1bec

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BETA CHAIN OF A T CELL ANTIGEN RECEPTOR

Structural highlights

1bec is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of the extracellular portion of the beta chain of a murine T cell antigen receptor (TCR), determined at a resolution of 1.7 angstroms, shows structural homology to immunoglobulins. The structure of the first and second hypervariable loops suggested that, in general, they adopt more restricted sets of conformations in TCR beta chains than those found in immunoglobulins; the third hypervariable loop had certain structural characteristics in common with those of immunoglobulin heavy chain variable domains. The variable and constant domains were in close contact, presumably restricting the flexibility of the beta chain. This may facilitate signal transduction from the TCR to the associated CD3 molecules in the TCR-CD3 complex.

Crystal structure of the beta chain of a T cell antigen receptor.,Bentley GA, Boulot G, Karjalainen K, Mariuzza RA Science. 1995 Mar 31;267(5206):1984-7. PMID:7701320[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
57 reviews cite this structure
Ligand recognition by alpha beta T cell receptors.
Davis et al. (1998)
56 more
125 other articles
No citations found

See Also

References

  1. ↑ Bentley GA, Boulot G, Karjalainen K, Mariuzza RA. Crystal structure of the beta chain of a T cell antigen receptor. Science. 1995 Mar 31;267(5206):1984-7. PMID:7701320

Contents


PDB ID 1bec

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