CD81

spinqualitylabelsall models Human CD81 (magenta) complex with mouse antibody heavy chain (cyan), light chain (green) and glycerol (PDB code 6u9s) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function CD81 is a cell-surface protein involved in a variety of biological responses like adhesion, morphology, activation, proliferation and differentiation of of B- and T-cells. CD81 belongs to the tetraspanin family - protein containing 4 transmembrane domains - which form microdomains in the cell surface with a variety of partner proteins. CD81 enables hepatitis C virus infection of human cells. Relevance CD81 is widely expressed on the majority of tumor cells. Antibodies that target CD81 are a novel treatment against B-cell lymphoma. CD81-defficient mice are impaired in their ability to suppress the anti-tumor immune response. Structural highlights The structure of the complex of human CD81 with mouse antibody shows interactions of the CD81 helix D with the antibody heavy chain and CD81 residues in helix C with the light chain.

3D structures of CD81

Updated on 02-June-2021

5tcx - hCD81 (mutant) - human
1g8q, 1iv5, 5m3t, 5m3d, 5m4r, 5m33, 5m2c, 3x0e - hCD81 extracellular domain 113-202
6ejm, 6ek2, 6ejg, 5dfw - hCD81 extracellular domain + Scfv
5dfv, 6u9s - hCD81 extracellular domain + antibody
3x0g - CD81 extracellular domain - green monkey
3x0f - CD81 extracellular domain - mouse

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Michal Harel, Alexander Berchansky