Ion channels 3D structures

3D structures of ion channels

Updated on 05-May-2024

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• Potassium channel See: Potassium Channels
• Calcium channel
  • 2d46 – hVDCC β 4a – human - NMR
    
  • 6nq0, 6nq1, 6nq2 – hTpc2 – Cryo EM
    
  • 8if4 – hCav alpha-2+delta-1 – Cryo EM
    
  • 8if3 – hCav alpha-2+delta-1 + drug – Cryo EM
    
  • 2f3y, 2f3z, 2be6 – hCav1.2 α 1C subunit+calmodulin
    
  • 3oxq - hCav2.1 α 1C subunit IQ domain+hCalmodulin
    
  • 2vay, 3oxq - hCav1.1 α 1S subunit IQ domain+hCalmodulin
    
  • 8eoi – hCav1.2 in EMC chaperone – Cryo EM
    
  • 8fd7 – hCav1.2 + drug – Cryo EM
    
  • 8eog – hCav1.2 + Leu – Cryo EM
    
  • 7uhg – hCav1.3 – Cryo EM
    
  • 7uhf, 8e59, 8e5a, 8e5b – hCav1.3 + drug – Cryo EM
    
  • 7vfs – hCav2.2 alpha-2+delta-1+beta1 – Cryo EM
    
  • 7vfu, 7vfv, 7vfw – hCav2.2 alpha-2+delta-1+beta1 + blocker – Cryo EM
    
  • 7miy – hCav2.2C – Cryo EM
    
  • 7mix – hCav2.2C + conotoxin – Cryo EM
    
  • 7xlq, 8epl, 8epm – hCav2.3 – Cryo EM
    
  • 6kzo – hCav3.1C – Cryo EM
    
  • 6kzp – hCav3.1C + antagonist – Cryo EM
    
  • 7wli – hCav3.3 – Cryo EM
    
  • 7wlj, 7wlk, 7wll – hCav3.3 + drug – Cryo EM
    
  • 6jp5, 6jp8, 7jpk, 7jpl, 7jpv, 7jpw, 7jpx – rCav1.1 – rabbit – Cryo EM
    
  • 6jpa, 6jpb – rCav1.1 + blocker – Cryo EM
    
  • 8e56, 8e57, 8e58 – rCav1.1 + drug – Cryo EM
    
  • 3bxx – rCav2.1 α 1A subunit+calmodulin - rabbit
    
  • 3bxl - rCav2.3 α 1E subunit+calmodulin
    
  • 1t0h – rVDCC β 2A subunit
    
  • 1t0j – rVDCC β 2A+α 1C
    
  • 1vyt - rVDCC β 3+α 1C
    
  • 1vyu – rVDCC β 3
    
  • 1vyv - rVDCC β 4
    
  • 6hw2 - rVDCC β 4 + chromobox protein
    
  • 1t3l - rVDCC β 2+α 1S
    
  • 1t3s - rVDCC β 2
    
  • 3dve, 3dvj, 3dvk, 3dvm, 3g43 - rCav2.2 α 1B subunit+hCalmodulin
    
  • 4dex - rCav2.2 α 1B + β 2 subunits
    
  • 4dey - rCav2.2 α 1C + β 2 subunits
    
  • 6byo – rCav1.1 α 1S
    
  • 5gjw – rCav1.1 α 2/δ 1 + α 1S + β 1 – Cryo EM
    
  • 5gjv, 3jbr – rCav1.1 α 2/δ 1 + α 1S + β 1 + γ 1 – Cryo EM
    
  • 5v2q, 5v2p - raCav1.2 alpha 1C + beta 2 - rat
    
  • 7qhh - raVDCC gamma 8 + glutamate receptor 1 – Cryo EM
    
  • 5vov, 5vou, 5vot, 5kk2 - raVDCC γ 2 + glutamate receptor 2 – Cryo EM
    
  • 6njl, 6njm, 6njn - raVDCC γ 2 + glutamate receptor 1 + glutamate receptor 2 + a’/c’ auxiliary protein + antibody – Cryo EM
    
  • 6qkc, 6qkz, 7ocd - raVDCC γ 8 + glutamate receptor 1 + glutamate receptor 2 – Cryo EM
    
  • 7oca, 7oce, 7ocf - raVDCC γ 8 + glutamate receptor 1 + glutamate receptor 2 + CNIH-2 – Cryo EM
    
  • 8e0e – raCav L-type 2 + nanobody
    
  • 6c9a, 6c96 – mTpc1 - mouse
    
  • 6c96, 6c9a – mTpc1 – Cryo EM
    
  • 4zw2 – mVDCC α 1S peptide + β 1
    
  • 7lep - mVDCC γ 8 + glutamate receptor 2 + AMPAR subunits + CNIH-2 – Cryo EM
    
  • 8dam – mCav L-type 1 + nanobody
    
  • 5tua, 5e1j, 5dqq, 7fhk, 7fhl – AtTpc1 – Arabidopsis thaliana
    
  • 6cx0 – AtTpc1 (mutant)
    
  • 6e1m, 6e1n, 6e1p, 7fhn, 7fho, 7tbg, 7tdd, 7tde, 7tdf – AtTpc1 (mutant) – Cryo EM
    
  • 6e1k – AtTpc1 + antibody – Cryo EM
    
  • 6mgv, 6mgw, 6ijz – AtOsca1.2 – Cryo EM
    
  • 4mtf, 4mtg, 4mto – AbCaV + Ca – Arcobacter butzleri
    
• See also Ryanodine receptor
• Sodium channel; Domains – extracellular 30-157
  • 7dtd - hNaV 1.1 + hNav beta 4 – Cryo EM
    
  • 6agf - hNaV 1 + hNav 1.4 – Cryo EM
    
  • 2kav, 2kbi – hNaV 1.2 C-terminal EF-hand domain – NMR
    
  • 7w77, 7w7f – hNaV 1.3 beta1+beta2 + hNaV type 3 subunit alpha – Cryo EM
    
  • 5fdy, 5feb - hNaV 2 extracellular domain (mutant)
    
  • 6vrr - hNaV 2 (mutant)
    
  • 4l1d - hNaV 3 extracellular domain
    
  • 4mz2 - hNaV 4 extracellular domain
    
  • 4mz3, 6vsv - hNaV 4 extracellular domain (mutant)
    
  • 6bqn – hENaC alpha+beta+gamma subunits – Cryo EM
    
  • 7dtc – hNaV 1.5 (mutant) – Cryo EM
    
  • 7l83 – hNaV 1.5 1597-1633 - NMR
    
  • 8fhd – hNaV 1.6 – Cryo EM
    
  • 8gz1 – hNaV 1.6 beta1+beta2 + hNaV type 8 subunit alpha – Cryo EM
    
  • 7xvf – hNaV 1.7 (mutant) – Cryo EM
    
  • 7w9l, 7w9t – hNaV 1.7 (mutant) + beta-1 + beta-2 – Cryo EM
    
  • 7w9k – hNaV 1.7 beta-1 + beta-2 – Cryo EM
    
  • 7wfw – hNaV 1.8 – Cryo EM
    
  • 7tj8 – hNaV type 7 alpha – Cryo EM
    
  • 7tj9 – hNaV type 7 alpha + beta-3 – Cryo EM
    
  • 1byy – rNaCh IIA inactivation fragment
    
  • 5jr0 – rNaV 1.4
    
  • 7fbs – raNaV 1.5 (mutant) – Cryo EM
    
  • 6uz3 – raNaV 5 - Cryo EM
    
  • 1qg9 – raNaCh IIA second repeat – NMR
    
  • 5ayq, 5xax, 5xaw - mNaV 4 residues 30-160
    
  • 5xsy – eeNaV 1.4 + beta 1 – electric eel - Cryo EM
    
  • 5x0m – coNaCh - cockroach
    
  • 4bgn – NaCh – Caldalkalibacillus thermarum – Cryo EM
    
  • 4lto, 4ltp, 4ltq, 5hk7 – AeNaCh pore + cytoplasmic domains – Alkalilimnicola ehrlichii
    
  • 4ltr, 5hkd, 5hk6, 5kj8 – AeNaCh pore + cytoplasmic domains (mutant)
    
  • 5iwn, 7pgh – AeNaCh pore domain
    
  • 7x5v – NaV – Emiliania huxleyi - Cryo EM
    
• Sodium channel complex
  • 6j8e - hNaV 2 + hNav 1.2 + Mu-conotoxin – Cryo EM
    
  • 6j8g, 6j8h, 6j8i, 6j8j - hNaV 2 + hNaV 1 + hNav 1.7 + toxin – Cryo EM
    
  • 6mba, 6mc9 – hNaV 1.4 C terminal + calmodulin
    
  • 6wth – hENaC alpha+beta+gamma subunits + antibody – Cryo EM
    
  • 6lqa – hNaV 1.5 + quinidine - Cryo EM
    
  • 4ovn, 5dbr, 4djc, 6mud – hNaV 1.5 C terminal + calmodulin
    
  • 4dck, 4jq0 – hNaV 1.5 C terminal + calmodulin + fibroblast growth factor
    
  • 4jpz – hNaV 1.2 C terminal + calmodulin + fibroblast growth factor 13
    
  • 8gz2 – hNaV 1.6 beta1+beta2 + hNaV type 8 subunit alpha + toxin – Cryo EM
    
  • 7w9m, 7w9p – hNaV 1.7 beta1+beta2 + hNaV type 9 subunit alpha + toxin – Cryo EM
    
  • 7xm9, 7xmf, 7xmg – hNaV 1.7 beta1+beta2 + hNaV type 9 subunit alpha + inhibitor – Cryo EM
    
  • 7we4, 7wel, 7wfr – hNaV 1.8 + inhibitor – Cryo EM
    
  • 6mue – raNaV 1.4 + calmodulin
    
  • 6uz0 – raNaV 5 + flecainide - Cryo EM
    
  • 7k18 – raNaV 5 + toxin - Cryo EM
    
  • 6a90, 6a91, 6a95 – coNaCh + toxin – Cryo EM
    
  • 7pg8, 7pgb – AeNaCh pore + antibody
    
• Sodium channel, pre-activated. NavAb
  • 4ekw, 4mw8, 5vb2, 5yua, 6mwa - AbNaVab – Arcobacter butzleri
    
  • 3rvy, 3rvz, 3rw0, 5yuc, 5yub, 6c1e, 6c1m, 6mwb, 6mwd, 6mwg, 6p6w, 6p6x, 6p6y - AbNaVab (mutant)
    
  • 6mvv, 6mvy - AbNaVab (mutant) + lidocaine
    
  • 6ke5 - AbNaVab + drug
    
• Sodium channel, activated. NavMs
  • 3zjz, 4cbc, 4f4l, 4x89, 4x8a, 5bzb, 5hvx – MmNavMs – Magnetococcus marinus
    
  • 4x88, 5hvd, 6sx5, 6sx7, 6yz2 – MmNavMs (mutant)
    
  • 4osx, 4p2z, 4p30, 4p9o, 4p9p, 4pa3, 4pa4, 4pa6, 4pa7, 4pa9 – MmNavMs + blocker
    
  • 6sxg – MmNavMs + tamoxifen derivative
    
  • 6sxc, 6sxe, 6sxf, 6z8c – MmNavMs (mutant) + tamoxifen derivative
    
  • 6yz0 – MmNavMs (mutant) + cannabidiol
    
• NH4+ channel
  • 2nmr, 2nop, 2now, 2npc, 2npd, 2npe, 2npj, 2npg, 2npk, 1u77, 1u7c, 1u7g, 1xqe, 1xqf, 3c1g – EcAmCh – Escherichia coli
    
  • 3c1h, 3c1i, 3c1j – EcAmCh (mutant)
    
  • 4nh2 – EcAmCh + phosphatidylglycerol
    
  • 2ns1, 2nuu – EcAmCh + nitrogen regulatory protein
    
  • 2b2h, 2b2i, 2b2j, 2b2f – AmCh – Archaeglobus fulgidus
    
  • 3b9w, 3b9y, 3bhs – AmCh – Nitrosomonas europaea
• MscL and MscS
  • 3hzq – MscL – Staphylococcus aureus
    
  • 2oar, 6ctd – MtMscL – Mycobacterium tuberculosis
    
  • 4lku – EcMscL C terminal
    
  • 4y7k, 4y7j – MscL – Methanosarcina acetivorans
    
  • 2oau, 2vv5, 4hwa - EcMscS
    
  • 6pwn, 6pwo, 6pwp, 6rld, 6uzh, 6vyk, 6vyl, 6vym, 7onj, 7onl, 7oo0, 7oo6, 7oo8, 7ooa – EcMscS – Cryo EM
    
  • 4age, 4agf, 5aji – EcMscS (mutant)
    
  • 3t9n, 3udc – MscS – Thermoanaerobacter tengcongensis
    
  • 4hw9 – MscS – Helicobacter pylori
    
  • 6lyp, 6vxm, 6vxn, 6vxp – AtMsc-like (mutant) – Cryo EM
    
• Chloride channel or H(+)/Cl(-) exchange transporter ClcA or human proton-activated chloride channel PAC or CLIC
  • 1rk4, 3swl - hClCh protein 1
    
  • 6qvu, 6qvd, 6qvc, 6qvb, 6qv6 - hClCh protein 1 – Cryo EM
    
  • 3o3t, 3p8w, 3p90, 1k0o, 3qr6, 3tgz, 1k0m, 3uvh, 4iqa, 4jzq, 4k0g, 4k0n - hClCh protein 1 (mutant)
    
  • 6coz - hClCh protein 1 C terminal
    
  • 6coy - hClCh protein 1 transmembrane domain
    
  • 1k0n - hClCh protein 1 (mutant) + glutathione
    
  • 2per, 2r4v, 2r5g - hClCh protein 2
    
  • 3kjy, 3fy7 - hClCh protein 3 residues 1-230
    
  • 2ahe, 2d2z – hClCh protein 4
    
  • 2pfi - hClCh KA
    
  • 6y2h - hClCh protein 5
    
  • 2j9l, 2ja3 - hClCh protein 5 + nucleotide
    
  • 7bxu, 7cq6 - hClCh protein 7 + OSTM1 – Cryo EM
    
  • 7cq7 - hClCh protein 7 + OSTM1 + ADP – Cryo EM
    
  • 7cq5, 7jm7 - hClCh protein 7 + OSTM1 + ATP – Cryo EM
    
  • 7jna, 7jnc - hClCh PAC – Cryo EM
    
  • 5tr1, 5tqq - bCIC (mutant) + antibody – bovine - Cryo EM
    
  • 6erz, 6ery - mClCh protein 6
    
  • 7jm6 - cClCh protein 7 + ATP – chicken - Cryo EM
    
  • 6lsc, 6v2j - EcERIC (mutant)
    
  • 1ots, 6k5f - EcERIC + antibody
    
  • 1ott, 1otu, 6ad7, 6ad8, 6ada, 6adb, 6adc, 6k5a, 6k5d, 7cvs, 7cvt - EcERIC (mutant) + antibody
    
  • 2d4z - TmClCh - Torpedo marmorata
    
  • 2yv9 - CeClCh EXC-4 – Caenorhabditis elegans
    
  • 3rif - CeClCh + antibody + Glu + Ivermectin
    
  • 7ji3 - CICh – Takifugu bimaculatus - Cryo EM
    
  • 5y7i - ClCh – Oreochromis mossabicus
    
• Calcium-activated chloride channel or anoctamin or scramblase see Anoctamin 3D structures
• Calcium-activated chloride channel or bestrophin see Bestrophin 3D structures
• CAMP-dependent chloride channel or cystic fibrosis transmembrane conductance regulator see CFTR in ABC transporter 3D structures
• Anion Channel (Outer mitochondrial membrane protein porin 1)
  • 2jk4, 2k4t, 5jdp, 5xdo, 5xdn, 6g73, 6g6u – hVDAC1
    
  • 6tiq – hVDAC1 – NMR
    
  • 7qi2 – hVDAC1 (mutant) – NMR
    
  • 6tir – hVDAC1 + NAD – NMR
    
  • 6djb, 5zsu, 7xzh – hVDAC1 subunit LRRC8A – Cryo EM
    
  • 8dxn, 8dxo, 8dxp, 8dxq, 8dxr – hVDAC1 subunit LRRC8A + LRRC8C – Cryo EM
    
  • 6m04 – hVDAC1 subunit LRRC8AD (mutant) – Cryo EM
    

3emn, 4c69 – mVDAC1

• • 7kuh – mVDAC – electron crystallography
    
  • 6g9o, 6g9l, 6g8z, 6o00, 6nzz, 6nzw, 7m17, 7m19 – mVDAC1 subunit LRRC8A – Cryo EM
    
  • 8b40 – mVDAC1 subunit LRRC8C – Cryo EM
    
  • 8ben – mVDAC1 subunit LRRC8C LRR domain – Cryo EM
    
  • 8b42, 8dr8, 8dra, 8dre, 8drk, 8drn, 8dro, 8drq, 8ds3, 8ds9, 8dsa, 8dxn – mVDAC1 subunit LRRC8A + LRRC8C – Cryo EM
    
  • 8f74, 8f75, 8f77, 8f79, 8f7b, 8f7d, 8f7e, 8f7j – mVDAC1 subunit LRRC8A + LRRC8C (mutant) – Cryo EM
    
  • 8b41 – mVDAC1 subunit LRRC8A + LRRC8C + nanobody – Cryo EM
    
  • 7p5v, 7p5w, 7p5y, 7p60, 7p6k – mVDAC1 subunit LRRC8A + nanobody – Cryo EM
    
  • 6fnw – mVDAC1 subunit LRRC8A C terminal
    
  • 4bum – zeVDAC2
    
  • 7en0 – VDAC1 – Brachypodium distachyon – Cryo EM
    
  • 7w6k – ALMT – soy bean – Cryo EM
    
  • 7wnq – AtSLAC1 – Cryo EM
    
• Ligand-gated ion channel
  • 5osa, 5osb – mGLIC + GABAAR
    
  • 5osc – mGLIC + GABAAR + drug
    
  • 2vl0, 3rqu, 2yn6 – EchELIC – Erwinia chrysanthemi
    
  • 2yks, 3uq4, 3uq5, 3uq7, 4twh, 5hej, 5heo, 5heu, 5hew – EchELIC (mutant)
    
  • 6v03, 6v0b, 8d63, 8d64, 8d65 - EchELIC – Cryo EM
    
  • 8d66, 8d67, 8vuw – EchELIC3 (mutant) – Cryo EM
    
  • 3rqw - EchELIC + acetylcholine
    
  • 5sxu - EchELIC + bromoethanol
    
  • 4twd, 4twf - EchELIC (mutant) + memantine derivative
    
  • 3zkr - EchELIC + anesthetic
    
  • 2yoe - EchELIC + drug + GABA
    
  • 4a97, 4a98, 5lid, 5lg3 – EchELIC + drug
    
  • 5sxv – EchELIC + inhibitor
    
  • 4yeu – EchELIC + GLIC
    
  • 6hk0 – DcELIC (mutant) – Dickeya chrysanthemi
    
  • 6hjx, 6hjy, 6ssi, 6ssp – DcELIC + nanobody
    
  • 6fl9, 6fli, 6fvq, 6fvr, 6fvs - ELIC – vent tica
    
  • 3eam, 3ehz, 4hfi, 4il4, 4ilc, 4npp, 4npq, 4qh1, 4qh5, 4qh4, 6f7a, 6f16, 4zzc, 6hzw – GvGLIC - Gloeobacter violaceus
    
  • 6zgd, 6zgj, 6zgk – GvGLIC – Cryo EM
    
  • 6hk0 – DcELIC (mutant) – Dickeya chrysanthemi
    
  • 6hjx, 6hjy, 6ssi, 6ssp – DcELIC + nanobody
    
  • 6fl9, 6fli, 6fvq, 6fvr, 6fvs - ELIC – vent tica
    
  • 3eam, 3ehz, 4hfi, 4il4, 4ilc, 4npp, 4npq, 4qh1, 4qh5, 4qh4, 6f7a, 6f16, 4zzc, 6hzw – GvGLIC – Gloeobacter violaceusbr />
  • 3lsv, 3tls, 3tlt, 3tlu, 3tlv, 3tlw, 3uu3, 3uu4, 3uu5, 3uu6, 3uu8, 3uub, 3ei0, 4hfb, 4il9, 4ila, 4ilb, 4ire, 4lmj, 4lmk, 4lml, 5hcj, 5hcm, 5heg, 5heh, 5iux, 5v6o, 5v6n, 5nkj, 5njy, 5mzt, 5mzr, 5mzq, 4zzb, 6hy5, 6hy9, 6hya, 6hyr, 6hyv, 6hyw, 6hyx, 6hyz, 6hz0, 6hz1, 6hz3, 6emx, 6f0i, 6f0j, 6f0m, 6f0n, 6f0r, 6f0u, 6f0v, 6f0z, 6f10, 6f11, 6f12, 6f13, 6f15, 6f16, 6i08 – GvGLIC (mutant)
    
  • 3igq – GvGLIC N-terminal
    
  • 2xq3, 2xq4, 2xq5, 2xq6, 2xq7, 2xqa, 2xq8 – GvGLIC+inhibitor
    
  • 2xq9 – GvGLIC (mutant)+inhibitor
    
  • 3p4w, 3p50, 4f8h, 4hfh – GvGLIC + general anaesthetic
    
  • 4hfd, 5mvn, 5mvm, 5mur, 5muo – GvGLIC (mutant) + general anaesthetic
    
  • 4hfc, 4hfe - GvGLIC (mutant) + alcohol
    
  • 5j0z - GvGLIC + choline derivative
    
  • 5l47, 5l4e, 5l4h - GvGLIC + barbiturate
    
  • 6hj3, 6hjb, 6hji, 6hja, 6hjz, 6hpp - GvGLIC + carboxylate
    
  • 6v4a, 6v4s, 7q3g - DeELIC – Desulfofustis
    
  • 7q3h – DeELIC – Cryo EM
    
• Cyclic Nucleotide-Gated channel
  • 7lg1 – hCNGA1 (mutant) – Cryo EM
    
  • 7lft – hCNGA1 + cGMP – Cryo EM
    
  • 7lfw, 7lfx, 7lfy – hCNGA1 (mutant) + cGMP – Cryo EM
    
  • 7rh9, 7rhl – hCNGA1 + CNGB1 – Cryo EM
    
  • 7rhg, 7rhh, 7rhi, 7rhj, 7rhk – hCNGA1 + CNGB1 + cGMP – Cryo EM
    
  • 8bx7 – bCNGA1 + CNGB1 + cGMP – Cryo EM
    
  • 7rhs – hCNGA3 + CNGB3 – Cryo EM
    
  • 3swf - bCNGC CLZ domain
    
  • 2zd9, 3beh - MlCNGC - Mesorhizobium loti
    
  • 4chv, 4chw – MlCNGC – Cryo EM
    
  • 2ptm - CNGC C-terminal - Strongylocentratus purpuratus
    
  • 2kxl, 1vp6 - MlCNGC ligand-binding domain
    
  • 3co2, 4muv, 3clp, 1u12 - MlCNGC ligand-binding domain (mutant)
    
  • 3cl1, 2k0g - MlCNGC ligand-binding domain + cyclic nucleotide
    
  • 5h3o – CeCNGC – Cryo EM
    
  • 6wej, 6wek, 6wel – CeCNGC + cGMP – Cryo EM
    
  • 6cju, 6vxz, 6vy0 – StCNGC + cAMP – Spitochaeta thermophila - Cryo EM
    
  • 6cjq – StCNGC - Cryo EM
    
  • 6cjt – StCNGC + cGMP - Cryo EM
    
• Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel
  • 5u6o, 5u6p, 6uqf, 6uqg – hCNGC 1 – Cryo EM
    
  • 2mpf – hCNGC 2 ligand-binding domain - NMR
    
  • 3swy – hCNGC 3 CLZ domain
    
  • 6gyn – hCNGC 4 – Cryo EM
    
  • 6gyo – hCNGC 4 + cAMP – Cryo EM
    
  • 3otf – hCNGC 4 ligand-binding domain
    
  • 2mng – hCNGC 4 ligand-binding domain - NMR
    
  • 4hbn – hCNGC 4 ligand-binding domain (mutant)
    
  • 4kl1 – hCNGC 4 C terminal + nucleotide
    
  • 4nvp – hCNGC 4 ligand-binding domain + 7-CH-cAMP
    
  • 7nmn, 7np3 – rCNGC 4 – Cryo EM
    
  • 7np4 – rCNGC 4 + cAMP – Cryo EM
    
  • 3etq, 3ffq, 3u0z, 3u10, 3u11 - mCNGC C-terminal
    
  • 1q3e, 1q43, 1q5o - mCNGC 2 fragment + nucleotide
    
  • 2q0a - mCNGC 2 C-terminal (mutant)
    
  • 3bpz - mCNGC 2 ligand-binding domain
    
  • 5khg, 5khh, 5khi, 5khj, 5khk – mCNGC 2 ligand-binding domain + nucleotide
    
• Acid sensing ion channel
  • 6l6i, 6l6n, 6l6p – hASC
    
  • 7cfs – hASC – Cryo EM
    
  • 7cft – hASC + toxin – Cryo EM
    
  • 7rnn – hASC + nanobody – Cryo EM
    
  • 3ij4, 2qts, 3s3w, 4nyk, 3ij4, 6ave, 5wku, 5wkv, 5wky, 5wkx, 6cmc – cASC – chicken
    
  • 7lie – cASC thumb domain 291-367
    
  • 6vtk, 6vtl – cASC – Cryo EM
    
  • 3s3x, 4fz0, 4fz1 – cASC + psalmotoxin
    
  • 4ntw, 4ntx, 4nty - cASC + neurotoxin + basic phospholipase A2
    
  • 6x9h – cASC + modulator
    
• ATP-Gated P2X channel (AGC) or P2X purinoceptor
  • 5svj, 5svs, 5svt – hAGC P2X3
    
  • 5yve – hAGC P2X3 + modulator
    
  • 5svq, 5svr – hAGC P2X3 + antagonist
    
  • 5svm, 5svp – hAGC P2X3 + agonist
    
  • 5svk, 5svl, 6ah4, 6ah5 – hAGC P2X3 + ATP
    
  • 5u1l – paAGC P2X - panda
    
  • 5u1u, 5u1v, 5u1w, 5u1x, 5u1y – paAGC P2X + antagonist
    
  • 5u2h – paAGC P2X + antagonist + ATP
    
  • 6u9v – raAGC P2X7 – Cryo EM
    
  • 6u9w – raAGC P2X7 + ATP – Cryo EM
    
  • 2rup – raAGC P2X4 head domain 111-167 – NMR
    
  • 5xw6 – cAGC P2X7 + antagonist
    
  • 3h9v, 3i5d – zeAGC P2X4
    
  • 4dw0 – zeAGC P2X4 (mutant)
    
  • 4dw1 – zeAGC P2X4 + ATP
    
  • 5wzy – zeAGC P2X4 + CTP
    
• Proton channel or matrix protein 2
  • 2kj1, 2l0j - IVproton channel – Influenza virus - NMR
    
  • 2kih, 2kwx – IVproton channel (mutant)
    
  • 3bkd, 4qkm, 4qkl, 4qkc, 4qk7, 3lbw, 5ttc, 5um1, 5joo - IVproton channel transmembrane domain
    
  • 1nyj, 1mp6, 2kad, 6pvr, 6pvt - IVproton channel transmembrane domain - NMR
    
  • 5c02, 4rwc, 4rwb, 2kih, 6mjh - IVproton channel transmembrane domain (mutant)
    
  • 2n70 - IVproton channel transmembrane domain (mutant) - NMR
    
  • 6bkk, 6bkl, 6bmz, 6boc, 6us8, 6us9 - IVproton channel transmembrane domain + drug
    
  • 2h95, 2kqt - IVproton channel transmembrane domain + drug - NMR
    
  • 2ly0 - IVproton channel transmembrane domain (mutant) + drug - NMR
    
  • 2rlf - IVproton channel + inhibitor - NMR
    
  • 3c9j, 6oug - IVproton channel transmembrane domain + inhibitor
    
  • 6nv1 - IVproton channel transmembrane domain (mutant) + inhibitor
    
  • 8bdz, 8ber - proton channel M2 – Hepatitis virus – Cryo EM
    
• Voltage-gated hydrogen channel (VGHC)

• • 3a2a – hVGHC C-terminal - NMR
    
  • 5oqk – hVGHC residues 82-226 - NMR
    
  • 3wkv – mVGHC
    
  • 3vmx, 3vmy, 3vmz – mVGHC C-terminal
    
  • 3vn0, 3vyi – mVGHC C-terminal (mutant)
    
• Transient receptor potential cation channel, vanilloid subfamily (TRPV)
• TRPV1 or capsaicin receptor
  • 7lp9, 7lpa, 7lpc, 7lpd, 8gf8, 8gf9, 8gfa – hTRPV1 – Cryo EM
    
  • 6l93 – hTRPV1 ankyrin repeat domain 101-365
    
  • 2nyj – hTRPV1 ankyrin repeat domain + ATP
    
  • 7lqy, 7lqz – sTRPV1 – squirrel - Cryo EM
    
  • 7lr0 – sTRPV1 + capsaicin - Cryo EM
    
  • 3j5p, 3j5r, 3j9j, 5irz – rTRPV1 – Cryo EM
    
  • 5is0 – rTRPV1+ capsaicin derivative – Cryo EM
    
  • 5irx – rTRPV1+ DKTX – Cryo EM
    
  • 3j5q – rTRPV1+ toxin – Cryo EM
    
  • 2pnn – rTRPV1 ankyrin repeat domain
    
  • 7l2h, 7l2i, 7l2j, 7l2k, 7l2l, 7l2m, 7l2n, 7l2o, 7l2p, 7l2r, 7l2s, 7l2t, 7l2u, 7l2v, 7l2w, 7l2x, 7lpb, 7lpe, 7mz5, 7mz6, 7mz7, 7mz9, 7mza, 7mzb, 7mzc, 7mzd, 7mze, 7rqu, 7rqv, 7rqw, 7rqx, 7rqy, 7rqz – raTRPV1 + drug – Cryo EM
    
• TRPV2
  • 5hi9 – hTRPV2 – Cryo EM
    
  • 2f37, 4n5q – hTRPV2 ankyrin repeat domain 69-367
    
  • 2eta, 2etb, 2etc – rTRPV2 ankyrin repeat domain - rat
    
  • 6bo4, 6bo5, 6u84, 6u86 – rTRPV2 – Cryo EM
    
  • 6wkn, 7n0m, 7n0n, 7t37, 7t38, 7zjh, 8slx, 8sly – raTRPV2 + cannabidiol – Cryo EM
    
  • 6u88, 6u8a – rTRPV2 + cannabidiol – Cryo EM
    
  • 6bwm – raTRPV2 – rabbit
    
  • 5an8, 6oo3, 6oo4, 6oo5, 6oo7 – raTRPV2 – Cryo EM
    
  • 6bwj – raTRPV2 (mutant) + resiniferatoxin
    
  • 6b5v – raTRPV2 + inhibitor – Cryo EM
    
  • 7xeu – mTRPV2 – Cryo EM
    
  • 7xer, 7xew – mTRPV2 (mutant) – Cryo EM
    
  • 7xem – mTRPV2 + cholesterol – Cryo EM
    
  • 7xeo, 7xev, 7yep – mTRPV2 + ligand – Cryo EM
    
• TRPV3
  • 6mho, 6mhs, 6mhv, 6mhw, 6mhx, 6uw4 – hTRPV3 – Cryo EM
    
  • 6ot2, 6uw6, 6uw8, 6uw9 – hTRPV3 (mutant) – Cryo EM
    
  • 6ot5 – hTRPV3 (mutant) + inhibitor – Cryo EM
    
  • 7xj0 – hTRPV3 + drug – Cryo EM
    
  • 6dvw, 6dvy, 6lgp, 6pvl, 6pvm, 7mik – mTRPV3 – Cryo EM
    
  • 7mij, 7mik, 7mil, 7mim, 7min, 7mio, 7ras, 7rau, 7ugg – mTRPV3 + drug – Cryo EM
    
  • 6dvz, 6pvn, 6pvp, 6pvo, 6pvq – mTRPV3 (mutant) – Cryo EM
    
  • 4n5q – mTRPV3 ankyrin repeat domain 118-367
    
• TRPV4
  • 7aa5 – hTRPV4 + agonist – Cryo EM
    
  • 4dx1, 4dx2 – hTRPV4 ankyrin repeat domain 149-397
    
  • 6c8f, 6c8g, 6c8h – fTRPV4 (mutant) – frog
    
  • 6bbj – fTRPV4 – Cryo EM
    
  • 3jxi, 3jxj, 3w9g – cTRPV4 ankyrin repeat domain 133-382
    
  • 3w9f – cTRPV4 ankyrin repeat domain + inositol-3-phosphate
    
• TRPV5
  • 5oeo – hTRPV5 655-725 + calmodulin – NMR
    
  • 6dmr, 6dmu, 6o1n, 6o1p, 6pbe, 6pbf, 7t6j, 7t6k, 7t6l, 7t6m, 7t6n, 7t6o – rTRPV5 – Cryo EM
    
  • 6o1u, 7t6p, 7t6q, 7t6r – rTRPV5 (mutant) – Cryo EM
    
  • 6dmw, 6o20 – raTRPV5 + calmodulin – Cryo EM
    
• TRPV6
  • 6bo8, 6bo9, 7k4a, 8fob – hTRPV6 – Cryo EM
    
  • 6boa, 6d7s, 6d7t – hTRPV6 (mutant) – Cryo EM
    
  • 7k4b, 7k4c, 7k4d, 7k4e, 7k4f, 7s8c, 8foa – hTRPV6 + inhibitor – Cryo EM
    
  • 7s88, 7s89, 7s8b – hTRPV6 + blocker – Cryo EM
    
  • 5iwk, 5iwp, 5iwr, 5iwt, 5wo6, 5wo7, 5wo8, 5wo9, 5woa, 6d7o, 6d7v – rTRPV6
    
  • 6d7p, 6d7q, 6d7x – rTRPV6 (mutant)
    
  • 6bob – rTRPV6 – Cryo EM
    
  • 6e2f, 6e2g – rTRPV6 + calmodulin – Cryo EM
    
  • 2rfa – mTRPV6 ankyrin repeat domain 44-265
    
  • 7d2k – raTRPV6 + inhibitor – Cryo EM
    
• Glycerol facilitator
  • 1lda, 1ldi - EcGlpF
    
  • 1fx8 - EcGlpF + glycerol
    
  • 1ldf - EcGlpF (mutant)

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Jaime Prilusky