1jdo

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SPERM WHALE MYOGLOBIN (FERROUS, NITRIC OXIDE BOUND)

Structural highlights

1jdo is a 1 chain structure with sequence from Physeter catodon. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:HEM, NO, SO4
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MYG_PHYMC Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The structure of the ferrous nitric oxide form of native sperm whale myoglobin has been determined by X-ray crystallography to 1.7 angstroms resolution. The nitric oxide ligand is bent with respect to the heme plane: the Fe-N-O angle is 112 degrees. This angle is smaller than those observed in model compounds and in lupin leghemoglobin. The exact angle appears to be influenced by the strength of the proximal bond and hydrogen bonding interactions between the distal histidine and the bound ligand. Specifically, the N(epsilon) atom of histidine64 is located 2.8 angstroms away from the nitrogen atom of the bound ligand, implying electrostatic stabilization of the FeNO complex. This interpretation is supported by mutagenesis studies. When histidine64 is replaced with apolar amino acids, the rate of nitric oxide dissociation from myoglobin increases tenfold.

Nitric oxide myoglobin: crystal structure and analysis of ligand geometry.,Brucker EA, Olson JS, Ikeda-Saito M, Phillips GN Jr Proteins. 1998 Mar 1;30(4):352-6. PMID:9533619[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
6 reviews cite this structure
Interactions of multiple gas-transducing systems: hallmarks and uncertainties of CO, NO, and H2S gas biology.
Kajimura et al. (2010)
5 more
30 other articles
No citations found

See Also

References

  1. ↑ Brucker EA, Olson JS, Ikeda-Saito M, Phillips GN Jr. Nitric oxide myoglobin: crystal structure and analysis of ligand geometry. Proteins. 1998 Mar 1;30(4):352-6. PMID:9533619

Contents


PDB ID 1jdo

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