Dioxygenase 3D structures

3D structures of dioxygenase

Updated on 16-April-2025

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• Dioxygenase Intradiol family
• Protocatechuate 3,4-dioxygenase (PCD)
  • 2pcd, 4who, 4whp – PpPCD α,β + Fe+3 – Pseudomonas putida
    
  • 3pcd, 1ykk, 1ykm, 1yko, 3lkt, 3mfl, 3mi1, 3mv4, 3t63 – PpPCD α,β (mutant) + Fe+3
    
  • 1eo2, 1eo9, 1eoa, 2bum, 2but – AcPCD α,β + Fe+3 - Acinetobacter
    
  • 2bux – AcPCD α,β (mutant) + Fe+3
    
• PCD complex with aromatic compound
  • 3pcf, 3pch, 3pci, 4whq, 4whr, 4whs – PpPCD α,β + Fe+3 + HB derivative
    
  • 3pca, 3pcb, 3pcc – PpPCD α,β + Fe+3 + HB
    
  • 1ykl, 1ykn, 1ykp, 3lmx, 3mv6 – PpPCD α,β (mutant) + Fe+3 + DHB
    
  • 3pcj, 3pck, 3pcl, 3pcm – PpPCD α,β + Fe+3 + hydroxynicotinic acid derivative
    
  • 3pcn, 3pce, 3pcg – PpPCD α,β + Fe+3 + hydroxyphenyl acetate derivative
    
  • 1eob – AcPCD α,β + Fe+3 + DHB
    
  • 2buv, 2bv0 – AcPCD α,β (mutant) + Fe+3 + DHB
    
  • 2bur – AcPCD α,β + Fe+3 + HB
    
  • 2buw – AcPCD α,β (mutant) + Fe+3 + HB
    
  • 1eoc, 2buq – AcPCD α,β + Fe+3 + catechol derivative
    
  • 2buu, 2buy, 2buz – AcPCD α,β (mutant) + Fe+3 + catechol derivative
    
  • 3lxv, 3mi5, 3t67 – PpPCD α,β (mutant) + Fe+3 + catechol derivative
    
• Protocatechuate 4,5-dioxygenase (PCD)
  • 1b4u – SpPCD α,β + Fe+3 + DHB – Sphingomonas paucimobilis
    
  • 1bou – SpPCD α,β + Fe+3
    
• Catechol 1,2-dioxygenase (CTD)
  • 1dlm, 1dlq – AcCTD + Fe+3
    
  • 2azq – PpCTD + Fe+3
    
  • 5umh, 9dr5, 9dr6 – BmCTD + Zn+2 – Burkholderia multivorans
    
  • 9dr8 – BmCTD + Fe+2
  • 5td3 – CTD – Burkholderia vietnamiensis
    
  • 5vxt – BaCTD + Fe+3 + catechol – Burkholderia ambifaria
    
• CTD complex with aromatic compound
  • 1dlt, 1dmh – AcCTD + Fe+3 + catechol derivative
    
  • 3hgi – RoCTD + Fe+3 + benzoic acid
    
  • 3hhy, 3hkp – RoCTD + Fe+3 + DHB
    
  • 3hj8, 3hjq, 3hjs, 3i4v, 3i4y, 3i51 – RoCTD + Fe+3 + catechol derivative
    
  • 3hhx – RoCTD + Fe+3 + pyrogallol
    
  • 9dra – BmCTD + Fe+3 + catechol derivative
    
  • 2xsu – ArCTD + Fe+3 + phosphoinositol derivative – Acinetobacter radioresistens
    
  • 2xsv, 2xsr – ArCTD + Fe+3 + phosphoinositol derivative
    
• Catechol 2,3-dioxygenase (CT23D)
  • 5zsz – DiCT23D + Fe+3 - Diaphorobacter
    
  • 5znh, 5zsx – DiCTD + Fe+3 + catechol derivative
    
• Chlorocatechol 1,2-dioxygenase (CCTD)
  • 3th1 – PpCCTD + Fe+3
    
  • 1s9a – RoCCTD + Fe+3
    
  • 3o32, 3o5u – RoCCTD + Fe+3 + dichlorocatechol derivative
    
  • 3o6j – RoCCTD + Fe+3 + hydroxyquinol
    
  • 3o6r – RoCCTD + Fe+3 + pyrogallol
    
  • 2boy – RoCCTD + Fe+3 + benzhydroxamate
    
• Hydroxyquinol 1,2-dioxygenase (HQX) or hydroquinone dioxygenase
  • 1tmx – PsiHDX + Fe+3 – Pimelobacter simplex
    
  • 4zxd – PsHDX - Pseudomonas
    
  • 4zxa – PsHDX + Cd+2 + benzonitrile
    
  • 4zxc – PsHDX + Fe+3
    
  • 5m22 – SpHDX + Fe+3
    
  • 5m4o – SpHDX + Fe+3 + nitrophenol
    
  • 5m26 – SpHDX + Fe+3 + hydroquinone derivative
    
  • 5m21 – SpHDX + Fe+3 + hydroxybenzoate
    
  • 3n9t – PpHDX + Fe+3
    
  • 8r2w – HDX + Fe+3 + phosphatidylethanolamine – Trametes versicolor
    
  • 8r2v – HDX + Fe+3 + phosphatidylethanolamine – Gelatoporia subvermispora"
    
  • 8r2x - RjHDX + Fe+3 + phosphatidylethanolamine - Rhodococcus jostii
    
  • 8z4q - AwHDX + Fe+3 – Aspergillus westerdijkiae
    
  • 8z4r, 8z4s - AwHDX + Fe+3 + substrate
    
• Nitrobenzene dioxygenase (NBDO)
  • 2bmo – CtNBDO + Fe+3 + Fe2S2
    
  • 2bmq – CtNBDO + Fe+3 + Fe2S2 + nitrobenzene
    
  • 2bmr – CtNBDO + Fe+3 + Fe2S2 + nitrotoluene
    
• α-ketoglutarate-dependent dioxygenase (Alkb)
  • 3khb – hAlkb (mutant) + Co+2 + oxoglutarate
    
  • 3i3q – hAlkb + Mn+2 + oxoglutarate
    
  • 3thp – hAlkb + Mn+2 + Zn+2 + oxoglutarate
    
  • 3tht – hAlkb (mutant) + Mn+2 + Zn+2 + oxoglutarate
    
  • 3t4h, 3t4v, 3t3y – EcAlkb + Fe+3 + inhibitor – Escherichia coli
    
  • 2fdj, 2fdg – EcAlkb + Mn+2 + succinate
    
  • 4jht, 7nro – EcAlkb + Mn+2 + inhibitor
    
  • 4rfr – EcAlkb + Mn+2 + rhein
    
  • 2fdf – EcAlkb (mutant) + Co+2 + oxoglutarate
    
  • 4zhn – EcAlkb (mutant) + Co+2 + oxoglutarate + trinucleotide
    
  • 6ypv – EcAlkb + Fe+3 + oxoglutarate
    
  • 2fd8 – EcAlkb (mutant) + Fe+2 + oxoglutarate
    
  • 6y0q – EcAlkb + Fe+3 + oxoglutarate + pyrimidine derivative
    
  • 6f9p – FlAlkb + Re+2 - Flavobacterium
    
  • 6exf – FlAlkb + Fe+3 + lysine
    
  • 6eur – FlAlkb + Fe+3 + oxoglutarate
    
  • 6euo – FlAlkb + Fe+3 + succinate
    
  • 6exh – FlAlkb + Fe+3 + succinate + hydroxylysine
    
  • 6f6e, 6p77 – CaAlkb – Catenulispora acidiphila
    
  • 6f2b – CaAlkb + Fe+2 + oxoglutarate
    
  • 6f2a – CaAlkb + Fe+2 + lysine
    
  • 6f6j – CaAlkb + Fe+3 + succinate + hydroxylysine
    
• Alkb complex with DNA
  • 3rzm, 3rzl, 3rzh, 3rzg, 3btz, 4mg2, 4mgt – hAlkb (mutant) + DNA
    
  • 3h8x, 3h8r, 3h8o, 3bty – hAlkb (mutant) + DNA + inhibitor
    
  • 3btx – hAlkb (mutant) + Mg+2 + DNA
    
  • 3i49, 3i2o – hAlkb + Fe+2 + oxoglutarate + DNA
    
  • 4nid – hAlkb + Mn+2 + oxoglutarate + DNA
    
  • 4nig, 4nih, 4nii – hAlkb (mutant) + Mn+2 + oxoglutarate + DNA
    
  • 3o1s – hAlkb + DNA
    
  • 3i3m – hAlkb + Mn+2 + oxoglutarate + DNA
    
  • 3s5a, 3s57, 3rzk, 3rzj, 3buc, 3bu0, 3bkz – hAlkb (mutant) + Mn+2 + oxoglutarate + DNA
    
  • 3o1r, 3o1p, 3o1o, 3o1m – hAlkb (mutant) + Mn+2 + oxoglutarate + DNA + inhibitor
    
  • 3bie, 3bi3, 2fdh – EcAlkb (mutant) + Mn+2 + oxoglutarate + DNA + inhibitor
    
  • 2fdi – EcAlkb + Fe+2 + oxoglutarate + DNA + inhibitor
    
  • 3khc – hAlkb (mutant) + Co+2 + oxoglutarate + DNA + inhibitor
    
  • 3o1v, 3o1u, 3o1t, 3t1s – hAlkb (mutant) + Fe+3 + succinate + DNA + inhibitor
    
• α-ketoglutarate-dependent dioxygenase homolog (Alkbh)
  • 6ima – hAlkbh1 catalytic domain 37-369
    
  • 6ie3 – hAlkbh1 + Mn
    
  • 6ie2 – hAlkbh1 + Mn + oxoglutarate
    
  • 8k62 – hAlkbh1 + Mn + inhibitor
    
  • 6imc – hAlkbh1 catalytic domain + Mn + oxalylglycine
    
  • 6ksf – mAlkbh1 catalytic domain 4-384 + succinate + DNA
    
  • 6l94 – mAlkbh1 catalytic domain + Fe+2
    
  • 8jnk, 8jnr – hAlkbh3 + DNA
    
  • 9ncz – hAlkbh3 + Mn + oxoglutarate
    
  • 4nj4, 4o7x – hAlkbh5 residues 66-292 + Mn
    
  • 4o61 – hAlkbh5 residues 74-294 + citrate
    
  • 4nrm – hAlkbh5 residues 66-292 + citrate + acetate
    
  • 4nro – hAlkbh5 residues 66-292 + Mn + ketoglutarate
    
  • 4oct – hAlkbh5 residues 66-292 + Mn + oxoglutarate
    
  • 7v4g – hAlkbh5 residues 66-292 + Mn + RNA
    
  • 7wkv – hAlkbh5 residues 66-292 + Mn + oxoglutarate + RNA
    
  • 7wl0 – hAlkbh5 residues 66-292 + Mn + oxalylglycine + RNA
    
  • 4nrp – hAlkbh5 residues 66-292 + Mn + oxalylglycine
    
  • 4nrq – hAlkbh5 residues 66-292 + Mn + pyridine dicarboxylate
    
  • 4npl – zfAlkbh5 residues 38-287 + Mn + ketoglutarate – zebra fish
    
  • 4npm – zfAlkbh5 residues 38-287 + Mn + succinate
    
  • 7vjs – hAlkbh6 + Ni
    
  • 7vjv – hAlkbh6 + Mn + ketoglutarate
    
  • 4qkb, 4qkd – hAlkbh7 residues 17-215 (mutant) + Mn + ketoglutarate
    
  • 4qkf – hAlkbh7 residues 17-215 (mutant) + Mn + oxalylglycine
    
• α-ketoglutarate-dependent dioxygenase (Fto)
  • 9kni – hFto + inhibitor
    
  • 4idz – hFto + Ni+2 + oxalylglycine
    
  • 7ckk – hFto + inhibitor + oxalylglycine
    
  • 8it9 – hFto + inhibitor + Akg
    
  • 4ie0, 4ie5, 4qho – hFto + Zn+2 + pyrimidine derivative
    
  • 4ie4, 4ie6 – hFto + Zn+2 + quinoline derivative
    
  • 4ie7 – hFto + Zn+2 + rhein
    
  • 4qkn – hFto + Mn+2 + meclofenamic acid
    
  • 4cxw, 4cxx, 4cxy – hFto + Ni+2 + inhibitor
    
  • 6aej, 7e8z – hFto + Zn+2 + inhibitor
    
  • 6ak4 – hFto (mutant) + Zn+2 + inhibitor
    
  • 6akw – hFto + oxoglutarate + inhibitor
    
  • 5f8p, 5dab – hFto + Fe+2 + oxoglutarate + inhibitor
    
  • 4zs2, 4zs3 – hFto + Mn+2 + oxoglutarate + fluorescin
    
  • 7wcv – hFto + Mn+2 + oxoglutarate
    
  • 5zmd – hFto (mutant) + Mn+2 + AMP derivative + DNA + oxalylglycine
    
  • 6eoz – EnFto + Ni+2 + cyclopeptin – Emericela nidulans
    
  • 5y7t, 5y7r – EnFto + Fe+3 + oxoglutarate + cyclopeptin
    
  • 5oa8, 5oa7, 5oa4 – EnFto (mutant) + Ni+2 + oxoglutarate + cyclopeptin
    
• α-ketoglutarate-dependent dioxygenase (ANDA)
  • 5zm2 – EvANDA – Emericella variicolor
    
  • 5zm4, 5zm3 – EvANDA + Fe+3 + oxoglutarate + preandiloid
    
• α-ketoglutarate-dependent dioxygenase (DAO)
  • 6kun – DAO + oxoglutarate – rice
    
• Iron/α-ketoglutarate-dependent dioxygenase (AsqJ)
  • 5dav – AnAsqJ + Ni+2 + cyclopeptin – Aspergillus nidulans
    
  • 5oa4, 5oa7, 5oa8, 6eoz – AnAsqJ (mutant) + Ni+2 + cyclopeptin
    
  • 5dap – AnAsqJ + Ni+2 + oxoglutarate
    
  • 5daq, 5daw, 5dax, 5y7r, 5y7t – AnAsqJ + Fe+3 + cyclopeptin + oxoglutarate
    
  • 6k0e – AnAsqJ + Fe+3 + O2 + cyclopeptin + oxoglutarate
    
  • 6k0f – AnAsqJ + Fe+3 + H2O2 + cyclopeptin + oxoglutarate
    
  • 6jzm, 6k30, 6kd9 – AnAsqJ + Fe+3 + cyclopeptin + succinate
    
  • 7eyt, 7eyu, 7eyw – AnAsqJ (mutant) + Fe+2 + terpenoid
    
  • 7olk – EnAsqJ + Ni+2 + inhibitor
    
  • 7oll, 7olm, 7olo, 7olq – EnAsqJ (mutant) + Ni+2 + inhibitor
    
  • 7olt – EnAsqJ + Ni+2 + cyclopeptin
    
  • 7olr – EnAsqJ + Ni+2 + oxoglutarate + cyclopeptin
    
  • 7v2u, 7v3o, 8hiv – SoBcmB + Fe+2 + Akg – Streptomyces ossamyceticus
    
  • 7v2t, 7v2x, 7v34, 7v36, 7v3e – SoBcmB + Fe+2 + Akg + inhibitor
    
  • 7v3n – SoBcmB (mutant) + Fe+2 + Akg + inhibitor
    
  • 7wpy – AsqJ (mutant) + Fe+3 – Aspergillus stellatus
    
• Fe(II)/(alpha)-ketoglutarate-dependent dioxygenase (PrhA)
  • [[8s7b] – riHis1 + Mn+2 + oxoglutarate
    
  • 5ybm – PbPrhA – Penicillium brasilianum
    
  • 5ybn, 7olp – PbPrhA + Fe+3 + oxoglutarate + cyclopeptin
    
  • 5ybs, 5ybt – PbPrhA (mutant) + Fe+3 + oxoglutarate + berkeleyone
    
  • 5ybo, 5ybp, 5ybq, 5ybr – PbPrhA (mutant) + Fe+3 + oxoglutarate + preaustinoid
    
  • 7qtf – StPlaO1 + succinate - Streptomyces
    
  • 7qtg – StPlaO1 + Fe+2
    
  • 7qtd – StPlaO1 + Fe+2 + oxoglutarate
    
  • 7qte – StPlaO1 + Co + succinate
    
  • 5ybl – EnAusE + Mn+2 + oxoglutarate
    
  • 7vbq, 7vbr – TlxI – Talaromyces purpureogenus
    
• Gamma-butyrobetaine dioxygenase
  • 4bhf – hGBBD + inhibitor
    
  • 3n6w – hGBBD + Zn
    
  • 3o2g – hGBBD + Zn + oxalylglycine
    
  • 3ms5 – hGBBD + Ni + Zn + oxalylglycine
    
  • 4bg1, 4bgk, 4bgm, 4bhf, 4bhi – hGBBD + Zn + inhibitor
    
  • 4c8r – hGBBD + Ni + Zn + inhibitor
    
  • 4bhg, 4c5w – hGBBD + Zn + oxalylglycine + inhibitor
    
  • 4cwd – hGBBD + Ni + Zn + oxalylglycine + inhibitor
    
• Leucoanthocyanidin dioxygenase (LACD)
  • 1gp5, 1gp6 – AtLACD + dihydroquercetin – Arabidopsis thaliana
    
  • 2brt – AtLACD + naringenin
    
• Methylcytosine dioxygenase (TET)
  • 6asd – hTET1 + DNA
    
  • 5d9y, 5deu, 4nm6, 7ne6 – hTET2 + DNA
    
  • 7ne3 – hTET2 (mutant) + DNA
    
  • 4z3c – hTET3 + DNA
    
  • 5exh – mTET3 + DNA – mouse
    
  • 7w5p, 8jkk – CcTET + DNA – Coprinopsis cinerea
    
  • 7vpn – CcTET + oxalylglycine + Mn
    
• Dioxygenase extradiol family
• Homoprotocatechuate 2,3-dioxygenase (HPCD)
  • 1f1r, 1f1u – AgHPCD + Mn+2 – Arthrobacter globiformis
    
  • 1f1x, 1q0o – BfHPCD + Fe+3 – Brevibacterium fuscum
    
  • 2ig9, 3ojt, 5trx – BfHPCD + Fe+2
    
  • 3ecj, 4ghc, 5bwg, 5bwh, 4z6l, 4z6m, 4z6n, 4z6o, 4z6p, 4z6q – BfHPCD (mutant) + Fe+2
    
  • 4z6z – BfHPCD + Fe+2 + catechol derivative
    
  • 4z6r, 4z6s, 4z6t, 4z6u, 4z6v, 4z6w – BfHPCD (mutant) + Fe+2 + catechol derivative
    
  • 3bza, 3ojn – BfHPCD + Mn+2
    
  • 3ojj – BfHPCD + MCo+2
    
• HPCD complex with aromatic compound
  • 1f1v – AgHPCD + Mn+2 + dihydroxyphenyl acetate
    
  • 1q0c, 4ghg – BfHPCD + Fe+2 + dihydroxyphenyl acetate
    
  • 4ghd – BfHPCD (mutant) + Fe+2 + dihydroxyphenyl acetate
    
  • 2iga – BfHPCD + Fe+2 + O2 + reaction intermediates
    
  • 3eck – BfHPCD (mutant) + Fe+2 + reaction intermediates
    
  • 3ojk – BfHPCD + Co+2 + catechol derivative
    
  • 4ghe, 4ghf – BfHPCD (mutant) + Fe+2 + catechol derivative
    
  • 4ghh – BfHPCD + Fe+2 + catechol derivative
    
• Catechol 2,3-dioxygenase (MPC)
  • 1mpy – PpMPC + Fe+2
    
  • 3hpv – PsMPC + Fe+2
    
  • 3hpy – PsMPC + Fe+2 + catechol derivative
    
  • 3hq0 – PsMPC + Fe+3 + product
    
  • 2wl3, 2wl9 - RoMPC + Fe+3 - Rhodococcus opacus
    
  • 3lm4 – RoMPC + Fe+3 + H2O2
    
  • 5zsz – DiMPC + Fe+3 - Diaphorobacter
    
  • 5znh – DiMPC + Fe+3 + catechol derivative
    
  • 6l3w – MPC + Fe+3 - metagenome
    
  • 7q2a - RjMPC + Fe+3 + catechol derivative
    
• Naphthalene 1,2-dioxygenase (NDO)
  • 2qpz – PpNDO ferredoxin subunit 1-104 + Fe2S2
    
  • 1ndo, 1o7h, 1o7w – PpNDO alpha+beta subunits + Fe+3 + Fe2S2
    
  • 2hmj – PpNDO (mutant) alpha+beta subunits + Fe+3 + Fe2S2
    
  • 2b1x – RoNDO alpha+beta subunits + Fe+3 + Fe2S2
    
• NDO complex with aromatic compound
  • 1eg9 – PpNDO + Fe+3 + Fe2S2 + indole
    
  • 1o7g – PpNDO + Fe+3 + Fe2S2 + naphthalene
    
  • 1o7m – PpNDO + Fe+3 + Fe2S2 + O2
    
  • 1o7n – PpNDO + Fe+3 + Fe2S2 + O2 + indole
    
  • 1o7p – PpNDO + Fe+3 + Fe2S2 + dihydronaphthalene
    
  • 1uuv, 1uuw – PpNDO + Fe+3 + Fe2S2 + NO3
    
  • 2hmk, 2hml – PpNDO (mutant) + Fe+3 + Fe2S2 + phenanthrene
    
  • 2hmm, 2hmn – PpNDO (mutant) + Fe+3 + Fe2S2 + anthracene
    
  • 2hmo – PpNDO + Fe+3 + Fe2S2 + nitrotoluene
    
  • 2b24 – RoNDO + Fe+3 + Fe2S2 + indole
    
  • 4hm0, 4hm1, 4hm4, 4hm5 – PsNDO + Fe+3 + Fe2S2 + indole derivative
    
  • 4hm2, 4hm3, 4hm6, 4hm7, 4hm8 – PsNDO + Fe+3 + Fe2S2 + phenyl derivative
    
  • 4hjl – PsNDO + Fe+3 + Fe2S2 + chloronaphthalene
    
  • 4hkv – PsNDO + Fe+3 + Fe2S2 + benzamide
    
• Dihydronaphthalene 1,2-dioxygenase (HNDO)
  • 2ehz, 2ei2 – PsHNDO + Fe+2
    
  • 2ei0, 2ei1, 2ei3 – PsHNDO + Fe+2 + dihydroxybephenyl
    
• 2,3-dihydroxybiphenyl 1,2-dioxygenase (DHBP)
  • 1dhy, 1eil, 1eiq, 1eir – PsDHBP + Fe+3
    
  • 1kw3 – PsDHBP + Fe+2
    
  • 1kw8 – PsDHBP + Fe+2 + NO
    
  • 1kwb – PsDHBP (mutant)
    
  • 1han, 1kmy – BxDHBP (mutant) + Fe+3 – Burkholderia xenovorans
    
  • 3huh – DHBP – Salmonella typhimurium
    
• DHBP complex with aromatic compound
  • 1knd, 1knf – BxDHBP + Fe+3 + catechol derivative
    
  • 1lgt, 1lkd – BxDHBP + Fe+2 + dihydroxybephenyl
    
  • 1kw6, 1kw9 – PsDHBP + Fe+2 + dihydroxybephenyl
    
  • 1kwc – PsDHBP (mutant) + dihydroxybephenyl
    
• Salicylate 1,2-dioxygenase (SDO)
  • 2phd – PssSDO + Fe+3 – Pseudaminobacter salicylatoxidans
    
  • 4fah, 4fbf – PssSDO (mutant) + Fe+3
    
  • 3nst – PssSDO (mutant) + Fe+2
    
  • 3njz – PssSDO + Fe+2 +salicylate
    
  • 3nvc – PssSDO (mutant) + Fe+2 +salicylate
    
  • 3nkt – PssSDO + Fe+2 +naphthoate
    
  • 3nl1 – PssSDO + Fe+2 +gentisate
    
  • 3nw4, 4fag – PssSDO (mutant) + Fe+2 +gentisate
    
• Biphenyl 1,2-dioxygenase (BDO)
  • 3gzy – CtBDO + Fe+2 + Fe2S2 – Comamonas testosteroni
    
  • 2xr8 – BxBDO + Fe+2 + Fe2S2
    
  • 2xso, 2yfi, 5aeu – BxBDO (mutant) + Fe+2 + Fe2S2
    
  • 1uli - RoBDO + Fe+2 + Fe2S2
    
  • 2gbw - SyBDO + Fe+2 + Fe2S2 + O2 – Sphingobium yanoikuyae
    
• BDO complex with aromatic compound
  • 3gzx – CtBDO + Fe+2 + Fe2S2 + biphenyl
    
  • 2xrx – BxBDO + Fe+2 + Fe2S2 + biphenyl
    
  • 2xsh, 5aew – BxBDO (mutant) + Fe+2 + Fe2S2 + biphenyl
    
  • 2yfj, 2yfl – BxBDO (mutant) + Fe+2 + Fe2S2 + dibenzofuran
    
  • 1ulj - RoBDO + Fe+2 + Fe2S2 + biphenyl
    
  • 2gbx - SyBDO + Fe+2 + Fe2S2 + biphenyl
    
• Tryptophan 2,3-dioxygenase (TDO)
  • 4pw8 - hTDO + Co+2
    
  • 5tia, 5ti9 – hTDO + heme + Trp
    
  • 8r5q, 8r5r, 8vug, 8vzv, 8w1h, 8w2k, 9at2 – hTDO + inhibitor
    
  • 6pyy, 6pyz, 6vbn, 9b17, 9b1q – hTDO + heme + inhibitor
    
  • 6a4i, 7lu7 – hTDO + heme + Trp + inhibitor
    
  • 6ud5 – hTDO + heme + Trp + CO
    
  • 7ui3, 8qv7 – hTDO + Trp derivative
    
  • 1yw0 – XcTDO + Mg – Xanthomonas campestris
    
  • 2nw7 – XcTDO + heme
    
  • 7p46 – XcTDO + heme + kynurenine + Trp
    
  • 4hka – DmTDO + heme – Drosophila melanogaster
    
  • 9foz – DmTDO + heme + inhibitor
  • 3bk9, 3e08 – XcTDO (mutant) + heme + Trp
    
  • 2nw8, 2nw9 – XcTDO + heme + Mn + Trp derivative
    
  • 8vyy – StTDO + heme + Trp derivative
    
  • 2nox – CmTDO + heme – Cupriavidus metallidurans
    
• Cysteine dioxygenase type I (CDO) or ergothioneine dioxygenase
  • 6bgm, 6bgf, 6e87 – hCDO + Fe+2
    
  • 2ic1, 6n42 – hCDO + Fe+2 + cysteine
    
  • 6cdh, 6bpw, 6bpu, 6bpt – hCDO + Fe+2 + Tyr derivative
    
  • 6cdn, 6bpx, 6bpv, 6bps – hCDO + Fe+2 + cysteine + Tyr derivative
    
  • 6bpr – hCDO + Fe+3 + cysteine + Tyr derivative + NO
    
  • 6n43 – hCDO + Fe+3 + cysteine + NO
    
  • 8vl9, 8vlb – hCDO + Fe+3 + VHL + elongin b,c
    
  • 2gh2, 4ieo, 4iep, 4ieq, 4ier, 4ies, 4iet, 4ieu, 4iev, 4iew, 4iex, 4iey, 4iez, 4jtn, 4jto, 4kwj, 4kwk, 4kwl, 2b5h – rCDO + Fe+2 – rat
    
  • 4ubg, 4ubh, 5ezw, 5efu, 4ysf, 4yyo – rCDO (mutant) + Fe+2
    
  • 5fdb – rCDO (mutant)
    
  • 4yni – rCDO
    
  • 6u4s, 6u4v – rCDO + Fe+3
    
  • 5i0r, 4xet, 4xfb, 4xfc, 4pix, 6u1m, 6u4l – rCDO (mutant) + Fe+3
    
  • 4pjy – rCDO + Fe+3 + N3
    
  • 3eln – rCDO + Fe+2 + cysteine derivative
    
  • 4z82 – rCDO (mutant) + Fe+2 + cysteine derivative
    
  • 5i0u, 5i0t, 5i0s, 4xf4, 4xf9, 4xfa, 4piz – rCDO + Fe+3 + cysteine derivative
    
  • 4xf0, 4xf1, 4xfg, 4xfh, 4xfi, 4piy – rCDO (mutant) + Fe+3 + cysteine derivative
    
  • 4xez, 4xff – rCDO (mutant) + Fe+3 + inhibitor
    
  • 4xf3 – rCDO (mutant) + Fe+3 + inhibitor + cysteine
    
  • 2q4s, 2atf – mCDO + Ni+2
    
  • 6xb9 – AvCDO + Fe+3 + hydroxyl propionic acid – Azotobacter vinelandii
    
  • 7kov – AvCDO + Fe+3 + SCN
    
  • 8qfm, 8qfn, 8qfp – TtCDO + Mn+2 – Thermocatellispora tenchongensis
    
  • 8qfo, 8qfq – TtCDO (mutant) + Mn+2
    
  • 8qfl – TtCDO + Fe+3
    
  • 8qfr – TtCDO + Ni+2 + inhibitor
    
• 4-hydroxyphenylpyruvate dioxygenase (HPPD) or Acmp1
  • 3isq, 5ec3 – hHPPD + Co+2
    
  • 8im2 – hHPPD + Co+2 + inhibitor
    
  • 1sqi – rHPPD + Fe+3 + inhibitor
    
  • 7x7l – HPPD + Co+2 + inhibitor - maize
    
  • 6jx9, 6lgt, 6m6d, 7cjk, 7cqr, 7cqs, 7ezq, 7vo8, 7v6x, 7vc8, 7wj8, 7wjj, 7wjk, 7x5r, 7x5s, 7x5u, 7x5w, 7x5x, 7x5y, 7x5z, 7x62, 7x64, 7x67, 7x69, 7x6m, 7x6n, 7x8e, 7x8h, 7x8i, 7xvh, 8gwd, 8h6a, 8h6b, 8how, 8hwr, 8hx2, 8hx4, 8hxf, 8hxg, 8hxh, 8hym, 8hyo, 8hyp, 8hys, 8hz6, 8hz7, 8hz9, 8hza, 8hzu, 8i0g, 8i0y, 8i2u, 8i15, 8i2p, 8i2s, 8i36, 8im3, 8iok, 8j3c, 8j8w, 8j8x, 8who, 8whp, 8whq, 8wi6, 8wl0, 8wpc, 8wpd, 8wqm, 8x42. 8x5c, 8x68, 8x69, 8x6a, 8x6c, 8xhj, 8xib, 8xii, 8xin, 8xlw, 8xlx, 8xqv, 8xqz, 8xqy, 8xr0, [8xtv]], 8xu9, 8xuc, 8xue, 8xug – AtHPPD + Co+2 + inhibitor
    
  • 8wjz, 8wk2 – AtHPPD (mutant) + Co+2 + inhibitor
    
  • 8xly – AtHPPD + Co+2 + Phe
    
  • 1sqd, 1sp9 – AtHPPD + Fe+3
    
  • 1tfz, 1tg5, 6j63, 5ywh, 5ywg – AtHPPD + Fe+3 + inhibitor
    
  • 7x8c, 7x8d – AtHPPD + Co + phenylpyruvate
    
  • 7e0x – AtHPPD + Co + phenylacetate
    
  • 5xgk – AtHPPD + Fe+3 + hydroxyphenylpyruvate
    
  • 6isd – AtHPPD + Fe+3 + sulcotrione
    
  • 5yy7, 5yy6, 5ywk – AtHPPD + Co+2 + benquitrione
    
  • 5ywi – AtHPPD (mutant) + Co+2 + NTBC
    
  • 1sp8 – HPPD + Fe+2 – corn
    
  • 7yvv – HPPD + Fe+3 - Amycoaltopsis
    
  • 1cjx – PfHPPD + Fe+2 – Pseudomonas fluorescens
    
  • 7xnt – PfHPPD + Co+2 + inhibitor
    
  • 1t47 – HPPD + Fe+2 – Streptomyces avermitilis
    
  • 3zgj – HPPD + Co+2 + mandelic acid – Streptomyces coelicolor
    
  • 5hmq – PpHPPD + Mg+2
    
  • 8jbw – HPPD + Co+2 + usnic acid – Zymoseptoria tritici
    
• Quercetin 2,3-dioxygenase (QDO) or pirin
  • 4ewa, 4gul – hQDO + Fe+3
    
  • 1j1l – hQDO + Fe+2
    
  • 4ero – hQDO + Co
    
  • 4ewd, 4ewe – hQDO + Mn
    
  • 4hlt – hQDO (mutant) + Fe+2
    
  • 5jct, 6h1h, 6h1i, 6n0j, 6n0k – hQDO + Fe+3 + inhibitor
    
  • 3acl – hQDO + Fe+2 + inhibitor
    
  • 1juh – AjQDO + Cu+2 – Aspergillus japonicus
    
  • 2h0v – BsQDO + Fe+3 – Bacillus subtilis
    
  • 8hfb – BsQDO (mutant) + Ni+2
    
  • 1gqg, 1gqh – AjQDO + Cu+2 + inhibitor
    
  • 1h1i – AjQDO + Cu+2 + quercetin
    
  • 1h1m – AjQDO + Cu+2 + kaempferol
    
  • 6d0g, 6d0p – QDO + Mn+2 – Acinetobacter baumannii
    
  • 6uts – EcQDO + Ni+2
    
• Taurine/α-ketoglutarate dioxygenase (TauD)
  • 1gqw, 1gy9, 1os7 – EcTauD + Fe+2 + taurine + oxoglutarate
    
  • 6edh – EcTauD + VO+2 + taurine + succinate
    
  • 1otj – EcTauD + taurine
    
  • 3pvj, 3v15 – PpTauD
    
  • 3v17 – PpTauD + oxoglutarate
    
  • 3r1j – HAD + Fe+3 – Mycobacterium avium
    
  • 4j5i – HAD + Fe+3 – Mycobacterium smegmatis
    
  • 3swt – HAD + Fe+3 – Mycobacterium marinum
    
  • 6l86 – HAD + Fe+3 + malate – Streptomyces thioluteus
    
  • 5keu – BxHAD + Mg+2
    
  • 5vn6 – BaHAD + Mg+2
    
• 3-hydroxyanthranilate 3,4-dioxygenase (HAD)
  • 2qnk – hHAD + Ni+2
    
  • 5tkq – hHAD + Zn+2
    
  • 5tk5 – hHAD + Fe+3
    
  • 3fe5 – HAD + Fe+3 - bovine
    
  • 1zvf – HAD + Ni+2 - yeast
    
  • 5v28, 4r52, 6vi5 – CmHAD + Fe+2 – Cupriavidus metallidurans
    
  • 5v27, 5v26, 6d60, 6bvr, 6bvp – CmHAD (mutant) + Fe+2
    
  • 1yfu, 4hvq, 4hvr, 4i3p, 4l2n – CmHAD + Fe+3
    
  • 4hvo – CmHAD + Fe+3 + Cu+2
    
  • 1yfw – CmHAD + Fe+3 + O2 + hydroxyanthranilate
    
  • 1yfx – CmHAD + Fe+3 + NO + hydroxyanthranilate
    
  • 4hsj – CmHAD + Fe+2 + picolinic acid
    
  • 4hsl, 6vi7 – CmHAD + Fe+2 + hydroxyanthranilate
    
  • 1yfy – CmHAD + Fe+3 + hydroxyanthranilate
    
  • 6d62, 6d61, 6cd3, 6bvs, 6bvq – CmHAD (mutant) + Fe+2 + hydroxyanthranilate derivative
    
  • 6vi6, 6vi8, 6vi9, 6vib, 6x11 – CmHAD + Fe+2 + inhibitor
    
  • 6via – CmHAD + Fe+2 + Fe+3 + OH + dihydroxepine derivative
    
  • 4wzc – HAD + Fe+2 + enedioate derivative – Ralstonia metallidurans
    
• Carbazole 1,9a-dioxygenase (CDO); Domains – ferredoxin 1-115; terminal oxygenase 1-384
  • 1vck – CDO ferredoxin component + Fe+3 + Fe2S2 – Pseudomonas resinovorans
    
  • 2de5, 2de6, 6llf, 6llh – JaCDO ferredoxin and terminal oxygenase components + Fe+3 + Fe2S2 – Janthinobacterium
    
  • 2de7, 3vmg – JaCDO ferredoxin and terminal oxygenase components + Fe+3 + Fe2S2 + carbazole
    
  • 7c3b – JaCDO ferredoxin reductase component + Ni + Fe2S2
    
  • 7c3a – JaCDO ferredoxin reductase component + Ni + Fe2S2 + FAD
    
  • 1ww9, 6llk, 7bug – JaCDO terminal oxygenase component + Fe+2 + Fe2S2
    
  • 6ll1 – JaCDO terminal oxygenase component + O2 + Fe2S2
    
  • 6ll0, 6ll4 – JaCDO terminal oxygenase component + Fe+2 + Fe2S2 + carbazole derivative
    
  • 7bui – JaCDO ferredoxin and terminal oxygenase components + Fe+3 + Fe2S2
    
  • 3vmh – JaCDO ferredoxin and terminal oxygenase components + Fe+3 + Fe2S2 + O2
    
  • 4nb8, 4nb9, 4nba, 4nbb, 4nbc, 4nbd, 4nbe, 4nbf, 4nbg, 4nbh – JaCDO ferredoxin and terminal oxygenase components (mutant) + Fe+2 + Fe2S2
    
  • 3vmi – JaCDO ferredoxin and terminal oxygenase components + Fe+3 + Fe2S2 + carbazole + O2
    
  • 3gcf – CDO terminal oxygenase component + Fe+2 + Fe2S2 – Nocardioides aromaticivorans
    
  • 3gce – NaCDO ferredoxin component + Fe+2 + Fe2S2
    
  • 3gkq –Na SpCDO terminal oxygenase component + Fe+2 + Fe2S2
    
• Homogentisate 1,2-dioxygenase (HGDO)
  • 1ey2 – hHGDO + Fe+2
    
  • 1eyb – hHGDO
    
  • 4aq2 – PpHGDO + Fe+3
    
  • 4aq6 – PpHGDO + Fe+3 + substrate
    
  • 3zds – PpHGDO + Fe+3 + O2
    
• Hydroxyethylphosphonate dioxygenase (PHPD)
  • 4yar, 3g7d – SvPHPD + Cd+2 – Streptomyces viridochromogenes
    
  • 3rzz – SvPHPD (mutant) + Cd+2
    
  • 3gbf – SvPHPD + Cd+2 + hydroxyethylphosphonate
    
  • 6b9r – PHPD + Fe+3 + hydroxyethylphosphonate - Streptomyces albus
    
• Gallate dioxygenase (GD)
  • 3wrc – SpGD + Fe+2 + dehydroxybenzoate
    
  • 3wku, 3wpm, 3wr4 – SpGD + Fe+3 + gallate
    
  • 3wr3, 3wr9 – SpGD + Fe+2 + gallate
    
  • 3wrb – SpGD (mutant) + Fe+2 + gallate
    
  • 3wr8, 3wra – SpGD + Fe+2
    
• Glyoxalase/bleomycin resistant protein/dioxygenase (GBD)
  • 2rbb – GBD – Burkholderia phytofirmans
    
  • 2rk9 – GBD – Vibrio splendidus
    
  • 3b59 – GBD – Novosphingobium aromaticivorans
    
  • 3kol – GBD – Nostoc punctiforme
    
  • 3rri – GBD – Alicyclobacillus acidocaldarius
    
  • 3vb0 – GBD – Sphingomonas wittichii
    
  • 3vcx – GBD – Pseudomonas palustris
    
  • 4g6x – CaGBD – Catenulispora acidiphila
    
  • 4n04 – CaGBD (mutant)
    
  • 4gym – GBD – Conexibacter woesei
    
  • 4hc5 – GBD – Sphaerobacter thermophilus
    
  • 4mym – GBD – Nocardioides
    
  • 4qb5 – GBD – Albidiferax ferrireducens
    
  • 4rt5 – GBD – Planctomyces limnophilus
    
  • 2np9, 5ump, 5umq – StGBD – Streptomyces
    
  • 5uhj, 5ujp – GBD + Ni+2
    
  • 6bbx – StGBD + inhibitor
    
  • 5umw, 5umx, 5umw – StGBD + riboflavin
    
  • 5umy, 5w27 – StGBD + antibiotics
    
  • 5c4p, 5c68, 5cb9 – TcGBD + Ni+2 – Thermomonospora curvata
    
  • 5c6x – TcGBD + Co+2
    
  • 5v0f – TcGBD + Fe+3 + roxasone
    
  • 4z04 – GBD + Zn+2 + glutathione – Brucella abortus
    
  • 6a4x – GBD + Fe+2 – Streptomyces curacoi
    
• Procollagen-proline dioxygenase (PPD)
  • 5iat – BaPDD – Bacillus anthracis
    
  • 5iax – BaPDD + Co+2 + oxoglutarate
    
  • 5v7y – BaPDD + Co+2 + oxoglutarate + imidazole
    
  • 5iav – BaPDD + Co+2 + malonate
    
• 1,2-dihydroxy-3-keto-methylthiopentene dioxygenase (KMTPD) or acereductone dioxygenase
  • 7jxg – hKMTPD + Fe+2
    
  • 4qgn – hKMTPD + Fe+3
    
  • 5i8s – mKMTPD + Ni+2 + pentanoate + valerate
    
  • 5i8t – mKMTPD + Ni+2 + lactate
    
  • 5i8y – mKMTPD + Co+2 + keto-methylthio-butyrate
    
  • 5i91 – mKMTPD + Ni+2 + keto-methylthio-butyrate
    
  • 5i93 – mKMTPD + Ni+2 + keto-pentanoate
    
  • 4qgl, 4qgm – BaKMTPD + Cd+2
    
• Indoleamine 2,3-dioxygenase 1 (IDO)
  • 6azu, 7a62 – hIDO 1 + heme
    
  • 6e45, 6e44, 7a62 – hIDO 1 (mutant) + heme
    
  • 2d0t, 5ek2, 5ek3, 5ek4, 4pk5, 4pk6, 5xe1, 5wn8, 7ah4, 7ah5, 7ah6, 8u5i – hIDO 1 + heme + imidazole derivative
    
  • 4u72, 4u74, 6e42, 6e41, 6e40 – hIDO 1 (mutant) + heme + imidazole derivative
    
  • 7yxt – hIDO 1 (mutant) + heme + O2
    
  • 6f0a – hIDO 1 + heme + imidazole derivative + Ala
    
  • 6azw, 6azv, 6v52, 6wjy, 6wpe, 6x5y, [[[8i7l|8i7l]], [8fur]], 9ese, 9esg, 9etv, 9ew0, 9ezj – hIDO 1 + inhibitor
    
  • 6e43 – hIDO 1 (mutant) + inhibitor
    
  • 5etw, 6mq6, 6dpr, 6dpq, 6kof, 6kps, 6kw7, 6o3i, 6pu7, 6pz1, 6r63, 7e0o, 7e0p, 7e0q, 7e0s, 7e0t, 7e0u, 7m63, 7m7d, 7rrb, 7rrc, 7rrd, 7zv3, 8abx – hIDO 1 + heme + inhibitor
    
  • 6ubp – hIDO 1 + heme + CO + Trp
    
  • 5wmu, 6e35 – hIDO 1 + heme + CN + Trp
    
  • 5wmw, 6cxv, 6cxu – hIDO 1 (mutant) + heme + CN + Trp
    
  • 7z2l – hIDO 1 (mutant) + heme + kynurenine + O2
    
  • 7nge, 7p0n, 7p0r – hIDO 1 (mutant) + heme + kynurenine + Trp
    
  • 5wmv – hIDO 1 + heme + CN + indole derivative + Trp
    
  • 5wmx – hIDO 1 (mutant) + heme + CN + indole derivative + Trp
    
  • 5whr – hIDO 1 + heme + pyrrolydine derivative
    
  • 6e46 – hIDO 1 + heme + Trp
    
  • 9esd, 9esf – DmIDO + inhibitor
    
• Thymine dioxygenase (TD)
  • 5c3o – NcTD – Neurospora crassa
    
  • 5c3p – NcTD + oxoglutarate + Ni+2
    
  • 5c3q – NcTD + oxoglutarate + Ni+2 + thymine
    
  • 5c3s – NcTD + oxoglutarate + Ni+2 + pyrimidine derivative
    
  • 5c3r – NcTD + oxoglutarate + Ni+2 + pyrimidine derivative + uracil derivative
    
  • 2xse, 8bbm – TD DBD – Leishmania tarentulae
    
• 2,4’-dihydroxyacetophenone dioxygenase (APD)
  • 5bpx, 4p9g – APD + Fe+3 – Alcaligenes
    
• Thiol dioxygenase (ThD)
  • 4tlf – PaThD + Fe+2 – Pseudomonas aeruginosa
    
  • 4wvz – PaThD (mutant) + Fe+2
    
• FT_T dioxygenase (FTTD)
  • 6d3j – ShFTTD + Co+2 + oxoglutarate – Sphingobium herbicidovorans
    
  • 6d3m – ShFTTD + Co+2 + oxoglutarate + quinoxalin
    
  • 6d3i, 6d3h – ShFTTD + Co+2 + oxoglutarate + phenoxy derivative
    
• Ring-cleavage dioxygenase (RCD)
  • 5vg2 – RCD + Fe+3 – spider mite
    
  • 5hl4 – SmRCD + Fe+3 + Fe2S2 – Sinorhizobium melioli
    
  • 3vcp – SmRCD + Fe+3 + Fe2S2 + Pro
    
  • 6xma – SphRCD + Fe+3 - Sphingomonas
    
  • 2ckf – SphRCD + Fe+3 + Fe2S2
    
  • 8t1t, 9chk – SoRCD + SAM + TP-methylase – Shewanella oneidensis
    
  • 9ch0, 9ch1, 9ch2, 9ch3, 9ch5, 9ch7 – SoRCD + SAH + TP-methylase
    
  • 9cgw – SoRCD (mutant) + Zn+2 + TP-methylase
    
• L-dopa dioxygenase (LDD)
  • 6on1 – SsLDD + Fe+3 – Streptomyces sclerotialus
    
  • 6on3 – SsLDD + Fe+3 + Phe derivative
    
• Kanamycin B dioxygenase (KBD)
  • 6s0r, 6s0t, 7cl2 – SkKBD + Ni+2 – Streptomyces kanamyceticus
    
  • 6s0v – SkKBD + Ni+2 + neamine
    
  • 6s0w, 7cl3 – SkKBD + Ni+2 + kanamycin
    
  • 6s0u – SkKBD + Ni+2 + oxoglutarate
    
  • 6s0s – SkKBD + Ni+2 + ribostamycin + oxoglutarate
    
  • 7cl4 – SkKBD + Ni+2 + oxalylglycine
    
  • 7cl5 – SkKBD + Ni+2 + oxalylglycine + kanamycin
    
  • 7cl6 – SkKBD + Ni+2 + oxalylglycine + neamine
    
• Phytanoyl-CoA dioxygenase or trans-3/4-proline-hydroxylase H11
  • 2opw – hPhyH
    
  • 2a1x – hPhyH + Fe+2 + oxoglutarate
    
  • 7e05, 8h7t – ubPhyH – uncultured bacteria
    
  • 7dzz, 8h81, 8h85 – ubPhyH + Pro
    
  • 8h7v – ubPhyH + Akg
    
  • 8h7y – ubPhyH + Akg + Pro
    
  • 7e06 – ubPhyH + Fe+3 + oxoglutarate
    
  • 7e01, 7e08, 7e09 – ubPhyH + Pro derivative
    
  • 7e00 – ubPhyH + oxoglutarate + Pro
    
  • 7e07 – ubPhyH + Fe+3 + oxoglutarate + Pro
    
  • 7dt0 – ubPhyH (mutant) + Fe+3 + oxoglutarate + Pro derivative
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman