Pre-mRNA splicing factors 3D structures

3D Structures of pre-mRNA splicing factors

Updated on 09-July-2026

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• Pre-mRNA-splicing factor 2
  • 3beg – hPrp P33 subunit + Ser/Thr-protein kinase – human
    
  • 2o3d – hPrp P33 subunit
    
  • 7dcq – yPrp – yeast – Cryo EM
    
  • 7dcr – yPrp + Prp spp2 – Cryo EM
    
  • 7dd3 – yPrp + Prp spp2 + RNA – Cryo EM
    
  • 7dcp – yPrp + Prp spp2 + ADP – Cryo EM
    
• Pre-mRNA-splicing factor 3
  • 1x4q – hPrp PWI domain - NMR
    
  • 4yhu, 4yhv – yPrp C-terminal
    
  • 4yhw – yPrp C-terminal + snRNA
    
• Pre-mRNA-splicing factor 3B
  • 3lqv, 2f9d, 2f9j – hPrp residues 377-415 + pre-mRNA branch site protein 14
    
  • 2fho - hPrp residues 379-424 + spliceosomal protein P14 - NMR
    
  • 2do5 – hPrp subunit 2 – NMR
    
  • 1x5t - hPrp subunit 4 – NMR
    
  • 5gvq - hPrp subunit 4 RNA-binding domain – NMR
    
  • 6en4 - hPrp subunits 1,3,5 + SF3B14B
    
  • 5ife - hPrp subunits 1,3,5 + PHD finger-like protein 5A
    
  • 5zya - hPrp subunits 1,3,5 + PHD finger-like protein 5A + splicing modulator
    
• Pre-mRNA-splicing factor 8
  • 3e9l, 3enb, 3lru – hPrp endonuclease domain 1769-1990
    
  • 6s8q, 6s9i – hPrp residues 2064-2320 + U5 small nuclear ribonudleoprotein
    
  • 2p8r – CePrp C terminal (mutant) – Caenorhabditis elegans
    
  • 2p87 – CePrp C terminal
    
  • 6nqi – Prp RH domain – red alga
    
  • 9dtr – yPrp in spliceosome – Cryo EM
    
  • 6teo – yPrp residues 315-555 + yPro SNU114
    
  • 3sbt, 4ilh – yPrp RNAse H like domain 1835-2096 + A1 cistron-splicing factor AAR2
    
  • 4jk7, 4jk9, 3e9o, 3e9p, 3e66 - yPrp RNAse H like domain
    
  • 4ilj, 4jk8, 4jka, 4jkb, 4jkc, 4jkd, 4jke, 4jkf, 4jkg, 4jkh - yPrp RNAse H like domain (mutant)
    
  • 5qy1, 5qy2, 5qy3, 5qy4, 5qy5, 5qy6, 5qy7, 5qy8, 5qy9, 5qya, 5qyb, 5qyc, 5qyd, 5qye, 5qyf, 5qyg, 5qyh, 5qyi, 5qyj, 5qyk, 5qyl, 5qyn, 5qyo, 5qyp, 5qyq, 5qyr, 5qys, 5qyt, 5qyu, 5qyy, 5qyw, 5qyx, 5qyz, 5qz0, 5qz1, 5qz2, 5qz3, 5qz4, 5qz5, 5qz6, 5qz7, 5qz8, 5qz9, 5qza, 5qzb, 5qzc, 5qzd, 5qze, 5qzf, 5qzg, 5qzi, 5qzj, 5qzk, 5qzl, 5qzm, 5qzn, 5qzo, 5qzp, 5qzq, 5qzr, 5qzs, 5qzt, 5qzu, 5qzv, 5qzw, 5qzx, 5qzy, 5qzz, 5r00, 5r01, 5r03, 5r04, 5r05, 5r065r07, 5r08, 5r09, 5r0a, 5r0b, 5r0c, 5r0d, 5r0e, 5r0f, 5r0g, 5r0h, 5r0i, 5r0j, 5r0k, 5r0l, 5r0m, 5r0n, 5r0o, 5r0p, 5r0q, 5r0r, 5r0s, [[[5r0t|5r0t]], 5r0u, 5r0x, 5r0y, 5r0z, 5r10, 5r11, 5r12, 5r13, 5r14, 5r15, 5r16, 5r17, 5r18, 5r19, 5r1a, 5r1b, 5r1c, 5r1d, 5r1e, 5r1f, 5r1g, 5r1h, 5r1i, 5r1j, 5r1l, 5r1k, 5r1m, 5r1n, 5r1p, 5r1q, 5r1s, 5st0, 5st1, 5st2, 5st3, 5st4, 5st5, 5st6, 5st7, 5st8, 5st9, 5sta, 5stb, 5stc, 5ste, 5stf, 5stg, 5sth, 5sti, 5stj, 5stk, 5stl, 5stm, 5stn, 5sto, 5stp, 5stq, 5str, 5sts, 5stt, 5stu, 5stv, 5stw, 5stx, 5sty, 6stz, 5su0, 5su1, 5su2, 5su3, 5su4, 5su5, 5su6, 5su7, 5su8, 5su9, 5sua, 5sub, 5suc, 5sud, 5sue, 5suf, 5sug, 7fju, 7fjv, 7fjw, 7fjx, 7fjy, 7fjz, 7fk0, 7fk1, 7fk2, 7fk3, 7fk4, 7fk5,7fk6, 7fk7, 7fk8, 7fk9, 7fka, 7fkb, 7fkc, 7fkd, 7fke, 7fkf, 7fkg, 7fkh, 7fki,7fkj, 7fkk, 7fkl, 7fkm, 7fkn, 7fko, 7fkp, 7fkq, 7fkr, 7fks, 7fkt, 7fku, 7fkv, 7fkw, 7fkx, 7fky, 7fkz, 7fl0, 7fl1, 7fl2, 7fl3, 7fl4, 7fl5, 7fl6, 7fl7, 7fl8, 7fl9, 7fla, 7flb, 7fld, 7fle, 7flf, 7flg, 7flh, 7fli, 7flj, 7flk, 7fll, 7flm, 7fln, 7flo, 7flp, 7flq, 7flr, 7fls, 7flt, 7flu, 7flv, 7flw, 7flx, 7fly, 7flz, 7fm0, 7fm1, 7fm2, 7fm3, 7fm4, 7fm5, 7fm6, 7fm7, 7fm8, 7fm9, 7fma, 7fmb, 7fmc, 7fmd, 7fme, 7fmf, 7fmg, 7fmh, 7fmi, 7fmk, 7fml, 7fmm, 7fmn, 7fmo, 7fmp, 7fmq, 7fmr, 7fms, 7fmt, 7fmu, 7fmv, 7fmw, 7fmx, 7fmy, 7fmz, 7fn0, 7fn1, 7fn2, 7fn3, 7fn4, 7fn5, 7fn6, 7fn7, 7fn8, 7fn9, 7fna, 7fnb, 7fnc, 7fnd, 7fne, 7fnf, 7fng, 7fnh, 7fni, 7fnj, 7fnk, 7fnl, 7fnm, 7fnn, 7fno, 7fnp, 7fnq, 7fnr, 7fns, 7fnt, 7fnu, 7fnv, 7fnw, 7fnx, 7fny, 7fnz, 7fo0, 7fo1, 7fo2, 7fo3, 7fo4, 7fo5, 7fo6, 7fo7, 7fo9, 7foa, 7fob, 7foc, 7fod, 7foe, 7fof, 7fog, 7foh, 7foi, 7foj, 7fok, 7fol, 7fom, 7fon, 7foo, 7fop, 7foq, 7for, 7fos, 7fot, 7fou, 7fov, 7fow, 7fox, 7foy, 7foz, 7fp0, 7fp1, 7fp2, 7fp3, [[[7fp4|7fp4]], 7fp5, 7fp6, 7fp7, 7fp8, 7fp9, 7fpa, 7fpb, 7fpc, 7fpd, 7fpe, 7fpf, 7fpg, 7fph, 7fpi, 7fpj, 7fpk – yPrp H-like domain + A1 cistron-splicing factor AAR2
    885-2413
  • 3zef, 4i43 885-2413 – yPrp + A1 cistron-splicing factor AAR2
    
  • 2og4 - yPrp Jab1/MPN domain 2147-2397
    
  • 4bgd, 5dca, 5m52, 5m5p – yPrp Jab1/MPN domain + pre-mRNA-splicing helicase BRR2
    
  • 3sbg - yPrp C-terminal domain 1836-2397
    
  • 4kit – yPrp Jab1/MPN domain + U5 small nuclear ribonucleoprotein helicase
    
  • 4ilg – yPrp Jab1/MPN+RNA-binding domains + A1 cistron-splicing factor AAR2
    
  • 6mwy, 6myl – Prp – Cryptococcus gattii
    
  • 6mx6 – Prp – Cryptococcus neoformans
    
• Pre-mRNA-splicing factor 9
  • 4dgw – yPrp + Prp 21 + Prp 11
• Pre-mRNA-splicing factor 11
  • 4dgw – yPrp + Prp 21 + Prp 9
• Pre-mRNA-splicing factor 18
  • 2dk4 – hPrp splicing factor motif domain - NMR
    
  • 1dvk – yPrp functional domain
    
• Pre-mRNA-splicing factor 19
  • 8ro2 – hPrp in spliceosome – Cryo EM
    
  • 3lrv – yPrp WD40 domain
    
  • 2bay – yPrp U-box
    
  • 1n87 - yPrp U-box - NMR
    
  • 8xi2 – Prp in spliceosome – Chlamydomonas reinhardtii - Cryo EM
    
  • 9l5r, 9l5s, 9l5t – Prp in spliceosome – Thermochaetoides thermophila - Cryo EM
    
• Pre-mRNA-splicing factor 20
  • 2i38 - hPrp RNA-binding domain (mutant) – NMR
    
  • 2i2y – Prp RNA-binding domain + RNA – Streptococcus – NMR
    
• Pre-mRNA-splicing factor 21
  • 4dgw – yPrp + Prp 9 + Prp 11
• snRNA-associated-splicing factor 24
  • 2l9w – yPrp C terminal – NMR
    
  • 2kh9 – yPrp residues 115-197 + RNA – NMR
    
  • 2go9 – yPrp RNA-binding domains – NMR
    
  • 2ghp - yPrp RNA-binding domains
• Pre-mRNA-splicing factor 31
  • 2ozb – hPrp + RNA + tri-snRNP
    
  • 3siu, 3siv – hPrp + NHP2-like protein + snRNP
    
• Pre-mRNA-splicing factor 38A
  • 4rz9, 4rza – hPrp
    
  • 5f5s – hPrp + microfibrillar-associated protein 1
    
  • 8h6k, 8h6l, 8qo9, 8qpe, 8y7e, 9k1r, 9r3d – hPrp in spliceosome – Cryo EM
    
• Pre-mRNA-splicing factor 40
  • 1o6w – yPrp WW domain - NMR
    
  • 2b7e – yPrp FF1 domain - NMR
    
  • 2kfd – yPrp FF4 domain - NMR
    
• Pre-mRNA-splicing factor 43P or Pre-mRNA-splicing factor ATP-dependent RNA helicase Prp43
  • 8rdy – hPrp+ Pxr1 – Cryo EM
    
  • 2xau, 3kx2 – yPrp + ADP
    
  • 5jpt – yPrp + CDP
    
  • 5i8q – yPrp + ADPNP + RNA
    
  • 5d0u, 5ltj, 5ltk – TtPrp + ADP – Thermochaetoides thermophila
    
  • 5lta – TtPrp + ADP + RNA
    
• Pre-mRNA-splicing factors in spliceosome or C* complex
  • 3jcr, 5o9z, 5xjc, 5yzg, 5z56, 5z57, 5z58, 6ah0, 6ahd, 6ff4, 6ff7, 6icz, 6id0, 6id1, 6qdv, 6qw6, 6qx9, 6y50, 6y53, 6y5q, 6zym, 7a5p, 7aav, 7abf, 7abg, 7abh, 7abi, 7dvq, 7evo, 7onb, 7q4o, 7q4p, 7qtt, 7vpx, 7w59, 7w5a, 7w5b, 8c6j, 8ch6, 8hk1 – hPrp - CryoEM
    
  • 3jb9 – yPrp
    
  • 3jcm, 5gam, 5gan, 5gao, 5gap, 5gm6, 5gmk, 5lj3, 5lj5, 5lqw, 5mps, 5mq0, 5mqf, 5nrl, 5wsg, 6g90, 6exn, 6bk8, 5ylz, 5y88, 6j6q, 6j6n, 6j6h, 6j6g, 5zwo, 7b9v, 7dco, 7oqb, 7oqe – yPrp - CryoEM
    
• Pre-mRNA-splicing factor cwc2
  • 3tp2, 3u1l, 3u1m – yPrp
    
• Pre-mRNA-splicing factor cwc22
  • 6yvh – hPrp + cwc27 + EIF-4A
    
  • 4c9b – yPrp 116-406 + EIF-4A
    
  • 9fmd – yPrp in spliceosome – Cryo EM
    
• Pre-mRNA-splicing factor cwc26
  • 2my2 – yPrp 215-255 + U2 SNRNP component IST3 - NMR
    
  • 2mkc – yPrp + U2 SNRNP component IST3 + Pre-mRNA leakage protein
    
  • 4uqt – yPrp + U2 SNRNP component IST3
    
• Pre-mRNA-splicing factor cwf
  • 9esh, 9esi – Prp in spliceosome – fission yeast – Cryo EM
    
• Pre-mRNA-splicing factor bud31
  • 2my1 – yPrp - NMR
    
• Pre-mRNA-splicing factor cef1
  • 6jui – Prp – rice fungus
    
• Pre-mRNA-splicing factor sad1
  • 4msx – yPrp
    
• Pre-mRNA-splicing factor RBM22
  • 8i0p, 8i0r, 8i0s, 8i0t, 8i0u, 8i0v, 8i0w, 8ro0, 8ro1 – hPrp in spliceosome – Cryo EM
    
  • 2ytc – yPrp RNA-binding domain - NMR
    
• Pre-mRNA-splicing factor RDS3
  • 2k0a – yPrp - NMR
    
• Pre-mRNA-splicing factor URN1
  • 2juc – yPrp FF domain - NMR
    

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Michal Harel