1a0p

Structural highlights

Function

XERD_ECOLI Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids at ColE1 xer (or cer) and pSC101 (or psi) sites. In the complex XerD specifically exchanges the bottom DNA strands (By similarity).^{[1] [2]}

Evolutionary Conservation

Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Resolvase 3D structures

References

1. ↑ Arciszewska LK, Sherratt DJ. Xer site-specific recombination in vitro. EMBO J. 1995 May 1;14(9):2112-20. PMID:7744017
2. ↑ Cornet F, Hallet B, Sherratt DJ. Xer recombination in Escherichia coli. Site-specific DNA topoisomerase activity of the XerC and XerD recombinases. J Biol Chem. 1997 Aug 29;272(35):21927-31. PMID:9268326