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Structural highlights

Function

3SA2_NAJOX This three-finger cytotoxin is a basic protein that interacts and penetrates into the cell membrane, with the tips of all the three loops. Cytotoxins which have a Pro-30 (P-type) interacts with membrane stronger that those which have a 'Ser-28' (S-type). CTII interacts with membrane stronger than CTI.^{[1] [2] [3]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Cardiotoxin 3D structures

References

1. ↑ Dubinnyi MA, Dubovskii PV, Utkin IuN, Simonova TN, Barsukov LI, Arsen'ev AS. [ESR study of the interaction of cytotoxin II with model membranes]. Bioorg Khim. 2001 Mar-Apr;27(2):102-13. PMID:11357394
2. ↑ Dubovskii PV, Lesovoy DM, Dubinnyi MA, Utkin YN, Arseniev AS. Interaction of the P-type cardiotoxin with phospholipid membranes. Eur J Biochem. 2003 May;270(9):2038-46. PMID:12709064
3. ↑ Dubovskii PV, Lesovoy DM, Dubinnyi MA, Konshina AG, Utkin YN, Efremov RG, Arseniev AS. Interaction of three-finger toxins with phospholipid membranes: comparison of S- and P-type cytotoxins. Biochem J. 2005 May 1;387(Pt 3):807-15. PMID:15584897 doi:10.1042/BJ20041814