Protein phosphatase 3D structures

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3D Structures of protein phosphatase

Updated on 09-August-2026 {{#tree:id=OrganizedByTopic|openlevels=0|

  • Protein phosphatase 1 regulatory subunit
    • 5zqv - hPP1 regulatory subunit 3A + PP1A - human
    • 6dno - hPP1 regulatory subunit 3A + PP1A + microcystin-LR
    • 2mb3 - raPP1 regulatory subunit 3A CBD 102-237 - rabbit
    • 2eef - hPP1 regulatory subunit 3B CBM domain 8-156 – NMR
    • 5zt0 - hPP1 regulatory subunit 3B 31-105 + PP1A
    • 7qf7, 7qfa - hPP1 regulatory subunit 3C CBM21 domain 132-264 (mutant) + cyclodextrin
    • 6hkw, 6mky - hPP1 regulatory subunit 7
    • 6obn, 6obp - hPP1 regulatory subunit 7 + PP1-A
    • 6zv2 – hPP1A regulatory subunit 10 N-terminal - NMR
    • 2kjy, 5huz - hPP1 regulatory subunit 12A - NMR
    • 4xpn - hPP1 regulatory subunit 15A + PP1A
    • 7nxv – hPP1A regulatory subunit 15A + actin + DNase I
    • 9hvf – hPP1A regulatory subunit 15B + EIF2 + EIF2B – Cryo EM
    • 2rlt - PP1 regulatory subunit 14A - pig - NMR
    • 6vti - rPP1 regulatory subunit 1G N-terminal - rat - NMR
    • 9ci7 - rPP1 regulatory subunit 10 (mutant) + Tox4
    • 7lqt - rPP1 regulatory subunit 10/Myc homology box - NMR
    • 4v0u - mPP1 regulatory subunit 15B + PP1G + actin + ATP - mouse
    • 7nd2 – hPP1A regulatory subunit 21 in Ferry complex – Cryo EM
    • 8b5r – hPP1A regulatory subunit 22 in p97-p37-SPI complex – Cryo EM
    • 8iyj – mPP1A regulatory subunit 32 in sperm flagellar microtubule complex – Cryo EM
    • 8otz – bPP1A regulatory subunit 32 in sperm flagellar microtubule complex – Cryo EM
  • Protein phosphatase 1 regulatory subunit 9A or neurabin-1
    • 1wf8 - hPP1 regulatory subunit 9A PDZ domain 144-237 - NMR
    • 9gsu - hPP1 regulatory subunit 9A 423-593 + PP - NMR
    • 2fn5 - rPP1 regulatory subunit 9A PDZ domain 502-594 - NMR
    • 2gle - rPP1 regulatory subunit 9A SAM domain 986-1056 - NMR
  • Protein phosphatase 1 regulatory subunit 9B or neurabin-2 or spinophilin
    • 2g5m - rPP1 regulatory subunit 9B PDZ domain 493-602 - NMR
  • Protein phosphatase 1A catalytic subunit 1-330


    • 2bdx, 6obq, 6obr, 6obu – hPP1A catalytic subunit + microcystin
    • 5ioh – hPP1A catalytic subunit + cell division cycle-associated protein
    • 3hvq – hPP1A catalytic subunit + neurabin
    • 3egg – hPP1A catalytic subunit + spinophilin
    • 3egh – hPP1A catalytic subunit + spinophilin + nodularin
    • 1u32 – hPP1A catalytic subunit + okadaic acid
    • 3e7b – hPP1A catalytic subunit + tautomycin
    • 6czo – hPP1A catalytic subunit + CASC5 protein
    • 6ghm – hPP1A catalytic subunit + ASPP2
    • 6dcx – hPP1A catalytic subunit + RelA-associated inhibitor
    • 6zee, 6zef, 6zeg, 6zei, [[6zej] – hPP1A catalytic subunit + Phactr1
    • 6b67 – hPP1A (mutant) + cyclic peptide
    • 7t0y – hPP1A (mutant) + RRP1 peptide
    • 6alz – hPP1A catalytic subunit + inhibitor + Mn
    • 8dwk, 8dwl – hPP1A catalytic subunit + E3 ubiquitin-protein ligase + Mn
    • 7sd0, 7upi, 9o65 - hPP1A catalytic subunit + SHOC-2 + MRAS + Mn – Cryo EM
    • 7tvf, 7txh - hPP1A catalytic subunit + SHOC-2 + MRAS + Mn
    • 9nb9 - hPP1A catalytic subunit (mutant) + DP7IL + actin + DNAse I – Cryo EM
  • Protein phosphatase 1A catalytic+regulatory subunits
    • 5zqv – hPP1A catalytic subunit + regulatory subunit 3A
    • 7qm2 – hPP1A catalytic subunit (mutant) + regulatory subunit 3C (mutant)
    • 4moy, 4mp0 – hPP1A catalytic subunit + regulatory subunit 10
    • 4xpn – hPP1A catalytic subunit + regulatory subunit 15A
    • 6obn, 6obp – hPP1A catalytic subunit + regulatory subunit 7
    • 6dno – hPP1A catalytic subunit + regulatory subunit 3A + microcystin
    • 7qfb – hPP1A catalytic subunit + regulatory subunit 3C peptide
    • 7nzm – hPP1A catalytic subunit + regulatory subunit 15A + EIF-2A + actin – Cryo EM
  • Protein phosphatase 1B or PP! beta
    • 1s70 - hPP1B catalytic subunit + MYPT1
  • Protein phosphatase 1D
    • 8t2j - hPP1D catalytic subunit (mutant)
  • Protein phosphatase 1G or PP! gamma
    • 4ut2, 4ut3 - hPP1G catalytic subunit
    • 5inb, 5j28 - hPP1G catalytic subunit + peptide
    • 1it6 - hPP1G catalytic subunit + inhibitor
    • 2bcd - hPP1G catalytic subunit + peptide inhibitor
    • 1jk7 – hPP1G catalytic subunit + okadaic acid
    • 9ijj – mPP1G catalytic subunit in axoneme
    • 4v0v, 4v0w, 4v0x - mPP1G catalytic subunit + hPP1 regulatory subunit 15B peptide
    • 4v0u – mPP1G catalytic subunit + regulatory subunit 15B + actin + Mn + ATP
  • Protein phosphatase 1H
  • Protein phosphatase 1K
    • 4da1 - hPP1K + Mn
    • 6ak7 – hPP1K (mutant) + Mg
  • Protein phosphatase 2A regulatory subunits or serine/threonine-protein phosphatase 2A regulatory subunits
    • 4i5j, 4i5k, 4mew – hPP2A b” regulatory subunit
    • 2g62, 2ixm – hPP2A b’ regulatory subunit
    • 2hv6 – hPP2A b regulatory subunit
    • 2hv7 – hPP2A b regulatory subunit + ADP
    • 2jak – hPP2A 56 regulatory subunit
    • 1b3u – hPP2A 65 regulatory subunit
    • 5jja, 5k6s, 5swf – hPP2A 56 regulatory subunit + BUBR1
    • 5sw9 – hPP2A 56 regulatory subunit + RepoMan
    • 6toq – hPP2A 56 regulatory subunit + pol protein
    • 6voy – hPP2A 56 regulatory subunit + DNA-binding protein DNA - Cryo EM
    • 6oyl – hPP2A 56 regulatory subunit + KIF4A
    • 6vro – hPP2A 56 regulatory subunit + AIM1
    • 9gnj – hPP2A 56 regulatory subunit + BRCA2
    • 7ouf, 7oug, 7ouh, 7pel – hPP2A 56 regulatory subunit in virus intasome + drug – Cryo EM
    • 8szk – hPP2A 56 regulatory subunit + elongin B,C + CBFB – Cryo EM
    • 2pf4, 2pkg – hPP2A 65 regulatory subunit + small T antigen
    • 6ef4 – mPP2A regulatory subunit (mutant) - mouse
    • 5w0w – mPP2A + TIPRL
    • 7xvk – AtPP2A 65 regulatory subunit + PSR2 - Arabidopsis thaliana
  • Protein phosphatase 2A catalytic subunit
    • 4lac – hPP2A catalytic subunit + activator + PP2A scaffold subunit
    • 9o04 – hPP2A catalytic subunit in degradosome complex – Cryo EM
    • 9o0l – hPP2A catalytic subunit + CCDC6 – Cryo EM
    • 3p71 – hPP2A catalytic + LCMT-1
    • 4iyp – hPP2A catalytic subunit + immunoglobin-binding protein
  • Protein phosphatase 2A regulatory subunits + catalytic subunit
    • 7k36 – hPP2A 65 regulatory subunit + catalytic subunit in STRIPAK complex – Cryo EM
    • 7ycx – hPP2A 65 regulatory subunit + catalytic subunit in integrator-PEC complex – Cryo EM
    • 9vd9 – hPP2A 65 regulatory subunit + catalytic subunit in dss1-integrator-PEC complex – Cryo EM
    • 8rbx – hPP2A 65 regulatory subunit + catalytic subunit in RNA polymerase-nucleosome complex – Cryo EM
    • 8rbz – hPP2A 65 regulatory subunit + catalytic subunit in integrator-SOSS complex – Cryo EM
    • 8rc4, 8yjb – hPP2A 65 regulatory subunit + catalytic subunit in integrator-DSS1 complex – Cryo EM
    • 7soy – hPP2A catalytic subunit + regulatory subunits 56,65 + PME-1 – Cryo EM
    • 8uwb, 9mf5, 9mip, 9mzw – hPP2A catalytic subunit + regulatory subunits 56,65 – Cryo EM
    • 8u1x, 8u89 – hPP2A catalytic subunit + regulatory subunits 56 (mutant),65 – Cryo EM
    • 2ie3, 2ie4, 2npp, 2nyl, 2nym – hPP2A catalytic + regulatory 56 subunit + tumor-inducing toxin
    • 3c5w – hPP2A catalytic + regulatory subunit + PP2A-specific methyltransferase
    • 6nts – hPP2A catalytic + regulatory subunits 56,65 + activator – Cryo EM
    • 9c7t, 9n0y – hPP2A catalytic + regulatory subunits 56,65 + EYA3 – Cryo EM
    • 9c6b – hPP2A catalytic + regulatory subunits 56,65 + retinoblastoma-like protein – Cryo-EM
    • 8so0, 8twe, 8twi – hPP2A catalytic + regulatory subunits 56,65 + Fam122A – Cryo EM
    • 8ttb – hPP2A catalytic + regulatory subunits 56,65 + CAMP-regulated phosphoprotein – Cryo EM
    • 9n0z – hPP2A catalytic + regulatory subunits 56,65 + B55I inhibitor – Cryo EM
    • 2iae, 3dws – hPP2A catalytic + regulatory subunits 56,65 + microcystin-LR
    • 3fga – hPP2A catalytic + regulatory subunits 56,65 + microcystin-LR + shugoshin
    • 4i5l, 4i5n – hPP2A catalytic + regulatory subunits 65,b” + MCLR
    • 3k7w – hPP2A catalytic + regulatory subunit 65 + toxin
    • 7cun, 7pks – hPP2A catalytic + regulatory subunit 65 + integrator complex – Cryo EM
    • 8uo5 – hPP2A catalytic + regulatory subunit 55 + IER5 – Cryo EM
    • 5w0w – mPP2A 65 regulatory subunit + catalytic subunit + TIPRL
    • 9j5n, 9j5r – AtPP2A 65 regulatory subunit + catalytic subunit + PSR2
  • Protein phosphatase 2C or pyruvate dehydrogenase phosphatase
    • 4ra2, 4raf, 4rag - hPP2C α (mutant) + Mn
    • 2iq1 – hPP2C κ <br /
    • 3mq3, 6v0t - bPP2C catalytic subunit + Mn
    • 2pnq - rPP2C catalytic subunit
    • 3d8k – PP2C – Toxoplasma gondii
    • 4la7, 4lg5, 4lga, 4lgb – AtPP2C 16 + abscisic acid receptor Pyl2 + ligand
    • 5vr7, 5vro, 5vs5, 5vsq, 5vsr, 5vt7 – AtPP2C 16 + abscisic acid receptor Pyl2 + quinolone derivative
    • 4ds8, 5jo1, 5jo2 – AtPP2C 16 + abscisic acid receptor Pyl3 + Mn
    • 3rt0 – AtPP2C 16 (mutant) + abscisic acid receptor Pyl10
    • 3ujg - AtPP2C 16 + SRK2E
    • 5mn0 – AtPP2C 16 + ABA receptor
    • 6zuc, 7avw – AtPP2C 16 + CSPYL1 + agonist
    • 3qn1, 3zvu, 4wvo – AtPP2C 16 + abscisic acid receptor Pyr1
    • 5or2, 5or6, 8ay3, 8ay6, 8ay7, 8ay8, 8ay9, 8aya, 9tb5, 9tb6, 9tb7, 9tb8, 9tb9, 9tbb, 9tbc – AtPP2C 16 + abscisic acid receptor Pyr1 + abscisic acid analog
    • 8ey0 – AtPP2C 16 + abscisic acid receptor Pyr1 + fungicide
    • 9h0h, 9h0i, 9h0j – AtPP2C 16 + abscisic acid receptor Pyr1 + agonist
    • 4n0g – AtPP2C 37 + abscisic acid receptor Pyl13
    • 3jrq, 3nmn – AtPP2C 56 + abscisic acid receptor Pyl1 + pyrabactin
    • 3kdj - AtPP2C 56 + abscisic acid receptor Pyl1 + abscicic acid
    • 4yzg – AtPP2C 57 (mutant)
    • 4yzh – AtPP2C 57 (mutant) + chlorophyll-binding protein peptide
    • 3ujk – AtPP2C 77
    • 3kb3, 3nmt, 3nmv, 3ujl – AtPP2C 77 + abscisic acid receptor Pyl2
    • 5zch – PP2C + abscisic acid receptor Pyl3 - rice
  • Protein phosphatase 4
    • 6r8i – PP4 regulatory subunit + peptide
    • 4wsf – DmPP4 regulatory subunit + Cenp-C – Drosophila melanogaster
  • Protein phosphatase 5 or Protein phosphatase T
    • 1wao – hPP5 + Mn
    • 5muf – hPP5
    • 1a17 – hPP5 protein-interacting domain
    • 2bug – hPP5 protein-interacting domain (mutant) + Hsp90 peptide - NMR
    • 1s95, 3h60 – hPP5 catalytic domain + Mn
    • 3h61, 3h62, 3h63, 3h64, 3h66, 3h67, 3h68, 3h69, 4zvz, 4zx2, 4zvz, 4zx2, 5ui1 – hPP5 catalytic domain + inhibitor + Mn
    • 5wg8 – hPP5 catalytic domain + cancer drug + Mn
    • 5hpe – hPP5 catalytic domain/Hsp90 peptide + Mn
    • 4ja7, 4ja9 - rPP5 catalytic domain + inhibitor
    • 3icf - yPP5 catalytic domain + Fe - yeast
    • 5jjt – AtPP5 + Ni
    • 7obe – AtPP5 + Mn
  • Protein phosphatase
    • 8jfw, 8jfy – DmPP rdgC + calmodulin – Cryo EM
    • 8zlw – DmPP rdgC + MBP + calmodulin – Cryo EM
    • 9tp5 – AtPP BSU1 kelch domain 1-357
    • 9tp7 – AtPP BSU1 421-793
    • 9tp8 – AtPP BSU1 421-793 (mutant)
    • 8pq7 – PP + RXLR effector protein – potato
    • 1g5b – PP + Mn – Enterobacteria phage λ
    • 2pk0 – PP + Mg – Streptococcus agalactiae
    • 2cm1 – PP + Mn – Mycobacterium tuberculosis
    • 3pu9 – PP + Mg – Sphaerobacter thermophilus
    • 5f1m – PP Stp1 + Mn – Staphylococcus aureus
    • 5jpe – CaPP Z1 + Mn – Candida albicans
    • 5jpf – CaPP Z1 + microcystin-LR + Mn

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Michal Harel, Joel L. Sussman

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