1bwm

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A SINGLE-CHAIN T CELL RECEPTOR

Structural highlights

1bwm is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR, 15 models
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q5R1G1_MOUSE

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Using NMR spectroscopy, we determined the solution structure of a single-chain T-cell receptor (scTCR) derived from the major histocompatibility complex (MHC) class II-restricted D10 TCR. The conformations of complementarity-determining regions (CDRs) 3beta and 1alpha and surface properties of 2alpha are different from those of related class I-restricted TCRs. We infer a conserved orientation for TCR V(alpha) domains in complexes with both class I and II MHC-peptide ligands, which implies that small structural variations in V(alpha) confer MHC class preference. High mobility of CDR3 residues relative to other CDR or framework residues (picosecond time scale) provides insight into immune recognition and selection mechanisms.

Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor.,Hare BJ, Wyss DF, Osburne MS, Kern PS, Reinherz EL, Wagner G Nat Struct Biol. 1999 Jun;6(6):574-81. PMID:10360364[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
15 reviews cite this structure
T cell antigen receptor recognition of antigen-presenting molecules.
Rossjohn et al. (2015)
14 more
43 other articles
No citations found

See Also

References

  1. ↑ Hare BJ, Wyss DF, Osburne MS, Kern PS, Reinherz EL, Wagner G. Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor. Nat Struct Biol. 1999 Jun;6(6):574-81. PMID:10360364 doi:10.1038/9359

Contents


PDB ID 1bwm

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