1bqf
From Proteopedia
GROWTH-BLOCKING PEPTIDE (GBP) FROM PSEUDALETIA SEPARATA
Structural highlights
FunctionGBP_MYTSE Biogenic peptide that prevents the onset of metamorphosis from larva to pupa. Has repressive activity against juvenile hormone esterase. Induces cell proliferation at low concentrations and inhibits it at high concentrations. Mediates the spreading of plasmatocytes to foreign surfaces. May have a role in the regulation of dopamine concentrations.[1] [2] [3] Publication Abstract from PubMedGrowth-blocking peptide (GBP) is an insect growth factor consisting of 25 amino acid residues that retards the development of lepidopteran larvae at high concentration while it stimulates larval growth at low concentration. In this study, we determined the solution structure of GBP by two-dimensional 1H NMR spectroscopy. The structure contains a short segment of double-stranded beta-sheet involving residues 11-13 and 19-21 and a type-II beta-turn in the loop region (residues 8-11), whereas the N and C termini are disordered. This is the first report of the three-dimensional structure of the peptiderigic insect growth factor, and the structure of the well defined region of GBP was found to share similarity with that of the C-terminal domain of the epidermal growth factor (EGF). Because GBP has been reported to stimulate DNA synthesis of not only insect cells but also human keratinocyte cells at the same level with EGF, the structural similarity between GBP and EGF may lead to the interaction of GBP to EGF receptor. Solution structure of an insect growth factor, growth-blocking peptide.,Aizawa T, Fujitani N, Hayakawa Y, Ohnishi A, Ohkubo T, Kumaki Y, Kawano K, Hikichi K, Nitta K J Biol Chem. 1999 Jan 22;274(4):1887-90. PMID:9890941[4] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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Categories: Cotesia kariyai | Large Structures | Aizawa T | Fujitani N | Hayakawa Y | Hikichi K | Kwano K | Nitta K | Ohkubo T | Ohnishi A
