
**[[4wq0]] - SaP450 CYP107W1 + oligomycin<br />
**[[4wq0]] - SaP450 CYP107W1 + oligomycin<br />
**[[2vzm]] – SvP450107L1 (mutant)+narbomycin<br />
**[[2vzm]] – SvP450 CYP107L1 (mutant)+narbomycin<br />
**[[2c7x]] - SvP450107L1+narbomycin<br />
**[[2c7x]] - SvP450 CYP107L1+narbomycin<br />
**[[2cd8]], [[2ca0]], [[2c6h]] – SvP450107L1+YC-17<br />
**[[2cd8]], [[2ca0]], [[2c6h]] – SvP450 CYP107L1+YC-17<br />
**[[2zqx]] - BsP450152A1+heptanoic acid<br />
**[[1izo]] – BsP450 BS beta+ palmitoleic acid<br />
**[[1jin]], [[1jip]] - SeP450107A1+ ketoconazole <br />
**[[1jio]], [[1oxa]] - SeP450107A1+6DEB<br />
**[[1eup]] – SeP450107A1+androstendione<br />
**[[1egy]] - SeP450107A1+aminophenanthrene<br />
**[[2jjp]] - SeP450 CYP113A1 (mutant)+ketoconazole<br />
**[[2jjp]] - SeP450 CYP113A1 (mutant)+ketoconazole<br />
**[[2xfh]] - SeP450 CYP113A1 (mutant)+clotrimazole<br />
**[[2xfh]] - SeP450 CYP113A1 (mutant)+clotrimazole<br />
**[[3a1l]] – StrP450 CYP245A1+dichlorochrompyrrolic acid <br />
**[[1f4t]] - SsP450 CYP119+ phenylimidazole<br />
**[[3cv9]], [[2zbz]] - SgP450 CYP105A1 (mutant)+vitamin D3<br />
**[[4tt5]], [[4tuv]], [[4wpd]], [[4wqj]] - P450 CYP119+ imidazole derivative – ''Sulfolobus acidocaldarius''<br />
**[[2zbx]] - SgP450 CYP105A1+imidazole<br />
**[[5yhj]] - P450 CYP152N1 + myristic acid - ''Exiguobacterium''<br />
**[[5x7e]] - SsP450 CYP105A1 (mutant)+vitamin D2<br />
**[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br />
**[[5fsa]] – P450 CYP51 (mutant) + posaconazole - ''Candida albicans''<br />
**[[6a7j]] - SvP450 CYP154C4 + testosterone <br />
**[[2rch]], [[3dsi]] – AtP45074A+13(S)-HOD <br />
**[[3r9c]] – MsP450 CYP164A2 + econazole<br />
**[[3dsj]] - AtP45074A (mutant)+13(S)-HOD<br />
**[[4do1]], [[4egm]], [[6c3j]], [[6c3h]], [[6c2d]], [[5yqh]], [[5yqa]], [[5uvb]], [[5u6w]], [[5u6u]], [[5u6t]], [[5kt1]], [[5kdb]] – RpP450 CYP199A4 + benzoate derivative<br />
**[[2rcl]] - AtP45074A+vernolic acid<br />
**[[5kdz]], [[5kdy]] – RpP450 CYP199A4 (mutant) + benzoate derivative<br />
**[[3dsk]] - AtP45074A (mutant)+ vernolic acid<br />
**[[3r9c]] – MsP450 CYP16A2 + econazole<br />
**[[2rfc]] – PtP450+phenylimidazole<br />01D2<br />
**[[3tkt]] – NaP450 CYP108D1<br />
**[[3awm]] – SpP450-α + palmitic acid <br />
**[[3a50]], [[3a51]] - PaP450 VDH (mutant) + vitamin D3<br />
**[[4do1]], [[4egm]] – RpP450 CYP199A4 + benzoate derivative<br />
**[[4egn]] – RpP450 CYP199A4 + veratric acid<br />
**[[4egn]] – RpP450 CYP199A4 + veratric acid<br />
**[[4egp]] – RpP450 CYP199A4 + naphthoic acid<br />
**[[4egp]] – RpP450 CYP199A4 + naphthoic acid<br />
**[[4ego]] – RpP450 CYP199A4 + indole derivative<br />
**[[4ego]] – RpP450 CYP199A4 + indole derivative<br />
**[[3wec]] – P450 + dihydroxy-aurachin Re – ''Rhodococcus erythropolis''<br />
**[[3a1l]] – StrP450 CYP245A1+dichlorochrompyrrolic acid <br />
**[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br />
**[[4oqr]] - AoP450 CYP105AS1 (mutant) + compactin<br />
**[[6f88]], [[6f8c]] - ScP450 CYP260A1 (mutant) + progesterone<br />
**[[6f88]], [[6f8c]] - ScP450 CYP260A1 (mutant) + progesterone<br />
**[[6f8a]] - ScP450 CYP260A1 (mutant) + histidine<br />
**[[6f8a]] - ScP450 CYP260A1 (mutant) + histidine<br />
**[[6gk6]] - ScP450 CYP267B1 + myristic acid<br />
**[[6bld]] - MmP450 CYP268A2 + pseudoionone<br />
**[[4r20]] - zP450 17A2 + abiraterone – zebra fish<br />
**[[6b82]] - zP450 17A1 (mutant) + abiraterone <br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:19, 28 May 2019

Cytochrome P450 CypC2 with heme C complex with warfarin (PDB entry 1og5)

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3D Structures of Cytochrome P450

Updated on 28-May-2019

  • human P450 2 family complex
    • 3ebs – hP4502A6 (mutant)+phenacetin
    • 2fdu, 2fdv, 2fdw, 2fdy - hP4502A6+pyridine derivative
    • 1z10 - hP4502A6 catalytic domain+coumarin
    • 4ejj - hP4502A6 + nicotine
    • 3t3q, 3t3r - hP4502A6 (mutant) + pilocarpine
    • 2z10 – hP4502A6+coumarin
    • 1z11 - hP4502A6+methoxalen
    • 4rui – hP450 2A6 + volatile hydrocarbon
    • 3t3s - hP4502A13 + pilocarpine
    • 4ejg - hP4502A13 + nicotine
    • 4ejh, 4eji - hP4502A13 + pyridine derivative
    • 2p85 – hP4502A13 (mutant)+indole
    • 3ibd – hP4502B6 (mutant)+4-(4-chlorophenyl)imidazole
    • 3ua5 – hP4502B6 (mutant) + amlodipine
    • 4i91, 4zv8 - hP4502B6 (mutant) + pinine
    • 5wbg - hP4502B6 (mutant) + HIV drug
    • 3qoa, 2qu8, 3qu8 – hP450 2B6 (mutant) + inhibitor
    • 4rql, 4rrt – hP450 2B6 (mutant) + volatile hydrocarbon
    • 5ufg, 5uec, 5uap – hP450 2B6 (mutant) + Br derivative
    • 5uda – hP450 2B6 (mutant) + monoterpene borane
    • 5e58 – dwP450 2B35 + inhibitor – desert woodrat
    • 5e0e – dwP450 2B37 + inhibitor
    • 2nnh – hP4502C8+retinoic acid
    • 2nni - hP4502C8+montelukast
    • 2nnj - hP4502C8+felodipine
    • 1r9o – hP4502C9 (mutant)+flurbiprofen
    • 5xxi, 5x23, 5x24 - hP4502C9 (mutant) + blood pressure drug
    • 5a5i, 5a5j, 5w0c, 5k7k - hP4502C9 + inhibitor
    • 4nz2 - hP4502C9 (mutant) + inhibitor
    • 3tbg, 4wnw – hP4502D6 + thioridazine
    • 6csb - hP4502D6 (mutant) + thioridazine
    • 3tda – hP4502D6 + prinomastat
    • 6csd - hP4502D6 (mutant) + prinomastat
    • 4wnt - hP4502D6 + ajmalicine
    • 4wnu, 4wnv - hP4502D6 + quinine derivative
    • 5tft, 5tfu, 4xry, 4xrz - hP4502D6 + Bace1 inhibitor
    • 3gph, 3koh, 3lc4 – hP4502E1 fragment +imidazole derivative
    • 3e6i – hP4502E1 fragment+indazole
    • 3e4e – hP4502E1 fragment+methylpyrazole
    • 3t3z - hP4502E1 + pilocarpine
    • 3czh, 3dl9, 3c6g – hP4502R1+vitamin D
  • human P450 3 family
  • human P450 7 family
    • 3dax – hP4507A1
    • 3sn5 - hP4507A1 + cholest-4-en-3-one
  • human P450 11 family
    • 6m7x - hP450 CYP11B1 + fadrozole
    • 4dvq - hP450 CYP11B2 + corticosterone
    • 4fdh - hP450 CYP11B2 + fadrozole
    • 4zgx - hP450 CYP11B2 + inhibitor
  • human P450 17 A1 family (steroid 17-α-hydroxylase 17,20 lyase)
    • 5uys, 3ruk - hP450 C17 + abiraterone derivative
    • 4nkv - hP450 C17 (mutant) + abiraterone derivative
    • 5irq - hP450 C17 + orteronel
    • 5irv - hP450 C17 + inhibitor
    • 4nkw, 4nkz - hP450 C17 (mutant) + pregnenolone derivative
    • 4nkx, 4nky - hP450 C17 (mutant) + progesterone derivative
    • 3swz - hP450 C17 + drug
  • human P450 19 family (aromatase)
  • human P450 46 family
    • 2q9f – hP45046A1+cholesterol
    • 2q9d, 2q9g - hP45046A1
    • 2vn0 – hP450105A1+troglitazone
    • 2zby - hP450105A1 (mutant)
  • P450 from Mycobacterium tuberculosis or sterol 14-α demethylase
  • P450cam or camphor-5 momooxygenase
  • P450nor or NADP nitrous oxide-forming nitric-oxide reductase or nitric oxide reductase
  • P450epoK
    • 1q5e - ScP450epoK - Sorangium cellulosum
    • 1q5d, 1pkf – ScP450epoK+epothilone
  • P450cin
  • rabbit P450
    • 2bdm – rP450 CYP2B4 – rabbit
    • 1po5, 3mvr, 3r1a, 3r1b, 5iut, 5iuz, 5em4, 6bww - rP450 CYP2B4 (mutant)
    • 1suo,3g5n, 3g93, 2q6n, 3tk3 - rP450 CYP2B4 (mutant)+imidazole derivative
    • 4mgj - rP450 CYP2B4 (mutant)+ thiol derivative
    • 3kw4, 3me6, 3tmz, 4h1n - rP450 CYP2B4 (mutant)+anti-platelet drug
    • 4jlt - rP450 CYP CYP2B4 (mutant) + anti-depressant drug
    • 3uas - rP450 CYP CYP2B4 (mutant)+ inactivator
    • 5t6q - rP450 CYP4B1 + octane
    • 6c93 - rP450 CYP4B1 (mutant) + octane
    • 6c94 - rP450 CYP4B1 + inhibitor
    • 1dt6 - rP450 CYP2C5 (mutant)
    • 1nr6 – rP450 CYP2C5+diclofenac
    • 1n6b - rP450 CYP2C5+sulfaphenazole
  • P450 BM3 or bifunctional P450/NADPH-P450 reductase; Domains – heme 1-458; FMN 459-647; FAD 659-1049
  • Other CYPs
    • 1ued – AoP450 oxyC – Amycolatopsis orientalis
    • 1lfk, 1lg9, 1lgf - AoP450 oxyB
    • 5ex6, 5ex9, 5ex8 - P450 – Streptomyces toyocaensis
    • 5vws - P450 – Thermobispora bispora
    • 3p3l, 3p3o, 3p3x, 3p3z – P450 – Streptomyces thioluteus
    • 2rfb – PtP450 – Picrophilus torridus
    • 6gii – P450 – Tepidiphilus thermophilus
    • 1wiy – TtP450 – Thermus thermophilus
    • 4e2p, 5xw2 - P450 – Streptococcus himastatinicus
    • 6g5q, 6g5o - P450 – Zobellia galactanivorans
    • 5ysm – AmP450 – Amycolatopsis mediterranei
    • 6f0c, 6f0b - P450 TXTC – Streptomyces acidiscabies
    • 5gwe – CgP450 CREJ – Corynebacterium glutamicum
    • 5y1i - P450 GFSF – Streptomyces graminofaciens
    • 1cpt – PsP450 TERP - Pseudomonas sp.
    • 4l0e, 4l0f - StP450 SKY32– Streptomyces
    • 3awp, 3awq - SpP450-α (mutant) - Sphingomonas paucimobilis
    • 3a4g, 3a4h – PaP450 VDH – Pseudonocardia autotrophica
    • 3a4z, 5gnm, 5gnl - PaP450 VDH (mutant)
    • 3qi8 – P450 – synthetic
    • 3dam, 3dan, 3dbm – P45074A2 – Parthenium argentatum
    • 2rcm, 3cli - AtP45074A - Arabidopsis thaliana
    • 5kyo - P450 CYP101J2 – Sphingobium yanoikuyae
    • 3nv5, 3nv6, 4dxy - NaP450 CYP101D2
    • 4oqs - AoP450 CYP105AS1
    • 3abb – SaP450 CYP105D6 - Streptomyces avermitilis
    • 3e5j, 3e5l - SaP450 CYP105P1 (mutant)
    • 2z3u - SsP450 CYP105A1 (mutant) – Streptomyces griseolus
    • 5xnt - P450 CYP106A2 – Bacillus butanolivorans
    • 4wpz - SaP450 CYP107W1
    • 2whw, 2wi9, 2vz7 – SvP450107L1 (mutant) – Streptomyces venezuelae
    • 2bvj - SvP450107L1
    • 3tkt – NaP450 CYP108D1
    • 5ofq - BmP450 CYP109A2
    • 4rm4 - BsP450 CYP109B1
    • 2jjn, 2jjo - SeP450 CYP113A1 (mutant) - Saccharopolyspora erythraea
    • 1io8, 5bv5 – SsP450 CYP119 (mutant) – Sulfolobus solfataricus
    • 1io9, 1io7, 1f4u - SsP450 CYP119
    • 6cvc – MmP450 CYP124A1 – Mycobacterium marinum
    • 5dqn - MsP450 CYP125A3 (mutant) – Mycobacterium smegmatis
    • 3nc3, 3nc5, 3nc6, 3nc7 - BsP450 CYP134A1 (mutant)
    • 2zqj – BsP450152A1 – Bacillus subtilis
    • 5fyf - MhP450 CYP153A – Marinobacter hydrocarbonoclasticus
    • 6hqg - P450 CYP153 – Phenylobacterium zucineum
    • 6hqd – PsP450 CYP153
    • 1gwi - ScP450 CYP154C1
    • 6a7i - SvP450 CYP154C4 – Streptomyces violaceruber
    • 2nz5, 2nza, 2dkk – ScP450 CYP158A1 – Streptomyces coelicolor
    • 3r9b – MsP450 CYP164A2
    • 6dcd – MmP450 CYP164A6
    • 3o1a – P450 CYP165D3 – Actinoplanes teichomyceticus
    • 1n97 – TtP450 CYP175A1
    • 4dnz – RpP450 CYP199A4 – Rhodopseudomonas palustris
    • 2z3t - StrP450 CYP245A1 - Streptomyces sp.
    • 5liv - ScP450 CYP260A1
    • 6f85 - ScP450 CYP260A1 (mutant)
    • 5hiw - ScP450 CYP260B1
    • 6gk5 - ScP450 CYP267B1
    • 6g71 - P450 CYP1232A24 - Arthrobacter
  • Other CYPs complexes
    • 2rfc – PtP450+phenylimidazole
    • 3wec – P450 + dihydroxy-aurachin Re – Rhodococcus erythropolis
    • 5ysw – AmP450+ rifamycin
    • 5omu – AmP450+ syringol
    • 5oms – AmP450+ guaethol
    • 5ncb – AmP450+ guayacol
    • 5omr – AmP450+ vanilin
    • 4pwv, 4pxh - StP450 SKY32 + peptidyl carrier protein domain
    • 2zqx - BsP450 BS b +heptanoic acid
    • 1izo – BsP450 BS beta+ palmitoleic acid
    • 3awm – SpP450-α + palmitic acid
    • 3a50, 3a51 - PaP450 VDH (mutant) + vitamin D3
    • 5xjn – CgP450 CREJ + ethylphenyl derivative
    • 5fsa – P450 CYP51 (mutant) + posaconazole – Candida albicans
    • 2rch, 3dsi – AtP450 CYP74A+13(S)-HOD
    • 3dsj - AtP450 CYP74A (mutant)+13(S)-HOD
    • 2rcl - AtP450 CYP74A+vernolic acid
    • 3dsk - AtP450 CYP74A (mutant)+ vernolic acid
    • 3cv9, 2zbz - SgP450 CYP105A1 (mutant)+vitamin D3
    • 2zbx - SgP450 CYP105A1+imidazole
    • 5x7e - SsP450 CYP105A1 (mutant)+vitamin D2<br /
    • 3aba – SaP450 CYP105P1+filipin I
    • 3e5k - SaP450 CYP105P1 (mutant)+4-phenylimidazole
    • 4oqr - AoP450 CYP105AS1 (mutant) + compactin
    • 1jin, 1jip - SeP450 CYP107A1+ ketoconazole
    • 1jio, 1oxa - SeP450 CYP107A1+6DEB
    • 1eup – SeP450 CYP107A1+androstendione
    • 1egy - SeP450 CYP107A1+aminophenanthrene
    • 4wq0 - SaP450 CYP107W1 + oligomycin
    • 2vzm – SvP450 CYP107L1 (mutant)+narbomycin
    • 2c7x - SvP450 CYP107L1+narbomycin
    • 2cd8, 2ca0, 2c6h – SvP450 CYP107L1+YC-17
    • 2jjp - SeP450 CYP113A1 (mutant)+ketoconazole
    • 2xfh - SeP450 CYP113A1 (mutant)+clotrimazole
    • 1f4t - SsP450 CYP119+ phenylimidazole
    • 4tt5, 4tuv, 4wpd, 4wqj - P450 CYP119+ imidazole derivative – Sulfolobus acidocaldarius
    • 5yhj - P450 CYP152N1 + myristic acid - Exiguobacterium
    • 5fyg - MhP450 CYP153A + dodecanoic acid
    • 6a7j - SvP450 CYP154C4 + testosterone
    • 3r9c – MsP450 CYP164A2 + econazole
    • 4do1, 4egm, 6c3j, 6c3h, 6c2d, 5yqh, 5yqa, 5uvb, 5u6w, 5u6u, 5u6t, 5kt1, 5kdb – RpP450 CYP199A4 + benzoate derivative
    • 5kdz, 5kdy – RpP450 CYP199A4 (mutant) + benzoate derivative
    • 4egn – RpP450 CYP199A4 + veratric acid
    • 4egp – RpP450 CYP199A4 + naphthoic acid
    • 4ego – RpP450 CYP199A4 + indole derivative
    • 3a1l – StrP450 CYP245A1+dichlorochrompyrrolic acid
    • 6f88, 6f8c - ScP450 CYP260A1 (mutant) + progesterone
    • 6f8a - ScP450 CYP260A1 (mutant) + histidine
    • 6gk6 - ScP450 CYP267B1 + myristic acid
    • 6bld - MmP450 CYP268A2 + pseudoionone
    • 4r20 - zP450 17A2 + abiraterone – zebra fish
    • 6b82 - zP450 17A1 (mutant) + abiraterone

References

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Alexander Berchansky, Joel L. Sussman, Michal Harel

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