1jeh

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CRYSTAL STRUCTURE OF YEAST E3, LIPOAMIDE DEHYDROGENASE

Structural highlights

1jeh is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:FAD
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DLDH_YEAST Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes. This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). Acts also as component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of eucaryotic lipoamide dehydrogenase from yeast has been determined by an X-ray analysis at 2.7 (partially at 2.4) A resolution. The enzyme has two identical subunits related by a pseudo twofold symmetry. The tertiary structure is similar to those of other procaryotic enzymes. The active site, consisting of FAD, Cys44, and Cys49 from one subunit and His457' from the other subunit, is highly conserved. This enzyme is directly bound to the core protein E2 of the 2-oxoglutarate dehydrogenase complex, whereas it is bound to the pyruvate dehydrogenase complex through a protein X. The calculated electrostatic potential suggests two characteristic regions for binding with these two proteins.

Crystal structure of eucaryotic E3, lipoamide dehydrogenase from yeast.,Toyoda T, Suzuki K, Sekiguchi T, Reed LJ, Takenaka A J Biochem. 1998 Apr;123(4):668-74. PMID:9538259[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
3 reviews cite this structure
The alpha-ketoglutarate dehydrogenase complex.
Sheu et al. (1999)
2 more
9 other articles
No citations found

See Also

References

  1. ↑ Toyoda T, Suzuki K, Sekiguchi T, Reed LJ, Takenaka A. Crystal structure of eucaryotic E3, lipoamide dehydrogenase from yeast. J Biochem. 1998 Apr;123(4):668-74. PMID:9538259

Contents


PDB ID 1jeh

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