Structural highlights
Function
[ACTP_ACACA] Forms a one to one complex with monomeric actin. Can regulate the pool available for polymerization. Severs actin filaments in a dose-dependent manner.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Actophorin is a member of the actin-depolymerizing factor/cofilin family. It severs actin filaments and sequesters actin monomers. The crystal structure of actophorin will help to elucidate actin-ADF/cofilin interactions.
Crystal structure of the actin-binding protein actophorin from Acanthamoeba.,Leonard SA, Gittis AG, Petrella EC, Pollard TD, Lattman EE Nat Struct Biol. 1997 May;4(5):369-73. PMID:9145107[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Leonard SA, Gittis AG, Petrella EC, Pollard TD, Lattman EE. Crystal structure of the actin-binding protein actophorin from Acanthamoeba. Nat Struct Biol. 1997 May;4(5):369-73. PMID:9145107
